Enzyme

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

HIDH

Enzyme

2-hydroxyisoflavanone dehydratase

Enzyme name

EC:4.2.1.105

Entry

Lyases;Carbon-oxygen lyases;Hydro-lyases

Class

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Sysname

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction

daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]

Product

Species information

Catharanthus roseu

Species name

Species info

Gene sequence info

Catharanthus_roseu.HIDH.fa

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>CRO_T026549
MVCTIKEVSSELLPFLQVYKDGSVERFLDSPFVPPCLNDKVTGVSSKDITISPDVTARIYLPQDYNYNKKFPILVYFHGGGFCIDSAFSFLCHRYLNILVCRAKVIAISVEYRRAPENPLPIAYEDSWVALQWIAKQSIEKSEPWFAHYANFDRCFLGGDSAGANIAHHLAIRAGSEGREGSMKIYGVIMSHPYFLGTEPIGAESANVDRDKSIFYQTWKFVYPNAEGGFDNPLINPFSTEAPSLSRLGCSRLLVCVSEKDELRERGVKYFDEVKKSGWRGKMELFEVEGEEHCFHIFNLESQNAKILIKRFASFLNPNCTEFENEVINLEKRVYLTMKYSYKI
>CRO_T031164
MASQTPTSDETLFDLSPYIRIFKDGRVERLHNTPYVPPSLSDPETGVSWKDIPISSKVSARIYLPKISDQQENEEKLPIFVYFHGAGFCLESAFRSFFHTFIKHFVSEAKAIGVSVEYRLAPEHPLPAAYEDCWEALQWVASHVRLDNSSLKRSMDKDPWIINYGDFDRLYLGGDSPGGNIVHNVLLRAGKEKLNGGVKILGAIQYYPYFLIRTSSKQSDYMENDYRCYWKLAYPNAPGGTDNPMINPTVENAPDLAGYGCSRLLISMVADETRDITLLFIEALKKSGWKGQLDVADFEAEFFDLFQTQTEVGKNMIRRLTSFIK
>CRO_T027137
MSANPEPIDPNVNPYGYMGFVKNPDGSLTRLPPILPETPASDDPANPFHLSKDITINQSNNTWVRLFVPRKSFQSDPGSKLPILIYFHGGGFVVASPASTVFYNIYNGISTQIPAIVVAGKYRLAPEHRLPAAYEDSMEVLHW
>CRO_T014354
MASPSSNEIITDISPYIRVYKDGTVERMFSSPFVPPSREDPITGVSSKDINISSDVSARLYLPKITDLSHDEKLPILVYFHGGAFCLESAYSFLDHRYLNLLVSQAKVIAISVEYRLAPECPLPVCYNDSWTALQWVASHVEKNSNTDDKLDPWILNYANFNKLYIGGDSAGANIVHNLAIGAGDERLKGNLKIFGAFLSFPYFWGSKAENIRGLTEEKSYPYRLWLFVYPSVPGGIDNPLINPLIDDAPNLSGLDCQKLLVCVGEKDELREMGIHYVEELKKSDWKGEVDLVDVEGEGHCFHIFDTETEKAKNLITRLASFMRG
>CRO_T024379
MDSTSSNQVLHDFSPVFRIYKDGRIERFNLSPFVPASEDPSSTAGGGGVRSKDVVVSPENNVSVRLFLPQSVDKDLKLPVLIYIHGGAFAVGSAFASAYHSYVSSLVEESNILAVSIEYRLAPENPIPACFEDCLQVLNWVASDPPEPWINEHADLSKVFVAGDSAGATLTHYTVARASVELEEKVKIAGMILVHPFFGCGNQVDGLWETLCADETGPEDPRLNPMADSDALTKLRCGGVLVCTAEKDFLRNRGVMYVEGLKKSGWGGEIETVETEGEGHVFHLWNPNCEKAKLLRNRVVAFIKSKL
