Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Cannabis sativa
Species name
Cannabis sativa is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Cannabis_sativa.HIDH.fa
Download
>rna-XM_030634712.1
MVPDKKIVEDVSGWLRLYDDGSVDRTWTGPPEVKFMVDSVPPHEQYIDGVATRDVLADPNSGLRVRIYLPEKTPEEEAAKLPLLLHFHGGGFCISEADWFMYYAIYTRFARQARAIVVSVYLRKAPEHRLPAAADDAFSALLWLSSQAKSCTEPWLEGADFNRVFLIGDSSGGNLVQETAVRAGKEDLRPLRVAGAIPIQPGFVRPERSRSEMEQPETPFLTLEMLDKFIALALPVGSTKEHPMTCPMGPAAPPLEELKLPPMLLCLADKDKLLETEMEFYEAMKKANKEIEIVMSCGMSHIFYLNKIAVDSDPATAAQTEAFLAGVIEFIRKH
>rna-XM_030647614.1
MSFHSTNDSSSSHHEPYEVDECRGVLRVYSDGSIVRSSKPSFNVPINDDGSVIWKDVVFDKVNHLSLRLYKPAAAQSGSKLPVFFYIHGGGFCIGSRTWPNCQNYCLRLASDLQAVIVAPDYRLAPENRLPAAIEDGYTAVKWLQGEAESVYEPDKWMCDVADFGNVFICGDSAGGNIGHHLAIRLGKESAELGRVRVKGYVLLAPFFGGTVRCKSEAEGPKDAFLNLDLIDRFWRLSIPIGETTDHPLVNPFGPFSSSLEKVELDPILVVVGGSDLLQDRAKDYAMKLQNWGKKIEYVEFEGQQHGFFTINPNSQPSNHLMSIIKGFIAQNFT
>rna-XM_030623605.1
MRWVASHSSSGGGVRSPPAKEPWLKNHVDFNQIFLAGDSAGANIAHHLIYQISEQNPGRRLIKICGVASIQPYFWGKEAIGSEVHDLVQKSMVDQGWSVVCPSDKGNDDPLINVFPEEAPSLEGLETCPKILVVVAGKDILRDRGWLYYEIEKEKEIGIEAEDEMINLLLSEVMGGADVAPATAAESKKEEKVEEKEESDEDDMIFSLFD
>rna-XM_030629359.1
MGAVVLNQSVHINPSKGPQKLINNDVIEEIGGLIKVYKDGKVERPEVVPCVTASLADHDQLGSAAVISTDVVIDKSTNVWARFYVPILAQKDKIPLIVYFHGGGFCVGSAAWSCYHDFLSKLSAELSCLIMSVNYRLAPENPLPAAYEDGFKALSWLKRQAVARNDSVLARCDFSKIFLVGDSAGANIAYNLTTRLINSAEAKRLKPLSFKGSVLVQPFFGGESRTESEKLSAAAGRRSALSLAASDTYWRLALPGGATRDHPWCNPLGKGSVIEKACNDDDEVLGMMVCVSEDDILKDRNLEFCGALGKKMKVDYVVYGGVGHAFQILNKSQLSQIRTQEMMTHIKAFINKY
>rna-XM_030628694.1
