Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Benincasa hispida
Species name
Wax gourd (Benincasa hispida) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Benincasa_hispida.HIDH.fa
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>Bhi01M001693
MPEHHSHLIYYMKFKRMATISIDPRLKLQMPKLHIQNEATVEEIEGLIRVYADGHVERFPIIPNVSCNTTASDKGVTAKDVLIDNFTNTWARIYVANSQRNLPLLVYFHGGGFCVGSAAWSCYHEFLLDLASKAKCVILSVNYRLSPENRLPAAYEDGFNTLMWLKQLAITNPIEHKWWLGNCNQSKLFLAGDSAGANIAYNIAARVGLNEPTILKPLNLKGIILIQPFFGGESRTKSEKLATQPSSASALTLDAADTYWRLSLPPGANRDHTWSNPLVNGGVKLRETKVPPLMVCISELDILVDRNLEFCAAMTAAGKKVERVILKGVGHSFQILNKDQISSARRREMMVCIQRFIQL
>Bhi04M000291
MESGKPEVAFELLPLLRVYKNGRIERLVGTDFVPPGTDPLTGVTSKDVMILPEFGISARLFLPILTRSTQRLPLVVYFHGGCFCTQSPFTAKYHNYLNALTAEARVVAVSVNYRKAPEHPIPAAYEDSWAALQWVISHRDEKGPEIWLNEHVDFRRVFLVGASAGANIAHNLAMVAGDPDCGVNLELIGVALEHPYFWGSVRIGKEAGNPVKARLFDQLWGFICPVRPENDDPWVNPVAEGAARLAGLGSGRVLVCVAEKDVLRDRGRLYFEALGSSGWLGVAEIEETEDEDHLFHLNDLEGQKAKDLIQRLGDFFNRDMPPSLLF
>Bhi04M000001
MTKEKSLILDVSGWLRLFDDGSVDRTWTGPPEVKFVAESVPPHDDFIDGVAVRDLVIDQNSGLRVRIYLPEVKCGRGKKLPVIVHFHGGGFCISEADWFMYYHTYTNLVRSAEAICVSVYLRRAPEHRLPAAIDDGFSALKWLQSVALGNEIEPWIVENADFNRVFLIGDSSGGNLVHSVAALAGETDLTPLKLAGGIPIHPGFVRAKRSKSEMENPQSPFLTLDMVDKFLSLALPVGSSKDHPITCPMGIDAPPLERLNLPPFLLCIADKDLIIDTEMEYYKAMKVANKEVELLMSKGMGHSFYLNKIAMKMDPETAAESDHLFAGIARFIKQH
>Bhi07M001124
MRTKRMPTINLDQIPSFEEHGNGFDQHDVLVEEIEGLIRVYGNGYVERPQIVPCVSNALPPELGVTSWDVVMDKLNNIWARFYIPTQCQEKLPLIVYFHGGGFCVGSAAWSCYHEFLAKLSAKADCIIMSVNYRLAPENPLPAPYEDGLKTLQWLKQVAFVGAKQNWWSRYCDFTKIYLSGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIKGSILIQPFFGGESRTKSEKFLVQPPRSPLTLAVSDTYWRLALPSGTNRDHPWCNPSAKGLFKVEDLRVLPSLICISEMDILKDRNLEFCSALHRAGKLINYVVYEGVGHAFQVLNKSQLSQTRTLEMIDHIKDFLCV
>Bhi09M002750