>CRO_T028209
MASNANEGVTDLSPLLKVYKDGTVERLFGSPFVPPSPEDSPTGVSSKDVQISSNVSARLYLPKMLDGSVEKLHILIYFHGGGFCTESAFSLFFHRFLLEILNYFGFYKRLFASNIIFLCALNFLTISKPLVAESKVIAVSVEYRRHLEHLLPAAYEDSWAALNWVADKKDPWLLNHGDSKKFYLGGDSAGGNIVHNILIIRAGDEKLLSYLKIEGSFMTFPLFWGSKFEKSTKRDDRSLAYILRLIFSSFHN
>CRO_T011344
MASSDETIFDLPPYIRSRKTPFFPLCFPSLNDPETGVSWKDVPISSQVSVRIYLPKITDHEKGEKLPILVYVHGAGFCLESAFKSFFHTYVKHFVTEAKAIVVSVEFRLAPEHHLPSAYEDCWEALQWVASHVGLDTSSLKTSIDKDPWIINYGDFERLYLWGDSTGANIVHNILIRAGKEKLKGGVKILGAILYYPYFLIRTSSKQSDYMENEYRSYWKLAYPNAPGGNDNLMINPTAENGPDLRGYGCSRLLVSMVADEARDITLLYIDALERSGWKGELDVADFEGDYFEIFSPDTELGKNKLRRSTSFIR
>CRO_T019099
KDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINAVYIEALEKSGWKGELEVADFDADYFELFTLETEMGKNMFRRLASFIKHE
>CRO_T021217
MNSSTDPISDETIWDLSPYIKXFKDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINA
>CRO_T011212
MGSSDETIFDLPPYIKVFKDGRVERLHSSPYVPPSLNDPETGGVSWKDVPISSVVSARIYLPKINNHDEKLPIIVYFHGAGFCLESAFKSFFHTYVKHFVAEAKAIAVSVEFRLAPENHLPAAYEDCWEALQWVASHVGLDISSLKTCIDKDPWIINYADFDRLYLWGDSTGANIVHNTLIRSGKEKLNGGKVKILGAILYYPYFLIRTSSKQSDYMENEYRSYWKLAYPDAPGGNDNPMINPTAENAPDLAGYGCSRLLISMVADEARDITLLYIDALEKSGWKGELDVADFDKQYFELFEMETEVAKNMLRRLASFIKIILILIKYDNNNNVKCLFLSISKFMGITVIVYVLG
>CRO_T006777
MATSSTEIVHDFFPLIRVYKDGRIERMRDRQIAPASVDQETGVKSKDVEISKEFNVSARLYLPNNSKPGEKLPLLVYFHGGAFVIESAFSPEYQKHLNLLVNEANVMIVSVDYRLAPEFPLPCAYEDSWLALQWIASHSIGEGSDQWLKDYADFNRVYFGGDSAGGNIAHNMAIKVEMEKLEGINLLGFFLNCPYFWGKDPIGDEMVKTDIKKFLDNLWLFLHPNTTGLNDPLINPVVDPNLYKLEGKKVLIFVAEKDILKHRGLYYKEALEKIGNVEFVEFEGEEHVFNLASPQCENALLMVKKLAVFLNQNGDKL
>CRO_T006778
MDSALSVDDQAVTLDFFPYFRMYKDGRVERFFDSPIVPASNDHQSTGAAVRSKDVVISPENKVSARLFLPNSVEKDEKLPILIYFHGGAFAIESAFSSQYHSYVSSVVVEAKILAVSVEYRLAPENPLPACYEDAWAALNWVISHAKNRHLGPDPWITDHADFSRIFVAGDSAGGNIAHDTVARASTEGIEDGVKILGMILAHPYFGSGEIEKIWEVICSDSKGPEDPRLNPMAHPDLLLKLKCSKVLIFIAEKDFIRERGQIYYEALKNSGWSGELGIIESEGEEHCFHLKRLDSDNARILMERLVNFINK
