Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Artocarpus altilis
Species name
Breadfruit (Artocarpus altilis) is a species of eudicot in the family Moraceae (mulberry family).
Species info
Gene sequence info
Artocarpus_altilis.4CL.fa
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>Aa000189g0455.1
MEKSGYGRDGIFRSLRPPSVFPKDPNLSMVSFLFRNSSSYPHKPALIDADSGETLSFSHFKSTVAKVSHGFLNLGIKKNDVVLIFAPNSVHFPVCFLGVVAIGAIVTTCNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGLDLPTIFLSPKQHKSKIPEKVLSFDDLVNLSGSASDFPPVNVRQNDTATLLYSSGTTGTSKGVVLTHRNFISASLMITMDQDLAKEMHNVFLCVLPMFHVFGLAVIMYSQLQRGNAVVSMARFDLEKILITVEKFKITNLWVVPPIVLALAKNSVVRKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVFQGYGMTETCGIVSVEDTRGGKRNTGSAGTLVSGVEAQIVSVETSKPLPPNQLGEIWVRGPNMMQGYLNNPQATKSTIDKKGWVHTGDLGYFDEDGHLFVIDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPVAYAVRSLNSSLTEEDVKKFIAN
>Aa000219g0137.1
MEKSGYGRDGIFRSLRPPLVFPKDHPNLSMVSFLFRNSSSYPHKPALIDADSGETLSFSHFKSTVAKVSHGFLNLGIKKNHVVLIFAPNSIHFPVCFLGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFDLPTIFLSPKQHISNIPEKVLTFDDLVNLSGSDSDFPPVNIKQNDTAALLYSSGTTGTSKGVVLTHGNFISASLMIVMDQDLAKEMHQVFLCVLPMFHVFGLAVIMYSQLQRGNAIVSMARFNLEMILMTVEKYKITHLWVVPPVVLALAKNSVVRKYNLSSLKHIGSGAAPLGKELMDECAKIIPQGVVAQGYGMTETCGIVSMEDIREGKRNTGSAGTLASGVEAQIVSVEASKPLPPNQLGEIWVRGPNMMQGYFNNPEATKLTIDEKGWVHTGDLGYFDEDGLLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVMKFIANQVAPFKRLRKVTFINSVPKSASGKILRRELIQKVRSKL
>Aa000276g0089.1
MAELAERNQKDNIFRSKLPDINIPTHLPLHTYCLSNKSQKGWRPCLINGPTGEVYTYEDVDLKARKVAAGLYKLGVQKGDVVMVLLPNSPEFVLTFLGASYRGALTTAANPFFTSAEILKQAKASNAKLIITLACYYDKVKDFKLDSEDDIRIVCVDSPVPEGCFHFSELTKADENELPKVDISPDDVVALPYSSGTTGLPKGVMLTHKGMVTSVAQQVDGENPNLFYSEDDVVLCVLPLFHIYSLNSVLLCGLRAGATILIMPKFEIGKLLELIQKYKVSVAPIVPPIMLAIANHPNLDKYNLSSLRILKSGGAPLGKELEDTVRAKFPNVTLAQGYGMTEAGSVLTMSLAFAKKPMEVKPGACGTVVRNAELKIVDPETGSSLPRNQAGEICIRGHQIMKGYLNDPEATKNTIDKEGWLHTGDIGFVDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPHISDAAVVPMKDEAAGEVPVAFVVRSNNSLITEDEIKQFVSKQVVFYKRINRVFFMEAIPKSPSGKILRKDLRAKVASGFSN
>Aa000429g0044.1