MAADSNNPELDLELLPYLRLYRNGVVERLLGTRITPPGLDTRTGVDSKDIIIVPETGVSARLYRPTAVDPHRKLPLVVYFHGGAFLVASSAEPIYHNNCLIPLAAEAQTVLLSVNYRLAPEHPLPAAYDDSWAALQWIAAQSQTSADEPGHEPWLKELVDFEKVFLVGDSAGGNISHHMALRAKSSNLGAKIKVVGIALIQPYFWGQEPIGSEITEHHKRAEVDRWWNFVCPSDRGNDDLLINPFSDGSPAIDGLTGEKVVVIVAEKDILRDRGKLYYENLAKSEWKGKVEIYETEGEDHAFHMLDPTSEKAKALIKRLAFFLNED
>Bhi09M001937
MALIGEVPGYFEVYSDGSVRRSIPEVVVSTGTQSSKNYNFKDVVIDSKKLVTGRLFRPNVTNSTTKLPILVYFHGGGFCIGSTTWIGYHNFLKDLAIASESIILSVDYRLAPENRLPAAYEDCYNSLEWLSYQESSEPCEKRTENEKGRGVEGFVEMNDMFWRLSIPTGCDRDYFGCNYETNAQQVSKEEWNHFPNVVVFVAALDFLKERGELYAKFLQKMKVKEVKLIEAANESHVYHVFHPQSEATRLLQEQMSHFMKSYW
>Bhi10M001697
MAEQICSFGSGLFGWFISRAIRRSEGGGNGFDSPILRRRGRRYAVEVSVFRSDQVGESNHRGSGKAAMWESGFFLAEEDFLKFRGRNYDEDLKRSGWNGAVEMVEHDEKGHVFHLKKPESEKAVDLLEKLAAFINLD
>Bhi10M001694
MDSDAVAGDEVVFEFLPVFRVFQSGRVERLFPTDRLPPSTDPLTGVQSKDILIDPQTQLSVRIYLPHISDSTKKLPLLIYIHGGAFAIGSVASPIYHPHLISLAAESNAVAVSVEYRLAPENPLPAAYDDAWAAVEWAASHSNGDGAEIWLNQHADFSRVFVIGDSAGANISYNVVDRASESDNGPKGMKIIGLGLVHPFFMIDKPDKLIEYVFPTSAGLEDPRMNPWANPRLGKLRCERVLILAAELDSLKDRARGIHAALRESGFEGSVEIEETEGKDHVFHLLKPETEKAVALVKKIASFTQSA
>Bhi10M000356
MATTPFEVDECRGVLRVYSDGSIVRSSNPSFNVPVFDDGSVLWKDLLFDPIHDLHLRLYKPASISSSKLPVLFYIHGGGFCIGSRTWPNCQNYCFRLAAELPALVISPDYRLAPENRLPAAIDDGFAALRWLQAQAESDHPDPWLADVADFSRVFISGDSAGGNIAHHLAAGLGLGSPELAPVRVRGYVLLAPFFGGTVRTRSEAEGSKEAFLNLELIDRFWRLSIPIGSSADHPLVDVFGPSSRNLKAVEMDPIMVVVGGADLLKDRAVEYAEKLKKQGKKIELVEFEGKQHGFFTIDPNSEASNQLMLLINHFIAQHSL
>Bhi10M001755
MASTEIAHDFSPMLVVYKDGRIHRLAGNELIDPSLDPLTGVESKDVVISPETPVSARIYKPKPTAQPHKLPLLVYFHGGGFCIESAFSSFYHRHLNSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWDALKWVAAHSAGTGPEEWLNGIADLDRVYFAGDSAGANIANRMAIRVGTEGLAGLNLRGLLLVHAYFWGGKLIGDEEKLNPEHRSFIEKLWYFVCPKISGLDDPIVNPGFDPELGRVAAERVAVFVAEKDALKNRGWFYSECLKKSGWGGAVDVIETKGQGHVFHLFNPTSDEAVDFVGKLAAFINGERRE
>Bhi10M001754
MASDEISLNAAPYFIVYKDSRIDRLIGNDIDPPGLDPNTGVESKDVDISPEVAVRVYRPKSAAGKQEKLPLLVYFHGGGFCIETAFSPFYHQHINAWVAEGNIAAVSVNYRRAPEYQLPIPFEDSWAAMKWIAAHSEGKGPDEWLNEIADLNQVYLAGDSAGGNIAHRMALRVATEGLDGVKIKGLQLIHPHFWGGKLIGEEKEWDPKDLFVVENLWFVVSKDIKTLDHPIVNPEHDPDLGKLPAERVAVYVAEKDNLKVRGRHYAECLKKSGWGGTVEVVETDGEGHVFHLFNPTCDMAGELIKCLAAFINSGRHG
