Enzyme

Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.

COMT

Enzyme

Flavone 3'-O-methyltransferase

Enzyme name

EC:2.1.1.76

Entry

Transferases;Transferring one-carbon groups;Methyltransferases

Class

S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase

Sysname

S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]

Reaction

S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]

Product

Species information

Catharanthus roseu

Species name

Species info

Gene sequence info

Catharanthus_roseu.COMT.fa

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>CRO_T023084
MQLLFSRALPMVLNTVIKLNVFEIIAREGPNAQLSPFQIRVYGLGTVSKYFVKNENGSSLGAAVLDGGILFERAHRMPIYKYAGLDQKFNETFNVSMLHQIKMVVANIIENYKGFENLKTLVDVGDGAGIALSVITSKFPNIKGINYDLPHVILHAPKYPGVEHIGALPENGNLIVVDAIIPMNPDNRSSTKHTAQVDMFILLNQQLGVKERTKQEFFTLATKAGFKGIQKKCVFFDLWVMEFNK
>CRO_T016238
MTNEEEEEACLSAMRLASASVLPRVLKLAIELDLLELIKKSGTGAYVSPSELAAQLPTQNLEAPVMLDRILRLLACYSVLNCTLKDLPDGGVESLYGLAPVCKFFTKNEDGVSMAALLLMNQDKVLMESCYHLKDAAYGMSAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYLIIKGINFDLPHVIEDAPSYSGVDHIGGPKGDAIFFKVHYYYYFTSLSLLFVPSLLISDSVNGFFLLALDCHDWSDEDRLKLLKNCHEALPENGKKPQTTLSTQNTVQVDVIMLAYNPGGKEGTENEFEALAKAADFRGFTKVCCPYNTWIMEFLK
>CRO_T031219
MDSSHTNQTKREVNINEEEEQHFSYAMQLVTTGSLPMVLLAAIRLDVFEIIAEAGPSAQLSPSEIATRLSLKNPDASLMLDRMLRLLATHSVLTCAGAAGEGEGAIPRVYGLSPVSKYFVRNPEGASLGALLALLQDKVFTDSWYELEDSVREGGIPFNRVHGTHAFEYPGRDPRFNEVFNKAMIDHTTIVINRILEIYKGFDEHLIRSLVDVGGGLGITLNMITMKYPNIKGINFDLPHVIQHAPAYPGVEHVGGDMFQRVPKGDAIFMKWILHDWDDNHCLKLLKNCHDALSDGGKVIVVDALLPAKPGEDDADTINSSAYGKATCQVDLIMMTQNPGGKERSKEEFVALAAAAGFRSINIEFFVCNLWIMEFYK
>CRO_T002029
MEAEFQINLIRVLLFIYLWQWVLHDWGDDHCVTILKNYYEALPENGKLIVIELVVPETPNGDTISKSGYQFNINMLSVNTGGKERTEKEFEHLATQSGFASIKLICRADCDWIIEFYKN
>CRO_T013254
MVFNSVVKLNVLKIIARAGTDAKLSPSQTVSQMPMLASYSVVTSYVVDPCRGFGQSQRVYGLGPVAKYFVNNENGASRGPLLDLLQDKVLNDIWNKLELILKGVQHSIGPTTCIYSNTEINIKFNYKFNATMIHHTKLVVQRILKSYEGFENLKTLVDVDGGLDIVLRVITCKHSNLKGINYDLSSFRNKSYSRIATRLPLPVNGKVIAVDAILPLNPHNSLSNKHTTQVDLFILASYHPGGKERTEQEFLALAIEAGFKEIRKVCVCYDSWVMEFYKRN
>CRO_T004788
