Enzyme
The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.
LAR1
Enzyme
Leucoanthocyanidin reductase
Enzyme name
EC:1.17.1.3
Entry
Oxidoreductases;Acting on CH or CH2 groups;With NAD+ or NADP+ as acceptor
Class
(2R,3S)-catechin:NADP+ 4-oxidoreductase
Sysname
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+ [RN:R06532]
Reaction
2,3-trans-3,4-cis-leucocyanidin [CPD:C05906];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Bombax ceiba
Species name
Indian kapok (Bombax ceiba) is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Bombax_ceiba.LAR1.fa
Download
>evm.model.Scaffold48.666
MYEFYFVAGSDIGKFTMKTVDDIRTMNKSVHFRPACNFYNMSELVTLWERKIGRTLPRVTVTENDLISVAAENRIPQSIAASFTHDIS
>evm.model.Scaffold48.665
MTVSTANGRALVVGATGLIGQFVAEASLDAGRPTYILIRPTSGNHAMNKVAKPSRTEAPYCCMDRQMTQLKLLVQLRFLPSEFGHDVDRVDPVDPGLTMYKEKRQVRRQTEKLGIPYTYICCNSIVSWPYYDNTHSS
>evm.model.Scaffold59.37
MTVSTASSRVLIVGATGFIGQFVAEASLGAGRATYVLVRPSSGNNSKSKVAKSLQDRGAILLHGLANDKELMEKLLREHQIDIVISAVGGAKILDQLCLIEAIKAAGTVKRFLPSEFGHDVDRADPVEPGLTMYKEKRQVRRLIEKLAIPYTYICCNSIASWPYYDNRHPSEVIPPLDQFQIYGDGSVKAYFVAGTDIGKFTMKTVDDIRTLNKSVHFRPACNFYNMNELAALWERKIQRTLPRVTVTENDLLSAAAENCIPQSIVASFTHDIFIKGCQINFSIEGPNEIEVSSLYPNEPFRTLDDCFNDFLVKMKDENMKQSNGIPAQKPVVEALAITAKCA
>evm.model.Scaffold144.173
MNSTTLMNGSFPDDSETGRTIVIGSSGFIGRFVTEACLDSGRPTYILIRSSLNSPSKGDTIRFLQDKGAIVIYGSISDQEFMEKVLREYKIEVVISAVGGDSILEQLNLIEAIKNVGTVKRFLPSEFGHDIDRAEPVEPGLTMYEQKRKIRRQIEKCGIPYTYICCNSIAAWPYHDNTHPADVLPPLDRFQIYGDGTVKAYFVAGTDIGKFTMMSINDDRTLNKTVHFQPPSNLLNMNNMAALWEEKIGRTLPRVSITEDDLLQRAREMRIPQSIVAALTHDIFINGCQINFSLDKPTDVEVCSLYPDSPFQTIAECFDDFAKKIPDNAKAVSKPAAAGNNAGFVPPAKPEALAITATCT
>evm.model.Scaffold163.95
MKSAIMNGSSPNVSETSRTMVIGSSGFIGRFVTEACLDSGRPTYILIRSTSNSPTKASTIKFLQDKGAIVIYGSITDKEFMEKVMREYKIEVVISTVGGGSILDQFNLIEAIKSVGTLKRFLPSEFGHDIDRAEPVEPGLTMYEQKRKIRRHIEMCGIPYTYICCNSIAAWPYHDNTHPADVLPPLDTFHIYGDGTVKAYFVAGTDIGKFTMMSINDDRTVNKTVHFRPPGNVLNMNEMASLWEEKIGRTLPRVTITEDDLLQRAQEMRIPQSVVAALTHDIFIKGCQINFSLDKPTDVEVCSLYPDVPLRTIGECFDNFAKKIFDNTKAVSSKPASNNAIFVPTAQPEAFAITAICT
