Enzyme
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
ANR
Enzyme
Anthocyanidin reductase
Enzyme name
EC:1.3.1.77
Entry
Oxidoreductases;Acting on the CH-CH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Sysname
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction
anthocyanidin with a 3-hydroxy group [CPD:C21381];NADH [CPD:C00004];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Areca catechu
Species name
Areca-nut (Areca catechu) is a species of monocot in the family Arecaceae (palm family).
Species info
Gene sequence info
Areca_catechu.ANR.fa
Download
>Acat_1g002300
MSGRGKVVCVTGASGFIASWLVKLLLQRGYTVRATVRDLADPMKTKHLCTLEGANERLHLFKANLLEEGSFDSVIEGCEGVFHTASPCYLNATDPQAELIEPAVKGTLNVFSSCIKTPSVKRVVVTSSMATVVCNGRPRTPDCVVDETWFSSVEFCEQEKLWYPLSKTLAEEAARKFSKDNSIDMVTIHPAVVLGPLLQPTLNGSATTILKLINGSSTYPNTTYGWVSVKDVAMAHILAFEVPSASGRYNLVGKVAHYSEIVKILHEQYPTFKLPEKCEDDKPFAPIYQVYKEKATSLGIDYIPLETSIREIVESNKLRYRLYSLETSIREIVESLKEKDLLLIQGKSEHLRALEGANERLYLFKANLLEEGSFDLAVEGCEGVFHTASPLIIAIDPQAELIDPAVKGTLNVLSSCIKTPSVKRVVITSSMATVSYNERPRTPDVVVDETWFSSIEFCKQSKLWYHLSKIFAEEAAWKFSKDNSLDMVTIHPAGIIGPLLQPTLNASAGEFLKLINGSSTYANAAYGLVNVKDVAMAHILAFEVPSASGRYCLAERVAHYSDMVKILHEQYPTLKLPEKCADDKPFVPIYQISKKKAASLGIDYIPLETSIKETIESLKEKGFVSL
>Acat_1g002340
LIRKKPSNCVPWKEPMRDCPCLKQTCWKRAFLIQWLRGVRAELINPAVKGTLNVFSSCIKTPVKRVVMLSEEAAWKFLKDNSIGMVTINPAMVIGPLLQPTLNTSAAAIRNLIN
>Acat_1g019820
MTGKGKLACVTGGTGFLASVLIKQLLEKGYAVNTTARDPEKSEKLSHLKEMQNLAPVNLNADDPENELIKPAVQGILNVMKSCLKAKSVKRFVLTSSAVSVSIKKLRENGLVLDEESWSDMEFLTAEKPPTWGYSVSKMLTEREASRFAQQNNINLLTIIPPISIGPSPVAKDVPGNALALSLITGNEMLLNGLKIVQSLNGVISLSHIEDVCRAHIFVAENESASGRYICCSINTTLPEVASFLSKRYPQYEVPTDFGELPEKAELILSSEKLIKAGFEFKYKKLEEIYDPAVKYAKAIGLLPSK
>Acat_1g019860
MERTGLRGGFPTERQGLGVPRWRCSFSVHLQSTDEIISEYFGFSCPFFTPAARGMGNAATYESHGCGASCPGGIFGDEYSRHLREAEGAWRRNEMLLNGLKIVQSLNGAFSLSHIEDGHIFVAGNESASGHYICCSINITLPEVSSFLFGELPEKAELILSSEKLIKAGFEFKYKKLEEIYDPAIKYAKAIGLLPSK
