Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Cannabis sativa
Species name
Cannabis sativa is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Cannabis_sativa.4CL.fa
Download
>rna-XM_030638632.1
MAKCFNAETQIYSSHRPAVDFPTDPNLSLTSFLFRSTASYPNRTALIDADSGQTLTFLQLKTLVSNLAHSLIKLNIKKNDVVLIFAPNSIHFPVCFFSVASLGAITTTCNPSYTLTELSNQAKDCNPTLVITVPELWEKAKNLNLPAIILPSQSNLNLHCFNAEIWFYSDLIRKSNRFSELPISDVRQSDVAGLLYSSGTTGKSKGVVLSHKNFIRTSLMVTSDQDRYGEGQNMCLCFLPMFHIFGLSVIVYSQLRRGNGVVSMGKFELESCLRGVEMYRVTHFFVVPPVMIALAKESVVVRRYDLSSVKEILCGAAPLGKNVMEQCARNFPAAAVIQGYGMTETCGIISIEDSKEGCRFSGSTGMLVPGIESKIMNTQTWMPLPPNQEGEIWLRGPNMMQGYLNNLEATKTTIDEQGWVKTGDIGYFDEEGQLFVVDRLKELIKCYSFQVAPAELEALLLSHSEILDAVVIPFPDEKAGEVPIAYVVRSPNSSLSEEDVQRFIEKQVAPYKKLRRVTFVSSVPKSPAGKILRRELIQNVRSKI
>rna-XM_030640845.1
METSPQHHNDDHHEEHIFRSRYGAVEVPENVILPEFVLQGGEEYGDKVAFVDAVSGKEYTHGEVVRDTKRFGAALRSLGLRKGHVVVVVLPNVVEYAIVALGIMAAGGVFSGSNPAAHVLEIKKQVEDSGAKLIVTNASFYDKVKGLEVPVIAVEEEVVVEGAINWHKLLEAADRAGTCHIKEEVHQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFAIKPEMIGQVTVLGLMPFFHIYGITGICCATLRNKGKVVVMERYDLRTFVKALVSHEVTFAPVVPPIISDLVKKPMVDEFDLTNLKLQAVMSAAAPLAPELLRAFETKFPKVHVQEAYGLTEHSCITLTHGDDPANGYSRAKKNSVGFILPNLEVKFLDPDTARSLPKNTPGELCVRSQCVMQGYYNNKEETARAIDKEGWLHTGDIGYIDEDGDVFIVDRIKEMIKYKGFQVAPAELEAILLTHPSVEDAAVFPMVDEEAGEIPAACVVLVPEAKESEEEIMKYVASNVAHYKKVRVVHFVDSIPKSPSGKIMRRLLKQAMAKIHP
>rna-XM_030646244.1
MISIAPPLKTQNKQEISTIDHNDHNQEHIFKSKLPEIPISNNIPLHSYIFQNLPEKSNRPCLITGTTTQTTYSYSQTHHIAKKIAKGLSKLNINKNDVIMILLPNCPEFIFSFFGASMIGAAITTANPFYTSPEIFKQLQISKAKLVITQTQFVSKLIDFPEKVIGRDFTVVTVDGDENPSPENCLPFSILTGEDETEEISIDPNDPIAIPFSSGTTGLPKGVVLTHKNLITSVAQQVDGDNPNMYLRSDDVVLCVLPLFHIYSLNSVLLCALRVGASVLLVPKFEIGTLLELIQKHRVTVAPVVPPLVLGLAKNPVVSEFDLSSIRMVLSGAAPLGMELEDALRRRVPQAVIGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAQLKVIDPETGASLSYNQPGEICIRGHQIMKGYLDNSDATASTIDVDGWLHTGDIGYVDDNDEIFIVDRVKEIIKFKGFQVPPAELEALLISHPSIADAAVVPQKDEVAGEVPVAFVVKSNNKDFDLSEDAVKEFIAKQVVFYKKLHKVYFVHSIPKSPSGKILRKDLVAKLALASTLITSS
>rna-XM_030654419.1
