Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Calamus simplicifolius
Species name
Calamus simplicifolius is a species of monocot in the family Arecaceae (palm family).
Species info
Gene sequence info
Calamus_simplicifolius.C4H.fa
Download
>Maker00016240
MAPISPRKLALSTLLSLTFIFAAKSLFPAQSPSIALSIPLLFFLSLLFSNSKHSNTPPGPPSLPIFGNWLQVGNDLNHSFLANLCQKYGNVFLLKLGARNLVVVSDPKLATEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTAYGDHWRKMRRIMTLPFFTNKVVQQYREMWEEEMDLVVKDLCDDSLAQEQGMVIRRRLQLMLYNVMYRMMFDARFDSVTDPLFLEATRFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCRDLQSRRLAFFNNYYVEKRRKVMATKGDRQNLRCAIDHILEAEKNGEISTENVIYIVENINVAGRNLSIETTLWSMEWAIAELVNHPAVQDKLRREIADVLKGEPVTESNLQRLPYLQAVVKETLRLHTPIPLLVPHMNLEEARLGGYTIPEGSKVVVNAWWLANNPAWWDKPEEFRPERFLEEEGAVDAVVGGKVDFRFLPFGMGRRSCPGIILALPILGLVLGKLVTSFEMTPPPGVEKVDVSEKGGQFSLHIAKHSVVAFRPVEK
>Maker00009879
MDLILLEKALLGLFAAVTVAIAVSKLRGKRFKLPPGPFPIPIFGNWLQVGDDLNHRNLTAFAKRFGDIFLLRMGQRNLVVVSSPDLAREVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRRGWEEEARRVVEDVKANPKAATEGIVLRRRLQLMMYNNLFRIMFDRRFESEDDPLFNKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKICQEVKDRRLQLFKNHFVEERKELASTKGASNAELKCAIDHILEAERKGEINEDNVLYIVENINVAAIETTLWSVEWAIAELVNHPEIQRKLRNELDTVLGPGVQITEPDTHKLPYLQAVIKETLRFRMAIPLLVPHMNLHDAKLGGCDIPAESKVLVNAWWLANNPDSWKNPEEFRPERFFEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGTLVQNFELLPPRGQSKLDTTEKGGQFSLHILKHSTIVCKPRVF
>Maker00001815
MASDGAVGARAAGQKISSTGFFWVSSSLASAEVSRLKSAFPEVVSVPVDDLKVEMEDWPSRALIIRSFMKWVPAEAYVREFRRAGIQGDIKPVSLAFRCHIFLFEDPKAADLVMNRPWIINGQIIAMERWKPEFVPTADATPFALIWLRLPNLPLEFWKEDFLRMITETAGQFHCVDLSTLARSRGGFARVCLRVDLRRPLRPGTRVQGLNLPFWQQFVYEALEGFCSSCGSLHLEGPCSVSAGSSKDGDSPSPAFGSWLTAVRQRRDAPGSSREMRKKPSSLSTPDAPGCDSVPLMAKEKQRSAATGADEWRTPAKVARRHVPPSSKTVVISDVVPVEVGGEMQKSGMEASPAFVSVPVSSCAVIVAIEKLELKAGKKFSKAGIGSNSFMPIANPFSSSSLDVGRGSDPGSGDAFPGPLKRARPVESPAPRTNPKNVKRKGKGKVALPKNTEAARYFPVNPSLSQCSSGVDLEPSRRCCGPSSGASPIELVNHPEIQRKLRRELDTVLGPGVPITDPNIHNLPYLQAVIKETLRLRMAIPAPSSSPT
>Maker00001831
MLWSIEWGIADRAGEPPGDPAQAPARTRHRARPRRPDHRSRHPQSPLPPGRHQGDPPPPHGHPGPLLVSHMNLQVLHDVKLGGYDIPVESKILVNAWWLANNPDSWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALHELFMLKYF
>Maker00003234
MDLALLDKVLLGLFAAVTLAIAVSKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTALAKRFGDIFLLRMGQRNLVVVSSPDHARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRHGWEEEARRVVEDVKANPRASTEGIVLRRRLQLMMYNNMFRIMFGRRFESEDDPLFNKLKALNGERSRLAQSFEYNYGDFIPILRPFLKGYLKICQDVKDRRLQLFKDYFIEERKNLTSTKGTTNMELKCAIDHILEAERKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRRELDTVLGPGVPITEPDVHNLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDSWKNPEEFRPERFLEEDSNVEANGNDFRYLPFGVGRRSCPGIILALPILSITIGRLVQNFELLPPPGQSKLDTTEKGGQFSLHILKHSTIVCKPRAF
>Maker00039536
MAAFSTKKTVVAISTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYREMWEEEMDAVVKDLRAAGAQKEGMVIRRRLQLMLYNIMYRMMFDARFDSDSDPLFLQATKFNSERSRLLRASSTTTGTSFPSSGPS
>Maker00043759