MPEHHSHLIYYMKFKRMATISIDPRLKLQMPKLHIQNEATVEEIEGLIRVYADGHVERFPIIPNVSCNTTASDKGVTAKDVLIDNFTNTWARIYVANSQRNLPLLVYFHGGGFCVGSAAWSCYHEFLLDLASKAKCVILSVNYRLSPENRLPAAYEDGFNTLMWLKQLAITNPIEHKWWLGNCNQSKLFLAGDSAGANIAYNIAARVGLNEPTILKPLNLKGIILIQPFFGGESRTKSEKLATQPSSASALTLDAADTYWRLSLPPGANRDHTWSNPLVNGGVKLRETKVPPLMVCISELDILVDRNLEFCAAMTAAGKKVERVILKGVGHSFQILNKDQISSARRREMMVCIQRFIQL
>Bhi04M000291
MESGKPEVAFELLPLLRVYKNGRIERLVGTDFVPPGTDPLTGVTSKDVMILPEFGISARLFLPILTRSTQRLPLVVYFHGGCFCTQSPFTAKYHNYLNALTAEARVVAVSVNYRKAPEHPIPAAYEDSWAALQWVISHRDEKGPEIWLNEHVDFRRVFLVGASAGANIAHNLAMVAGDPDCGVNLELIGVALEHPYFWGSVRIGKEAGNPVKARLFDQLWGFICPVRPENDDPWVNPVAEGAARLAGLGSGRVLVCVAEKDVLRDRGRLYFEALGSSGWLGVAEIEETEDEDHLFHLNDLEGQKAKDLIQRLGDFFNRDMPPSLLF
>Bhi04M000001
MTKEKSLILDVSGWLRLFDDGSVDRTWTGPPEVKFVAESVPPHDDFIDGVAVRDLVIDQNSGLRVRIYLPEVKCGRGKKLPVIVHFHGGGFCISEADWFMYYHTYTNLVRSAEAICVSVYLRRAPEHRLPAAIDDGFSALKWLQSVALGNEIEPWIVENADFNRVFLIGDSSGGNLVHSVAALAGETDLTPLKLAGGIPIHPGFVRAKRSKSEMENPQSPFLTLDMVDKFLSLALPVGSSKDHPITCPMGIDAPPLERLNLPPFLLCIADKDLIIDTEMEYYKAMKVANKEVELLMSKGMGHSFYLNKIAMKMDPETAAESDHLFAGIARFIKQH
>Bhi07M001124
MRTKRMPTINLDQIPSFEEHGNGFDQHDVLVEEIEGLIRVYGNGYVERPQIVPCVSNALPPELGVTSWDVVMDKLNNIWARFYIPTQCQEKLPLIVYFHGGGFCVGSAAWSCYHEFLAKLSAKADCIIMSVNYRLAPENPLPAPYEDGLKTLQWLKQVAFVGAKQNWWSRYCDFTKIYLSGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIKGSILIQPFFGGESRTKSEKFLVQPPRSPLTLAVSDTYWRLALPSGTNRDHPWCNPSAKGLFKVEDLRVLPSLICISEMDILKDRNLEFCSALHRAGKLINYVVYEGVGHAFQVLNKSQLSQTRTLEMIDHIKDFLCV
>Bhi09M002750
MAADSNNPELDLELLPYLRLYRNGVVERLLGTRITPPGLDTRTGVDSKDIIIVPETGVSARLYRPTAVDPHRKLPLVVYFHGGAFLVASSAEPIYHNNCLIPLAAEAQTVLLSVNYRLAPEHPLPAAYDDSWAALQWIAAQSQTSADEPGHEPWLKELVDFEKVFLVGDSAGGNISHHMALRAKSSNLGAKIKVVGIALIQPYFWGQEPIGSEITEHHKRAEVDRWWNFVCPSDRGNDDLLINPFSDGSPAIDGLTGEKVVVIVAEKDILRDRGKLYYENLAKSEWKGKVEIYETEGEDHAFHMLDPTSEKAKALIKRLAFFLNED