MAAISMDPRFNRSSYKNHHHHNLNGGATVEEEIEGLIRVSKDGRVERPAIIPNVPATWSLNKNLVTSKDVVMDKNTNLWARIYVPAAAAPPLTGHQLKPLLVYFHGGGFCVGSAAWSCYHEFLANLCTKANCIIVSVNYRLAPENRLPAAYEDGFKALMWIKHQAQTQSSSSSSSSSWLSQCNMSSLFLAGDSAGASIAYHVATTRLAAAASDDAILRPFRLKGVILIQPFVGGETRTGSEKYGSQPSNNSALTLSASDTYWRLSLPLGANRDHPWCNPLININGESANKYLMRPNNNNHNNVGVMVCVSEMDILRDRNLALCNALVSSGKKVEMVMYKGVGHAFQILHNSSYSQLRTQEMMSHIKNFVHQ
>rna-XM_030625896.1
MGSLPHIVEDCMGVLQLYSDGTVHRCSDMAFKFRPFYEDNSVVFKDMVYDQKLDLSLRLYKPKSTTTTTKIPLVIYFHGGGFCVGSRLWPNCHNCCLRLASGLGALVVSPDYRLAPEHKLPAAVEDAAAVVEWLRSEADHDGDEEYWLSRKVIDFERVFVVGDSSGGNMAHHLAVRVGTGSVRTEPVRIRGFVLLAPFFGGVVRTKSEEGPGESLLSLDMLDRFWRLSMGEGETRDHPLANPLGPKSPRLEEVGLEPMLVIVGGNELLRDRVEEYAMRLKDMGKNVEYVEFEGQQHGFFTNDPYSHISNHVLQLIKRFILQNSSN
>rna-XM_030651711.1
MASTSNKDIVTEILPFIRIYKDGTVERLIESPFVPPSPYNNHHPETGVPVTSKDISISLQPLIGARLFLPLLPTNTNNNNKLPILVYFHGGGFCFESAFSADHHQFLNSLVSEAKIIAVSVEYRLAPEHHLPIAYEDCWTALQWVVSLSTNDHHGTSEEPWLTDYGDFERVFLGGDSAGANIVHNIAMRIGKEGLCNGMKAVSGAFLTHPYFWGSSEEDGDNGEISLAHVIWNFVYPSAAGGVDNPMMNPVAAGSPSLAGIGCSRLLVSVAEKDFLRKRGIGYYEAVKESGWNGEIELVDVKGEDHAFQILHWNTQNSKNLIKRLAHFLQN
>rna-XM_030633752.1
MDYSSKEVAVEFPSFRLYKDGTVDRFDGDITVLPSPYTENGVRSKDIVISPASGLSARLFLPKISDPTQKLPLLLYYHGGAFVIGSPFSPIFSAFVASVAAEANVIALSVNYRRAPENPLPAAFEDAWEAIQWVAAHYRGHGSEEWINQYADLERVFVGGDSAGGTLANNIVLRAAVDGPRTVGLILYFPFFDGDEERNKLLDYIFPSYSGPGDLLVNPLSDPNLAKLGCSKVVVFVAENDSLKDRGWAYYEALKKSGWSGLVEIMEIEGEGHDFHLIKPESEKARDVMKRTVSFLNQA
>rna-XM_030630705.1
MEAKPSNSKEVAIEFPFFRLFKDRTIDRFFGDPFLPPSPDSESGVKSKDVVISPQSGVTARIFLPQIPDPTRKLPLLIYYHGGAFCVGSPFSPPYSQYVPSLAEQANVVVLSVHYRRAPEDLLPTAFDDAWDAVKWAAAHSGGNGPESWINQFADLNKVFLGGDSAGATLAHNVAIRAGVDGLSGPKLMGMVLFHPYFGNDKPDKMLEVIFPTCEGVDDPRVNPSSDPNLVRLGCLRVLIFVAEKDFLRKRGWSYYEALKKSGWSGVVEIIETEDENHVFHLFDPTSEKAQAMMKKTVSILNQAQAHI
>rna-XM_030626943.1
