Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Catharanthus roseu
Species name
Species info
Gene sequence info
Catharanthus_roseu.4CL.fa
Download
>CRO_T014036
MNTIQQLKLTFPYKMPLDINQLHHSKTTKTNMGTNIPIFPEEEHIFRSRYPPVEVPHGITLPDFVLQNAEMFSDKVAFVDATTGRTYTYGEVNRDVRRFAKALRSLDSRKGLVAVVVLPNIVEYAVIALGIMAAGGVFSGANPASHASEIRKQVELAEAKLIVTDASTHDKTKLILKGANFKKNIESFGSILNIIDACTFLVNLDMFAVQKQVKDFGLPVIVVGEEPVEGSISWKRLLEAGDRISSDIINQVIEQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSSLFSVGPELIGKVTILGLIPFFHIYGLTGICCASIRNKGKVVVMPKYELRAFLDALIKHEVNFAPVVPPIILGLVKNPIVDEFDLSKLKLKSVMTAAAPLAPEILKEFEKKFPGIQVQEAYGMTEHSCITLSHGDPSKGHGISKRNSVGFILPNLEVKFVDPDSGRSLPKKTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAEIEGVLLTHPSVEDAAVVGVADEEAGEIPAACVVMNTEAKETEEEIMEFVASNVAHYKKVRKLRFVDSIPKSHSGKIMRRLIKEKMTQNVNNINNPTSVSL
>CRO_T003152
MAAAVAIEEQKKDIIFRSKLPDIYIPKNLPLHSYCFENISKFSSRPCLINGATDEIFTYADVELISRRVGSGLSKLGIKQGDTIMILLPNSPEFVFAFLGASFIGSISTMANPFFTSTEVIKQAKASNAKLIITQGCYVDKVKDYACENGVKIISIDTTTTADDAANILHFSELTGADENEMPKVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSDDVLLCVLPLFHIYSLNSVLLCGLRAGSGILIMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIAKSTVVDNYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPETGSSLPRNHPGEICIRGDQIMKGYLNDPEATARTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPCISDAAVVPMKDEAAGEVPVAFVVKSNGHNITEDEIKQFISKQVIFYKRINRVFFVEAIPKAPSGKILRKDLRARLAAAALPTN
>CRO_T029291
MEKSGYGRDGIYRSLRPPLVLPKASNNISMVSFLFRNFSAFPDKPALIDGRTSQTLSFMDLKSMVYKVSHGLHHQFGIKKNDVVLIFAPNSIQFPLCFFGIIAIGGIASTANPIYTTSELSKQVKDCAPKLIITVPELIPKVSGFNLPLLLLGSGRNTNISSNFSGKTMSFSDLIKNEGSLDLDYFTSAIKQSDTAALLYSSGTTGTSKGVVLTHRNFIASSLMVTADQEAAGEMHNLFLCVLPMFHVFGLAVIMYAQLQRGNGIVSMGKFDLEMILKAVEKYRVTHFWLVPPIMLALAKNAIVKKYDLTSLKQIGSGAAPLGRELMQECANNFPHAVVMQGYGMTETCGIVSVENPNLGPRHSGSTGMLVPGVEAQIVSVEKLKPLPPGQLGEIWVRGPNMMQGYFHNPEATKLTLDKQGWVHTGDLGYFNEAGQLFVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVGSKL
>CRO_T021295
MLSVEAPHNKELSSSTTTNPKQSSSHHELHIFRSKLPEIPISNHLPLHTYCFEKFSEFPDRTCLIVGSNGKTFTFAETHLICRKVAAGLTTLGIKQGDVIMILLQNSAEFVFSFMGASIIGAVTTTANPFYTSTEIFKQFKASKAKLIITQSHYVQKLRDAPDDCPRLGEEFRVITVDEPPKDCLHFSVLSEGNENEVPSVTINPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQKHRVSMAAVVPPLVLALAKNPTVDSYDLSSIRMVLSGAAPLGKELEEALRSRVPQATFGQGYGMTEAGPVLSMSASFAKQPLSSKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPLVADAAVVPQKDQVAGEVPVAFVVRSNGVELTEETVKDFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLALALAAQAS
>CRO_T028976
MESTAADHHHQQYIFRSKLPDIYIPHHLPLHTYCFENLSEFSSRPCLINGTNGDVFSYADVELTARKFASGLHKIKIQQGDVIMLLLHNSPEFVFAFLGASYIGATVTTANPFCTSAEIKKQAKLSNTKLIITQSCYIEKIKDFAVENCIKIIFSDESLPENDFFGLKLKLNFSELIEAADENEIPAVKINQNDVVCLPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSIMLCGIRVGAAILIMQKFEINALMELVEKYKVTIAPFVPPIILGIAKSGATEKYDLKSIRMVMSGAAPMGKELEETFRPKLPNAKLGQGYGMTEAGPVISMCLAFAKEPFEVKPGACGTVVRNAEMKITDPETGLSLPPNQPGEICIRGNQIMKGYLNDPEATERTIDKDGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEGAGEVPIAFVVRGNGSNISEDDVKQFISKQVVFYKRIHRVIFTDTIPKAPSGKILRRDLRAKLAAEAFC
