Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Cannabis sativa
Species name
Cannabis sativa is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Cannabis_sativa.CHS.fa
Download
>rna-XM_030636816.1
MGKVPSQLIPQECLVEGYIQDTKCQDISIKEKLERLCKTTTVKTRYTVMSKDILEKYPELATEGSPTIAQRLEIANPAVEMAMEASLACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLASQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNQARPYDLVGAALFGDGAAAVIVGTDPVKGIECPFMELNYAVQQFLPETHNVINGKLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAQLKDYNELFWAVHPGGPAILNKLETTLKLSSDKLQCSRRALMDYGNVSSNTIFYVIENMRELLKRGGEEWGLGLAFGPGITFEGVLIRSL
>rna-XM_030644341.1
MGKAFPSQLIPQECLVEGYIRDTKCQDISIKEKLERLCKTTTVKTRYTVMSKDILEKYPELATEGSPTIAQRLEIANPAVVEMAMEASLACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLASQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNQARPYDLVGAALFGDGAAAVIVGTDGKGIECPFMELNYAVQQFLPETHNVINGKLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAQLKDYNELFWAVHPGGPAILNKLETTLKLSSDKLQCSRRALMDYGNVSSNTIFYVIENMRELLKRGGEEWGLGLAFGPGITFEGVLIRSL
>rna-XM_030626628.1
MASITVDQIRKSQRADTPAAILAIGTANPANFVTQANYPDYYFNVTKSQHMTNLKNKFQHICNNTTIRKRYTHLDEEYLKQNPNMCEYMAPSLNARQSMLVTEVPKLGKEAAMKAIKEWGQPNKSKITHLIFCTMSGIDMPGADYHCAKLLELEPTVKRVMLYQHGCHGGGTVLRLAKDLAENNKGARVLAVCSDIMAFMFRGPTKSHLASMVGQALFGDGASAVIVGAEPNESMGERPIFELVSAAQTILPNSDKAIIGNVREMGLTFDLRKDVHLLISNNIEKSLMEAFTPIGISDWNSLFWITHPGGPTILNAVEAELQLKKEKLEISRYVLSEYGNMSSSCVFFIMDELRKRSLKEGKSTTGDGFEWGVLFGFGPGLTVETLVLHSVAIKN
>rna-XM_030628326.1
MNHLRAEGPASVLAIGTANPENILIQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLAEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDIMACLFRGPSDSDLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTILPNSEGTIGGHIREAGLIFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLDLKKEKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVVRSVPIKY
>rna-XM_030626629.1
MNHLRAEGPASVLAIGTANPENILIQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLAEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDIMACLFRGPSDSDLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTILPNSEGTIGGHIREAGLIFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLDLKKEKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVVRSVPIKY
>rna-XM_030653598.1
MTSSIVKQSQKAQRANGCAAILAIGTATPPNCMIQADYPDYYFRVTKSDHMTELKKKFKRICESSKIKKRYMHLTEDILKQHPNIGEYMAPSLDARQDMLVVEVPKLKKEAAMKAIKEWGQPKSKITHLVFCTTSSIDMPSADYQCAKLLGLNTSVKRVMLHQLGCYGGTVLRVAKDLAENNKGARVLAVCTEITTSTFHGPSESNLECLVGQALFGDGASCLIVGADPDALAGEKPIFELVSAAQTMLPDTETAIKGDLREAGLIINLSKDVPELISNNIEKCLIDAFTPLGISDWNSLFWIAHPGGRAILDAVEAKLQLRKDKMRATRHVMSEFGNMAGACSFFIVDEMRKKSLEEGKSTTGEGLEWGVVFGFGPGLTVETVVLRSVAINV
