Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Citrus sinensis
Species name
Sweet orange (Citrus sinensis) is a species of eudicot in the family Rutaceae (rue family).
Species info
Gene sequence info
Citrus_sinensis.4CL.fa
Download
>rna-XM_006474105.3
MEAKQDHQEFIFRSKLPDIYIPNHLPLHTYCFENISQFADRPCIINGPTGDVYTYADVELTSRKFAAGLSKLGVQKGDVIMLLLQNCPQFVFAFLGASYIGATSTTANPFYTPAEIAKQAIASKAKIIITQAVYNDKVRDLSEHHGARIVTIDPPPENCLHFSELITQADENEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYLHKEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMQKFEIVKLMELVQKYKVTVAPFVPPIVLAVAKSGDVDKYDMSSIRTVMSGAAPMGKELEDAVRAKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVHPDTGISLPRNQAGEICIRGAQIMKGYLNDREATETTIDKEGWLHTGDIGYIDDEDELFIVDRLKELIKFKGFQVAPAELEAMLIAHPNISDAAVVPMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKRINRVFFTDSIPKAPSGKILRKDLRTKLAAGDLRN
>rna-XM_006478851.2
MISIATKKPELSLDISSPAPPAPSNEKIATHIFKSKLPDIPISNHLPLHTYCFQDRLSDDPCLIVGLTGKTYSYAETHLICRKTAAGLSNLGIKKGDVIMILLQNCAEFVFSFMGASMIGAVTTTANPFYTSAEILKQFRTSGAKLIITMSQYVDRLPKTDKDFTVITIDAPPENCLHFTVLSEADEDQIPEVAIEPDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLTNGDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGALLELIQRHRVSVAAVVPPLVLALAKNPMVADYDLSSIRVVLSGAAPLGKELEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPEIGASLPHNQPGEICIRGPQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKEIIKFKGFQVPPAEIEALLLSHPSIGDAAVVPQKDEVAGEVPVAFVVRSNGFELTEEAIKEYIAKQVVFYKRLHKIYFVHAIPKSPSGKILRKDLRAKLASSMPLN
>rna-XM_006484281.2
MAMPNSFSVPVPLAAAHDEEHIFRSRHPAVPVLENVTLPDFVLQDAELYADKVAFVEAVSGKAYTYAQVARDTRRFAKALRSLGLRKGQVVIVVLPNVAEYGIVALGIMAAGGVFSGANPTAHASELKKQVDAADAKLIVSYAPIYEKVKGLGLPIIVLGEERIESAINWSELLEAADKAGNNFSNDDDVKQTDLCALPFSSGTTGISKGVMLTHRNLVANLCSTLFSVVPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVMMNRFELRAFLDALITHEVTFAPIVPPIILSLVKDPIVDEFDLSKLQLRAVMTAAAPLAPDLLSSFEKKFPGVQVQEAYGLTEHSCITLTYGDPANPSAGSKKNSVGFILPNLEVKFINPETGKSLPSNTPGELCVRSQCVMQGYYNNEEETARTIDKNGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVSLPDEEAGEIPAACVVMNPNAKESEDDIMDFVASNVATYKKVRVLHFVDGIPKSHSGKIMRRILKDKMLEKMRK
>rna-XM_006487969.3