MNTIQQLKLTFPYKMPLDINQLHHSKTTKTNMGTNIPIFPEEEHIFRSRYPPVEVPHGITLPDFVLQNAEMFSDKVAFVDATTGRTYTYGEVNRDVRRFAKALRSLDSRKGLVAVVVLPNIVEYAVIALGIMAAGGVFSGANPASHASEIRKQVELAEAKLIVTDASTHDKTKLILKGANFKKNIESFGSILNIIDACTFLVNLDMFAVQKQVKDFGLPVIVVGEEPVEGSISWKRLLEAGDRISSDIINQVIEQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSSLFSVGPELIGKVTILGLIPFFHIYGLTGICCASIRNKGKVVVMPKYELRAFLDALIKHEVNFAPVVPPIILGLVKNPIVDEFDLSKLKLKSVMTAAAPLAPEILKEFEKKFPGIQVQEAYGMTEHSCITLSHGDPSKGHGISKRNSVGFILPNLEVKFVDPDSGRSLPKKTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAEIEGVLLTHPSVEDAAVVGVADEEAGEIPAACVVMNTEAKETEEEIMEFVASNVAHYKKVRKLRFVDSIPKSHSGKIMRRLIKEKMTQNVNNINNPTSVSL
>CRO_T003152
MAAAVAIEEQKKDIIFRSKLPDIYIPKNLPLHSYCFENISKFSSRPCLINGATDEIFTYADVELISRRVGSGLSKLGIKQGDTIMILLPNSPEFVFAFLGASFIGSISTMANPFFTSTEVIKQAKASNAKLIITQGCYVDKVKDYACENGVKIISIDTTTTADDAANILHFSELTGADENEMPKVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSDDVLLCVLPLFHIYSLNSVLLCGLRAGSGILIMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIAKSTVVDNYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPETGSSLPRNHPGEICIRGDQIMKGYLNDPEATARTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPCISDAAVVPMKDEAAGEVPVAFVVKSNGHNITEDEIKQFISKQVIFYKRINRVFFVEAIPKAPSGKILRKDLRARLAAAALPTN
>CRO_T029291
MEKSGYGRDGIYRSLRPPLVLPKASNNISMVSFLFRNFSAFPDKPALIDGRTSQTLSFMDLKSMVYKVSHGLHHQFGIKKNDVVLIFAPNSIQFPLCFFGIIAIGGIASTANPIYTTSELSKQVKDCAPKLIITVPELIPKVSGFNLPLLLLGSGRNTNISSNFSGKTMSFSDLIKNEGSLDLDYFTSAIKQSDTAALLYSSGTTGTSKGVVLTHRNFIASSLMVTADQEAAGEMHNLFLCVLPMFHVFGLAVIMYAQLQRGNGIVSMGKFDLEMILKAVEKYRVTHFWLVPPIMLALAKNAIVKKYDLTSLKQIGSGAAPLGRELMQECANNFPHAVVMQGYGMTETCGIVSVENPNLGPRHSGSTGMLVPGVEAQIVSVEKLKPLPPGQLGEIWVRGPNMMQGYFHNPEATKLTLDKQGWVHTGDLGYFNEAGQLFVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVGSKL
>CRO_T021295
MLSVEAPHNKELSSSTTTNPKQSSSHHELHIFRSKLPEIPISNHLPLHTYCFEKFSEFPDRTCLIVGSNGKTFTFAETHLICRKVAAGLTTLGIKQGDVIMILLQNSAEFVFSFMGASIIGAVTTTANPFYTSTEIFKQFKASKAKLIITQSHYVQKLRDAPDDCPRLGEEFRVITVDEPPKDCLHFSVLSEGNENEVPSVTINPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQKHRVSMAAVVPPLVLALAKNPTVDSYDLSSIRMVLSGAAPLGKELEEALRSRVPQATFGQGYGMTEAGPVLSMSASFAKQPLSSKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPLVADAAVVPQKDQVAGEVPVAFVVRSNGVELTEETVKDFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLALALAAQAS
>CRO_T028976
MESTAADHHHQQYIFRSKLPDIYIPHHLPLHTYCFENLSEFSSRPCLINGTNGDVFSYADVELTARKFASGLHKIKIQQGDVIMLLLHNSPEFVFAFLGASYIGATVTTANPFCTSAEIKKQAKLSNTKLIITQSCYIEKIKDFAVENCIKIIFSDESLPENDFFGLKLKLNFSELIEAADENEIPAVKINQNDVVCLPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSIMLCGIRVGAAILIMQKFEINALMELVEKYKVTIAPFVPPIILGIAKSGATEKYDLKSIRMVMSGAAPMGKELEETFRPKLPNAKLGQGYGMTEAGPVISMCLAFAKEPFEVKPGACGTVVRNAEMKITDPETGLSLPPNQPGEICIRGNQIMKGYLNDPEATERTIDKDGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEGAGEVPIAFVVRGNGSNISEDDVKQFISKQVVFYKRIHRVIFTDTIPKAPSGKILRRDLRAKLAAEAFC
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University