Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Citrus sinensis
Species name
Sweet orange (Citrus sinensis) is a species of eudicot in the family Rutaceae (rue family).
Species info
Gene sequence info
Citrus_sinensis.CHS.fa
Download
>rna-XM_006464400.3
MSQINGSGSDGHHSASARRTPTPGKATVLAIGKAFPSQLIPQECLVEGYLRDTKCEDESIKEKLERLCKTTTVKTRYTVMSKAILDKYPELTTEGSATIKQRLEIANPAVVEMALEASLACIKEWGRPAEDITHIVYVSSSEIRLPGGDLYLSSKLGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAVIVGADPFLDKESSPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAGLQDFNDLFWAVHPGGPAILNRLESNLKLNNQKLECSRRALMDYGNVSSNTIFYVMDYMREELKRKGDEEWGLALAFGPGITFEGILLRGL
>rna-NM_001320057.1
MATVQEIRNAQRADGPATVLAIGTATPAHSVNQADYPDYYFRITKSEHMTELKEKFKRMCDKSMIKKRYMYLTEEILKENPNMCAYMAPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPADTHLDSLVGQALFGDGAAAVIVGADPDTSVERPLYQLVSTSQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLSEAFAPVGISDWNSIFWIAHPGGPAILDQVESKLGLKEEKLKATRQVLSEYGNMSSACVLFILDEMRKKSAEEAKATTGEGLDWGVLFGFGPGLTVETVVLHSVPIKA
>rna-XM_006472956.3
MGTTHIHIVPTAQTILPDSEDAIKGHFREVGPTVHLSKNLSPLIAENIDKFLAEAFDQVSLNDHDWNSLFWMMHPIGPAVLDQIEGKLGLEKTKLRETRHVLSEYGNMASPTASFVLDEMRKRSVEEGKATTGEELEWGVLLGFGAGPTVEATVLRSIPMVSN
>rna-XM_006472841.2
MASMGNIMESRQARGRGPAAILAIGTANPPNIFYQSDYPDFYFSVTKSEHLTHLKDKFKRMCEKSTIRKRHMYLTEDIIKENPNIGTPNAPSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
>rna-XM_006472682.3
MEKVKDGKNQQQGGGLATILAIGTANPPNCIYQADYPDYYFRVTNSDHMTLLKQKFKRICEKSNVKKRYFHVTEDILKKNPNICAYDGSSLDSRQDILVREVPKLGEEAATKAIKEWGQSKSQITHLIFCSLVGVDMPGADYQLTKMLGLNPSVKRVMLYFQGCYIGATAIRMAKDFAENNPGARVLVVCSDLSLGTFRGPSDANLGCLAGQALFGDGAAALIIGANPDTTLSEKPLFQIVSGAQTILPGSDSDVAGQFREMGLTVHLSKNVATVVSENIEKCLDEAFSPFGIKDWNSLFWIVQPGGPAIVNQIEAKLGLKQEKLSATRHVLSEYGNMGGVSVFFILDEIRRKSAEEGKVTTGEGLEWGVMFGIGAGVTVDTVLLRSFPFPTVTA
>rna-XM_006472843.2
MASMGNIMESRQARGRGPAAILAIGTANPPNIFYQSDYPDFYFSVTKSEHLTHLKDKFKRMCEKSTIRKRHMYLTEDIIKENPNIGTHNAPSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
>rna-XM_006472966.3
MESMAKVKIFLSAKRSKGPASILAIGTANPPTCFNQSDYPDFYFRVTDCEHKTELKDKFKRICDRSAVKKRYLHVTEEVLKENPSMRSYNAPSLDARQALLIEQVPKLGKEAAAKAIKEWGQPLSKITHLVFSAMAGVDIPGADLRLMNLLGLEPSVKRLMIYSQGCFIGGAAIRCAKDFAENNAGARVLVVFSDIMNMYFHEPQEAHLDVLVGHAVFGDGAAAVIVGADPEVSIERPLFHVVSSTQMSVPDTNKFIRAHVKEMGMELYLSKDVPATVGKNIEKLLVDAVSPFGISDWNSLFYSVHPGGRAILDQVELNLGLGKEKLRASRHVLSEYGNMGGSSVYFILDEIRKKSMQEAKATTGDGLEWGVLFAIGPGLTVETVILLSVPIDSAC
>rna-XM_006487414.3