MEKSGYGRDGIYRSLRPPLVLPSEPNLSMVHFLFRNSASYPSKPALIDADSGESLTFSQLKSTVIKASHGFRHLGITKNDVVMIFAPNSIQFPVCFLGVIATGAIATTANPVYSVSELSKQVIDSNPKLIVTVPELWDKVKDFNLPAVLLGSKSKLASCGLSSSSKIVHFHDLIELSGNISNFPDVSIKQTDTAALLYSSGTTGVSKGVILTHKNFIASSLMVTMDQETAGELDYVFLCVLPLFHVFGLAVITCGQLQKGNCIILMAKFDLEMFLRAIEKFRVTHIWVVPPLILALAKHGLVKKFDLSSLKLVGSGAAPLGKELMEECAKNVPSATVIQGYGLTETSGIATMENSFAGSRNIGSAGALAPGVEALIVSVDTQKPLPPNQLGEIWLRGPNMMRGYYNNEQATKLTIDKKGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPLAYVVRSPNSSLTEEDVQKFIAKQVAPFKRLRRVTFINSVPKSASGKILRRELIAKVRAKM
>rna-XM_025102387.1
MTETCGVVTVENPLLGVQNSGSAGRLVAGVEAQIVCVDTLKPLPPNQVGELWVRGPILMPGYFNNEQATKLIIDKEGWLHTGDLGYFDEHGQLFIVDRIKELIKCNGFQGNTNDPHDFYY
>rna-XM_006487966.3
MEKSGYGRDGIYRSLRPPLVLPSDPSFSMVHFLFRNSASYSSKLALIDADSDESLSFSQFKSIVIKVSHSFRHLGITKKDVVLIFAPNSIQFPICFLGVIAIGAIASTANTVYTVSELSKQVKDSNPKLVITVPELWDKVKGLNLPAVLLGSKDKVSSSGLISRSSKIVSFHDLIELSGSVTDIPDVSVKQTDAAALLYSSGTTGVSKGVILTHKNFVAASLMISAHQELAGELDHVVLCVLPMFHVFGLSVILYDQLQKGNCVVSMGKFDIEMALRAIEKYRVTVWWVVPPIILALAKNSLVRKFDISSLKLVGSGAAPLGKELMEDCQKNIPGATIFQGYGMTETCAPISLENPLVGVRRSGSAGTLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNVTPGYFKNEQATKQTIDERGWLHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDPESGEVPIAYVVRSPNSSLTAEDVQKFVAEQVSPYKRLRKVTFINSVPKSASGKILRRELIAKVRSKI
>rna-XM_025102386.1
MEKSGYGRDGIYRSLRPALVLPQDPNLSMVHFLFRNSASYGSKSALIDADSGESLTFSQFKSIVIKVSHGFRHLGVTKHDVVLIFAPNSIQFPICLLGVIAIGGIATTANPVYTVSELSKQVKDSSPKLVVTVPELWERVKDFNIPAVLLGSNHIVSPRGLRSSSNIVYFDELIELSGNASNFPDVSVKQTDTAALLYSSGTTGVGKGAILTHKNFIASSLMTAMDQELAGALDYVTLCVLPMFHVFGLSFVVYAQLQKGNCVVSMRKFDLETALRAIEKYRVTHWWVVPPIILALAKNVSLVKKFDLSSLKGIGSGAAPLRKELVEECSKNLPTVTVFQVQLITVHLIFLI
>rna-XM_006494749.3
MFIKKASVRNHFHHTNFLVSSMETQAQTQTQTKQQEEIIFRSKLPDIYIPKHLPLHSYCFENISKVASRPCLINGSTGDVYTYGEVEQTARKIASGLNKLGIGQRDVIMLLLPNVPEFVLSFLGASYLGAIATAANPFFTPAETCKQAKASGAKLIITKACYVDKVKDLEEVKIMCIDSPPDGCLHFSELTQADEKDLPHVEILPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFTKEDAILCVLPLFHIYALNSIMLCGLRAGAAILIMQKFEINSLLQLIERYKVTVAPVVPPIVLAIAKSPETEKYDLSSIRILKSGAAPLGKELEDAVRIKLPNAILGQGYGMTEAGPVLAMCLSFAKEPFEIKAGACGTVVRNAEMKIVDPETGASLPTNKPGEICIRGDQIMTGYLNDPEATKSTIDKEGWLHTGDIGYIDDNDELFIVDRLKELIKYKGFQVAPAELEALLLSHSSITDAAVVPMKDDAAGEVPVAFVVKSNDSQITEDEIKQFISKQVVFYKRINRVFFIDAIPKAPSGKILRKELRAKLAADYQN
