Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Catharanthus roseu
Species name
Species info
Gene sequence info
Catharanthus_roseu.CHS.fa
Download
>CRO_T030250
MAQISTITTVSSRRAPTPGKATLLSIGKAFPSQLVPQEHLVEGYIRDTKCDDIIIKEKLERLCKTTTVKTRYTVMSKEILEKYPELATEGSPTIKQRLEIANPAVVKMAKEASLACIKEWGRPVEEITHIVYVSSSEIRLPGGDLYLASELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAIIIGADPIVGKEFPFMELNFAVQQFLPGTNDVIDGRLSEEGINFRLGRDLPQKIEENIEEFCKKLMSKADNLKEYNDLFWAVHPGGPAILNRLESILKLKHEKLDCSRRALMDFGNVSSNTIFYVMEYMREELKKNKEEDSEEWGLALAFGPGITFEGILMRRKRKTGYTGGLAEKFGRLTPLIKTSAILHPSLHSGPLFLTANFFHRLPSSISASSSTISYQGYRLLSSLLTKIIAEHAVRDSDGREMETFVSAETRPLLGNDASSSGSTFSISETSSAALDAPPVHDGTSRASAGNSFQNSHSHTNSSNSNQSGISLFQGLIDRVRKTVRGSADDIGWMQRDPHMPPVEDGTEKFVEILDDIRHGLHRLPSSMVYLLVPGAHHDMSRGEMLQPSLFSNHGPLYFTATKTSFSKMGLTCHIAKIHSEASVEKNAREIKDYIEEIYWGSRKRVLLLGHSKGGIDAAAALSMYWMDLKDKVAGLALAQSPYGGSPIASDILREGQLGDYVNIRKLMEILICKVIKGDMQALEDLTYDKRKDFLRKYHLPQELPVVSFHTEASISPAVLATLSRVAHAELPMFSTGQATTLPVVMPLGAVMAACAQLLQIRYGEKSDGLVTCRDAEVPGSVVVRPKRKLDHAWMVYSSLNDDPSEADASQVCEALLALVVEVGHKKRHQLANKDE
>CRO_T004269
MACIQKIWRAQRAEGPASIMAIGTSVPVNCVPQSTFPDYYFRVTNAEHLTELKEKFRRICKGSTIKKRYMYLNEEILKQHPNLCSFMAHSLDARQDMAMKEVPKLGKDAAEKAIEEWGQPKSTITHLIFCTSTGSELPGADYRLTRLLDLNPSIKRIMLYQLGCYGGGEALRVAKDMAENNKGARVLVVCSEISSVGMLCHPNNTNSNPIVANALFGDGAGACIVGSDPINGCEKPLFELISASQTIIPNSECAIESFISEVGISLRILRDIPELISSRAENILREVFQPLGIYDWNSIFWVVHPGGRAIFDQIEKKLALDPERLNVSRHVLSEYGNPLGASIFFVLDEMRNYSAKNGFCTTGEGLEWGVLFAFGPGLTCETIVLHSIPN
>CRO_T014717
MIKKRYMHLTEEILQENPNICAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQSKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIVGSDPIPEIERPLFELVSTAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIGKALDEAFQPLGISDWNSIFWIAHPGGPAILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASARDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSLNV
>CRO_T018966