MGTLEINEDTYTSQGPSAMILAIGTATPPNCFYQADYPDFFFRITNSEHKTELKEKFKRICDRSSIKKRYLYLTEDILKENPKMCCYKTPSLDARHAMLIDEVPKLGKEAALKAIKEWGQPVSKITHLIFSAFYGVDMPGADVRLMKLLGLEPSVNRLMIYTQGCYMGGTVLRLAKDIVENNPGARVLVVCSDIKVLDFHEPSETHLDILVVQAIFGDGAGAAIIGADPDISNGERPLFQLLSCTQTTVPDTENYIVGHLKEMGTDYYLSKDLPVTIGKHIDKLLADAMSPIGISDWNSLFYIVHPGGKGILDQVEKNLGLGKDKLWASRYVLSEFGNLGAPSVFFILDEVRKKSLEETKATSGEGLDCGVLFGFGPGLTVETVVLRSIPIDSTN
>rna-XM_006487453.3
MTTVKSNQGPTATILAIGTSTPPNCFYQADYPDFYFRVTNSDHKTELKEKFKRICERQSIKKRYFHLTEEILKENPNMCCYEAPSLDARQAMLIDEVPKLGKEAALKAIKEWGQPVSKITHLIFSAFYGVDMPGADVRLMRLLGLKPSVNRLMIYTQGCYMGGTVIRLAKDIAENNPGARVLVVCSDIRVLDFHEPSETHLDVLVVQAVFGDGAGAAIIGADSDISNHESPLFQILSCTQTTVPDTENYISGQLKEMGTYCHLSRDVPVAIGNYVDKCLSNAMSPIGISDWNSLFYVVHPGGDGLLDQVEKTLGLRKEKLWASRYVLREYGNMGAPSVFFILDEVRKKSIEEMKATTGEGLECGVLFGFGPGLTVETVVLQSVSTNFTNY
>rna-XM_006487413.2
MGTVKSNGDVHRSRGPSAKILAIGTATPPNCFYQADYPDFFFRVTNSEHKIELKEKFRRICERSSIRKRYFYLTEEILKENPNMSCYKAPSLDARHAMLIEEVPKLGKEAALKAIKEWGQPVSKITHLIFGAVYGVDMPGADVRLMNLLGLERSVNRLMIYSQGCYMGGAVIRHAKDIAENNPGARVLVVCCDITVLHFHEPTEARLDMLVGQAIFGDGAAAAIIGADPDVSLNERPLFQVLSCSQMTVPNTENNVVGHLKEMGWDYTLSKDLPVIIGKYIDKLLADAMSPIGISDWNSLFYIVHPGGKVILDQVEQNLGLGKEKLGASRYALSEYGNLGAPSVLFILDDVRKKSTEERKATTGEGLEYGVLFGFGPGITVETVVLRSIPIDSAN
>rna-XM_006487335.3
MGSLAGFAKKASPGKATVLALGKAFPHQLVMQEFLVDGYFKNTNCDDPELKQKLTRLCKTTTVKTRYVVMSDEILKKYPELAMEGLPTVKQRLDICNKAVTQMAIEASQACIKSWGRPITDITHVVYVSSSEARLPGGDLYLARGLGLSPETQRVMLYFMGCSGGVSGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSAERPYDLVGVALFGDGAGAMIVGSDPVPSERPLFELHTAIQNFLPNTEKTIDGRLTEEGISFKLARELPQIIEDNIEGFCGKLMGNIGFTNNDYNKMFWAVHPGGPAILNKLEKRLNLLPDKLNASRRALMDYGNASSNTIVYVLEYMLEESLKMKSQDHEDTDWGLILAFGPGITFEGILARNLTV
>rna-XM_006490293.3
MRCCQVPIAESSLPQTRSVAANHDLCFTTTTATMTFVRSGLTSILLSPVYYCCHCHYRWPCPYRFQFVATRKRYVHLTEEMMKQNPNISTYMASSPNKRQDIVPEEVPKPGAKVASAAIKEWGSAQIKDDTPCILYNLMCTDARRRLSANQPPRSLTVCDVIPSGLLLRRHCAEAREAESCQGHCYKQCRLLCACRLMRYHSSHHIPDKQFFNFFLNSPD
>rna-XM_006489733.2
MLTVDEVRKAQRAEGPATIMAIGTATPPNCVDQSTYPDYYFRITNSEHMTDLKEKFKRMCDKSMIKKRYMYLTEEILKENPNVCAYMAPSLDTRQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYRLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIIGADPIPEIEKPMFELVSTAQTILPDSDGSIDGHLREVGLTFHLLKDVPGLISKNIQKSLTEAFKPLGISDWNSIFWIAHPGGPTILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKKSAEDGLETAGEGLEWGVLFGFGPGLTVETVVLHSVAAA
>rna-XM_006495360.2
APSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