MEAKQDHQEFIFRSKLPDIYIPNHLPLHTYCFENISQFADRPCIINGPTGDVYTYADVELTSRKFAAGLSKLGVQKGDVIMLLLQNCPQFVFAFLGASYIGATSTTANPFYTPAEIAKQAIASKAKIIITQAVYNDKVRDLSEHHGARIVTIDPPPENCLHFSELITQADENEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYLHKEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMQKFEIVKLMELVQKYKVTVAPFVPPIVLAVAKSGDVDKYDMSSIRTVMSGAAPMGKELEDAVRAKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVHPDTGISLPRNQAGEICIRGAQIMKGYLNDREATETTIDKEGWLHTGDIGYIDDEDELFIVDRLKELIKFKGFQVAPAELEAMLIAHPNISDAAVVPMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKRINRVFFTDSIPKAPSGKILRKDLRTKLAAGDLRN
>rna-XM_006478851.2
MISIATKKPELSLDISSPAPPAPSNEKIATHIFKSKLPDIPISNHLPLHTYCFQDRLSDDPCLIVGLTGKTYSYAETHLICRKTAAGLSNLGIKKGDVIMILLQNCAEFVFSFMGASMIGAVTTTANPFYTSAEILKQFRTSGAKLIITMSQYVDRLPKTDKDFTVITIDAPPENCLHFTVLSEADEDQIPEVAIEPDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLTNGDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGALLELIQRHRVSVAAVVPPLVLALAKNPMVADYDLSSIRVVLSGAAPLGKELEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPEIGASLPHNQPGEICIRGPQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKEIIKFKGFQVPPAEIEALLLSHPSIGDAAVVPQKDEVAGEVPVAFVVRSNGFELTEEAIKEYIAKQVVFYKRLHKIYFVHAIPKSPSGKILRKDLRAKLASSMPLN
>rna-XM_006484281.2
MAMPNSFSVPVPLAAAHDEEHIFRSRHPAVPVLENVTLPDFVLQDAELYADKVAFVEAVSGKAYTYAQVARDTRRFAKALRSLGLRKGQVVIVVLPNVAEYGIVALGIMAAGGVFSGANPTAHASELKKQVDAADAKLIVSYAPIYEKVKGLGLPIIVLGEERIESAINWSELLEAADKAGNNFSNDDDVKQTDLCALPFSSGTTGISKGVMLTHRNLVANLCSTLFSVVPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVMMNRFELRAFLDALITHEVTFAPIVPPIILSLVKDPIVDEFDLSKLQLRAVMTAAAPLAPDLLSSFEKKFPGVQVQEAYGLTEHSCITLTYGDPANPSAGSKKNSVGFILPNLEVKFINPETGKSLPSNTPGELCVRSQCVMQGYYNNEEETARTIDKNGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVSLPDEEAGEIPAACVVMNPNAKESEDDIMDFVASNVATYKKVRVLHFVDGIPKSHSGKIMRRILKDKMLEKMRK
>rna-XM_006487969.3