MDNHLVLFLTFVNINSPMYGLAATFNKTFNVSILQHTKVILAKIVENYKGFENLKPFVDVSCGACITLSVITSEFPTLNGGHYDLLWVEYAPTYPNMTGTHWRWNTLEMICLRRSLFEIVEELLLKKGNLTVVDAILPMNPDNSSYTKEKTRVDLLLLLNQQSGGKERIEPEFLTVATKAGFEGIRKK
>CRO_T013593
MVLNYVIKLNVLKIIARANTGALSPSQTVSQMPMLASYSVVTSYVVDPSRGSVNGKVIAVDAFLPLNPDNSPSTEHTTQVDLFTLASYHSGGKERTEHEFLALAIEAGFKEIRKACVCYDSWLMEFYKRN
>CRO_T015775
MGLIFASFLVVQYFELPCGNAVSCLFPYYSARIYEGKKTTEPINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSVSGDINPAINFHNRDEEQEDPIDQSWLLDLSENSTVNETKSTNCSLENGRNVSDHSKWPGKFVLGANDELNTTEGNDKSRLRHCDSGILGRNSPANKGISKGKVVSISAMNNMLIQSHDLSLSNSMEEQCYSARDQELLHARSSIQEAPIYKTNPALYAPIYWNVSRFQRSYELMEQTLKVYIYREGKRPVFHQPNLKGIYASEGWFMKLMESSKQYITTNPKEAHLFYLPFSSQMLEQTVYVPNSHSFDKLKQYLGNYLDLIKTKYSFWNRTNGADHFLVACHDWAPEETRRLMANCIRALCNADMIEGFQLGKDVSLPETFVQTARFSPKEFRGKPPSGRQFLAFFAGNMHGYVRPILLKYWENKDPDMKIFGRMNKGSYINHMKSSKYCICARGYEVNSPRLVEAIMYGCVPVIISDNFVPPFLEVLNWEKFAVFVLEKDIPNLKNILVSISERRYLVMQRRVKMIRQHFVWHPVPEKYDIFHMILHSIWYNRYFELPYGNVFLSLLSAGKTKFASAGNFTIGNSSSSFQIRNSSDSRNLTFSDSLNFSNPSAVDYMADVSELSDGNNSNKKEADDNSDNADPEDESPSKDLEPNHKHIMGNVGINDTLAPEKARVYDYNAPTPAVAATPHITVAPTSGEDEIYNSSMSNSSASAQPLDLSPPLASPVGVRKNSGTSNLFNPNATSVNRDATKAVEKSKNSGLQMSDVSPLFNYTLAKEFPKMKESSLGPPGVAVSISEMNDKLLHSLALRHPVRPQWTSGADQELLHVKSLIENAPNSQDDLDLHAPLFRNISMFKRSYELMEQTLKVYIYKEGERPIYHTPVLKGIYASEGWFMKLIKRSKQFVTKNPKNAHLFYLPFSSRMLEETLYVPNYDSRDNLIQNLSDYLNVIIRRYQFWNRTGGSDHFLVACHDWAPEETRGIMANCIRALCNADVKEGFVFGKDVSLPETNVRSPQNPLKLLGGKPPSQRKILAFFAGRMHGYLRPILLKYWENDRDMKILGKMPRVKGQMNYVQHMQSSKYCICAKGYEVNSPRVVEAIFFECVPVIISDNLVPPYFETLNWESFAVFIMEKDIPNLKNILLSIPAKKYLQMQRRVKLVQRHFLWNPKPVKYDIFHMILHSIWFTRGVAVSISEMNDKLLHSLALPHSVRPRWTSRADQELLHVKSLIENAPNAQDDPNLHAPLFRNISMFKRSYELMAQTLKVYIYKEGARPIYHTPVLKGIYASEGWFMKLMKTSKQFVTKNPKSAHLFYLPFSSRLLEETLYVPNSHSRDNLIQNLSDYLNVIMRRYQFWNRTGGSDHFLVACHDWAPSETRRIMANCIRALCNADVKEGFVFGKDASLPETNVRSPQNPLKQVGGKPASKRKILAFFAGRMHGYLRPILLKYWENKDPDIKIFSKMPKVKGQMSYIQHMQSSKYCICAKGYEVNSPRVVEAIFYECIPVIISDNFVPPFFETLNWESFAVFIMEKDIPNLKNILLSIPKKKYIQMQRRVKLVQKHFLWNPKPVKYDIFHMILHSIWLNRPPKWYSNADQELLYAKSRILNAMTVNNAAGLQAPIYRNVSMFQRSYELMEKMLKVYIYKDGERPIFHDSILEGIYASEGWFIKLMESNKQYVTDDPAKAHLFFLPFSSRLLQLTLYKRHSHSRDNLIKYMKDYVEMLAQKYPFWNRTEGEDHFLAACHDWAPTETRGLLKNSLRALCNADIRVGFDIGKDVSLPTTYVRSSQKPLKDIGGEPPSQRHILAFFAGYMHGYVRPVLLDHWGKDPDMRIFDRMPHVKGDKNYIEHMKSSKYCICARGYAVNSPRVMESILYECVPVIISDNYVPPLFEVLNWESFAVFISEKDIPKLKSILLSISMEKYIEMQKRVKQVKEHFVWHADPVEYDLFHMILHSVWYNRVFRIKPP