MDAHHQKQDDHQEEYIFRSKLPDIYIPNHLPLHSYCFENISNYKDKPCLINGSTGEAHSYADVELTARKVAAGLDKLEIKQGDVIMLLLQNCPEFVFAFLAASYIGAISTTANPFYTPAEIAKQATASKAKLILTIAAYVDKVKDFADANGVRIVCVDAPPEGCLHFSELSNADEAEIPAVKINPDDAVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLALIEKYKVTIAPFVPPIVLAIAKSPDLHRYDLSSIRTVMSGGAPMGKDLEEAVKDKLSHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIVDPDTGASLPRNQTGEICIRGSQIMKGYINDPEATKATIDEGGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNIVDAAVVPMKDEAAGEVPVAFVARANGSKISEDEIKKYISDQVVFYKRLGRVIFVDKIPKSPSGKILRKDLRARLAAEVLAH
>Aa000798g0036.1
MISVANNSSLETQQMPAENNISTTSSEHVFKSKLPDIPISNNIPLHAYCFEKLFEVADRPCLISGSTGKTYTFAETHLIARRFAAALSRLGIKKGDVIMILLHNCPEFVFSFMASSMLGAVATTANPFYTPTEIFKQFTGSNAKLIITQSPYVDKLRENATNDKNFPVMGQDFKVITTDEPPHDCLDFWALEKSSQVSEEETLNVDINAEEAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLNLTKEDVVLCVLPLFHIYSLNSVLLCSLRAGAAMLLMHKFEIVALLDLIQKYKVSMAAVVPPLVLALTKNPKVAEYDLSSIRIVLSGAAPLGKELQDALGSRVPQALLGQGYGMTEAGPVISMSLSFAKQPVPTKSGSCGSVVRNAELKIIDPETGSSLGYNQPGEICIRGAQIMKGYLNDDKATAATIDVEGWLHTGDIGYVDDDDEIFIVDRVKELIKFKGFQVPPAELESLLVSHPLIADAAVVPQKDDVAGEVPVAFVVRSTSDLTEETVKEFIAKQVVFYKKLHKVYFVHAIPKSASGKILRKDLRAKIAAASPLT
>Aa001499g0010.1
MEASCPLNPPQYDHEHIFRSRYPPVQVPDNVTLPEFVLEGSELYADKVAFVEAVTGKGYTHGEVAKDTRRFGAALRSLGLRKGHVVIVVLPNLAEYAIVALGIMSAGGVFSGSNPQALASEIAKQVKDADAKLIVTNSLNYEKVKCLGLPVITMDEEPIEGAINWRKLLEAADRAGTNNATKEQVLETDLCALPFSSGTTGVSKGVMLSHKNLVANLCCTLFSVKPELVGQVTVLGLMPFFHIYGITGICCATLRNKGKVVVMGRYDVRIYLNALITHEVNFAPIVPPIISDMVNNPIVDEFDLSKLKLQAVMSAAAPLAPPLLRAFEAKFPSIHVQEAYGLTEHSCITLTHGDLENYSKSKKNSVGFILPNLEVKFIDPDTGHSFPKNTPGEICVRSPCVMQGYYKNKEETERAIDKEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILLTHPSVEDAAVFPLPDEEAGEIPAACVVLAPDTKETEEEIVSFVASNVANYKKVRAVYFVDFIPKSPSGKIMRRLLRDAYIKSSSTALRKL
>Aa001499g0054.1
MRHEGFGGMAKTGDLCYINNEGYLFFVDRLKELMKNKGYQVAPAELEHLLQSRRDITDAAVVPCPNEEGGQVPMTFVVKRPGSVVAPYNKIRKLKVH
>Aa001499g0055.1
MYGFGYRARTLELGETLVTMGTRFDLRRMLRMIEELRERHVAVAPPVIVAMAKDTSVMDGCDLSSLEVVACGGIWANGQSTGQVFATVGLKESLVEGARGKIMPNFQAKIVDLQTGTNLPPPMPG
>Aa010477g0009.1
MEKPTHALQEKNDDEQFIFRSKLPNIYIPSHLLLHTYCFENIAKFKDRPCLINSSTGETHTYADVDLTARRVAAGLNKLGIRHGDVIMLLLHNCPEFVFAFLGASHIGAVTTGANPLFSPAEVAKQVTASGAKLVVTLSAYVEKVKELAPGKNYNFLKIACIDGPLPEGCLDFSELMRASEAKKPEAEIKPDDVVALPYSSGTTGLPKGVMLTHKALVTNVAQQVDGENPNLHFHCEDVILCVLPLFHIYALNSILLCGIRTGAAILIMQRFEIGKLLDLVEYYKVTVTPFVPPILLSIAKNPDIDRYDLSSIRMIITGGAPMGKELEEAVKDKLPNAKLGQGYGMTEAGSVSMCLAFAKEPFPKKSGSCGTVLRNAEMKIIDPNTNASLARNQAGEICIRGAQIMEGFLNDPEATKATIDKGGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQIAPAELEALLINHPSISDAAVVPMKDEAAGEVPVAFIVKSSASDITEEDIKQYISKQVVFYKRIRRVLFIEKITKSPSGKILRKDLREKLAAGLPS