MEKSGYGRDGIYRSLRPPLVLPSEPNLSMVHFLFRNSASYPSKPALIDADSGESLTFSQLKSTVIKASHGFRHLGITKNDVVMIFAPNSIQFPVCFLGVIATGAIATTANPVYSVSELSKQVIDSNPKLIVTVPELWDKVKDFNLPAVLLGSKSKLASCGLSSSSKIVHFHDLIELSGNISNFPDVSIKQTDTAALLYSSGTTGVSKGVILTHKNFIASSLMVTMDQETAGELDYVFLCVLPLFHVFGLAVITCGQLQKGNCIILMAKFDLEMFLRAIEKFRVTHIWVVPPLILALAKHGLVKKFDLSSLKLVGSGAAPLGKELMEECAKNVPSATVIQGYGLTETSGIATMENSFAGSRNIGSAGALAPGVEALIVSVDTQKPLPPNQLGEIWLRGPNMMRGYYNNEQATKLTIDKKGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPLAYVVRSPNSSLTEEDVQKFIAKQVAPFKRLRRVTFINSVPKSASGKILRRELIAKVRAKM
>rna-XM_025102387.1
MTETCGVVTVENPLLGVQNSGSAGRLVAGVEAQIVCVDTLKPLPPNQVGELWVRGPILMPGYFNNEQATKLIIDKEGWLHTGDLGYFDEHGQLFIVDRIKELIKCNGFQGNTNDPHDFYY
>rna-XM_006487966.3
MEKSGYGRDGIYRSLRPPLVLPSDPSFSMVHFLFRNSASYSSKLALIDADSDESLSFSQFKSIVIKVSHSFRHLGITKKDVVLIFAPNSIQFPICFLGVIAIGAIASTANTVYTVSELSKQVKDSNPKLVITVPELWDKVKGLNLPAVLLGSKDKVSSSGLISRSSKIVSFHDLIELSGSVTDIPDVSVKQTDAAALLYSSGTTGVSKGVILTHKNFVAASLMISAHQELAGELDHVVLCVLPMFHVFGLSVILYDQLQKGNCVVSMGKFDIEMALRAIEKYRVTVWWVVPPIILALAKNSLVRKFDISSLKLVGSGAAPLGKELMEDCQKNIPGATIFQGYGMTETCAPISLENPLVGVRRSGSAGTLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNVTPGYFKNEQATKQTIDERGWLHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDPESGEVPIAYVVRSPNSSLTAEDVQKFVAEQVSPYKRLRKVTFINSVPKSASGKILRRELIAKVRSKI
>rna-XM_025102386.1
MEKSGYGRDGIYRSLRPALVLPQDPNLSMVHFLFRNSASYGSKSALIDADSGESLTFSQFKSIVIKVSHGFRHLGVTKHDVVLIFAPNSIQFPICLLGVIAIGGIATTANPVYTVSELSKQVKDSSPKLVVTVPELWERVKDFNIPAVLLGSNHIVSPRGLRSSSNIVYFDELIELSGNASNFPDVSVKQTDTAALLYSSGTTGVGKGAILTHKNFIASSLMTAMDQELAGALDYVTLCVLPMFHVFGLSFVVYAQLQKGNCVVSMRKFDLETALRAIEKYRVTHWWVVPPIILALAKNVSLVKKFDLSSLKGIGSGAAPLRKELVEECSKNLPTVTVFQVQLITVHLIFLI
>rna-XM_006494749.3
MFIKKASVRNHFHHTNFLVSSMETQAQTQTQTKQQEEIIFRSKLPDIYIPKHLPLHSYCFENISKVASRPCLINGSTGDVYTYGEVEQTARKIASGLNKLGIGQRDVIMLLLPNVPEFVLSFLGASYLGAIATAANPFFTPAETCKQAKASGAKLIITKACYVDKVKDLEEVKIMCIDSPPDGCLHFSELTQADEKDLPHVEILPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFTKEDAILCVLPLFHIYALNSIMLCGLRAGAAILIMQKFEINSLLQLIERYKVTVAPVVPPIVLAIAKSPETEKYDLSSIRILKSGAAPLGKELEDAVRIKLPNAILGQGYGMTEAGPVLAMCLSFAKEPFEIKAGACGTVVRNAEMKIVDPETGASLPTNKPGEICIRGDQIMTGYLNDPEATKSTIDKEGWLHTGDIGYIDDNDELFIVDRLKELIKYKGFQVAPAELEALLLSHSSITDAAVVPMKDDAAGEVPVAFVVKSNDSQITEDEIKQFISKQVVFYKRINRVFFIDAIPKAPSGKILRKELRAKLAADYQN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University