Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Brachypodium distachyon
Species name
Stiff brome (Brachypodium distachyon) is a species of monocot in the family Poaceae (grass family).
Species info
Gene sequence info
Brachypodium_distachyon.4CL.fa
Download
>rna-XM_003563290.4
MGSVAAEEFPAPVPTPAAAETVFRSKLPDIEIPAHLTLQAYCFERLAEVSARPCLIDAQSGAVHTYGEVDALSRRAAAGLRRRLGVGKGDVVMLLLRNCAEFAFVFLGAARLGAAATTANPFCTPHEIHRQASAAGAKVIVTEPCAAEKVRAFAAERGVAVVVVVEGDGAAPDGCLEFKDAILGEDCGAGEEEEEEEAVVDPDDVVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGENPNLYFRKEDVVLCLLPLFHIYSLNSVLLAGLRAGCAIVVMRKFDHGALAAAVRAHGVTVAPFVPPIVVEITKSDRVTAGDLASIRMVMSGAAPMGKDLQDSFMAKLPNAVLGQGYGMTEAGPVLAMCLAFAKEPFEVKSGSCGTVVRNAELKIVDPDTGASLGRNQPGEICIRGQQIMKGYLNDPEATKNTIDKDSWLHTGDIGYVDDDEEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMQDELAGEVPVAFVVRTQGSEISENDIKQFVAKEVVFYKRIHKVFFADSIPKSPSGKILRKDLRAKLAAGIPSDDNTQSKS
>rna-XM_003558739.4
MATAAVPSAGYGADGVYRSLRPAARIESNPGLSAVDLLLRRAAACPSALALVDAATGHALTFSGLRSAILASAVALSSRAGVRPGDSVLLVAPNCVLYPVCFFAVTALGAVASTANPLYTPREIAKQASDARARLVITVAELLPKVADLRLPVILLDDTAAKSGSSATLYSDLVSGVDEADYRRPPTKQSDTAGLLYSSGTTGESKGVVLTHRNFIAAATMVTSDQDDRGEGPNVFLCFLPMFHIFGLSVITYGQLQRGNTVVVMSGFALDTVMSAVQQHRVTHLFCVPPVMIALAKHGKAGKYDLSSLKFIGSGAAPLGKDVMEAVAKNFPDALICQGYGMTETCGIISLEYPEKGQVRQFGSTGTLVTGVEAKIVDVETLKHLPPNQLGEICVRGPHIMQGYFNNVQATEFTIRQGWLHTGDLGLFDDEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSPDSSLTEVDVQKFIETQVTYYKRLKRVTFVSSVPKSASGKILRRELIAKVRSSKL
>rna-XM_010236885.3
MGSLPEHGAAEAETSTVIFRSTLPDIAIPDHLPLHDYVFERLASRRDRACLIDGATGETLTLGDVHALSLRVAAGFHRSLGVRHGSVVMLLLPNSVEFALAFLAASRLGAVTTTANPLHTPPEIAKQVSASGATVVITEPAFVSKVQNLTGVTIVATGVGAEGCTSFADLAATEDAASLPETRIDVANDVVALPYSSGTTGLPKGVMLLHRGLVTSVSQLVDGDNPNLHIREDDVVLCVLPMFHVYSLHSILLCGMRAGAALVIMKRFETVRMFELVERHGITIAPLVPPIVVEMAKSDAVGKYDLSSVRMVISGAAPMGKELQDIVHAKLPRAVLGQGYGMTEAGPVLSMCMAFAKEPLPVKSGACGTVVRNAELKIVDPETGLCLGRNQPGEICIRGRQIMKGYLNNPDATAETVDKDGWLHTGDVGYVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPSIADAAVVPMKDDASGEIPVAFVVPSDGAGITEDEIKQYVAKQVVFYKRLQKVFFATSIPKAPSGKILRKDLRAKLAAGSC
>rna-XM_003570465.4