>evm.model.Scaffold344.46
MEKVLRDYKIEVVISAVGGESILDQFNLIEAIKNVDTVKRFLPSEFGHDLDRADPVEPGLTMYNEKRKIRREIEESGIPYTYICCNSIAAWPYHDNTHPADVLPPLDKFQIYGDGTVKAYFVAGTDIGKFTLMSINDDRTLNKTVHFQPPSNLLNLNEMASLWEEKIGRTLPRVTITEQDLLHRAQDTPFRTIADCFEEFAKKIFDNAQAVTKPATATNNDVFAPTASPEALSITAMSS
MYEFYFVAGSDIGKFTMKTVDDIRTMNKSVHFRPACNFYNMSELVTLWERKIGRTLPRVTVTENDLISVAAENRIPQSIAASFTHDIS
>evm.model.Scaffold48.665
MTVSTANGRALVVGATGLIGQFVAEASLDAGRPTYILIRPTSGNHAMNKVAKPSRTEAPYCCMDRQMTQLKLLVQLRFLPSEFGHDVDRVDPVDPGLTMYKEKRQVRRQTEKLGIPYTYICCNSIVSWPYYDNTHSS
>evm.model.Scaffold59.37
MTVSTASSRVLIVGATGFIGQFVAEASLGAGRATYVLVRPSSGNNSKSKVAKSLQDRGAILLHGLANDKELMEKLLREHQIDIVISAVGGAKILDQLCLIEAIKAAGTVKRFLPSEFGHDVDRADPVEPGLTMYKEKRQVRRLIEKLAIPYTYICCNSIASWPYYDNRHPSEVIPPLDQFQIYGDGSVKAYFVAGTDIGKFTMKTVDDIRTLNKSVHFRPACNFYNMNELAALWERKIQRTLPRVTVTENDLLSAAAENCIPQSIVASFTHDIFIKGCQINFSIEGPNEIEVSSLYPNEPFRTLDDCFNDFLVKMKDENMKQSNGIPAQKPVVEALAITAKCA
>evm.model.Scaffold144.173
MNSTTLMNGSFPDDSETGRTIVIGSSGFIGRFVTEACLDSGRPTYILIRSSLNSPSKGDTIRFLQDKGAIVIYGSISDQEFMEKVLREYKIEVVISAVGGDSILEQLNLIEAIKNVGTVKRFLPSEFGHDIDRAEPVEPGLTMYEQKRKIRRQIEKCGIPYTYICCNSIAAWPYHDNTHPADVLPPLDRFQIYGDGTVKAYFVAGTDIGKFTMMSINDDRTLNKTVHFQPPSNLLNMNNMAALWEEKIGRTLPRVSITEDDLLQRAREMRIPQSIVAALTHDIFINGCQINFSLDKPTDVEVCSLYPDSPFQTIAECFDDFAKKIPDNAKAVSKPAAAGNNAGFVPPAKPEALAITATCT
>evm.model.Scaffold163.95
MKSAIMNGSSPNVSETSRTMVIGSSGFIGRFVTEACLDSGRPTYILIRSTSNSPTKASTIKFLQDKGAIVIYGSITDKEFMEKVMREYKIEVVISTVGGGSILDQFNLIEAIKSVGTLKRFLPSEFGHDIDRAEPVEPGLTMYEQKRKIRRHIEMCGIPYTYICCNSIAAWPYHDNTHPADVLPPLDTFHIYGDGTVKAYFVAGTDIGKFTMMSINDDRTVNKTVHFRPPGNVLNMNEMASLWEEKIGRTLPRVTITEDDLLQRAQEMRIPQSVVAALTHDIFIKGCQINFSLDKPTDVEVCSLYPDVPLRTIGECFDNFAKKIFDNTKAVSSKPASNNAIFVPTAQPEAFAITAICT
>evm.model.Scaffold344.46
MEKVLRDYKIEVVISAVGGESILDQFNLIEAIKNVDTVKRFLPSEFGHDLDRADPVEPGLTMYNEKRKIRREIEESGIPYTYICCNSIAAWPYHDNTHPADVLPPLDKFQIYGDGTVKAYFVAGTDIGKFTLMSINDDRTLNKTVHFQPPSNLLNLNEMASLWEEKIGRTLPRVTITEQDLLHRAQDTPFRTIADCFEEFAKKIFDNAQAVTKPATATNNDVFAPTASPEALSITAMSS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University