Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Begonia fuchsioides
Species name
Begonia fuchsioides is a species of eudicot in the family Begoniaceae (begonia family).
Species info
Gene sequence info
Begonia_fuchsioides.DFR.fa
Download
>Begfu184S08949
MEREGKRERGAGTSYCVTGASGFIGSWLVKALLQDGYAVRATARDPAKCLNLTSEWGETQRLRLFKADLKEEGSFDEAVNGCHGVFHVAASMEFSVDHSQDDQNFENYVRSNIIEPQIKGVQNLLKSCLKSKSIKRVVFTSSISTLTARNNDGGWRPVVNELSRTPVNHVWQAKPSGWVYILSKILTEEAAYKFAAENGIDLVSVITSTVSGPFLTPSLPLSVRVLLSPVTGEGELFRLLSSVNERMGSIGLVHTEDICRAHVFVMEHPLAHGPYICCVDSRTISKLVGLIAGQFPALNPKRYEEEERGVPVEISSKKLRDLGFEYEHGIEDVIRQTIVFCVANGFLPLPE
>Begfu1129S16472
MASVDGEIVCVTGAAGFVGSWLVMRLLRRGYSVRATVRDPENLKKVKHLLDLPGAETRLSIWKADLSVEGSFEKPINGCHGVFHVATPMDFESTDPENEVIKPTISGMISIMKACKEAKTVRRLVFTSSAGTVAVQEDQNQSYDENCWSDVEFCRSAKMTGWMYFVSKTLAEQAAWKFAKEQNMDFISIIPTLVIGPFLIPSMPPSLITGLSLITRTESHYSITKQCQYVHLDDLCNAHIFLYENPNAEGRYICSSHNANIHDIANMLQEKYPEYNIPTQFEGIEGKLNVVDFSSKKLTDLGFEFKYSLEEMFEGAVEACRARGLLPPAAAVHVHGNEQI
>Begfu41469S11944
MGSESQVVCVTGASGFVGSWLVMRLLERGYTVRATVRDPGNEKKVKHLLDLPDAETRLTLWKADLSVEGSFEEPIRGCTGVFHVATPMDFESKDPENEVIKPTISGMLSIMKACKDAKTVRRLVFTSSAGTVNVQEHLKQHYDETDWSDVEFCRSKKMTGWMYFVSKSLAEQAAWEYAKEHDIDFISIIPTLVIGSFLMSSMPPSLITGLSPLTRTESHYSIIKQCQYVHLDDLCEAHIFLYENPKAEGRYVCSSHDATIYDVAKLLKEKYPEYDVPTKFKGIDENLNLIEFSSKKLTDMGFEFKYSLEDMFVGAVETCQAKGLIAPATGSHGHGD
>Begfu91346S43924
MHKKILNFCLISNHKGETIGREIEEYLLECKIENVMTVTVDNAFANDVAISYLIKCVRNWNDLLLDGEYMHMRCFAHILNLIVCDGLKDHEESISRVRRAVKYVRSSPARLKNFKSCVQNVKIACKCNVSLDVCTRWNSTYLMLANAEKFEKTFDKLMETDNNYIGTESHYSITKQCQYVHLDDLCNAHIFLYANPKAEGRYICSSHNANIHDIANLLKEKYPEYNIPTGKQLDRVLELIWASSSRFGGIEENLNLVDFSSKKLTDLGFEFKYSLAEMFTGAIETCRAKGLIPYVAPIHDGNKRHKKDLPAREESIERLHKKSSQRVYLTTDTWTSNQNMNYMVMIGHFIDGNWKVHKKILNFCKIEDHKGETISNMLQKQIAHVLNLIVAEGVKDHQGTIDKVRKVALYVKSSPQRLRIFKTCIDNLNIQFKGNVTLDVATRWLPECLENLRTLLLDPNCKNKIVKHCLTILFGAHKAHDLYTQAVFERLHVEYRGDDDSECAFVRQQKQDNDDHISAFFGSEVAFSRSKTKIEAFLNETWWKLKERKYPVLSRIARDVLAIPISTVTSESTFSCGGRIVDSSRTSLLPTTVEAIICMKSWIRPEDPTVTTSPPPIVDDYETIDEYEQ
>Begfu91434S44275
MWSEAQIVCVTGASGFVDSWLVMRLLERGYTVRATVRDPGNVKKVKHLLELPEADTRLTLWKADLSVDGSFEEPIRGCTGVFHVATPMDFESKDPENEVIKPTITGMLSIMKACKEAKTVRRLVFTSSAGTVNVQENLKQIYDETCWSDVEFCRSKKMTGWMYFVSKTLAEQAAWQYAKEHDIDFISIIPTLVIGSFLMPSMPPSLITGLSPMTRTESHYSIIKQCQYVHLDDLCEAHIFLFENPGAEGRYICSSHDATIYDVAKLLKEKYPEYDVAKRHRFDLFLLGCSHMGYSKSYSAVATLQYHKIEEKHPKKDRMVR
>Begfu91844S44851
MEKKSRARVCVTGGAGFIGSWLVKKLLEEGHSVHATLRDLDDRSKVEFLRSFPNAETGLVLFKADIYDPESFDDAIQGCEFVFNVATPLLHSHGSRFKNTAEATVAAARSIGLSCAGSGSVRRLIYTASVFAASPMKEDGSGFKDAMDETCWTPLDISFPFCLPFLKDYVDSKTLTEKETLSFGGGASNGGMEVVSLVIGMVGGDSLNSDNPVTTAVTLAQFLDSPINYNSLRFTEELDGKVPLVHVEDVSAALLFCMNQSSMDGRFLCASSYLSTAEIARYILEKYPETELKHRDGADVEERDVKLSSRKLEEKGFSFKYGGEMILDDCFKVCKARKMM