MENINNNNKQDLEEEFIFRSKLPDIYIPNHLPLHSYCFENISQFKDRPCLINGATGETITYADVDLTSRKVAAGLDKIGIKQGDVIMLLLQNSPEFVYSFLAASYIGAIITTANPFYTPAEVAKQAAASKTKLVITLSGYIDKVKDFTSNENGGGVKVMCIDAPPIESECLHFSLLTQADESEIPAVKIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHQNDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLELIEKFKVTIAPFVPPIVLSVAKCPDLHRYDLSSIRTVMSGGAPMGKELEEAVKEKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIVDPDTGASLPRNQSGEICIRGKQIMKGYINDFEATKGTIDEAGWLHTGDIGFIDNDDELFIVDRLKELIKYKGFQVAPAELESMLIAHPNISDAAVVSMKDEAAGEVPVAFVVRSNGSKISEEDIKQYISKQVVFYKRIAKVFFIEEIPKSPAGKILRKSLRARLVTEQAI
>rna-XM_030621866.1
MEMKQENHNNNNGDEQEEFIFRSKLPDIYIPDHLPIHTYCFQNLSQFNHKPCLINSATAQIITYSDVHLTSRRVAAGLHKLGIKQGDVIMLLLRNCPEFVYSFLAASHIGAVVTTANPFYTAAEVAKQAAASNTKLVITLSGFIDKVRDFTGDGIKVVCVDAPPDESEYLHFSVLTQADESEIPDVEIKPDDVVALPYSSGTTGLPKGVMLTHRVMVTGVAQQVDGDNPNWHFHQNDVILCVLPVFHIYCLNAILLCGLRVGASILIMEKFEMKKMVELIEKFKVTIAPVVPPIVLSVVKFPDLHRYDLSSIRTIMSGGAPMGKDLEEAVKEKFPHVTLGQGYGMTEAECLSLCLGFAKEPFPTKFGTCGTVVRNAEMKIVDPNTGASLPRNQAGEICIRGKQLMKGYLNDVEATKATIDERGWLHTGDIGFVDNDDELFIVDRLKELIKYKGFQVAPAELESLLIAHPNISDAAVVPMKDEAAGEVPVAFVVTSNGSKITEDDIKQYISKQVVFYKRISKVFFIEEIPKSPSGKILRKILRTRLVTKQAI
>rna-XM_030626378.1
MEKSGYGRDGIYRSLRPPLHLPNNNNLSMVSFLFRNSSSYPQKPALIDSETNQILSFSHFKSTVIKVSHGFLNLGIKKNDVVLIYAPNSIHFPVCFLGIIASGAIATTSNPLYTVSELSKQVKDSNPKLIITVPQLLEKVKGFNLPTILIGPDSEQESSSDKVMTFNDLVNLGGSSGSEFPIVDDFKQSDTAALLYSSGTTGMSKGVVLTHKNFIASSLMVTMEQDLVGEMDNVFLCFLPMFHVFGLAIITYAQLQRGNTVISMARFDLEKMLKDVEKYKVTHLWVVPPVILALSKNSLVKKFNLSSIKYIGSGAAPLGKDLMEECSKVVPYGIVAQGYGMTETCGIVSMEDIRGGKRNSGSAGMLASGVEAQIVSVDTLKPLPPNQLGEIWVKGPNMMQGYFNNPQATKLTIDKKGWVHTGDLGYFDEDGHLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTENDVKKFIAGQVASFKRLRKVTFINSVPKSASGKILRRELIQKVRSNM
>rna-XM_030626724.1
MALVTEITKQEQQQDIIFRSKLPDIYIPKHLPLHTYCFGNKTQHDLSHPCLIYGPTGQVFTYAEVDLTARKLASGLNKLGVKQGDVVMVLLPNSPEYVFTFLGASYRGAMTTAANPFFTAAEIQKQAKASKTKLIVTQASYYDKVKDLDQEGLVKFVCVDSPVPEGWFHFSELCNNSDENDMAEVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYYSKNDVVLCVLPLFHIYSLNSVMLCSLRAGATILIMPKFEIGSLLGLIERYKVSVAPIVPPIVLAIAKYPDLHKYDLSSLKVLKSGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEAFDVKAGACGTVVRNAEMKIVDPETGSSLPRNQPGEICIRGDQIMKGYLNDPESTKNTIDKEGWLHTGDIGFVDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVPMKDEAAGEVPVAFVVRSNNSEVTEDQIKQFISKQVVFYKRISRVFFIDAIPKSPSGKILRKDLRAKLALGNL