MDLALLEKALLGLFAAVVVAIAVSKFRGKRFRLPPGPLPVPVFGNWLQVGDDLNHRNLSALARRFGDILLLRMGQRNLVVVSSPTLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAARVVADVKADPKAATEGIILRRRLQLMMYNNMYRIMFDRRFESEEDPLFLRLRALNGERSRLAQSFEYNYGDFIPLLRPFLRGYLKICKEVKERRLQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEINEDNVLYIVENINVAAIETTLWSIEWAIAELVNHPEIQQKLRKELDTVLGPGVQVTEPDTQKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDNWKKPEEFRPERFLEEEANVDANGNDCRYLPFGVGRRSCPGIILALPILGITIGHLVQNFELLPPAGQKKLDTTEKGGQFSLHILKHSTIVASLGCSDCLGLLSVHWHAIFLIVLFF
>Maker00044389
MWDCVRGDVCRLGGYTIPEGSKVVVNAWWLSNNPEWWDRPEEFRPERFLEEEEEVETLVHLQVPALWGWQAELPGDHTSAAHPRTHRRKADHEFSTRAATWAGQDRRQ
>Maker00046806
MAAFSTKKNGSGHLTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLQTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYRRCGRRRWTRW
>Maker00046811
MVVAISTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYRRCGRRRWTRW
>Maker00046812
MVIRRRLQLMLYNIMYRMMFDARFDSDSDPLFLQATKFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCQDLQSSRLAFFNNHYVEKRRKLMATSGGRNKLRCAMDHILEAEKNGEISSENVIYIVENINVADRSNGREGRRSGDRH
>Maker00046818
MVIRRCLQLMLYNIMYRMMFNARFDSDSDPLFLQATKFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCRDLHSSRLA
>Maker00005597
MNLQVLHDVKLGGYDIPAESKILVNAWWLANNPDSWKNPDEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALHELFMEESEGKLKGLLAYVDEDLVSTDFIGDDRSSIFDAKGGISLNA
>Maker00005606
MQPSRPCCGPSSGASPIELVNHPEIQRKLRRELDTVLGPGVPITDPDIHNLPYLQAVIKETLRLRMAIPAPSSSPHEPPGPPRRQARRLRHPVESKILVNAWWLANNPDSWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALRMSFLSMKVPIRKLKAAMRKKRQEAGKEGPMQSPW
MAPISPRKLALSTLLSLTFIFAAKSLFPAQSPSIALSIPLLFFLSLLFSNSKHSNTPPGPPSLPIFGNWLQVGNDLNHSFLANLCQKYGNVFLLKLGARNLVVVSDPKLATEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTAYGDHWRKMRRIMTLPFFTNKVVQQYREMWEEEMDLVVKDLCDDSLAQEQGMVIRRRLQLMLYNVMYRMMFDARFDSVTDPLFLEATRFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCRDLQSRRLAFFNNYYVEKRRKVMATKGDRQNLRCAIDHILEAEKNGEISTENVIYIVENINVAGRNLSIETTLWSMEWAIAELVNHPAVQDKLRREIADVLKGEPVTESNLQRLPYLQAVVKETLRLHTPIPLLVPHMNLEEARLGGYTIPEGSKVVVNAWWLANNPAWWDKPEEFRPERFLEEEGAVDAVVGGKVDFRFLPFGMGRRSCPGIILALPILGLVLGKLVTSFEMTPPPGVEKVDVSEKGGQFSLHIAKHSVVAFRPVEK
>Maker00009879
MDLILLEKALLGLFAAVTVAIAVSKLRGKRFKLPPGPFPIPIFGNWLQVGDDLNHRNLTAFAKRFGDIFLLRMGQRNLVVVSSPDLAREVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRRGWEEEARRVVEDVKANPKAATEGIVLRRRLQLMMYNNLFRIMFDRRFESEDDPLFNKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKICQEVKDRRLQLFKNHFVEERKELASTKGASNAELKCAIDHILEAERKGEINEDNVLYIVENINVAAIETTLWSVEWAIAELVNHPEIQRKLRNELDTVLGPGVQITEPDTHKLPYLQAVIKETLRFRMAIPLLVPHMNLHDAKLGGCDIPAESKVLVNAWWLANNPDSWKNPEEFRPERFFEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGTLVQNFELLPPRGQSKLDTTEKGGQFSLHILKHSTIVCKPRVF
>Maker00001815
MASDGAVGARAAGQKISSTGFFWVSSSLASAEVSRLKSAFPEVVSVPVDDLKVEMEDWPSRALIIRSFMKWVPAEAYVREFRRAGIQGDIKPVSLAFRCHIFLFEDPKAADLVMNRPWIINGQIIAMERWKPEFVPTADATPFALIWLRLPNLPLEFWKEDFLRMITETAGQFHCVDLSTLARSRGGFARVCLRVDLRRPLRPGTRVQGLNLPFWQQFVYEALEGFCSSCGSLHLEGPCSVSAGSSKDGDSPSPAFGSWLTAVRQRRDAPGSSREMRKKPSSLSTPDAPGCDSVPLMAKEKQRSAATGADEWRTPAKVARRHVPPSSKTVVISDVVPVEVGGEMQKSGMEASPAFVSVPVSSCAVIVAIEKLELKAGKKFSKAGIGSNSFMPIANPFSSSSLDVGRGSDPGSGDAFPGPLKRARPVESPAPRTNPKNVKRKGKGKVALPKNTEAARYFPVNPSLSQCSSGVDLEPSRRCCGPSSGASPIELVNHPEIQRKLRRELDTVLGPGVPITDPNIHNLPYLQAVIKETLRLRMAIPAPSSSPT
