Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Carica papaya
Species name
Papaya (Carica papaya) is a species of eudicot in the family Caricaceae (papaya family).
Species info
Gene sequence info
Carica_papaya.HIDH.fa
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>rna-XM_022056376.1
MAADKKLVDEVSGWLRLYDDGSVDRTWTGPPEVKFMADSVPPHQQFINGVATRDVVVDAASGLKVRIYLPENTRGQNHKLPVLLHFHGGGFCISQPDWYMYYHIYTRLANSAQAIVVSVYLRLAPEDRLPAAIDDGYAALLWLRSLARGESREAWLDYRADFNRVFLIGDSSGGNLVHAVAARAGQVELAPLRLAGGIPIHPGFVRSRRSKSELEEKQSPLLTLDMVDKFLALALPVGSTKDHPITCPMGSDGGSEELEGLKLPPLLLCVAENDLIRDTEMEYYEAMNKAKKEVELVINGGMGHSFYLNKIAVDLDPDTGAQTTKLVNAVVDFINRH
>rna-XM_022056531.1
MEVINSINAVNNQVAKEFFPYFRVYKDGRIHRYKPIKKISPNSDYSRRVGVVSKDVIISNDPFISGRLFMPRVVDPVKKLPLLVYFHGGGFSLRSAFDPIYDQHVSSITAEANIVAISIDYRLAPEHPIPICYNDSWAALKWISAHANGVDQNLWLNNYVDFKQTFLLGDSAGANIVHNMLVQLGSNGLAGVKVVGAALIHPYFGGTGVFHNRLWMYLCQANTELQDRRKRPNIEDLKKTGCDKVLVFLCEKDIFKNGGMFYYENLKKSGWRGSVEIFESKGLGHTFHLKNPNSDQALDLMKTLVAASAMARRSGAVKVGRKRGVVPRAHGGDRGRNEKYGGVGGVWGAVGKDGGGAGRTE
>rna-XM_022032208.1
MGSIADHDHKEVATELLPYIRIYKDGCVERLMGSPTVPPPNDTETGVSSKDVIISETPLISARLYLPKHVNPNQKLPILVYFHGGAFIFESAFSFLETKFMNRLVAEARAVAVSVDYRLAPEHLLPSAYDDCWAALRWVASHSAADTTGINPDPWLLNHANFERVFIGGDSAGANIAHNIAMRAGSEELPGGVELLGAFTTHPYFWGWKPIGEERKEGLEQKLPYLLWKFLYPTAPGGIECPMINPHGEGAPSLSGLGCSQLLVSTTDMDGLRHRAFAYYNGVKESGWEGEAELVVVEGEPHGFHTCNYESESAKQMIKRLASFLLK
>rna-XM_022032197.1
MGSVDDKEVVTELLPYLIVYKNGSVDRLLQSPIVPHSLEDPETGVSSKDIAISQSPPISARIYLPKSIQPHQKLSILVYYHGGGFSFDSPFSFSETNYMNRLVSHGRVLAVSIDYRLAPEHPLPIAYEDGWAALRWVASHSAGTKTEPWISNHGNFDRVFIGGDSAGANLAHNILMRAGSEELPGGVKILGGFLTHPYFWGSKPIGEENGNEHEKKLPYRLWEFLYPTASGGMDSPLINPIGPGAPSLAGLGCRRLLVSVAGRDLMKYRGIGYYKGVKKVDGKEKLSWYGEDEDHAF
>rna-XM_022056822.1
MSILVAEAPGYLQVFSDGSVNRFAPEIATASPEMSIDGYKSKDVVIDPSKLVTARLFLPETKKPLDMLMPIVVYFHGGGFCVGSTTWLGYHHFLGDFSVKSKSIVFSIDYRLAPENRLPVAYDDCYSSLQWLSRHVNAEPWLKQGDLSRVFLSGDSAGGNIAHQVAIKVMRNKVPRVDIKGLMLIHPYFGSEKRTEREMADEDAGDVKSNDMFWMLSVPEGSNRDYFGCNLAMQEVSVREWRSEFPAVAVFVAELDFLKERGLMHAEFLQKKGVRHVKLMESEGESHVFHVFNPKSESTCLLQEQMSEFMRSY
>rna-XM_022032265.1