MGSVPEESPAAGEETVFRSRLPDIEIPSEQTLQSYCFAKMAEVGSRPCLIDGQTGESYTYSEVESLTRRAAAGLRRMGVGKGDVVMNLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEIHRQAEAAGAKLVVTEACAVEKVREFAAGKGIPVVTVDGRFDGCVEFEELIGGEEEMDEGEIHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKEDVVLCLLPLFHIYSLNSVLLAGLRAGSAIVIMRKFDIGALVDLVRAHGVTVAPFVPPIVVEIAKSDRVSAADLASIRMVMSGAAPMGKELQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAELKIVDPDTGASLARNQPGEICIRGEQIMKGYLNDPESTKNTIDKDGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVAPAELEALLITHPEIKEAAVVSLKDDLTGEIPVAFVKRIDGSEITEAEIKQFVAKEVVFYKRIHKVFFTDSIPKSPSGKILRKDLRARLAAGVPSDDTAPRS
>rna-XM_003570105.4
MITVAAPEVQQPHAAAAESVSRAPEETIFRSKLPDIDIPSHLPLHEYCFARAASLPDAPCLIAAATGRTYTFAETRLLCRKAAAALHGLGVGHGDRLMVLLHNSVEFALAFFGASFLGAVTTAANPLCTPQEIHKQLVASGAKLVVTQSAYVDKLRHECFPRIATSTTVDDETLAVITIDDAPDGDDECLSFWGIVEAADESRVPEAAISADDAVALPYSSGTTGLPKGVVLTHGGLVASVAQQVDGENPNLDMREGRDVVLCVLPLFHIFSLNSVLLCALRAGAAVLLMPRFEMGAMLEGIERWRVTVAAVVPPLVLALAKNPAVERHDLSSVRIVLSGAAPLGKDLEDALRRRVPQAVFGQGYGMTEAGPVLSMCPAFAREPTPAKSGSCGTVVRNAQLKVVDPDTGFSLARNLPGEICIRGPQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVSQKDDAAGEVPVAFVVRAADSDVTEQAIKEFVSKQVVFYKRLHKVYFTHAIPKSASGKILRKELRAKLASPATA
>rna-XM_003573556.4
MGSTELAVAEVATTPEPIIFRSKLPDIAITNTLPLHRYCFERLDSVSSRPCLIDGPTAAVLTYAEVDALSRRLAAALRRVLRVRRGAVVMNLLRNSAEFVLSFFAASRAGAAVTTANPASTPHEVAAQLAASRATVVFTESLAAHKLPPHAHDGSPLTVILIDDRRDGCLHFWDDLLSSAGDEDEDIEEDPEFDPDDVVALPYSSGTTGLPKGVMLTHRSLSTSVAQQVDGDNPNIALTEHDVILCALPLFHIYSLNTIMMCALRAGAAIVLMRRFDLADMAELVEKHRITVAPLVPPIVVAVAKSGAGDGEDVVAKRDLSSVRMVLSGAAPMGKDIEDAFMAKLPDAVLGQGYGMTEAGPVLSMSLAFAKEPFKVKSGACGTVVRNGELKVVDPGTGKSLGRNQNGEICIRGQQIMKGYLNDPEATRNTIDADRWLHTGDIGFVDDDDEIFIVDRLKEIIKYRGFQVAPAELEALLITHPSIADAAVVGEQIEPEIGEIPVAFVARSQGSDISEDDIKQFVSKEVIYYKKIRKVFFVDTIPKAPSGKILRKELRKQLQQQQQDQA
>rna-XM_003579309.4
MTQPNLTYTPLVLATHKNCVTITSMSSSSWSRHSSAKPLLVSTNASRAAAFPLTTTNTVLLEASNNNQQQQIISMGDAAIAVMDPEEDSEVEEHIFRSRFPPVSVPDGVTVPDFVMSGAEAYADKVALVEAAPGGRSYTYGEMSRDIARFARALRSVGIRKGHVIVVVLPNLAVYPVVSLGVMAAGAVFSGVNPRALAAEIRKQVEDSEAKLVVANEVAYDKVKDVGVPVIGITSNNNMPGAISWDELLAAADRTGAPVVPLDPVLQSDLCALPYSSGTTGVSKGVMLSHGNLVSNLCSSMFAVGPELRGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRTFLGALVTHRVMFAPVVPPVMLAMVKNPIAEEFDLSGLALKSVMTAAAPLAPDLLEAFQKKFPGVQVEEAYGLTEHSCVTLTHAGDDPEKGHIAKKNSVGFILPNLEVKFVDPDTGRSLPKNTPGELCVRSQCVMQGYYKKKAETERTIDSKGWLHTGDVGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEVPVSCVVRRSGAAESEADIMGYVASRVASYKRLRMLHLVDAIPKSVSGKILRRQLRDEFIKMIKLAA