>CRO_T019055
MDARSQFLDLSPGPEGVAFEFLPFIRAYKDGHVERFFGTDIVPPSIQEEESQFCISSKDVQILPQINLSARIFLPSKIINESQKNNSKLPLLIYFHGGAFCLGSPFCTVYHNYLTSIVKEANVIAISVDYRLAPENLIPAAYEDAWAVLNWVSTHSNGSGPESWLNHYADLQRVFLAGDSAGGNISANTVAQLGVESLPGLNVMGLCLIHPDFASKNGEVYKSWTFACPDSSGGDDPRMNPGKDSRVSNLGCKRVLVFVAGEDPMKERGVYYYETLKKSGWNGEVEMIETKGEGHVFHLFNPTCHNALTMLHQLASFLNYQL
>CRO_T009072
MLEELKPPSSNSDSSSSAELIENCFGYLKLYSDGTIFRSTEIKHKSTIQENPAVIWNDFLFDPLHNLHLRIYKPKKDPKSPNHKQLPILFYFHAGGFCFGERFYPNPHNSSLSLCSGLQSVVISPDYRLAPENRLPAAIEDGFTAIKWLRDSDCQTLTWLSDVEIDFDRVFVFGDSSGGNIAHHLAVRLGRGSPELKPIRVRGYILLSPFFGGVLRTKREEEKPHENFWSQDIYDQLWRLSIPHGANVDHPLVNPFGASSPSLEGLRLDPFLVMVGGDEVMRDRVEDYAMKMKASNHQVQYVEPKKIIKNNPNSPNHHKSIPIIFCFHATGFCIGERSYPNQHNSSLTLCSDLQAIIISPDHRLAPENRLPAAIEDGFTAMKWLRDQVSSSDCDAWLSDVEIDFDRLFVFGDSSGGNIAHHLAVRLGRGSPELKPIRVRGYILLSPFFGGILRTKREEEKPYEDFWSQEIYEQYLQKVSNQPHEILSNWLWKLSIPHGANLDHPLVNPFGPSSPSIEGLRLDPFLVMVGGDEVMRDRVEDYAMKMKASNHEVQYVEFEGKQHGFFASNSYLEESKDLIQLVKDFIAQIY
>CRO_T020093
MASSDEIAIDISPDIILYKSGKVVRDFVRPYVPPSLEDPTTGVSTKDVPISAEVSARIYLPKLDTDAQKFPILVYFHGGGFCLVSAFDSLYSTYLKSLASEAKTIIISVEFRLAPENPLPVGYEDCWTALQWVASHAVDNSLSCIDREPWLIHHGNLDKVYIGGDSTGGNMVHNILMKSGREKLNGDLKISGGILSYPYFLISSWAKKSDEELSDMVKMYKKYWLLSCPSAPGGFDNPMVNPVVEDAPSLAGIGCWRLLVIMAIDDLREAHLSYVEGLKKSGWKGELELADFEGYDHFFEIFNPTTQRAKNIIHRIASFIK
>CRO_T021730
MASQTPTSDETLFDLSPYIRIFKDGRVERLHNTPYVPPSLSDPETGVSWKDIPISSKVSARIYLPKISDQQENEEKLPIFVYFHGAGFCLESAFRSFFHTFIKHFVSEAKAIGVSVEYRLAPEHPLPAAYEDCWEALQWVASHVRLDNSSLKRSMDKDPWIINYGDFDRLYLGGDSPGGNIVHNVLLRAGKEKLNGGVKILGAIQYYPYFLIRTSSKQSDYMENDYRCYWKLAYPNAPGGTDNPMINPTVENAPDLAGYGCSRLLISMVADETRDITLLFIEALKKSGWKGQLDVADFEAEFFDLFQTQTEVGKNMIRRLTSFIK
>CRO_T027160
MNSSTDPTSDETIWDLSPYIKIFKDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINAVYIEALEKSGWKGELEVADFDADYFELFTLETEMG
>CRO_T022886
MGLDNSSLKNTCIDKDPWIIKYGDFDRLYLWGDSTGANIVHNTLIISGKEKLKGGVKILGAILYYPYFLIRTSSKQSDYMENEYRCYWKLAYPDAPGRNDNRMINPTAENAPDLAGYGCSRLLISMVADEARDISAIH
>CRO_T007630