MRSRRSMTTIFVDPRLNLQQSNKINNHQNGVIVEEIEGLIRVYNDGHVERSPIVSNVPCTATLNHSNVTARDVFIDKFTNLWARIYVPDCGADKQLMPLLVYFHGGGFCVGSAAWSCYHEFLANLASKARCVIMSINYRLAPEHRLPAAYDDGFNALMWLKHQALNHVSSEKFWLSKCNFSSLFLAGDSAGANIAYNVTMKLGSTHDIIKPYYLKGIILIQPFFGGETRMGSEKHSIQPVNSALTLSTSDTYWRLSLPLVANRDHPWCNPRANGVAKLRELRLPSTMVCISEMDILKDRNLDFCSLLIGAGKRVQTVVHKGVGHAFQVLHNSQFSQLRIQEMMSHLNAFINQ
>rna-XM_022036903.1
MSNTTGAAPFYEVDECRGVLRVYSDGSVWRSTKPSFNIPVHDDGSVLWKDVLFDPLHNLELRLYKPASLPSSAKLPIFFYIHGGGFCIGSRTWPNCQNYCLRLAFWRLSIPIGETTDHPLVNPFGPVSRSLEHVDFDPILVVVGGSDLLKDRADDYAKKLKNWGKMIDYVEFEGMQHGFFTIDPNSQQARELMLIIKRFINENSS
>rna-XM_022041074.1
MNKWLENQKEKDKQEKETVKGIGKNLIPSPVCRDLFPIRVLLQLLPMDPTKQEEIAQDFSPMLRVYKNGRVERLMGTATLPPSLDPTTNVQSKDVIYSPQTNQHARLFLPKSTHPNQKLPLLVYFHGGGFAIETAFSPTYHNHLNTLVAEANIIAVSVDYRRAPEHPLPAAHDDSWAALEWVASHSDGTGPEDWLNRHADIQNVFFAGDSAGANIAHHMAMRVGEKALPAVNLNGVVLVHPYFWGKEPVGDEVKDMSFRSKVDAMWLLAFPDSSGSDDPLLNVCGSSGPSLAGLGCRRVLVCVAGKDFLRARGWEYYEKLLASGWEGVVEIAEDEEENHVFHLLDPTKDSSKAAVKRIAAFIRHDRTI
>rna-XM_022041075.1
MDSSSSEIAHDFFPMARLYKDGRLERLRGTATVPPSLDPETSVESKDVVFSTEPNLSARLYIPKSATLHSQKLPLLIYFHGGGFIIESAFSPTYHAHLNTLVAEANVIAVSVDYRLAPEHPLPAAYDDSWAALKWVAAHSDGNGPEDWLNRYADLQKVFLAGDSCGANIAHHMAVRVGKEENHGKPYVALDGIILVHPYFWGKDPIVEEASYVAFRSMIDALWRFSCPGSSGLDDPLINVCGDSSCLARLRCRRVLVCVAERDGFRQSGVEYCEKVRRSEWGGVVEMMESEGENHVFHLLDPTREAVGPLLKTIVDFISQDHDP
>rna-XM_022040931.1
FLPPSAKTQNRLPLLFYIHGGGFCMLSAFSPQYHDFCNKVAADANAVVVSVEYGLFPTRPIPACYEDSWTALQWVASHVAGDGPEPWLNHHADFQRVFIGGDSAGANISHTLAVRVGSIGLPAGKVVGVIMVHPYFAGVDHIDRMCVFMGASNGGMEDPRIKPTMESRRLGCERVLFCAEKDEYELREVGIDYCEKLKKSGWNGSVEIVEHVGQSHVFHLKEETKLHEDAVVLVQKFVSLIKQD
>rna-XM_022055834.1
MGSVSNEVVIELTPFIRVYKDGYVERLAGSPIVPPSPEQDPDTGVSSKDVIISLNPPISARLYLPNNLPNKKLPILVYFHGGAFCIESAFSFLDHRYLNNMVSEAQVVGVSVEYRLAPEHPLPTAYQDCWDALQWVASHSIKDKLHNDPWLADFGDFSGLFIGGDSAGANIAHNVAMRAGNEGLSGGVKIEGTWLAQPFFWASSAIGVEPEKRLPAKVWNVVWPSAPGGVDNPMINPVGEGCRKELAGLGCSRLLVCVAEKDTFRERGVLYCDAVKESGWEGEVEFFEVKGEDHGFHIFHPYTVNSKAMIKRLASFLSGN
>rna-XM_022056288.1
MGSTEKEVSMEVFPYLRVLKDGNIERIAGTETVPAGLDSQTSVLSKDVVIVPETGVSARLYLPPSAITNQKLPLVVYFHGGAFCIATTSEPKYHASLNNLVAEANVVVVSVNYRLAPEHPLPAAYDDSWAALQWVASHNKGRTGPDDWLNNYVDFDRVFLAGDSAGANIAHHMGFRAKEWKAGEGLKFAGMGMIHPYFWGTEPIGMEIKDRFRKEMVDGWWEFVCPSEKGCDDPLINPFVDGAPSLKGLECEEVLVIVAGEDILRERGRVYYEELKKSGWEGRAEMVETGGKDHVFHIFDPNCDEAKALIKRLALFVNQIKHV