MSQINGSGSDGHHSASARRTPTPGKATVLAIGKAFPSQLIPQECLVEGYLRDTKCEDESIKEKLERLCKTTTVKTRYTVMSKAILDKYPELTTEGSATIKQRLEIANPAVVEMALEASLACIKEWGRPAEDITHIVYVSSSEIRLPGGDLYLSSKLGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAVIVGADPFLDKESSPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAGLQDFNDLFWAVHPGGPAILNRLESNLKLNNQKLECSRRALMDYGNVSSNTIFYVMDYMREELKRKGDEEWGLALAFGPGITFEGILLRGL
>rna-NM_001320057.1
MATVQEIRNAQRADGPATVLAIGTATPAHSVNQADYPDYYFRITKSEHMTELKEKFKRMCDKSMIKKRYMYLTEEILKENPNMCAYMAPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPADTHLDSLVGQALFGDGAAAVIVGADPDTSVERPLYQLVSTSQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLSEAFAPVGISDWNSIFWIAHPGGPAILDQVESKLGLKEEKLKATRQVLSEYGNMSSACVLFILDEMRKKSAEEAKATTGEGLDWGVLFGFGPGLTVETVVLHSVPIKA
>rna-XM_006472956.3
MGTTHIHIVPTAQTILPDSEDAIKGHFREVGPTVHLSKNLSPLIAENIDKFLAEAFDQVSLNDHDWNSLFWMMHPIGPAVLDQIEGKLGLEKTKLRETRHVLSEYGNMASPTASFVLDEMRKRSVEEGKATTGEELEWGVLLGFGAGPTVEATVLRSIPMVSN
>rna-XM_006472841.2
MASMGNIMESRQARGRGPAAILAIGTANPPNIFYQSDYPDFYFSVTKSEHLTHLKDKFKRMCEKSTIRKRHMYLTEDIIKENPNIGTPNAPSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
>rna-XM_006472682.3
MEKVKDGKNQQQGGGLATILAIGTANPPNCIYQADYPDYYFRVTNSDHMTLLKQKFKRICEKSNVKKRYFHVTEDILKKNPNICAYDGSSLDSRQDILVREVPKLGEEAATKAIKEWGQSKSQITHLIFCSLVGVDMPGADYQLTKMLGLNPSVKRVMLYFQGCYIGATAIRMAKDFAENNPGARVLVVCSDLSLGTFRGPSDANLGCLAGQALFGDGAAALIIGANPDTTLSEKPLFQIVSGAQTILPGSDSDVAGQFREMGLTVHLSKNVATVVSENIEKCLDEAFSPFGIKDWNSLFWIVQPGGPAIVNQIEAKLGLKQEKLSATRHVLSEYGNMGGVSVFFILDEIRRKSAEEGKVTTGEGLEWGVMFGIGAGVTVDTVLLRSFPFPTVTA
>rna-XM_006472843.2
MASMGNIMESRQARGRGPAAILAIGTANPPNIFYQSDYPDFYFSVTKSEHLTHLKDKFKRMCEKSTIRKRHMYLTEDIIKENPNIGTHNAPSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
>rna-XM_006472966.3
MESMAKVKIFLSAKRSKGPASILAIGTANPPTCFNQSDYPDFYFRVTDCEHKTELKDKFKRICDRSAVKKRYLHVTEEVLKENPSMRSYNAPSLDARQALLIEQVPKLGKEAAAKAIKEWGQPLSKITHLVFSAMAGVDIPGADLRLMNLLGLEPSVKRLMIYSQGCFIGGAAIRCAKDFAENNAGARVLVVFSDIMNMYFHEPQEAHLDVLVGHAVFGDGAAAVIVGADPEVSIERPLFHVVSSTQMSVPDTNKFIRAHVKEMGMELYLSKDVPATVGKNIEKLLVDAVSPFGISDWNSLFYSVHPGGRAILDQVELNLGLGKEKLRASRHVLSEYGNMGGSSVYFILDEIRKKSMQEAKATTGDGLEWGVLFAIGPGLTVETVILLSVPIDSAC
>rna-XM_006487414.3
MGTLEINEDTYTSQGPSAMILAIGTATPPNCFYQADYPDFFFRITNSEHKTELKEKFKRICDRSSIKKRYLYLTEDILKENPKMCCYKTPSLDARHAMLIDEVPKLGKEAALKAIKEWGQPVSKITHLIFSAFYGVDMPGADVRLMKLLGLEPSVNRLMIYTQGCYMGGTVLRLAKDIVENNPGARVLVVCSDIKVLDFHEPSETHLDILVVQAIFGDGAGAAIIGADPDISNGERPLFQLLSCTQTTVPDTENYIVGHLKEMGTDYYLSKDLPVTIGKHIDKLLADAMSPIGISDWNSLFYIVHPGGKGILDQVEKNLGLGKDKLWASRYVLSEFGNLGAPSVFFILDEVRKKSLEETKATSGEGLDCGVLFGFGPGLTVETVVLRSIPIDSTN