MAKCFNAETQIYSSHRPAVDFPTDPNLSLTSFLFRSTASYPNRTALIDADSGQTLTFLQLKTLVSNLAHSLIKLNIKKNDVVLIFAPNSIHFPVCFFSVASLGAITTTCNPSYTLTELSNQAKDCNPTLVITVPELWEKAKNLNLPAIILPSQSNLNLHCFNAEIWFYSDLIRKSNRFSELPISDVRQSDVAGLLYSSGTTGKSKGVVLSHKNFIRTSLMVTSDQDRYGEGQNMCLCFLPMFHIFGLSVIVYSQLRRGNGVVSMGKFELESCLRGVEMYRVTHFFVVPPVMIALAKESVVVRRYDLSSVKEILCGAAPLGKNVMEQCARNFPAAAVIQGYGMTETCGIISIEDSKEGCRFSGSTGMLVPGIESKIMNTQTWMPLPPNQEGEIWLRGPNMMQGYLNNLEATKTTIDEQGWVKTGDIGYFDEEGQLFVVDRLKELIKCYSFQVAPAELEALLLSHSEILDAVVIPFPDEKAGEVPIAYVVRSPNSSLSEEDVQRFIEKQVAPYKKLRRVTFVSSVPKSPAGKILRRELIQNVRSKI
>rna-XM_030640845.1
METSPQHHNDDHHEEHIFRSRYGAVEVPENVILPEFVLQGGEEYGDKVAFVDAVSGKEYTHGEVVRDTKRFGAALRSLGLRKGHVVVVVLPNVVEYAIVALGIMAAGGVFSGSNPAAHVLEIKKQVEDSGAKLIVTNASFYDKVKGLEVPVIAVEEEVVVEGAINWHKLLEAADRAGTCHIKEEVHQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFAIKPEMIGQVTVLGLMPFFHIYGITGICCATLRNKGKVVVMERYDLRTFVKALVSHEVTFAPVVPPIISDLVKKPMVDEFDLTNLKLQAVMSAAAPLAPELLRAFETKFPKVHVQEAYGLTEHSCITLTHGDDPANGYSRAKKNSVGFILPNLEVKFLDPDTARSLPKNTPGELCVRSQCVMQGYYNNKEETARAIDKEGWLHTGDIGYIDEDGDVFIVDRIKEMIKYKGFQVAPAELEAILLTHPSVEDAAVFPMVDEEAGEIPAACVVLVPEAKESEEEIMKYVASNVAHYKKVRVVHFVDSIPKSPSGKIMRRLLKQAMAKIHP
>rna-XM_030646244.1
MISIAPPLKTQNKQEISTIDHNDHNQEHIFKSKLPEIPISNNIPLHSYIFQNLPEKSNRPCLITGTTTQTTYSYSQTHHIAKKIAKGLSKLNINKNDVIMILLPNCPEFIFSFFGASMIGAAITTANPFYTSPEIFKQLQISKAKLVITQTQFVSKLIDFPEKVIGRDFTVVTVDGDENPSPENCLPFSILTGEDETEEISIDPNDPIAIPFSSGTTGLPKGVVLTHKNLITSVAQQVDGDNPNMYLRSDDVVLCVLPLFHIYSLNSVLLCALRVGASVLLVPKFEIGTLLELIQKHRVTVAPVVPPLVLGLAKNPVVSEFDLSSIRMVLSGAAPLGMELEDALRRRVPQAVIGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAQLKVIDPETGASLSYNQPGEICIRGHQIMKGYLDNSDATASTIDVDGWLHTGDIGYVDDNDEIFIVDRVKEIIKFKGFQVPPAELEALLISHPSIADAAVVPQKDEVAGEVPVAFVVKSNNKDFDLSEDAVKEFIAKQVVFYKKLHKVYFVHSIPKSPSGKILRKDLVAKLALASTLITSS
>rna-XM_030654419.1