MAADKKLVDEVSGWLRLYDDGSVDRTWTGPPEVKFMADSVPPHQQFINGVATRDVVVDAASGLKVRIYLPENTRGQNHKLPVLLHFHGGGFCISQPDWYMYYHIYTRLANSAQAIVVSVYLRLAPEDRLPAAIDDGYAALLWLRSLARGESREAWLDYRADFNRVFLIGDSSGGNLVHAVAARAGQVELAPLRLAGGIPIHPGFVRSRRSKSELEEKQSPLLTLDMVDKFLALALPVGSTKDHPITCPMGSDGGSEELEGLKLPPLLLCVAENDLIRDTEMEYYEAMNKAKKEVELVINGGMGHSFYLNKIAVDLDPDTGAQTTKLVNAVVDFINRH
>rna-XM_022056531.1
MEVINSINAVNNQVAKEFFPYFRVYKDGRIHRYKPIKKISPNSDYSRRVGVVSKDVIISNDPFISGRLFMPRVVDPVKKLPLLVYFHGGGFSLRSAFDPIYDQHVSSITAEANIVAISIDYRLAPEHPIPICYNDSWAALKWISAHANGVDQNLWLNNYVDFKQTFLLGDSAGANIVHNMLVQLGSNGLAGVKVVGAALIHPYFGGTGVFHNRLWMYLCQANTELQDRRKRPNIEDLKKTGCDKVLVFLCEKDIFKNGGMFYYENLKKSGWRGSVEIFESKGLGHTFHLKNPNSDQALDLMKTLVAASAMARRSGAVKVGRKRGVVPRAHGGDRGRNEKYGGVGGVWGAVGKDGGGAGRTE
>rna-XM_022032208.1
MGSIADHDHKEVATELLPYIRIYKDGCVERLMGSPTVPPPNDTETGVSSKDVIISETPLISARLYLPKHVNPNQKLPILVYFHGGAFIFESAFSFLETKFMNRLVAEARAVAVSVDYRLAPEHLLPSAYDDCWAALRWVASHSAADTTGINPDPWLLNHANFERVFIGGDSAGANIAHNIAMRAGSEELPGGVELLGAFTTHPYFWGWKPIGEERKEGLEQKLPYLLWKFLYPTAPGGIECPMINPHGEGAPSLSGLGCSQLLVSTTDMDGLRHRAFAYYNGVKESGWEGEAELVVVEGEPHGFHTCNYESESAKQMIKRLASFLLK
>rna-XM_022032197.1
MGSVDDKEVVTELLPYLIVYKNGSVDRLLQSPIVPHSLEDPETGVSSKDIAISQSPPISARIYLPKSIQPHQKLSILVYYHGGGFSFDSPFSFSETNYMNRLVSHGRVLAVSIDYRLAPEHPLPIAYEDGWAALRWVASHSAGTKTEPWISNHGNFDRVFIGGDSAGANLAHNILMRAGSEELPGGVKILGGFLTHPYFWGSKPIGEENGNEHEKKLPYRLWEFLYPTASGGMDSPLINPIGPGAPSLAGLGCRRLLVSVAGRDLMKYRGIGYYKGVKKVDGKEKLSWYGEDEDHAF
>rna-XM_022056822.1
MSILVAEAPGYLQVFSDGSVNRFAPEIATASPEMSIDGYKSKDVVIDPSKLVTARLFLPETKKPLDMLMPIVVYFHGGGFCVGSTTWLGYHHFLGDFSVKSKSIVFSIDYRLAPENRLPVAYDDCYSSLQWLSRHVNAEPWLKQGDLSRVFLSGDSAGGNIAHQVAIKVMRNKVPRVDIKGLMLIHPYFGSEKRTEREMADEDAGDVKSNDMFWMLSVPEGSNRDYFGCNLAMQEVSVREWRSEFPAVAVFVAELDFLKERGLMHAEFLQKKGVRHVKLMESEGESHVFHVFNPKSESTCLLQEQMSEFMRSY
>rna-XM_022032265.1
MRSRRSMTTIFVDPRLNLQQSNKINNHQNGVIVEEIEGLIRVYNDGHVERSPIVSNVPCTATLNHSNVTARDVFIDKFTNLWARIYVPDCGADKQLMPLLVYFHGGGFCVGSAAWSCYHEFLANLASKARCVIMSINYRLAPEHRLPAAYDDGFNALMWLKHQALNHVSSEKFWLSKCNFSSLFLAGDSAGANIAYNVTMKLGSTHDIIKPYYLKGIILIQPFFGGETRMGSEKHSIQPVNSALTLSTSDTYWRLSLPLVANRDHPWCNPRANGVAKLRELRLPSTMVCISEMDILKDRNLDFCSLLIGAGKRVQTVVHKGVGHAFQVLHNSQFSQLRIQEMMSHLNAFINQ