MGSVAAEEFPAPVPTPAAAETVFRSKLPDIEIPAHLTLQAYCFERLAEVSARPCLIDAQSGAVHTYGEVDALSRRAAAGLRRRLGVGKGDVVMLLLRNCAEFAFVFLGAARLGAAATTANPFCTPHEIHRQASAAGAKVIVTEPCAAEKVRAFAAERGVAVVVVVEGDGAAPDGCLEFKDAILGEDCGAGEEEEEEEAVVDPDDVVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGENPNLYFRKEDVVLCLLPLFHIYSLNSVLLAGLRAGCAIVVMRKFDHGALAAAVRAHGVTVAPFVPPIVVEITKSDRVTAGDLASIRMVMSGAAPMGKDLQDSFMAKLPNAVLGQGYGMTEAGPVLAMCLAFAKEPFEVKSGSCGTVVRNAELKIVDPDTGASLGRNQPGEICIRGQQIMKGYLNDPEATKNTIDKDSWLHTGDIGYVDDDEEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMQDELAGEVPVAFVVRTQGSEISENDIKQFVAKEVVFYKRIHKVFFADSIPKSPSGKILRKDLRAKLAAGIPSDDNTQSKS
>rna-XM_003558739.4
MATAAVPSAGYGADGVYRSLRPAARIESNPGLSAVDLLLRRAAACPSALALVDAATGHALTFSGLRSAILASAVALSSRAGVRPGDSVLLVAPNCVLYPVCFFAVTALGAVASTANPLYTPREIAKQASDARARLVITVAELLPKVADLRLPVILLDDTAAKSGSSATLYSDLVSGVDEADYRRPPTKQSDTAGLLYSSGTTGESKGVVLTHRNFIAAATMVTSDQDDRGEGPNVFLCFLPMFHIFGLSVITYGQLQRGNTVVVMSGFALDTVMSAVQQHRVTHLFCVPPVMIALAKHGKAGKYDLSSLKFIGSGAAPLGKDVMEAVAKNFPDALICQGYGMTETCGIISLEYPEKGQVRQFGSTGTLVTGVEAKIVDVETLKHLPPNQLGEICVRGPHIMQGYFNNVQATEFTIRQGWLHTGDLGLFDDEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSPDSSLTEVDVQKFIETQVTYYKRLKRVTFVSSVPKSASGKILRRELIAKVRSSKL
>rna-XM_010236885.3
MGSLPEHGAAEAETSTVIFRSTLPDIAIPDHLPLHDYVFERLASRRDRACLIDGATGETLTLGDVHALSLRVAAGFHRSLGVRHGSVVMLLLPNSVEFALAFLAASRLGAVTTTANPLHTPPEIAKQVSASGATVVITEPAFVSKVQNLTGVTIVATGVGAEGCTSFADLAATEDAASLPETRIDVANDVVALPYSSGTTGLPKGVMLLHRGLVTSVSQLVDGDNPNLHIREDDVVLCVLPMFHVYSLHSILLCGMRAGAALVIMKRFETVRMFELVERHGITIAPLVPPIVVEMAKSDAVGKYDLSSVRMVISGAAPMGKELQDIVHAKLPRAVLGQGYGMTEAGPVLSMCMAFAKEPLPVKSGACGTVVRNAELKIVDPETGLCLGRNQPGEICIRGRQIMKGYLNNPDATAETVDKDGWLHTGDVGYVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPSIADAAVVPMKDDASGEIPVAFVVPSDGAGITEDEIKQYVAKQVVFYKRLQKVFFATSIPKAPSGKILRKDLRAKLAAGSC
>rna-XM_003570465.4
MGSVPEESPAAGEETVFRSRLPDIEIPSEQTLQSYCFAKMAEVGSRPCLIDGQTGESYTYSEVESLTRRAAAGLRRMGVGKGDVVMNLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEIHRQAEAAGAKLVVTEACAVEKVREFAAGKGIPVVTVDGRFDGCVEFEELIGGEEEMDEGEIHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKEDVVLCLLPLFHIYSLNSVLLAGLRAGSAIVIMRKFDIGALVDLVRAHGVTVAPFVPPIVVEIAKSDRVSAADLASIRMVMSGAAPMGKELQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAELKIVDPDTGASLARNQPGEICIRGEQIMKGYLNDPESTKNTIDKDGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVAPAELEALLITHPEIKEAAVVSLKDDLTGEIPVAFVKRIDGSEITEAEIKQFVAKEVVFYKRIHKVFFTDSIPKSPSGKILRKDLRARLAAGVPSDDTAPRS