MGSHNLDSTTIPQQVSIEAFPYLRVYKDGTIERLAGTQIAPTGLDPQTGVVSKDVIIAPQTGVSARLYRPQLHIKLLPLVVYFHGGGFFISSTADPLYHNSLNQLAAEAKVIIVSVNYRLAPENPLPAAYDDCWEALSWVASHSSSGGGVQSPATEEPWLKNHVDFNRIFLAGDSAGANIAHHLICRISEQNPSRRLIKICGVASIQPYFWGKEAIGSEVHDLVRKSMVDRWWSVVCPSDKGNDDPLINPFAEGAPSLEGLETCPKILVVVAGKDILRDRGWLYYEKVAKMSSSLGWGGTIEIMETLEEDHVFHILNPNSENAKALIKRLATFLN
>rna-XM_030629828.1
MDNEIAQDLSPLIKLYKNGRIERLVGTATVSASLDPETGVNSNDVVISPETTLSARLYIPKSAGSIQTKLPLLVYFHGGGFCVETAFSPVYHNHLNSLSSQVNIAIISVNYRLAPEHPLPAAYDDSWAVFKWALAHSNAKGPNEWLNSLVDFGRVFLAGDSAGGNIAHHVALRAGFEGINLRGIVLIHPYFWGKEPIGDEGKDGGSTGDEAYPGMLWKFVNPSSKNGSDDPLINPSKDPNVGKLGCGRVMVCVAEKDGLKDRGWFYKEVLKKSGWDGCVEVVETKGEGHVFHLFNPNSANAVEFMAQISSFINQ
>rna-XM_030630378.1
MSSIINSIQTLQFSTSLHFFSSTPSSSSSSLPKLRLKPSTTTTKLFCISSTPDAMAAPTTDEVARDFFPFLRIYKSGRIERIAGADVVPPSIDPKTGVESKDVVISPETGVKARLYVPNSSVAGQSQSPKKLPLVVYFHGGGFCVETPFCAKYHNAVNTLVAEANVVAVSVDYRLAPENPIPIAYDDSWDAVKWVVSHSEGTGPEEWLNSRADHERVFFAGDSAGANIAHHMAIRVGLEGGLSNGSKLLGIALIHPYFWGTEPIGNEVKFPEKGKWAEGIWRFVSPTTTGVDDPYINPGKDSNLGKLGCERVLICVAENDLLRDRGLYYKEILEKSDWVGRVEVVEAAGDEHVFHLTKPTCENAVAMLKKISSFIEQS
MVPDKKIVEDVSGWLRLYDDGSVDRTWTGPPEVKFMVDSVPPHEQYIDGVATRDVLADPNSGLRVRIYLPEKTPEEEAAKLPLLLHFHGGGFCISEADWFMYYAIYTRFARQARAIVVSVYLRKAPEHRLPAAADDAFSALLWLSSQAKSCTEPWLEGADFNRVFLIGDSSGGNLVQETAVRAGKEDLRPLRVAGAIPIQPGFVRPERSRSEMEQPETPFLTLEMLDKFIALALPVGSTKEHPMTCPMGPAAPPLEELKLPPMLLCLADKDKLLETEMEFYEAMKKANKEIEIVMSCGMSHIFYLNKIAVDSDPATAAQTEAFLAGVIEFIRKH
>rna-XM_030647614.1
MSFHSTNDSSSSHHEPYEVDECRGVLRVYSDGSIVRSSKPSFNVPINDDGSVIWKDVVFDKVNHLSLRLYKPAAAQSGSKLPVFFYIHGGGFCIGSRTWPNCQNYCLRLASDLQAVIVAPDYRLAPENRLPAAIEDGYTAVKWLQGEAESVYEPDKWMCDVADFGNVFICGDSAGGNIGHHLAIRLGKESAELGRVRVKGYVLLAPFFGGTVRCKSEAEGPKDAFLNLDLIDRFWRLSIPIGETTDHPLVNPFGPFSSSLEKVELDPILVVVGGSDLLQDRAKDYAMKLQNWGKKIEYVEFEGQQHGFFTINPNSQPSNHLMSIIKGFIAQNFT
>rna-XM_030623605.1