MEKSGYGRDGIFRSLRPPSVFPKDPNLSMVSFLFRNSSSYPHKPALIDADSGETLSFSHFKSTVAKVSHGFLNLGIKKNDVVLIFAPNSVHFPVCFLGVVAIGAIVTTCNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGLDLPTIFLSPKQHKSKIPEKVLSFDDLVNLSGSASDFPPVNVRQNDTATLLYSSGTTGTSKGVVLTHRNFISASLMITMDQDLAKEMHNVFLCVLPMFHVFGLAVIMYSQLQRGNAVVSMARFDLEKILITVEKFKITNLWVVPPIVLALAKNSVVRKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVFQGYGMTETCGIVSVEDTRGGKRNTGSAGTLVSGVEAQIVSVETSKPLPPNQLGEIWVRGPNMMQGYLNNPQATKSTIDKKGWVHTGDLGYFDEDGHLFVIDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPVAYAVRSLNSSLTEEDVKKFIAN
>Aa000219g0137.1
MEKSGYGRDGIFRSLRPPLVFPKDHPNLSMVSFLFRNSSSYPHKPALIDADSGETLSFSHFKSTVAKVSHGFLNLGIKKNHVVLIFAPNSIHFPVCFLGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFDLPTIFLSPKQHISNIPEKVLTFDDLVNLSGSDSDFPPVNIKQNDTAALLYSSGTTGTSKGVVLTHGNFISASLMIVMDQDLAKEMHQVFLCVLPMFHVFGLAVIMYSQLQRGNAIVSMARFNLEMILMTVEKYKITHLWVVPPVVLALAKNSVVRKYNLSSLKHIGSGAAPLGKELMDECAKIIPQGVVAQGYGMTETCGIVSMEDIREGKRNTGSAGTLASGVEAQIVSVEASKPLPPNQLGEIWVRGPNMMQGYFNNPEATKLTIDEKGWVHTGDLGYFDEDGLLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVMKFIANQVAPFKRLRKVTFINSVPKSASGKILRRELIQKVRSKL
>Aa000276g0089.1
MAELAERNQKDNIFRSKLPDINIPTHLPLHTYCLSNKSQKGWRPCLINGPTGEVYTYEDVDLKARKVAAGLYKLGVQKGDVVMVLLPNSPEFVLTFLGASYRGALTTAANPFFTSAEILKQAKASNAKLIITLACYYDKVKDFKLDSEDDIRIVCVDSPVPEGCFHFSELTKADENELPKVDISPDDVVALPYSSGTTGLPKGVMLTHKGMVTSVAQQVDGENPNLFYSEDDVVLCVLPLFHIYSLNSVLLCGLRAGATILIMPKFEIGKLLELIQKYKVSVAPIVPPIMLAIANHPNLDKYNLSSLRILKSGGAPLGKELEDTVRAKFPNVTLAQGYGMTEAGSVLTMSLAFAKKPMEVKPGACGTVVRNAELKIVDPETGSSLPRNQAGEICIRGHQIMKGYLNDPEATKNTIDKEGWLHTGDIGFVDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPHISDAAVVPMKDEAAGEVPVAFVVRSNNSLITEDEIKQFVSKQVVFYKRINRVFFMEAIPKSPSGKILRKDLRAKVASGFSN
>Aa000429g0044.1
MDAHHQKQDDHQEEYIFRSKLPDIYIPNHLPLHSYCFENISNYKDKPCLINGSTGEAHSYADVELTARKVAAGLDKLEIKQGDVIMLLLQNCPEFVFAFLAASYIGAISTTANPFYTPAEIAKQATASKAKLILTIAAYVDKVKDFADANGVRIVCVDAPPEGCLHFSELSNADEAEIPAVKINPDDAVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLALIEKYKVTIAPFVPPIVLAIAKSPDLHRYDLSSIRTVMSGGAPMGKDLEEAVKDKLSHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIVDPDTGASLPRNQTGEICIRGSQIMKGYINDPEATKATIDEGGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNIVDAAVVPMKDEAAGEVPVAFVARANGSKISEDEIKKYISDQVVFYKRLGRVIFVDKIPKSPSGKILRKDLRARLAAEVLAH