>rna-XM_030653640.1
MVTVEEFRKAQRAEGPATIMAIGTATPANCVLQSEYPDYYFRITNSEHKTELKEKFKRMCDKSMIRKRYMHLTEEILKENPNLCAYEAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGSAALIVGSDPIPEVEKPIFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPLGISDWNSLFWIAHPGGPAILDQVESKLALKTEKLRATRHVLSEYGNMSSACVLFILDEMRRKCVEDGLNTTGEGLEWGVLFGFGPGLTVETVVLHSVAI
>rna-XM_030631533.1
MGSEDNGEVILSKKANPGKATILALGKAFPHQLVMQEYLVDGYFRDTNCDDLDLKRKLTRLCKTTTVKTRYVVMSEEILRKYPELALEGKPTVKQRLDICNDAVTEMAIEASQSCINQWGRPISHITHLVYVSSSEVRLPGGDLYLAAGLGLNRHTQRLMLNFAGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSPDRPYDLVGVALFGDGAGAMIIGSDPDLGIEKPLFELHAAAQEFLPGTDKAIDGRLTEEGISFKLDRELPQVIEDNVEGFCEKLMEVVGFDKEYYNKMFWAVHPGGPAILNRIEKRLDLVPEKLVASRRALMDYGNASSNTIVYVLEYMIEESSKMMMMKKKQQGGSGHGHGLGLAQEEQNEWGLVLAFGPGITFEGILARNLTSFQP
>rna-XM_030641739.1
MMASISVDQIRKAQRANGPATVLAIGTANPPTSFYQADYPDFYFRVTKNQHMTELKDKFKRICEKTTIKKRHLYLTEDRLNQHPNLLEYMAPSLNTRQDMLVVEIPKLGKEAAMKAIKEWGQPKSRITHLIFCSTNGVDMPGADYECAKLLGLSSSVKRVMLYQQGCHAGGSVLRIAKDLAENNKGARILTINSEITIGIFHSPDETYFDGMVGQALFGDGASATIVGADPDKEIGERPIFEMVSAAQEFIPNSHGAVDGHLTEAGLVYHIHKDVPGLISKNIEKSLVEALNPIGISDWNSLFWIVHPGGPAILNAVEAKLHLKKEKMADTRYVLSEYGNMSSVSIFFIMDKLRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVETIVLHSLAN
MGKVPSQLIPQECLVEGYIQDTKCQDISIKEKLERLCKTTTVKTRYTVMSKDILEKYPELATEGSPTIAQRLEIANPAVEMAMEASLACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLASQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNQARPYDLVGAALFGDGAAAVIVGTDPVKGIECPFMELNYAVQQFLPETHNVINGKLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAQLKDYNELFWAVHPGGPAILNKLETTLKLSSDKLQCSRRALMDYGNVSSNTIFYVIENMRELLKRGGEEWGLGLAFGPGITFEGVLIRSL
>rna-XM_030644341.1
MGKAFPSQLIPQECLVEGYIRDTKCQDISIKEKLERLCKTTTVKTRYTVMSKDILEKYPELATEGSPTIAQRLEIANPAVVEMAMEASLACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLASQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNQARPYDLVGAALFGDGAAAVIVGTDGKGIECPFMELNYAVQQFLPETHNVINGKLSEEGINFKLGRDLPQKIEENIEEFCKKLMAKAQLKDYNELFWAVHPGGPAILNKLETTLKLSSDKLQCSRRALMDYGNVSSNTIFYVIENMRELLKRGGEEWGLGLAFGPGITFEGVLIRSL
>rna-XM_030626628.1
MASITVDQIRKSQRADTPAAILAIGTANPANFVTQANYPDYYFNVTKSQHMTNLKNKFQHICNNTTIRKRYTHLDEEYLKQNPNMCEYMAPSLNARQSMLVTEVPKLGKEAAMKAIKEWGQPNKSKITHLIFCTMSGIDMPGADYHCAKLLELEPTVKRVMLYQHGCHGGGTVLRLAKDLAENNKGARVLAVCSDIMAFMFRGPTKSHLASMVGQALFGDGASAVIVGAEPNESMGERPIFELVSAAQTILPNSDKAIIGNVREMGLTFDLRKDVHLLISNNIEKSLMEAFTPIGISDWNSLFWITHPGGPTILNAVEAELQLKKEKLEISRYVLSEYGNMSSSCVFFIMDELRKRSLKEGKSTTGDGFEWGVLFGFGPGLTVETLVLHSVAIKN