MRWVASHSSSGGGVRSPPAKEPWLKNHVDFNQIFLAGDSAGANIAHHLIYQISEQNPGRRLIKICGVASIQPYFWGKEAIGSEVHDLVQKSMVDQGWSVVCPSDKGNDDPLINVFPEEAPSLEGLETCPKILVVVAGKDILRDRGWLYYEIEKEKEIGIEAEDEMINLLLSEVMGGADVAPATAAESKKEEKVEEKEESDEDDMIFSLFD
>rna-XM_030629359.1
MGAVVLNQSVHINPSKGPQKLINNDVIEEIGGLIKVYKDGKVERPEVVPCVTASLADHDQLGSAAVISTDVVIDKSTNVWARFYVPILAQKDKIPLIVYFHGGGFCVGSAAWSCYHDFLSKLSAELSCLIMSVNYRLAPENPLPAAYEDGFKALSWLKRQAVARNDSVLARCDFSKIFLVGDSAGANIAYNLTTRLINSAEAKRLKPLSFKGSVLVQPFFGGESRTESEKLSAAAGRRSALSLAASDTYWRLALPGGATRDHPWCNPLGKGSVIEKACNDDDEVLGMMVCVSEDDILKDRNLEFCGALGKKMKVDYVVYGGVGHAFQILNKSQLSQIRTQEMMTHIKAFINKY
>rna-XM_030628694.1
MAAISMDPRFNRSSYKNHHHHNLNGGATVEEEIEGLIRVSKDGRVERPAIIPNVPATWSLNKNLVTSKDVVMDKNTNLWARIYVPAAAAPPLTGHQLKPLLVYFHGGGFCVGSAAWSCYHEFLANLCTKANCIIVSVNYRLAPENRLPAAYEDGFKALMWIKHQAQTQSSSSSSSSSWLSQCNMSSLFLAGDSAGASIAYHVATTRLAAAASDDAILRPFRLKGVILIQPFVGGETRTGSEKYGSQPSNNSALTLSASDTYWRLSLPLGANRDHPWCNPLININGESANKYLMRPNNNNHNNVGVMVCVSEMDILRDRNLALCNALVSSGKKVEMVMYKGVGHAFQILHNSSYSQLRTQEMMSHIKNFVHQ
>rna-XM_030625896.1
MGSLPHIVEDCMGVLQLYSDGTVHRCSDMAFKFRPFYEDNSVVFKDMVYDQKLDLSLRLYKPKSTTTTTKIPLVIYFHGGGFCVGSRLWPNCHNCCLRLASGLGALVVSPDYRLAPEHKLPAAVEDAAAVVEWLRSEADHDGDEEYWLSRKVIDFERVFVVGDSSGGNMAHHLAVRVGTGSVRTEPVRIRGFVLLAPFFGGVVRTKSEEGPGESLLSLDMLDRFWRLSMGEGETRDHPLANPLGPKSPRLEEVGLEPMLVIVGGNELLRDRVEEYAMRLKDMGKNVEYVEFEGQQHGFFTNDPYSHISNHVLQLIKRFILQNSSN
>rna-XM_030651711.1
MASTSNKDIVTEILPFIRIYKDGTVERLIESPFVPPSPYNNHHPETGVPVTSKDISISLQPLIGARLFLPLLPTNTNNNNKLPILVYFHGGGFCFESAFSADHHQFLNSLVSEAKIIAVSVEYRLAPEHHLPIAYEDCWTALQWVVSLSTNDHHGTSEEPWLTDYGDFERVFLGGDSAGANIVHNIAMRIGKEGLCNGMKAVSGAFLTHPYFWGSSEEDGDNGEISLAHVIWNFVYPSAAGGVDNPMMNPVAAGSPSLAGIGCSRLLVSVAEKDFLRKRGIGYYEAVKESGWNGEIELVDVKGEDHAFQILHWNTQNSKNLIKRLAHFLQN
>rna-XM_030633752.1