>Acat_1g019890
NELIKPAVQGVLNVMKSCQKAKSVKRFLVSIKKLRENGLVLGDESWSDMEFLTAENSPTWGYGVSKMLTERKASRFAQEKNINLLTIIPTLSIGPAPVARDAPSISMTLSLLTGEEQDLQGNEMLLNGLKIMQSLNGSISIVHIEDICNAHIFVAKNEPASDRYICWSINITLLELTSSLSKKYSHFSELPKKAELILSSEKLIKARFEYKQLEKICDPAIKYAKAIRLPPPK
>Acat_1g019940
MLPRCWVPCSISSMIPVDYLSHRPAAMMFTHCLSTGSLISPMKPYRQIFQIMFMLAEPSSDAIAGQGLTQLRQHYPDLDDPALAQVAHPPPLLRLTGHLLAPDRAPKGVMFLVEHYLEVPPNVERGLTQVQAKRFSGRHRSSTSDGNALHRLMTSSPLASTHPLLEGGGLGHDGILLLAPILLIFWHKDGGVSSTYFSGSSATGFLGFSITSRVGGEGTSVTATFTSTSSSILRIGFVALKHPKMTKLACVTGGTGYMASVIIKQLLEKGYAVNTTNELIKPAVQGVLNVMKSCLKAKSVKRFVLTSSAISVSVKKLRENGLVLDEESWSDMEFLTAEKPPTWGYGVSKMLTEREASRFAQENNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGFKIMQSLNGSISIVHIEDVSRAHIFVAENESASGRYICCSINTTLPELASFLSKRYPQYKVPTDFGELPEKAELMLSSEKLIKAGFEFKYKQLEEIYDPAVKYAKAIGLLPSK
>Acat_1g019920
MASAVINQMLEKGYAVNSTNELIKPAVQGVLNVMKSCLKAKSVKRFVLTSSAISVSVKKLRENGLVLDEESWSDMEFLTAEKPPTWGYGVSKMLTEREASRFAQENNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGFKIMQSLNGSISIVHIEDVSRAHIFVAENESASGRYICCSINTTLPELASFLSKRYPQYKVPTE
>Acat_1g019910
MASAVINQMLEKGYAVNSTVRGSCPNSVGAEKSEKLSYLKEMQNLGPLKTFRADLTDEGSFDEAVAGCDYVFHVAAPNELIKPAVQGVLNVMKSCQRQTSAVSVSIKKLRENGLVLDEESWSDMEFLTAENSPTWGYGVSKMLTERKASRFAQEKNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGLKIMQSLNGSISIVHIEDIYSAHIFVTKNESTSSHYICCAIITTLPELASFLSKQYPRYK
>Acat_8g005180
MDGPDSASLPSAVATTTVCVTGATGYIGSWLVRGNSQLKIFRSDLNEEGSFDEAVKGCLAVFHVAAPMEFNVYILSKLLTEEKAFQFVKEKGIDLVSIIPPTVAGPFLTTVVPSSVQVLLSPVTGDPNLYPILISVHSRLGSIPLVHIEDICNAHIFLMEQQGAEGRFICSVGSSTMPQLTDLLSLKYPSFSSKRFAKGFNDVVPPVISSKRLTNLGFKFKYGVEDIIEQSVACCIENGFLKQEIEITSSRHEADNAAITNENTQRFL
>Acat_8g009150
MQFHFYIMDMIPGNKGKVCVTGASGFIASWLVKRLLDSGYHVRGTVKDPGDYKKTSHLWELEGARERLQLMKADLMEEGSFDEAVMGCKGIFHIASPVLKGHSDPKACYSCPILLIRILVQKLTETPFSLGYIHMTCGRLLGILDPAINGTLNVLRSCKKNQALKRVVLTSSSSTVRIKEDIDPKVPLDETSWSSMELCKRLQEAGYVLLCPYNDFSFLFKLWYALAKILAEKAAWEFAKENNIDLVTVLPAFVIGPSLPRDLCLTASDVLGLLRGDNERFSLHGRMGYVHIDDVAHCHILAYEDTKAHGRYLCSSTVLDNHELAGIIAKRYPSLPIPKRFKNYYGKTPYYEFNTSKLQDLGFMFKGIEEMFDDCIRSLKEHGYHLDC