>rna-XM_030628326.1
MNHLRAEGPASVLAIGTANPENILIQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLAEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDIMACLFRGPSDSDLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTILPNSEGTIGGHIREAGLIFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLDLKKEKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVVRSVPIKY
>rna-XM_030626629.1
MNHLRAEGPASVLAIGTANPENILIQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLAEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDIMACLFRGPSDSDLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTILPNSEGTIGGHIREAGLIFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLDLKKEKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVVRSVPIKY
>rna-XM_030653598.1
MTSSIVKQSQKAQRANGCAAILAIGTATPPNCMIQADYPDYYFRVTKSDHMTELKKKFKRICESSKIKKRYMHLTEDILKQHPNIGEYMAPSLDARQDMLVVEVPKLKKEAAMKAIKEWGQPKSKITHLVFCTTSSIDMPSADYQCAKLLGLNTSVKRVMLHQLGCYGGTVLRVAKDLAENNKGARVLAVCTEITTSTFHGPSESNLECLVGQALFGDGASCLIVGADPDALAGEKPIFELVSAAQTMLPDTETAIKGDLREAGLIINLSKDVPELISNNIEKCLIDAFTPLGISDWNSLFWIAHPGGRAILDAVEAKLQLRKDKMRATRHVMSEFGNMAGACSFFIVDEMRKKSLEEGKSTTGEGLEWGVVFGFGPGLTVETVVLRSVAINV
>rna-XM_030653640.1
MVTVEEFRKAQRAEGPATIMAIGTATPANCVLQSEYPDYYFRITNSEHKTELKEKFKRMCDKSMIRKRYMHLTEEILKENPNLCAYEAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGSAALIVGSDPIPEVEKPIFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPLGISDWNSLFWIAHPGGPAILDQVESKLALKTEKLRATRHVLSEYGNMSSACVLFILDEMRRKCVEDGLNTTGEGLEWGVLFGFGPGLTVETVVLHSVAI
>rna-XM_030631533.1
MGSEDNGEVILSKKANPGKATILALGKAFPHQLVMQEYLVDGYFRDTNCDDLDLKRKLTRLCKTTTVKTRYVVMSEEILRKYPELALEGKPTVKQRLDICNDAVTEMAIEASQSCINQWGRPISHITHLVYVSSSEVRLPGGDLYLAAGLGLNRHTQRLMLNFAGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSPDRPYDLVGVALFGDGAGAMIIGSDPDLGIEKPLFELHAAAQEFLPGTDKAIDGRLTEEGISFKLDRELPQVIEDNVEGFCEKLMEVVGFDKEYYNKMFWAVHPGGPAILNRIEKRLDLVPEKLVASRRALMDYGNASSNTIVYVLEYMIEESSKMMMMKKKQQGGSGHGHGLGLAQEEQNEWGLVLAFGPGITFEGILARNLTSFQP
>rna-XM_030641739.1
MMASISVDQIRKAQRANGPATVLAIGTANPPTSFYQADYPDFYFRVTKNQHMTELKDKFKRICEKTTIKKRHLYLTEDRLNQHPNLLEYMAPSLNTRQDMLVVEIPKLGKEAAMKAIKEWGQPKSRITHLIFCSTNGVDMPGADYECAKLLGLSSSVKRVMLYQQGCHAGGSVLRIAKDLAENNKGARILTINSEITIGIFHSPDETYFDGMVGQALFGDGASATIVGADPDKEIGERPIFEMVSAAQEFIPNSHGAVDGHLTEAGLVYHIHKDVPGLISKNIEKSLVEALNPIGISDWNSLFWIVHPGGPAILNAVEAKLHLKKEKMADTRYVLSEYGNMSSVSIFFIMDKLRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVETIVLHSLAN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University