>rna-XM_022036903.1
MSNTTGAAPFYEVDECRGVLRVYSDGSVWRSTKPSFNIPVHDDGSVLWKDVLFDPLHNLELRLYKPASLPSSAKLPIFFYIHGGGFCIGSRTWPNCQNYCLRLAFWRLSIPIGETTDHPLVNPFGPVSRSLEHVDFDPILVVVGGSDLLKDRADDYAKKLKNWGKMIDYVEFEGMQHGFFTIDPNSQQARELMLIIKRFINENSS
>rna-XM_022041074.1
MNKWLENQKEKDKQEKETVKGIGKNLIPSPVCRDLFPIRVLLQLLPMDPTKQEEIAQDFSPMLRVYKNGRVERLMGTATLPPSLDPTTNVQSKDVIYSPQTNQHARLFLPKSTHPNQKLPLLVYFHGGGFAIETAFSPTYHNHLNTLVAEANIIAVSVDYRRAPEHPLPAAHDDSWAALEWVASHSDGTGPEDWLNRHADIQNVFFAGDSAGANIAHHMAMRVGEKALPAVNLNGVVLVHPYFWGKEPVGDEVKDMSFRSKVDAMWLLAFPDSSGSDDPLLNVCGSSGPSLAGLGCRRVLVCVAGKDFLRARGWEYYEKLLASGWEGVVEIAEDEEENHVFHLLDPTKDSSKAAVKRIAAFIRHDRTI
>rna-XM_022041075.1
MDSSSSEIAHDFFPMARLYKDGRLERLRGTATVPPSLDPETSVESKDVVFSTEPNLSARLYIPKSATLHSQKLPLLIYFHGGGFIIESAFSPTYHAHLNTLVAEANVIAVSVDYRLAPEHPLPAAYDDSWAALKWVAAHSDGNGPEDWLNRYADLQKVFLAGDSCGANIAHHMAVRVGKEENHGKPYVALDGIILVHPYFWGKDPIVEEASYVAFRSMIDALWRFSCPGSSGLDDPLINVCGDSSCLARLRCRRVLVCVAERDGFRQSGVEYCEKVRRSEWGGVVEMMESEGENHVFHLLDPTREAVGPLLKTIVDFISQDHDP
>rna-XM_022040931.1
FLPPSAKTQNRLPLLFYIHGGGFCMLSAFSPQYHDFCNKVAADANAVVVSVEYGLFPTRPIPACYEDSWTALQWVASHVAGDGPEPWLNHHADFQRVFIGGDSAGANISHTLAVRVGSIGLPAGKVVGVIMVHPYFAGVDHIDRMCVFMGASNGGMEDPRIKPTMESRRLGCERVLFCAEKDEYELREVGIDYCEKLKKSGWNGSVEIVEHVGQSHVFHLKEETKLHEDAVVLVQKFVSLIKQD
>rna-XM_022055834.1
MGSVSNEVVIELTPFIRVYKDGYVERLAGSPIVPPSPEQDPDTGVSSKDVIISLNPPISARLYLPNNLPNKKLPILVYFHGGAFCIESAFSFLDHRYLNNMVSEAQVVGVSVEYRLAPEHPLPTAYQDCWDALQWVASHSIKDKLHNDPWLADFGDFSGLFIGGDSAGANIAHNVAMRAGNEGLSGGVKIEGTWLAQPFFWASSAIGVEPEKRLPAKVWNVVWPSAPGGVDNPMINPVGEGCRKELAGLGCSRLLVCVAEKDTFRERGVLYCDAVKESGWEGEVEFFEVKGEDHGFHIFHPYTVNSKAMIKRLASFLSGN
>rna-XM_022056288.1
MGSTEKEVSMEVFPYLRVLKDGNIERIAGTETVPAGLDSQTSVLSKDVVIVPETGVSARLYLPPSAITNQKLPLVVYFHGGAFCIATTSEPKYHASLNNLVAEANVVVVSVNYRLAPEHPLPAAYDDSWAALQWVASHNKGRTGPDDWLNNYVDFDRVFLAGDSAGANIAHHMGFRAKEWKAGEGLKFAGMGMIHPYFWGTEPIGMEIKDRFRKEMVDGWWEFVCPSEKGCDDPLINPFVDGAPSLKGLECEEVLVIVAGEDILRERGRVYYEELKKSGWEGRAEMVETGGKDHVFHIFDPNCDEAKALIKRLALFVNQIKHV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University