>CRO_T028476
MVLNSVIKLNVLKIIARGGTAGGALTMVLNSVIKLNRWHWCSTIPSQTVSQMPMLASYSVVTSYVVDPSRGSGQSQRMYGLGPLAKYFVNNENGASLGHLLDLLQDKNLQFLKGVQHSIGLMTCIYSNIEINNKFNDKFNITMIHHTKLVVQCIHKSYQEFETLKTLVDVDSGLDIVLRVIACKHSNLKVINYDLSHVIEHTPSYSRRTIHFHWILHDWDDSHYLKLLKDCYKASFTSKVIAVDAILPLNPDNSPSTKHTTQVDLFTLASYHPGGKEQTEQEFLALAIEAGFKEIRKACICYDSWFMEFYKRN
>CRO_T024576
MDFQSVEFLKLGIADAIDNHNKKAFTLSKFTKELSIKPSKSSFLPRLMRQLVNNEQWNFRGIVLTMLDPAELKAWSVLNDWFQNDDPIAFQTAHEKNHWDYTVENTQHCPIFEDAMANDSVLVSKLLFLFEGLTSLIDLGGSTGTIAKAIAKSFPKSKCTVFDLPHVVANLKSTENLEFVGGDMFEKLPPTNAILLKWILHDWNDEDCVKILKNCKKAIQEKGNGGKVIIVDTIVYSQKKKSKELVDLQISMDMAMLINFTNILYCILA
>CRO_T030387
MVVANIIENYKGFENLKTLVDVGGGAGVALSVITSKFPNIKGINYDLPHVIEHAPKYPGVEHIGGDMFVSVPEGDAIFMKTVLHNWDDDHCLRLLKNXYKALPXXGNLIVVDAIIPMNPDNSSSTKHIAQVDMFMLLNQQPGAKERTEQEFFTLATKAGFKRIQRKCVFFDLWVMEFNK
>CRO_T016033
MGSHEAKTSSFSTEEENDNSSYAMQLLFSGALPMVYGLGTVSKYFVKNENGSSLGPFLDLLQHKLTNEAWYELGAAVLYGGIPFERAHQMPIYKYAGRDQKFNETFNVSMLHQTKMVLAKIIENYQGFENLKTLVDVGVGASVALSVITCKFPNIKGINYDLPHVTEHAPKYSGVKHIGGDMFVSVPEGDVIFMKNTSLQFLPNEKVQRKLLKNCYKALPESGNLIVVDAIIPMNPDNSSSTKHTT
>CRO_T017895
MSSLVQDETTNIISNEKEDFLRVMQLSSGLILPMILKTVIELDLFELMAKAGPNAQLSAIEISSLLPTKNPEAPVMLDRILKFLASFSFLNCNVIADEQGGAKTLYSLAPICKKFLPDEDGISLASLLMLPVDKAHFDSWYHLKDAILEGGIPFIRAHGADAFEQPIKDTRFFDVFNKALHNHACMVMKRLLEVYKGFEEVKELVDVGGGHGGTLSCIVAKYPNIRAINYDIPQVVECAAPRSGVEFVRGNMFESIPKGEVMMMKWVLHDWDDDHCVTILKNCYEALPENGKLIVIELVLPETPNGDTISKIGYQFDINMLSVNTGGKERTEKEFEHLATQAGFASIKLICRADCDWVIEFYKN
>CRO_T020559
MSSANPDNKKSMTNEEEEEEACLSAMRLASASVLPMVLKSAIELDLLELIKKSGPGAYVSPSELAAQLPTQNPDAPVMLDRILRLLASYSVLNCTLKDLPDGGIERLYSLAPVCKFLTKNEDGVSMAALLLMNQDKVLMESWYHLKDAVLEGGIPFNKAYGMSAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVDHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCHEALPENGKVILAECVLPEAPDSTLSTQNTVHVDVIMLAHNPGGKERTEKQFDALAKAAGFRGFNKVCCAYNSWIMELLK
>CRO_T013053