MASMTLDHPNLSLQISKEHQKSRVLIEEIDGLIRVYKDGYVERSHILPSVSCTVAPELCLTSRDVVIDKYTNIWVRCYIPKGQGSNKFPLLVYFHGGGFCVGSASWICYHEFLTKLSSKLNCLIMSVNYRLAPENRLPAQYDDGFKAILWLKEQALTRANEWFSSKCNFSNIFLAGDSAGANIAYNLAARLAGHEALNLKPLDFKGTILIQPFFGGESRTQSEKNTANSTKSALTLAASDTYWRLSLPIGTNRDHPWCNPTSKYGASLKDLNLFPTLVCISEMDILKDRNLEFCSALVSGGKKVEHFVYKGVGHAFQILNKSQLSQVRTEELICHIKNFISR
>CRO_T021243
MSDVRIPGVVKAVDAAASPPYEVDECRGVLRVYSDGSIVRSTKPIVPVSMNDDGSVLWKDVIFDAAHNLQLRLYKPASPTSAKLPIFYFIHGGGFCIGSRTWPSFQNYCFKLALELQAVVVSPDYRLAPENRLPAAIEDGFKAVKWLQGQGVTEEPDRWLTDVGDFRRVFICGDSAGGNIAHNLAVKLGAGSPELAPVQIKGYVLLEPFFSGTDLSRSETEGPKDTFLNLELIERFWRLAIADGNTKDDPLINPFGPLSPNMESMDIDPILVVVGGSDLLRDRVQDYAKRLKNWGKKVKYVEFEGQQHCFFTLINPNSLHSMELMKLIKTFIAENSA
>CRO_T010665
MSDFRIPGVLKPLDAAATPPYEVDECRGVLRVYSDGSIVRSSNPSFIVPVNDDGSVLWKDVIFDATHNLQLRLYKPASTPTRAKLPIFYYIHGGGFCIGSRSWPNCQNYCFKLALELEAVIISPDYRLAPENRLPAAIEDGYMAVKWLQSQAVAEEPDRWLTDVADFSRVFISGDSAGGNIAHNIAVKLGAGSAEVEPVKVKGYILLAPFFGGRVVSRSEAEGPKDAFLNLELIQRFWRLSIPEGETTDHPLINPFGPLSPNMETVDIHPILVVVGASDLLKDRAQDYANTLKNWGKKVEYVEFQGQQHGFFTIQPNSDPSIQLMKLIKTFIAANSA
>CRO_T010666
MDSAASTWQQSEVVERCGSLWIYGIGSIMSYSNKPIYSIFVNDDGSVLWKDLLFNATHNLYLRLYKPASSSSSAKLLPILYFIHGGGFCYGSRTWPHYQNYCFKLALELQAVIISPDYRLAPKHRLPAAITDCFMALEWLHSHVLSEEPDTWLTDVADFNNVFITGDSAGGNIAHHLAMKLGAGSPQLAPVQVR
>CRO_T007838
MDSEQPQVEIDYEFLPLIRVYKNGRVERLLGTESIPAGPDPKTGVLSKDVHNIISETEVYVRIYLPSNLKNGSQKLPLLVYFHGGGFCLSTPSSPNYHNYLNAIVSEAQIIAVSVHYRRAPEHRLPVAYEDSWAALHWIVSHRNGDGPEPWLNNHSDFGRLFMAGDSSGANIAHNLAMAIGKPDLGFELDVIGIALIHPYFWGSVPIGSESIDPDRKATVDRLWPFVCPNRADQDDPWVNPVAEDAPSLEGLGCKRVIVCVAEKDILKDRGWVYYQVLGRSGWTGVVEIHQTDGEDHAFHLYTLESEKAKNLIRKLADFFNRDMPPWLR
>CRO_T007837
MGSCSGPEIIHDVPPYIRVYKDGTVERLVATETAPPGFDPQTGVTSKDVLINPTTGLTARLYRPNLPATNNQRLPLVIYFHGGAFCIATAAEPKYHNIVNILVAEAKVIGISVNYRLVPEHPLPAAYEDSWEVIKWAVAGSDEWIRDDVDFGKLFLAGDSAGANISHHMAIRIGKSNPPEIGIQLKGILMIHPYFWGEKPVGIEIKDPFRKSMVDNWWKFVCPSNKGCDDPLINPFVNGLNCLENLACDRIIIFVAENDILSERGRIYYESLVNVRHWKGKAEIVETQGEDHIFHVFNPTTEKARHLIKRSALFLNQD