MDITEFRRAQRAEGPATIMAIGTATPPNCMDQSTYPDYYFRITNSEKSMIKKRYMYLTEEILKGNPNLCGYMEPSLNARQDMMVVEVPRLGKEAAQKAIREWGQPKSKITHLIFCTTSGIDIPGADYQLTKLLGLRPSVNRFMIYQQGCFAGGTALRLAKDLAENTKGARILIVCSEITAFTFRGPSLTHVDTLVGQALFADGAAAAIVGSDPIQDIEKPLFQIISASQTLIREGHGAIDGHVREAGLLIHLLKDIPGIISNNIETALDEAFQPFGISDWNSIFWIVHPGGPAILDQVEEKLALKPEKLRSTRHILSEYGNMSSACVLFILDEMRMSSLKDGLSTTGEGFEWGILFGLGPGLTVEKVVLRSTSI
>CRO_T011441
MAATVVSIRRAQRAEGPASIMAIGTAVPVNCVTQNTFPDYFFRVTNAEHLTELKEKFRRMCKGSLIKKRYMHMSEQILKENPNLSTYMAPSLGVRQKILLAELPKLGKEAAEKAIKEWGQSKSKITHLIFCTTFGGELPGADHCLTGLLDLNPSIKRIMLYQLGCYGGNAALRAAKDLAENNKGARILVVCSEIPSIAMFGHPDNSNIDTVLGHALYGDGAGACIVGSDPIIGFERPIFELAFADQTIIPDTDGAIESSIIEVGTRLHLEKGIPELISNNIENLLKDAFKPLGIFNWNSIFWVAHLGGSAIFDQVEKKLGLQPEKLYVSKYVLSEYGNPLGASTFFILDEMRRYSAKNGFNYSGEGLEWGVLFGFGPGLTCETMVLRSVSI
>CRO_T022112
MAGPKNEKPRKATILALGKAFPHQLVMQEFLVDGYFKNTNCDDPLLKQKLTRLCKTTTVKTRYVVMSEEILSKYPELATEGLPTVKQRLDICNSAVTQMAIEASQSCIKNWGRSISDITHLVYVSSSEVRLPGGDLYLAKGLGLSPETQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSAERPYDLVGAALFGDGAGAMIIGINPIPGSENPLFELHTSIQHFLPETEKIIDGRLTEEGISFKLARELPQIIEDNIEGFCSKLMKNSGFCEKDYNKLFWAVHPGGPAILNRIEKKFELSPEKLIASRRALADYGNVSSNTIVYVLEYMLEESKKKASKEENDDEWGLVLAFGPGITFEGILARNLTI
MAQISTITTVSSRRAPTPGKATLLSIGKAFPSQLVPQEHLVEGYIRDTKCDDIIIKEKLERLCKTTTVKTRYTVMSKEILEKYPELATEGSPTIKQRLEIANPAVVKMAKEASLACIKEWGRPVEEITHIVYVSSSEIRLPGGDLYLASELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAIIIGADPIVGKEFPFMELNFAVQQFLPGTNDVIDGRLSEEGINFRLGRDLPQKIEENIEEFCKKLMSKADNLKEYNDLFWAVHPGGPAILNRLESILKLKHEKLDCSRRALMDFGNVSSNTIFYVMEYMREELKKNKEEDSEEWGLALAFGPGITFEGILMRRKRKTGYTGGLAEKFGRLTPLIKTSAILHPSLHSGPLFLTANFFHRLPSSISASSSTISYQGYRLLSSLLTKIIAEHAVRDSDGREMETFVSAETRPLLGNDASSSGSTFSISETSSAALDAPPVHDGTSRASAGNSFQNSHSHTNSSNSNQSGISLFQGLIDRVRKTVRGSADDIGWMQRDPHMPPVEDGTEKFVEILDDIRHGLHRLPSSMVYLLVPGAHHDMSRGEMLQPSLFSNHGPLYFTATKTSFSKMGLTCHIAKIHSEASVEKNAREIKDYIEEIYWGSRKRVLLLGHSKGGIDAAAALSMYWMDLKDKVAGLALAQSPYGGSPIASDILREGQLGDYVNIRKLMEILICKVIKGDMQALEDLTYDKRKDFLRKYHLPQELPVVSFHTEASISPAVLATLSRVAHAELPMFSTGQATTLPVVMPLGAVMAACAQLLQIRYGEKSDGLVTCRDAEVPGSVVVRPKRKLDHAWMVYSSLNDDPSEADASQVCEALLALVVEVGHKKRHQLANKDE
>CRO_T004269