MDYSSKEVAVEFPSFRLYKDGTVDRFDGDITVLPSPYTENGVRSKDIVISPASGLSARLFLPKISDPTQKLPLLLYYHGGAFVIGSPFSPIFSAFVASVAAEANVIALSVNYRRAPENPLPAAFEDAWEAIQWVAAHYRGHGSEEWINQYADLERVFVGGDSAGGTLANNIVLRAAVDGPRTVGLILYFPFFDGDEERNKLLDYIFPSYSGPGDLLVNPLSDPNLAKLGCSKVVVFVAENDSLKDRGWAYYEALKKSGWSGLVEIMEIEGEGHDFHLIKPESEKARDVMKRTVSFLNQA
>rna-XM_030630705.1
MEAKPSNSKEVAIEFPFFRLFKDRTIDRFFGDPFLPPSPDSESGVKSKDVVISPQSGVTARIFLPQIPDPTRKLPLLIYYHGGAFCVGSPFSPPYSQYVPSLAEQANVVVLSVHYRRAPEDLLPTAFDDAWDAVKWAAAHSGGNGPESWINQFADLNKVFLGGDSAGATLAHNVAIRAGVDGLSGPKLMGMVLFHPYFGNDKPDKMLEVIFPTCEGVDDPRVNPSSDPNLVRLGCLRVLIFVAEKDFLRKRGWSYYEALKKSGWSGVVEIIETEDENHVFHLFDPTSEKAQAMMKKTVSILNQAQAHI
>rna-XM_030626943.1
MGSHNLDSTTIPQQVSIEAFPYLRVYKDGTIERLAGTQIAPTGLDPQTGVVSKDVIIAPQTGVSARLYRPQLHIKLLPLVVYFHGGGFFISSTADPLYHNSLNQLAAEAKVIIVSVNYRLAPENPLPAAYDDCWEALSWVASHSSSGGGVQSPATEEPWLKNHVDFNRIFLAGDSAGANIAHHLICRISEQNPSRRLIKICGVASIQPYFWGKEAIGSEVHDLVRKSMVDRWWSVVCPSDKGNDDPLINPFAEGAPSLEGLETCPKILVVVAGKDILRDRGWLYYEKVAKMSSSLGWGGTIEIMETLEEDHVFHILNPNSENAKALIKRLATFLN
>rna-XM_030629828.1
MDNEIAQDLSPLIKLYKNGRIERLVGTATVSASLDPETGVNSNDVVISPETTLSARLYIPKSAGSIQTKLPLLVYFHGGGFCVETAFSPVYHNHLNSLSSQVNIAIISVNYRLAPEHPLPAAYDDSWAVFKWALAHSNAKGPNEWLNSLVDFGRVFLAGDSAGGNIAHHVALRAGFEGINLRGIVLIHPYFWGKEPIGDEGKDGGSTGDEAYPGMLWKFVNPSSKNGSDDPLINPSKDPNVGKLGCGRVMVCVAEKDGLKDRGWFYKEVLKKSGWDGCVEVVETKGEGHVFHLFNPNSANAVEFMAQISSFINQ
>rna-XM_030630378.1
MSSIINSIQTLQFSTSLHFFSSTPSSSSSSLPKLRLKPSTTTTKLFCISSTPDAMAAPTTDEVARDFFPFLRIYKSGRIERIAGADVVPPSIDPKTGVESKDVVISPETGVKARLYVPNSSVAGQSQSPKKLPLVVYFHGGGFCVETPFCAKYHNAVNTLVAEANVVAVSVDYRLAPENPIPIAYDDSWDAVKWVVSHSEGTGPEEWLNSRADHERVFFAGDSAGANIAHHMAIRVGLEGGLSNGSKLLGIALIHPYFWGTEPIGNEVKFPEKGKWAEGIWRFVSPTTTGVDDPYINPGKDSNLGKLGCERVLICVAENDLLRDRGLYYKEILEKSDWVGRVEVVEAAGDEHVFHLTKPTCENAVAMLKKISSFIEQS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University