Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Carica papaya
Species name
Papaya (Carica papaya) is a species of eudicot in the family Caricaceae (papaya family).
Species info
Gene sequence info
Carica_papaya.4CL.fa
Download
>rna-XM_022032283.1
MLLLPNSPEFVLSFLGASYRGAVATAANPFFTPAEIGKQVKASGAKLVITQACYVDKVKEFEANDVKIMCIDSAPDGCLSFSELAQADENELPDVEIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYYNSEDVILCVLPMFHIYALNSIMLCGLRVGASILIMPKFEIGTLLGLIEKYRVTVMPAVPPIVLAIAKSPETEKYDLTSVRLMKSGAAPLGKELEDAVRAKFPNARLGQGYGMTEAGPVLAMGLGFAKEPFEVKSGACGTVVRNAEMKIVDPETGSSLPRNQAGEICIRGDQIMKGYLNDSEATARTIDKEGWLHTGDIGYIDDDEELFIVDRLKELIKYKGFQVAPAELEAMLIAHSDISDAAVVGMKDDAAGEVPVAFVVKSKDSQLSEDDIKKYISKQVVFYKRVSRVFFVESIPKAPSGKILRKELRARLAAESS
>rna-XM_022057051.1
MEGQKQPEQLEFIFRSKLPDIYIPNHLPLHTYCFENISKFKDRPCIINGADGKVFKHGEVELTARKVAAGLHKLGIKQGDVIMLLLQNSPEFVFTFIGASYLGAIITTANPFFTPSEVAKQATTSNTKLVITQSSYVDKVRNFSKNHGVKIVTVDDLEEDYCLSFSELSGADETEIPAVKINPDDVVALLYSSGTTGLPKGVMLTHRGLVTNVAQQVDGENPNMYFTEKDVVLCVSPLFHLYSLNSVMLCAFRVGAAILTMKKFEMVRLMELVEKHRVTVAPLVPPIVLAIGKSSDVRNYDLSSIRMIISSASPLGKKVEDAVRTKLPNAKLGQGYGMTEGGTLSMSLAFAKEPFEVKSGACGTVVRNAEMKIVDPETGLSLPPNQAGEICIRGAQIMKGYLNDEEATKRTVDKDGWLHTGDVGYIDDDDQVFIVDRFKELIKYKGFQVAPAELESMLIAHPDISDAAVIPMKDEVAGEVPVAFVVRSSGSKIVEDEIREYISKQVVFYKRLAGVFFTDSIPKAPSGKILRKELRARLAAALPN
>rna-XM_022037033.1
MATTTTFDPKTQIYTSPRPPINIPTEPNLSLTSFLFQSISISSSPQNTALVESDSDEALTFDQLKTNVCKLAHSLLHHLRLSANDVVLILSRNSIHLPVCFLAVVSLGAIFTTANPAYTPAEISHQFNDCNPKLIITTPDLLQKVKQFNVPVLLLKPIKTPLLKTDDNVFLYENLLELAGSVNELPEIVVKQSDVAGFLYSSGTTGMSKGVILTHGNFIAAALIATADQERYKEERNVFLCVVPMFHVLGLSVIVYAQLRRGDKVVSIEKFELEKLLRCVEKQRVTHLYMVPPLMLALAKKRKLMEEYNLSSLKEIVCGAAPVSKEMMEELAKKLPRVPILQGYGMTETCGMIAQEYAKQESPYHSGSTGILASTFQSKIISVYSSKALPPNQLGEICVRSPSITQGYLKNPQATKLTIDEEGWLHTGDLGYFDEAGRLFVVDRIKELIKCYGYQVAPFKRLRKVSFVAHIPKSASGKILRREVRDKVRSKI
>rna-XM_022037496.1