>rna-XM_003570105.4
MITVAAPEVQQPHAAAAESVSRAPEETIFRSKLPDIDIPSHLPLHEYCFARAASLPDAPCLIAAATGRTYTFAETRLLCRKAAAALHGLGVGHGDRLMVLLHNSVEFALAFFGASFLGAVTTAANPLCTPQEIHKQLVASGAKLVVTQSAYVDKLRHECFPRIATSTTVDDETLAVITIDDAPDGDDECLSFWGIVEAADESRVPEAAISADDAVALPYSSGTTGLPKGVVLTHGGLVASVAQQVDGENPNLDMREGRDVVLCVLPLFHIFSLNSVLLCALRAGAAVLLMPRFEMGAMLEGIERWRVTVAAVVPPLVLALAKNPAVERHDLSSVRIVLSGAAPLGKDLEDALRRRVPQAVFGQGYGMTEAGPVLSMCPAFAREPTPAKSGSCGTVVRNAQLKVVDPDTGFSLARNLPGEICIRGPQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVSQKDDAAGEVPVAFVVRAADSDVTEQAIKEFVSKQVVFYKRLHKVYFTHAIPKSASGKILRKELRAKLASPATA
>rna-XM_003573556.4
MGSTELAVAEVATTPEPIIFRSKLPDIAITNTLPLHRYCFERLDSVSSRPCLIDGPTAAVLTYAEVDALSRRLAAALRRVLRVRRGAVVMNLLRNSAEFVLSFFAASRAGAAVTTANPASTPHEVAAQLAASRATVVFTESLAAHKLPPHAHDGSPLTVILIDDRRDGCLHFWDDLLSSAGDEDEDIEEDPEFDPDDVVALPYSSGTTGLPKGVMLTHRSLSTSVAQQVDGDNPNIALTEHDVILCALPLFHIYSLNTIMMCALRAGAAIVLMRRFDLADMAELVEKHRITVAPLVPPIVVAVAKSGAGDGEDVVAKRDLSSVRMVLSGAAPMGKDIEDAFMAKLPDAVLGQGYGMTEAGPVLSMSLAFAKEPFKVKSGACGTVVRNGELKVVDPGTGKSLGRNQNGEICIRGQQIMKGYLNDPEATRNTIDADRWLHTGDIGFVDDDDEIFIVDRLKEIIKYRGFQVAPAELEALLITHPSIADAAVVGEQIEPEIGEIPVAFVARSQGSDISEDDIKQFVSKEVIYYKKIRKVFFVDTIPKAPSGKILRKELRKQLQQQQQDQA
>rna-XM_003579309.4
MTQPNLTYTPLVLATHKNCVTITSMSSSSWSRHSSAKPLLVSTNASRAAAFPLTTTNTVLLEASNNNQQQQIISMGDAAIAVMDPEEDSEVEEHIFRSRFPPVSVPDGVTVPDFVMSGAEAYADKVALVEAAPGGRSYTYGEMSRDIARFARALRSVGIRKGHVIVVVLPNLAVYPVVSLGVMAAGAVFSGVNPRALAAEIRKQVEDSEAKLVVANEVAYDKVKDVGVPVIGITSNNNMPGAISWDELLAAADRTGAPVVPLDPVLQSDLCALPYSSGTTGVSKGVMLSHGNLVSNLCSSMFAVGPELRGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRTFLGALVTHRVMFAPVVPPVMLAMVKNPIAEEFDLSGLALKSVMTAAAPLAPDLLEAFQKKFPGVQVEEAYGLTEHSCVTLTHAGDDPEKGHIAKKNSVGFILPNLEVKFVDPDTGRSLPKNTPGELCVRSQCVMQGYYKKKAETERTIDSKGWLHTGDVGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEVPVSCVVRRSGAAESEADIMGYVASRVASYKRLRMLHLVDAIPKSVSGKILRRQLRDEFIKMIKLAA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University