MSYNKDDIGNVDNDMVQVSHVRKIKKDAYYMTSSDGPGLIITMVKLKENDKDNNYEEWAKIMQLALHSKKNWDLSMEQFPFXKTIQTKRKNXEKSRLWNKLEPAVLEVLEGGSTTFNRAPDINIFKYTGTNDKLKINSIQRCYITPRVEHSSRDMFEMPFLXSYPRIATRLSLRVNGKVIAVDTILPLNPDNSSSTKHMTQVXIFTXASYHXGGKEXTEQEYLALAIEVIRKVCVGYDSWVMEFYK
>CRO_T016527
MGSQQKDQIIHISNKEEEDFLRVMQLPSGVVLSMMGFLLLPCRSFLWIKYNLSLGTYHLKDAILEGGIPFNRAHGMHAFEYPAKDSRFNELFNKGMYNHTCIAMKRLVQVYNGFEGVKQVVDVGGGFGATLGCIISKYPNIHAINFDLPHVIQNAPPRPGVEFVGGDMFESVPKGEVILMKWILHDWSDEHCVKLLKNCYKALPETSKVIVVETVLPETPEDGNIISKIGFQTDLCMMSINPGGKERTLKEFELVAKQAGFTSIQPICRAYSDWREQIIHISNKEEEDFLRVMQLPSGIVLPMVLKAAIELDLFQIMAKSGPNAQLSAAEIASNLPTKNPEAPVMLDRMMRFLANSSFLGCSVVTDEDGSSKRLYNLASICKNFLPNEDGVSLAPLYHLKDAILEGGIPFNRAHGMHAFEYPAKDSRFNEVFNKGMYNHTCIAMERLVQVYNGFEGVKQIVDVGGGFGATLGCIISKYPNIHAINFDLPHVIENAPPRPGVEFIGGDMFESVPKGEVILMKWILHDWSDEHCVKLLKNCYKALPETSKVIVVESILPETPEDGHILAKIGFQSDMSMMSINPGGKERTHKEFELVAKQAGFTSIQPICRAYSDWVIEFYKN
>CRO_T017236
MGSANPDNKNSMTKEEEEACLSAMRLASASVLPMVLKSAIELDLLELIKKSGPGAYVSPSELAAQLPTQNPDAPVMLDRILRLLASYSVLNCTLKDLPDGGIERLYSLAPVCKFLTKNEDGVSMAALLLMNQDKVLMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVDHVGGDMFVSVPKGDAIFMKWICHDWSDAHCLKFLKNCHEALPENGKVILAECLLPEAPDSTLSTQNTVHVDVIMLAHNPGGKERTEKEFEALAKGAGFRGFIKVCCAYNSWIMELLK
>CRO_T032965
MGSHEVKTSSLSREEEENDNSSYALQLLFSGALPMVLNTVIKLNVFEIIAREGPNAQLSPSQIVSQIPNNKNPQAPEMLDRMLRMLASYSIFTCSVVDSNKRVYGLGTVSKMKMDHHLILFLTCFNINSPTKHGNKISLLLLSILYELGAAVLEGGIPFERAHGMPIYKYAGLDQKFNEIFNTSMLHHTKVVVAKIVENYKGFENIKTLVDVGGGTGMALSVITSKFPNLKGINYDLPHVIEHALIYPGVEHIGGDMFESVPEGDAIFMKTVLHNWDDDHCLVLLKNCYKSLPENGNLIVVDAVLPMNPDSSSSTKHTTQVDMFMLLNQQPGAKERTEQEFLTLATKVGFKGIRKKYVSFDLWVMEFYK
>CRO_T009495
MSSHEEKPSSNKEDDDYSSYALQLVFSGALPMVLNAVIKLNVFEIIAKAGPGAKLSPSQIVSQMPTKNPEAPVVLDRMLRMLASYSVLTCSVVDFSHGSGQRVYGLSPVSKYFVKNENGGCFGPLLDLLQDKVLTDIWYELAPAVLEGGTAFNRAYNMHIFKYTGINQKFNETFNTATINHAKVIVQEILKNYKGFENLKTLVDVGGGLGVTLDLITSKYPNLKGINYDLPHVTQNAPTYPGVVHVGGDMFESVPKGDAIFMKWILHDWDDEHCLKLLKNCYKALPENGKVIAVDAILPMNPDNSSSTKHISQVDLFTLVLYHPGGKERTENEFLALVAEAGFGGIRKVCVCCDLWVMEFYK
>CRO_T022020
MVSYNKPQSLRSAVQLGIPDAIHQHGKPMKLSDLVSSIQIILLKHHPLMRIPATVSSKIQPHHRDDDNRKEELAYPHIRRSHCYAFLPSRYALEIRLLMNYLIGLWLNIHKFFLSLWNNIFEGLTSLVDVGDGSGALAKTIAGKFPDLVCIIVYPPHVVAGLEMEENLEF

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University