MEDKNHREQPECIFRSKLPDIYIPNHLPLHTYCFENISKFKDRPSIINGADGKVFTHGEAELTARKVAAGLHKLGIKQGDVIMLLLQNSPEFVFAFMGASYLGAITTTANPFFTSSEVAKQATASNTKLVITQSSYVEKVRNFAKNHGVKIVTVDELEADDCLPFSELSGADETEIPAVKINPDDVVALPFSSGTTGLPKGVMLTHRGLVTNVAQQVDGENPNLYFTEKDVLLCVLPLFHIYALNSLMLCAFRVGAAILIMKKFEILRLMELVEKHRVTVAPLVPPIVLAIAKSPDVGKYDLSSIRMIISGAAPLGKKLEDAVRPKLPNAKLGQGYGMTEAGALSMCLAFAKEPFEVKSGACGTVVRNAEMKIVDPETGLSLPPNQAGEICIRGAQIIKGYLNDEEATKRTVDKDGWLHTGDVGYIDDDDEVFIVDRLKELIKYKGFQVAPAELESLLIAHPDISDAAVIPMKDETAGEVPVAFVVRSSGSKIVEDEIREYISKQVVFYKRLARVFFTDSIPKAPSGKILRKELKARLAAVVPN
>rna-XM_022040481.1
MEKSGYCSDGIFRSLRPPIAFPTDPYLSMISFLFRNSSSYPTKPALIDADTGETLSFSQLKSLVIKLSHGFLHLGIKKKDVVLIFAPNSLQFPICFLAVIAAGAVASTANPVSTVTELSKQIKDSNPKLVITVPDLSDKVKHLNLPLLFLGDPKKAEQTRQIESNLRILHFHELINLSGSVADFPSVSIKQTDVAALMYSSGTTGTSKGVILTHKNFIAESLMVSMDQELRGDTHLVTLCALPMFHVTGLSVILYSHLRVGNVVVVMRKFEFEGMLRSIEKYRVENISVVPPIVLALAKQSVAKKYDLSSLKRIGSGAAPLGKDLQEECAKNLGGGVMVGQGYGLTETCGATTLEDLSTGKRNTGSAGSLLSEVECQIVNPETLKPLPPNQLGEIWFRGPNIMQGYHNNPEATKQTIDEKGWLHTGDLGYFNDDGCLFVVDRLKELIKYKGFQVAPAEIEGLLVSHPEILDAVVIPFPDLEAGEVPVAYVVRAPKSSLRGVDVQNFIAKQVSPYKRLQKVTFIESVPKSVSGKILRRALINQVRSKI
>rna-XM_022040512.1
MERSGYGRDGIYRSLRPPLVLPKDPNLSLVSFLFRNSSSYPNKPALIDADSGESLSFSQFKSTAIKLSHGFLHLGIKKKDVVLIFSPNSIQFPLSFLGVTAIGAIATTVNPLYTVTELSKQVKDSNPKLIITVPELWDKVKDFKLPVVFLGSKNPKQIPHVESDSKIYHFQDLLELSGSPSGFPAVAVKQTDVAALLYSSGTTGISKGVILTHKNFIAASLMMTMDQEIHGDKHLVFMCVLPMFHIFGLCIIVYSQLQKGNAVVSMKKFDLDMLLRTVEKYKVTNLWVVPPIILALSKQNEVKKYDISSLKQIGSGAAPLGKDLMEECARNVGHGVVMQGYGMTETCGIISLENPRIGKLNTGSAGRLVAGVESQIVSVDTLKPLHPHQLGEIWVRGPNMMQGYYNNPQATKLTIDKKGWVHTGDLGYFNEDGYLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPYSSLTEEDVQNFIAKQVAPFKKLRRVTFINSVPKSASGKILRRLLIEKVQSKI
>rna-XM_022043919.1
MDVPYQPKKMGDNYSQEFIFRSRLPPVVVPNNMTLPDFVLEDAELYADKVAFVEAVTGKSYTYGQVVKDTKRFAKALKSLGLRKGHLVILVLPNIAEYAIVALGIMAAGCVFSGANPTAHASEIKKQAQLGDAKLIVTDTINYEKVKSAGLPVIVLGEERVEEAMNWEDLLEAGDKAGNIKDEKIEQTEICALPFSSGTTGLSKGVMLTHRNLVSNLCSSLFSVGSDMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVVMNRFELRTLLNSLITHEITFAPVVPPIVLSLVKNPIVDEFDLSKLKLRAILTAAAPLAPELITAFEKKFPDVQIQQAYGLTEHSCITLTHGDPANDHPIAKKNSVGFILPNLEIKFIDPETGTSLPANTPGEICVRSQCVMQGYYKNDEETARTIDENGWLHTGDVGYIDGDGDIFIVDRIKELIKYKGFQVAPAELEAILLAHPSVEDAAVVPLPNEEAGEIPAACVVKNPKGEESEEEMIKYVASNVAHYKKVRVLKFVDSIPKSPSGKIMRRLLKDIMIAKMQPNPNPIP