>CRO_T007834
MVSSLSDELQFEFPPLVRVYKNGHVDRLLGTESIPAGSDPQTGVLSKDVSNIIPGTEVYVRIYIPSNINESNKRIPVLVYFHGGGFCLFTPSSPEYHNYINTLVNEAQIIAVSVHYRRAPEHRLPVAFDDSLIALEWIISHRTSNGPDAWLNNHADFGRVFLAGDSSGANIAHNVAMTVGKPDLRFGADILGIALVHPYFWGSVRTGSELVHLDRVELEGKWWPFVCPSRPNDDDPWINPIADGAPSLKGLGCKKVLVCVAEKDMMKDRGMLYYKALDRSGWKGTVEIEETQGEDHAFHLYNVQSEKAKELMKRLVAFFNSLNASLKYHTIELLVDETTTVWNAESGFLYALCFQSAKSSQAAGISIYWGQNGNEGSLADTCATGNYQFVKIAFLVTFGNYQPPVLNLAGHCEPSANTCTGLSNEIRACQTQNIKVLLSLGGGAGSYTLTSADDAKQVANYLWNNFLGGQSDSRPLGDAILDGIDFDIETGSGMYWDELARALSGFSSQRKVYLSAAPQCPIPDANLNTAISTGLFDYVWIQFYNNPPCQYTSNADNLIAAWKQWTSVPSNQIFLGLPAAPDAAPSGGYIPPDVLISQVLPSIKTSSKYGGVMLWSKFYDQGYSSAIKSSI
>CRO_T022701
MSMIIAEVPGFLQVFSDGSLKRFHPELAKASNETYSNGYKSKDVTIDSSKSITGRMFLPDAPESVGKIPVLVYFHGGGFCIGSTTWLGYHAFLGDLSVISKTIILSVDYRLAPENKLPIAYEDCYTSLEWLGKNRDSELWLQRADLSRVFLSGDSAGGNIVHQVTIRAIKTEIRNVRIKGLLPIHPYFGSETRTELEMANGSEEAVSTNDMFWKLSLPEGESRDYYGCNFENAQLSADEWKNQFPQVVVFIAGLDFLKERGFMYADFLKKKGVGKVNLIEAKDESHVYHVFHPESEATNLLQKQISDFIQNL
>CRO_T020110
MASRNSSEIITEMSPYIRVYKDGTVERMIGSPFVLPSSEDPITAVSSKDINISYVLARLYLPKITDPLEEKLPILIYFHGGGFFLESAFSFLNHRYLNLLVSQAKVLAISVEYRLAPEHPLPVCYNDSMTALQWVAAHVVENSINTDKLDPCLLNHGNFNKLYMGGDSAGANIVHNLAIRAGIETLPGDVKITERNRRKEEQSDQYRIWLFVYPSVPGGIDNPMINPLSEDAPSLTGLACQKLFVCGGERWAQADGKVVDLIDVEGEGHCFQIVDTNKEKSKNLISHIESFIRDENSEVLLLSVSEVVVR
>CRO_T010892
MCDLRIPAAAKVVATAQTSPYEVDEDRGILRVYSVGSIALSDKPIYTIILNDDGSVLWKDVHFNDTHNLHLRLYKPASASPTSAKLPIFYYIHGGGFCVGSRTWATFQNYCFKLALELQAVIISPDYRLAPEHRLPPAIEDSFMALKWLHNQAVDTKEASDPWLTDVADFSRVFVSGDSSGGNMAHHLVVKFGAGSPELAPVQVKGYLLLEPFFGGTVLTRSEAEGSKDAFLNLEAIEWN
>CRO_T014520
DETLFDLSPYIRIFKDGRVERLHNTPYVPPSLSDPETGVSWKDIPISSKVSARIYLPKISDQQENEEKLPIFVYFHGAGFCLESAFRSFFHTFIKHFVSEAKAIGVSVEYRLAPEHPLPAAYEDCWEALQWVASHVRLDNSSLKRSMDKDPWIINYGDFDRLYLGGDSPGGNIVHNVLLRAGKEKLNGGVKILGAIQYYPYFLIRTSSKQSDYMENDYRCYWKLAYPNAPGGTDNPMINPTVENAPDLAGYGCSRLLISMVADETRDITLLFIEALKKSGWKGQLDVADFEAEFFDLFQTQTEVGKNMIRRLTSFIK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University