MENINNNNKQDLEEEFIFRSKLPDIYIPNHLPLHSYCFENISQFKDRPCLINGATGETITYADVDLTSRKVAAGLDKIGIKQGDVIMLLLQNSPEFVYSFLAASYIGAIITTANPFYTPAEVAKQAAASKTKLVITLSGYIDKVKDFTSNENGGGVKVMCIDAPPIESECLHFSLLTQADESEIPAVKIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHQNDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLELIEKFKVTIAPFVPPIVLSVAKCPDLHRYDLSSIRTVMSGGAPMGKELEEAVKEKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIVDPDTGASLPRNQSGEICIRGKQIMKGYINDFEATKGTIDEAGWLHTGDIGFIDNDDELFIVDRLKELIKYKGFQVAPAELESMLIAHPNISDAAVVSMKDEAAGEVPVAFVVRSNGSKISEEDIKQYISKQVVFYKRIAKVFFIEEIPKSPAGKILRKSLRARLVTEQAI
>rna-XM_030621866.1
MEMKQENHNNNNGDEQEEFIFRSKLPDIYIPDHLPIHTYCFQNLSQFNHKPCLINSATAQIITYSDVHLTSRRVAAGLHKLGIKQGDVIMLLLRNCPEFVYSFLAASHIGAVVTTANPFYTAAEVAKQAAASNTKLVITLSGFIDKVRDFTGDGIKVVCVDAPPDESEYLHFSVLTQADESEIPDVEIKPDDVVALPYSSGTTGLPKGVMLTHRVMVTGVAQQVDGDNPNWHFHQNDVILCVLPVFHIYCLNAILLCGLRVGASILIMEKFEMKKMVELIEKFKVTIAPVVPPIVLSVVKFPDLHRYDLSSIRTIMSGGAPMGKDLEEAVKEKFPHVTLGQGYGMTEAECLSLCLGFAKEPFPTKFGTCGTVVRNAEMKIVDPNTGASLPRNQAGEICIRGKQLMKGYLNDVEATKATIDERGWLHTGDIGFVDNDDELFIVDRLKELIKYKGFQVAPAELESLLIAHPNISDAAVVPMKDEAAGEVPVAFVVTSNGSKITEDDIKQYISKQVVFYKRISKVFFIEEIPKSPSGKILRKILRTRLVTKQAI
>rna-XM_030626378.1
MEKSGYGRDGIYRSLRPPLHLPNNNNLSMVSFLFRNSSSYPQKPALIDSETNQILSFSHFKSTVIKVSHGFLNLGIKKNDVVLIYAPNSIHFPVCFLGIIASGAIATTSNPLYTVSELSKQVKDSNPKLIITVPQLLEKVKGFNLPTILIGPDSEQESSSDKVMTFNDLVNLGGSSGSEFPIVDDFKQSDTAALLYSSGTTGMSKGVVLTHKNFIASSLMVTMEQDLVGEMDNVFLCFLPMFHVFGLAIITYAQLQRGNTVISMARFDLEKMLKDVEKYKVTHLWVVPPVILALSKNSLVKKFNLSSIKYIGSGAAPLGKDLMEECSKVVPYGIVAQGYGMTETCGIVSMEDIRGGKRNSGSAGMLASGVEAQIVSVDTLKPLPPNQLGEIWVKGPNMMQGYFNNPQATKLTIDKKGWVHTGDLGYFDEDGHLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTENDVKKFIAGQVASFKRLRKVTFINSVPKSASGKILRRELIQKVRSNM
>rna-XM_030626724.1
MALVTEITKQEQQQDIIFRSKLPDIYIPKHLPLHTYCFGNKTQHDLSHPCLIYGPTGQVFTYAEVDLTARKLASGLNKLGVKQGDVVMVLLPNSPEYVFTFLGASYRGAMTTAANPFFTAAEIQKQAKASKTKLIVTQASYYDKVKDLDQEGLVKFVCVDSPVPEGWFHFSELCNNSDENDMAEVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYYSKNDVVLCVLPLFHIYSLNSVMLCSLRAGATILIMPKFEIGSLLGLIERYKVSVAPIVPPIVLAIAKYPDLHKYDLSSLKVLKSGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEAFDVKAGACGTVVRNAEMKIVDPETGSSLPRNQPGEICIRGDQIMKGYLNDPESTKNTIDKEGWLHTGDIGFVDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVPMKDEAAGEVPVAFVVRSNNSEVTEDQIKQFISKQVVFYKRISRVFFIDAIPKSPSGKILRKDLRAKLALGNL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University