MLLLPNSPEFVLSFLGASYRGAVATAANPFFTPAEIGKQVKASGAKLVITQACYVDKVKEFEANDVKIMCIDSAPDGCLSFSELAQADENELPDVEIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYYNSEDVILCVLPMFHIYALNSIMLCGLRVGASILIMPKFEIGTLLGLIEKYRVTVMPAVPPIVLAIAKSPETEKYDLTSVRLMKSGAAPLGKELEDAVRAKFPNARLGQGYGMTEAGPVLAMGLGFAKEPFEVKSGACGTVVRNAEMKIVDPETGSSLPRNQAGEICIRGDQIMKGYLNDSEATARTIDKEGWLHTGDIGYIDDDEELFIVDRLKELIKYKGFQVAPAELEAMLIAHSDISDAAVVGMKDDAAGEVPVAFVVKSKDSQLSEDDIKKYISKQVVFYKRVSRVFFVESIPKAPSGKILRKELRARLAAESS
>rna-XM_022057051.1
MEGQKQPEQLEFIFRSKLPDIYIPNHLPLHTYCFENISKFKDRPCIINGADGKVFKHGEVELTARKVAAGLHKLGIKQGDVIMLLLQNSPEFVFTFIGASYLGAIITTANPFFTPSEVAKQATTSNTKLVITQSSYVDKVRNFSKNHGVKIVTVDDLEEDYCLSFSELSGADETEIPAVKINPDDVVALLYSSGTTGLPKGVMLTHRGLVTNVAQQVDGENPNMYFTEKDVVLCVSPLFHLYSLNSVMLCAFRVGAAILTMKKFEMVRLMELVEKHRVTVAPLVPPIVLAIGKSSDVRNYDLSSIRMIISSASPLGKKVEDAVRTKLPNAKLGQGYGMTEGGTLSMSLAFAKEPFEVKSGACGTVVRNAEMKIVDPETGLSLPPNQAGEICIRGAQIMKGYLNDEEATKRTVDKDGWLHTGDVGYIDDDDQVFIVDRFKELIKYKGFQVAPAELESMLIAHPDISDAAVIPMKDEVAGEVPVAFVVRSSGSKIVEDEIREYISKQVVFYKRLAGVFFTDSIPKAPSGKILRKELRARLAAALPN
>rna-XM_022037033.1
MATTTTFDPKTQIYTSPRPPINIPTEPNLSLTSFLFQSISISSSPQNTALVESDSDEALTFDQLKTNVCKLAHSLLHHLRLSANDVVLILSRNSIHLPVCFLAVVSLGAIFTTANPAYTPAEISHQFNDCNPKLIITTPDLLQKVKQFNVPVLLLKPIKTPLLKTDDNVFLYENLLELAGSVNELPEIVVKQSDVAGFLYSSGTTGMSKGVILTHGNFIAAALIATADQERYKEERNVFLCVVPMFHVLGLSVIVYAQLRRGDKVVSIEKFELEKLLRCVEKQRVTHLYMVPPLMLALAKKRKLMEEYNLSSLKEIVCGAAPVSKEMMEELAKKLPRVPILQGYGMTETCGMIAQEYAKQESPYHSGSTGILASTFQSKIISVYSSKALPPNQLGEICVRSPSITQGYLKNPQATKLTIDEEGWLHTGDLGYFDEAGRLFVVDRIKELIKCYGYQVAPFKRLRKVSFVAHIPKSASGKILRREVRDKVRSKI
>rna-XM_022037496.1
MEDKNHREQPECIFRSKLPDIYIPNHLPLHTYCFENISKFKDRPSIINGADGKVFTHGEAELTARKVAAGLHKLGIKQGDVIMLLLQNSPEFVFAFMGASYLGAITTTANPFFTSSEVAKQATASNTKLVITQSSYVEKVRNFAKNHGVKIVTVDELEADDCLPFSELSGADETEIPAVKINPDDVVALPFSSGTTGLPKGVMLTHRGLVTNVAQQVDGENPNLYFTEKDVLLCVLPLFHIYALNSLMLCAFRVGAAILIMKKFEILRLMELVEKHRVTVAPLVPPIVLAIAKSPDVGKYDLSSIRMIISGAAPLGKKLEDAVRPKLPNAKLGQGYGMTEAGALSMCLAFAKEPFEVKSGACGTVVRNAEMKIVDPETGLSLPPNQAGEICIRGAQIIKGYLNDEEATKRTVDKDGWLHTGDVGYIDDDDEVFIVDRLKELIKYKGFQVAPAELESLLIAHPDISDAAVIPMKDETAGEVPVAFVVRSSGSKIVEDEIREYISKQVVFYKRLARVFFTDSIPKAPSGKILRKELKARLAAVVPN