MEREGKRERGAGTSYCVTGASGFIGSWLVKALLQDGYAVRATARDPAKCLNLTSEWGETQRLRLFKADLKEEGSFDEAVNGCHGVFHVAASMEFSVDHSQDDQNFENYVRSNIIEPQIKGVQNLLKSCLKSKSIKRVVFTSSISTLTARNNDGGWRPVVNELSRTPVNHVWQAKPSGWVYILSKILTEEAAYKFAAENGIDLVSVITSTVSGPFLTPSLPLSVRVLLSPVTGEGELFRLLSSVNERMGSIGLVHTEDICRAHVFVMEHPLAHGPYICCVDSRTISKLVGLIAGQFPALNPKRYEEEERGVPVEISSKKLRDLGFEYEHGIEDVIRQTIVFCVANGFLPLPE
>Begfu1129S16472
MASVDGEIVCVTGAAGFVGSWLVMRLLRRGYSVRATVRDPENLKKVKHLLDLPGAETRLSIWKADLSVEGSFEKPINGCHGVFHVATPMDFESTDPENEVIKPTISGMISIMKACKEAKTVRRLVFTSSAGTVAVQEDQNQSYDENCWSDVEFCRSAKMTGWMYFVSKTLAEQAAWKFAKEQNMDFISIIPTLVIGPFLIPSMPPSLITGLSLITRTESHYSITKQCQYVHLDDLCNAHIFLYENPNAEGRYICSSHNANIHDIANMLQEKYPEYNIPTQFEGIEGKLNVVDFSSKKLTDLGFEFKYSLEEMFEGAVEACRARGLLPPAAAVHVHGNEQI
>Begfu41469S11944
MGSESQVVCVTGASGFVGSWLVMRLLERGYTVRATVRDPGNEKKVKHLLDLPDAETRLTLWKADLSVEGSFEEPIRGCTGVFHVATPMDFESKDPENEVIKPTISGMLSIMKACKDAKTVRRLVFTSSAGTVNVQEHLKQHYDETDWSDVEFCRSKKMTGWMYFVSKSLAEQAAWEYAKEHDIDFISIIPTLVIGSFLMSSMPPSLITGLSPLTRTESHYSIIKQCQYVHLDDLCEAHIFLYENPKAEGRYVCSSHDATIYDVAKLLKEKYPEYDVPTKFKGIDENLNLIEFSSKKLTDMGFEFKYSLEDMFVGAVETCQAKGLIAPATGSHGHGD
>Begfu91346S43924
MHKKILNFCLISNHKGETIGREIEEYLLECKIENVMTVTVDNAFANDVAISYLIKCVRNWNDLLLDGEYMHMRCFAHILNLIVCDGLKDHEESISRVRRAVKYVRSSPARLKNFKSCVQNVKIACKCNVSLDVCTRWNSTYLMLANAEKFEKTFDKLMETDNNYIGTESHYSITKQCQYVHLDDLCNAHIFLYANPKAEGRYICSSHNANIHDIANLLKEKYPEYNIPTGKQLDRVLELIWASSSRFGGIEENLNLVDFSSKKLTDLGFEFKYSLAEMFTGAIETCRAKGLIPYVAPIHDGNKRHKKDLPAREESIERLHKKSSQRVYLTTDTWTSNQNMNYMVMIGHFIDGNWKVHKKILNFCKIEDHKGETISNMLQKQIAHVLNLIVAEGVKDHQGTIDKVRKVALYVKSSPQRLRIFKTCIDNLNIQFKGNVTLDVATRWLPECLENLRTLLLDPNCKNKIVKHCLTILFGAHKAHDLYTQAVFERLHVEYRGDDDSECAFVRQQKQDNDDHISAFFGSEVAFSRSKTKIEAFLNETWWKLKERKYPVLSRIARDVLAIPISTVTSESTFSCGGRIVDSSRTSLLPTTVEAIICMKSWIRPEDPTVTTSPPPIVDDYETIDEYEQ
>Begfu91434S44275
MWSEAQIVCVTGASGFVDSWLVMRLLERGYTVRATVRDPGNVKKVKHLLELPEADTRLTLWKADLSVDGSFEEPIRGCTGVFHVATPMDFESKDPENEVIKPTITGMLSIMKACKEAKTVRRLVFTSSAGTVNVQENLKQIYDETCWSDVEFCRSKKMTGWMYFVSKTLAEQAAWQYAKEHDIDFISIIPTLVIGSFLMPSMPPSLITGLSPMTRTESHYSIIKQCQYVHLDDLCEAHIFLFENPGAEGRYICSSHDATIYDVAKLLKEKYPEYDVAKRHRFDLFLLGCSHMGYSKSYSAVATLQYHKIEEKHPKKDRMVR
>Begfu91844S44851
MEKKSRARVCVTGGAGFIGSWLVKKLLEEGHSVHATLRDLDDRSKVEFLRSFPNAETGLVLFKADIYDPESFDDAIQGCEFVFNVATPLLHSHGSRFKNTAEATVAAARSIGLSCAGSGSVRRLIYTASVFAASPMKEDGSGFKDAMDETCWTPLDISFPFCLPFLKDYVDSKTLTEKETLSFGGGASNGGMEVVSLVIGMVGGDSLNSDNPVTTAVTLAQFLDSPINYNSLRFTEELDGKVPLVHVEDVSAALLFCMNQSSMDGRFLCASSYLSTAEIARYILEKYPETELKHRDGADVEERDVKLSSRKLEEKGFSFKYGGEMILDDCFKVCKARKMM
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University