>Aa000798g0036.1
MISVANNSSLETQQMPAENNISTTSSEHVFKSKLPDIPISNNIPLHAYCFEKLFEVADRPCLISGSTGKTYTFAETHLIARRFAAALSRLGIKKGDVIMILLHNCPEFVFSFMASSMLGAVATTANPFYTPTEIFKQFTGSNAKLIITQSPYVDKLRENATNDKNFPVMGQDFKVITTDEPPHDCLDFWALEKSSQVSEEETLNVDINAEEAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLNLTKEDVVLCVLPLFHIYSLNSVLLCSLRAGAAMLLMHKFEIVALLDLIQKYKVSMAAVVPPLVLALTKNPKVAEYDLSSIRIVLSGAAPLGKELQDALGSRVPQALLGQGYGMTEAGPVISMSLSFAKQPVPTKSGSCGSVVRNAELKIIDPETGSSLGYNQPGEICIRGAQIMKGYLNDDKATAATIDVEGWLHTGDIGYVDDDDEIFIVDRVKELIKFKGFQVPPAELESLLVSHPLIADAAVVPQKDDVAGEVPVAFVVRSTSDLTEETVKEFIAKQVVFYKKLHKVYFVHAIPKSASGKILRKDLRAKIAAASPLT
>Aa001499g0010.1
MEASCPLNPPQYDHEHIFRSRYPPVQVPDNVTLPEFVLEGSELYADKVAFVEAVTGKGYTHGEVAKDTRRFGAALRSLGLRKGHVVIVVLPNLAEYAIVALGIMSAGGVFSGSNPQALASEIAKQVKDADAKLIVTNSLNYEKVKCLGLPVITMDEEPIEGAINWRKLLEAADRAGTNNATKEQVLETDLCALPFSSGTTGVSKGVMLSHKNLVANLCCTLFSVKPELVGQVTVLGLMPFFHIYGITGICCATLRNKGKVVVMGRYDVRIYLNALITHEVNFAPIVPPIISDMVNNPIVDEFDLSKLKLQAVMSAAAPLAPPLLRAFEAKFPSIHVQEAYGLTEHSCITLTHGDLENYSKSKKNSVGFILPNLEVKFIDPDTGHSFPKNTPGEICVRSPCVMQGYYKNKEETERAIDKEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILLTHPSVEDAAVFPLPDEEAGEIPAACVVLAPDTKETEEEIVSFVASNVANYKKVRAVYFVDFIPKSPSGKIMRRLLRDAYIKSSSTALRKL
>Aa001499g0054.1
MRHEGFGGMAKTGDLCYINNEGYLFFVDRLKELMKNKGYQVAPAELEHLLQSRRDITDAAVVPCPNEEGGQVPMTFVVKRPGSVVAPYNKIRKLKVH
>Aa001499g0055.1
MYGFGYRARTLELGETLVTMGTRFDLRRMLRMIEELRERHVAVAPPVIVAMAKDTSVMDGCDLSSLEVVACGGIWANGQSTGQVFATVGLKESLVEGARGKIMPNFQAKIVDLQTGTNLPPPMPG
>Aa010477g0009.1
MEKPTHALQEKNDDEQFIFRSKLPNIYIPSHLLLHTYCFENIAKFKDRPCLINSSTGETHTYADVDLTARRVAAGLNKLGIRHGDVIMLLLHNCPEFVFAFLGASHIGAVTTGANPLFSPAEVAKQVTASGAKLVVTLSAYVEKVKELAPGKNYNFLKIACIDGPLPEGCLDFSELMRASEAKKPEAEIKPDDVVALPYSSGTTGLPKGVMLTHKALVTNVAQQVDGENPNLHFHCEDVILCVLPLFHIYALNSILLCGIRTGAAILIMQRFEIGKLLDLVEYYKVTVTPFVPPILLSIAKNPDIDRYDLSSIRMIITGGAPMGKELEEAVKDKLPNAKLGQGYGMTEAGSVSMCLAFAKEPFPKKSGSCGTVLRNAEMKIIDPNTNASLARNQAGEICIRGAQIMEGFLNDPEATKATIDKGGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQIAPAELEALLINHPSISDAAVVPMKDEAAGEVPVAFIVKSSASDITEEDIKQYISKQVVFYKRIRRVLFIEKITKSPSGKILRKDLREKLAAGLPS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University