>rna-XM_006487453.3
MTTVKSNQGPTATILAIGTSTPPNCFYQADYPDFYFRVTNSDHKTELKEKFKRICERQSIKKRYFHLTEEILKENPNMCCYEAPSLDARQAMLIDEVPKLGKEAALKAIKEWGQPVSKITHLIFSAFYGVDMPGADVRLMRLLGLKPSVNRLMIYTQGCYMGGTVIRLAKDIAENNPGARVLVVCSDIRVLDFHEPSETHLDVLVVQAVFGDGAGAAIIGADSDISNHESPLFQILSCTQTTVPDTENYISGQLKEMGTYCHLSRDVPVAIGNYVDKCLSNAMSPIGISDWNSLFYVVHPGGDGLLDQVEKTLGLRKEKLWASRYVLREYGNMGAPSVFFILDEVRKKSIEEMKATTGEGLECGVLFGFGPGLTVETVVLQSVSTNFTNY
>rna-XM_006487413.2
MGTVKSNGDVHRSRGPSAKILAIGTATPPNCFYQADYPDFFFRVTNSEHKIELKEKFRRICERSSIRKRYFYLTEEILKENPNMSCYKAPSLDARHAMLIEEVPKLGKEAALKAIKEWGQPVSKITHLIFGAVYGVDMPGADVRLMNLLGLERSVNRLMIYSQGCYMGGAVIRHAKDIAENNPGARVLVVCCDITVLHFHEPTEARLDMLVGQAIFGDGAAAAIIGADPDVSLNERPLFQVLSCSQMTVPNTENNVVGHLKEMGWDYTLSKDLPVIIGKYIDKLLADAMSPIGISDWNSLFYIVHPGGKVILDQVEQNLGLGKEKLGASRYALSEYGNLGAPSVLFILDDVRKKSTEERKATTGEGLEYGVLFGFGPGITVETVVLRSIPIDSAN
>rna-XM_006487335.3
MGSLAGFAKKASPGKATVLALGKAFPHQLVMQEFLVDGYFKNTNCDDPELKQKLTRLCKTTTVKTRYVVMSDEILKKYPELAMEGLPTVKQRLDICNKAVTQMAIEASQACIKSWGRPITDITHVVYVSSSEARLPGGDLYLARGLGLSPETQRVMLYFMGCSGGVSGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSAERPYDLVGVALFGDGAGAMIVGSDPVPSERPLFELHTAIQNFLPNTEKTIDGRLTEEGISFKLARELPQIIEDNIEGFCGKLMGNIGFTNNDYNKMFWAVHPGGPAILNKLEKRLNLLPDKLNASRRALMDYGNASSNTIVYVLEYMLEESLKMKSQDHEDTDWGLILAFGPGITFEGILARNLTV
>rna-XM_006490293.3
MRCCQVPIAESSLPQTRSVAANHDLCFTTTTATMTFVRSGLTSILLSPVYYCCHCHYRWPCPYRFQFVATRKRYVHLTEEMMKQNPNISTYMASSPNKRQDIVPEEVPKPGAKVASAAIKEWGSAQIKDDTPCILYNLMCTDARRRLSANQPPRSLTVCDVIPSGLLLRRHCAEAREAESCQGHCYKQCRLLCACRLMRYHSSHHIPDKQFFNFFLNSPD
>rna-XM_006489733.2
MLTVDEVRKAQRAEGPATIMAIGTATPPNCVDQSTYPDYYFRITNSEHMTDLKEKFKRMCDKSMIKKRYMYLTEEILKENPNVCAYMAPSLDTRQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYRLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIIGADPIPEIEKPMFELVSTAQTILPDSDGSIDGHLREVGLTFHLLKDVPGLISKNIQKSLTEAFKPLGISDWNSIFWIAHPGGPTILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKKSAEDGLETAGEGLEWGVLFGFGPGLTVETVVLHSVAAA
>rna-XM_006495360.2
APSFNTRQEILVDEVPKLGKEAALKAIKEWGQPLSKITHLIFCTSSGIDMPSADHKVAKLIGLQPSVQRFMIYQQGCFSGGTALRLAKDLAENNVGARVLIVCSELMVVCFHAPSDTYMDVLVGSTIFSDGAAAAIVGADPDTDTSTERPLFQLVSTAQTMIPDSDNAIVGRIREVGMQYYLSKGVPKVIGDNIVQCCIETFAPFGIGDWNSLFYVVHPGGPSVLRVVEEKLGLSKEKLRASKHVLSEYGNMWSPSVLFILDEMRNKSMDERKATTGEGLQWGVLFGFGPGLTIETIVLQSVAIH
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University