>Bhi09M001937
MALIGEVPGYFEVYSDGSVRRSIPEVVVSTGTQSSKNYNFKDVVIDSKKLVTGRLFRPNVTNSTTKLPILVYFHGGGFCIGSTTWIGYHNFLKDLAIASESIILSVDYRLAPENRLPAAYEDCYNSLEWLSYQESSEPCEKRTENEKGRGVEGFVEMNDMFWRLSIPTGCDRDYFGCNYETNAQQVSKEEWNHFPNVVVFVAALDFLKERGELYAKFLQKMKVKEVKLIEAANESHVYHVFHPQSEATRLLQEQMSHFMKSYW
>Bhi10M001697
MAEQICSFGSGLFGWFISRAIRRSEGGGNGFDSPILRRRGRRYAVEVSVFRSDQVGESNHRGSGKAAMWESGFFLAEEDFLKFRGRNYDEDLKRSGWNGAVEMVEHDEKGHVFHLKKPESEKAVDLLEKLAAFINLD
>Bhi10M001694
MDSDAVAGDEVVFEFLPVFRVFQSGRVERLFPTDRLPPSTDPLTGVQSKDILIDPQTQLSVRIYLPHISDSTKKLPLLIYIHGGAFAIGSVASPIYHPHLISLAAESNAVAVSVEYRLAPENPLPAAYDDAWAAVEWAASHSNGDGAEIWLNQHADFSRVFVIGDSAGANISYNVVDRASESDNGPKGMKIIGLGLVHPFFMIDKPDKLIEYVFPTSAGLEDPRMNPWANPRLGKLRCERVLILAAELDSLKDRARGIHAALRESGFEGSVEIEETEGKDHVFHLLKPETEKAVALVKKIASFTQSA
>Bhi10M000356
MATTPFEVDECRGVLRVYSDGSIVRSSNPSFNVPVFDDGSVLWKDLLFDPIHDLHLRLYKPASISSSKLPVLFYIHGGGFCIGSRTWPNCQNYCFRLAAELPALVISPDYRLAPENRLPAAIDDGFAALRWLQAQAESDHPDPWLADVADFSRVFISGDSAGGNIAHHLAAGLGLGSPELAPVRVRGYVLLAPFFGGTVRTRSEAEGSKEAFLNLELIDRFWRLSIPIGSSADHPLVDVFGPSSRNLKAVEMDPIMVVVGGADLLKDRAVEYAEKLKKQGKKIELVEFEGKQHGFFTIDPNSEASNQLMLLINHFIAQHSL
>Bhi10M001755
MASTEIAHDFSPMLVVYKDGRIHRLAGNELIDPSLDPLTGVESKDVVISPETPVSARIYKPKPTAQPHKLPLLVYFHGGGFCIESAFSSFYHRHLNSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWDALKWVAAHSAGTGPEEWLNGIADLDRVYFAGDSAGANIANRMAIRVGTEGLAGLNLRGLLLVHAYFWGGKLIGDEEKLNPEHRSFIEKLWYFVCPKISGLDDPIVNPGFDPELGRVAAERVAVFVAEKDALKNRGWFYSECLKKSGWGGAVDVIETKGQGHVFHLFNPTSDEAVDFVGKLAAFINGERRE
>Bhi10M001754
MASDEISLNAAPYFIVYKDSRIDRLIGNDIDPPGLDPNTGVESKDVDISPEVAVRVYRPKSAAGKQEKLPLLVYFHGGGFCIETAFSPFYHQHINAWVAEGNIAAVSVNYRRAPEYQLPIPFEDSWAAMKWIAAHSEGKGPDEWLNEIADLNQVYLAGDSAGGNIAHRMALRVATEGLDGVKIKGLQLIHPHFWGGKLIGEEKEWDPKDLFVVENLWFVVSKDIKTLDHPIVNPEHDPDLGKLPAERVAVYVAEKDNLKVRGRHYAECLKKSGWGGTVEVVETDGEGHVFHLFNPTCDMAGELIKCLAAFINSGRHG
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University