MACIQKIWRAQRAEGPASIMAIGTSVPVNCVPQSTFPDYYFRVTNAEHLTELKEKFRRICKGSTIKKRYMYLNEEILKQHPNLCSFMAHSLDARQDMAMKEVPKLGKDAAEKAIEEWGQPKSTITHLIFCTSTGSELPGADYRLTRLLDLNPSIKRIMLYQLGCYGGGEALRVAKDMAENNKGARVLVVCSEISSVGMLCHPNNTNSNPIVANALFGDGAGACIVGSDPINGCEKPLFELISASQTIIPNSECAIESFISEVGISLRILRDIPELISSRAENILREVFQPLGIYDWNSIFWVVHPGGRAIFDQIEKKLALDPERLNVSRHVLSEYGNPLGASIFFVLDEMRNYSAKNGFCTTGEGLEWGVLFAFGPGLTCETIVLHSIPN
>CRO_T014717
MIKKRYMHLTEEILQENPNICAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQSKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIVGSDPIPEIERPLFELVSTAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIGKALDEAFQPLGISDWNSIFWIAHPGGPAILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASARDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSLNV
>CRO_T018966
MDITEFRRAQRAEGPATIMAIGTATPPNCMDQSTYPDYYFRITNSEKSMIKKRYMYLTEEILKGNPNLCGYMEPSLNARQDMMVVEVPRLGKEAAQKAIREWGQPKSKITHLIFCTTSGIDIPGADYQLTKLLGLRPSVNRFMIYQQGCFAGGTALRLAKDLAENTKGARILIVCSEITAFTFRGPSLTHVDTLVGQALFADGAAAAIVGSDPIQDIEKPLFQIISASQTLIREGHGAIDGHVREAGLLIHLLKDIPGIISNNIETALDEAFQPFGISDWNSIFWIVHPGGPAILDQVEEKLALKPEKLRSTRHILSEYGNMSSACVLFILDEMRMSSLKDGLSTTGEGFEWGILFGLGPGLTVEKVVLRSTSI
>CRO_T011441
MAATVVSIRRAQRAEGPASIMAIGTAVPVNCVTQNTFPDYFFRVTNAEHLTELKEKFRRMCKGSLIKKRYMHMSEQILKENPNLSTYMAPSLGVRQKILLAELPKLGKEAAEKAIKEWGQSKSKITHLIFCTTFGGELPGADHCLTGLLDLNPSIKRIMLYQLGCYGGNAALRAAKDLAENNKGARILVVCSEIPSIAMFGHPDNSNIDTVLGHALYGDGAGACIVGSDPIIGFERPIFELAFADQTIIPDTDGAIESSIIEVGTRLHLEKGIPELISNNIENLLKDAFKPLGIFNWNSIFWVAHLGGSAIFDQVEKKLGLQPEKLYVSKYVLSEYGNPLGASTFFILDEMRRYSAKNGFNYSGEGLEWGVLFGFGPGLTCETMVLRSVSI
>CRO_T022112
MAGPKNEKPRKATILALGKAFPHQLVMQEFLVDGYFKNTNCDDPLLKQKLTRLCKTTTVKTRYVVMSEEILSKYPELATEGLPTVKQRLDICNSAVTQMAIEASQSCIKNWGRSISDITHLVYVSSSEVRLPGGDLYLAKGLGLSPETQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSAERPYDLVGAALFGDGAGAMIIGINPIPGSENPLFELHTSIQHFLPETEKIIDGRLTEEGISFKLARELPQIIEDNIEGFCSKLMKNSGFCEKDYNKLFWAVHPGGPAILNRIEKKFELSPEKLIASRRALADYGNVSSNTIVYVLEYMLEESKKKASKEENDDEWGLVLAFGPGITFEGILARNLTI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University