>Maker00001831
MLWSIEWGIADRAGEPPGDPAQAPARTRHRARPRRPDHRSRHPQSPLPPGRHQGDPPPPHGHPGPLLVSHMNLQVLHDVKLGGYDIPVESKILVNAWWLANNPDSWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALHELFMLKYF
>Maker00003234
MDLALLDKVLLGLFAAVTLAIAVSKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTALAKRFGDIFLLRMGQRNLVVVSSPDHARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRHGWEEEARRVVEDVKANPRASTEGIVLRRRLQLMMYNNMFRIMFGRRFESEDDPLFNKLKALNGERSRLAQSFEYNYGDFIPILRPFLKGYLKICQDVKDRRLQLFKDYFIEERKNLTSTKGTTNMELKCAIDHILEAERKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRRELDTVLGPGVPITEPDVHNLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDSWKNPEEFRPERFLEEDSNVEANGNDFRYLPFGVGRRSCPGIILALPILSITIGRLVQNFELLPPPGQSKLDTTEKGGQFSLHILKHSTIVCKPRAF
>Maker00039536
MAAFSTKKTVVAISTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYREMWEEEMDAVVKDLRAAGAQKEGMVIRRRLQLMLYNIMYRMMFDARFDSDSDPLFLQATKFNSERSRLLRASSTTTGTSFPSSGPS
>Maker00043759
MDLALLEKALLGLFAAVVVAIAVSKFRGKRFRLPPGPLPVPVFGNWLQVGDDLNHRNLSALARRFGDILLLRMGQRNLVVVSSPTLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAARVVADVKADPKAATEGIILRRRLQLMMYNNMYRIMFDRRFESEEDPLFLRLRALNGERSRLAQSFEYNYGDFIPLLRPFLRGYLKICKEVKERRLQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEINEDNVLYIVENINVAAIETTLWSIEWAIAELVNHPEIQQKLRKELDTVLGPGVQVTEPDTQKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDNWKKPEEFRPERFLEEEANVDANGNDCRYLPFGVGRRSCPGIILALPILGITIGHLVQNFELLPPAGQKKLDTTEKGGQFSLHILKHSTIVASLGCSDCLGLLSVHWHAIFLIVLFF
>Maker00044389
MWDCVRGDVCRLGGYTIPEGSKVVVNAWWLSNNPEWWDRPEEFRPERFLEEEEEVETLVHLQVPALWGWQAELPGDHTSAAHPRTHRRKADHEFSTRAATWAGQDRRQ
>Maker00046806
MAAFSTKKNGSGHLTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLQTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYRRCGRRRWTRW
>Maker00046811
MVVAISTSLVSLGFLVVAKSLQLLPIQSSLSIPGLSIFLFLLTATSLWRSRPANAPPGPASIPIFGNWLQVGNDLNHRFLAGMAKKFGNVFLLRLGARNLVVVSEPKLASEVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGEHWRKMRRIMTLPFFTNKVVQQYRRCGRRRWTRW
>Maker00046812
MVIRRRLQLMLYNIMYRMMFDARFDSDSDPLFLQATKFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCQDLQSSRLAFFNNHYVEKRRKLMATSGGRNKLRCAMDHILEAEKNGEISSENVIYIVENINVADRSNGREGRRSGDRH
>Maker00046818
MVIRRCLQLMLYNIMYRMMFNARFDSDSDPLFLQATKFNSERSRLAQSFEYNYGDFIPILRPFLRGYLNKCRDLHSSRLA
>Maker00005597
MNLQVLHDVKLGGYDIPAESKILVNAWWLANNPDSWKNPDEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALHELFMEESEGKLKGLLAYVDEDLVSTDFIGDDRSSIFDAKGGISLNA
>Maker00005606
MQPSRPCCGPSSGASPIELVNHPEIQRKLRRELDTVLGPGVPITDPDIHNLPYLQAVIKETLRLRMAIPAPSSSPHEPPGPPRRQARRLRHPVESKILVNAWWLANNPDSWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALSILGITIGRLVQNFELLPPPGQSKLVTKEALRMSFLSMKVPIRKLKAAMRKKRQEAGKEGPMQSPW
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University