>rna-XM_022040481.1
MEKSGYCSDGIFRSLRPPIAFPTDPYLSMISFLFRNSSSYPTKPALIDADTGETLSFSQLKSLVIKLSHGFLHLGIKKKDVVLIFAPNSLQFPICFLAVIAAGAVASTANPVSTVTELSKQIKDSNPKLVITVPDLSDKVKHLNLPLLFLGDPKKAEQTRQIESNLRILHFHELINLSGSVADFPSVSIKQTDVAALMYSSGTTGTSKGVILTHKNFIAESLMVSMDQELRGDTHLVTLCALPMFHVTGLSVILYSHLRVGNVVVVMRKFEFEGMLRSIEKYRVENISVVPPIVLALAKQSVAKKYDLSSLKRIGSGAAPLGKDLQEECAKNLGGGVMVGQGYGLTETCGATTLEDLSTGKRNTGSAGSLLSEVECQIVNPETLKPLPPNQLGEIWFRGPNIMQGYHNNPEATKQTIDEKGWLHTGDLGYFNDDGCLFVVDRLKELIKYKGFQVAPAEIEGLLVSHPEILDAVVIPFPDLEAGEVPVAYVVRAPKSSLRGVDVQNFIAKQVSPYKRLQKVTFIESVPKSVSGKILRRALINQVRSKI
>rna-XM_022040512.1
MERSGYGRDGIYRSLRPPLVLPKDPNLSLVSFLFRNSSSYPNKPALIDADSGESLSFSQFKSTAIKLSHGFLHLGIKKKDVVLIFSPNSIQFPLSFLGVTAIGAIATTVNPLYTVTELSKQVKDSNPKLIITVPELWDKVKDFKLPVVFLGSKNPKQIPHVESDSKIYHFQDLLELSGSPSGFPAVAVKQTDVAALLYSSGTTGISKGVILTHKNFIAASLMMTMDQEIHGDKHLVFMCVLPMFHIFGLCIIVYSQLQKGNAVVSMKKFDLDMLLRTVEKYKVTNLWVVPPIILALSKQNEVKKYDISSLKQIGSGAAPLGKDLMEECARNVGHGVVMQGYGMTETCGIISLENPRIGKLNTGSAGRLVAGVESQIVSVDTLKPLHPHQLGEIWVRGPNMMQGYYNNPQATKLTIDKKGWVHTGDLGYFNEDGYLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPYSSLTEEDVQNFIAKQVAPFKKLRRVTFINSVPKSASGKILRRLLIEKVQSKI
>rna-XM_022043919.1
MDVPYQPKKMGDNYSQEFIFRSRLPPVVVPNNMTLPDFVLEDAELYADKVAFVEAVTGKSYTYGQVVKDTKRFAKALKSLGLRKGHLVILVLPNIAEYAIVALGIMAAGCVFSGANPTAHASEIKKQAQLGDAKLIVTDTINYEKVKSAGLPVIVLGEERVEEAMNWEDLLEAGDKAGNIKDEKIEQTEICALPFSSGTTGLSKGVMLTHRNLVSNLCSSLFSVGSDMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVVMNRFELRTLLNSLITHEITFAPVVPPIVLSLVKNPIVDEFDLSKLKLRAILTAAAPLAPELITAFEKKFPDVQIQQAYGLTEHSCITLTHGDPANDHPIAKKNSVGFILPNLEIKFIDPETGTSLPANTPGEICVRSQCVMQGYYKNDEETARTIDENGWLHTGDVGYIDGDGDIFIVDRIKELIKYKGFQVAPAELEAILLAHPSVEDAAVVPLPNEEAGEIPAACVVKNPKGEESEEEMIKYVASNVAHYKKVRVLKFVDSIPKSPSGKIMRRLLKDIMIAKMQPNPNPIP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University