>Acat_8g011320
MSSEGGVCVTGGSGIIGSWVIRLLVERGYTVKAYHDEGETKHLPGLDGASQRLRLFQMDLPNCTSILAAVQGTTGGTVNVLRAAQESKVRRVVVTSSSAAIFPNPSWPAGVVYNEDSWTDVDYCKKLELWYPVSKTLAERAAWEFSAKEGLDVVAIHPGMVLGPILPPAIGVSATILLHLLEGNY
>Acat_10g010850
MEKLGEKRRVCVTGAGGFVASWLVKVLLDKGFMVHGTVRDPSDGKNAHLKKLDNASENLQLFKADLLDYNAVASAIAGCEGVFHVASPVEVITPAVTGTLNVLKACCEAKVKRVVVVSSSTAVMMIPNWPKDKVMDESCWSDKEYCRTIENWYRLSKTLAESEALEYAEKHGLDVVTVCPSVIIGPLLQPTVNSSSLCLIGLLKGGRELMENKCRTFVDVRDVVDALLLVYEKPEASGRYICASHMMKLRDLVEILRGMYPNYNYPKTFVEVDEVVLLSSEKLKMLGWECRRLEESLIDSRKRERGMERLGEKRRVCVTGAGGFVASWLVKLLLNKGFMVHGTVRDPSDEKNAHLKKLDDASENLQLFKADLLDYNAVASAVAGCEGVFHVASPVPAVKNWYCLSKTLAESEALEYAEKHGLDVVTVCPCMVIGPLLQPTVNSSSLFLISLLKGGRESVENKRRNLVDVRDVADALLLVYEKPEASGRYICASHMMKLRDLVDMLRGMYPNHDYPKTFVEVDEGVLVSSEKLKMLGWECRRLEESLIDSSERGMEKLREKTRVCVTGAGGFVASWLVKLLLNKGFMVHGTVRDPSDEKNAHLKKLENASENLQLFKADLLDYNAVASAIAGCEGVEVITPAVTGTLNVLKACCEAKVKRVVAVSSVAAVAMIPNWPKDKVMDESCWSDKEYCRTTENWYCLSKTLAESEALEYAEKHGLDVVTVCPSMVIGPLLQPTVNSSSLFFINILKGVPESMENRCWYFVDVRDVDALLLVYEKPEASGRYICAPHRMEVRDLADMLKSMYPNYNYPKTFVEVDEGVLVSSEKLKMLGWECRRLEESLIDGVECCRNAGLLSKD
>Acat_11g018180
MGHRLLKFLQALLGSVPLVHIEDVCEAHTFCMEKPSMAGRFLVAGRRIPDDARACGLLHETVEGDGHGIGCRTTKLADLGFEYRYDSQQILYESVEFWQEIGSSKNWQ
>Acat_11g018170
EDIYCQSRGSCGPEYIAVLRTIRDSEASHLHRFCHSCITIEGRRHRERRIRSGKPNLWPGWRRYNSSLGTIEVSSHYVATCRRRDELWQLKFLLACACPSMQEIVDYYATEYPDLDSKRRLYCLAFWSWRNFSYGYGNVVLDSDFRVEALREKGMQGIQSKRKLVDMGFKYGLRSKVCVTGASGFLGSWLVQKLLKKGHAVHVTLRNLGLSPTLTSPSFVLRFFFFPSEQSDVVNKISRRHKDTRLHLFEAELYDPFTFEAAIQGCEFVFLLATPMQHNNSYPEYKDTTQAAVAAVRSILQSCERSRTVKRSSRLHRTTGPVLKISLMNPAGRHFISRLLAAKILRRSSFSLAILLLIIVLLISTLA
MSGRGKVVCVTGASGFIASWLVKLLLQRGYTVRATVRDLADPMKTKHLCTLEGANERLHLFKANLLEEGSFDSVIEGCEGVFHTASPCYLNATDPQAELIEPAVKGTLNVFSSCIKTPSVKRVVVTSSMATVVCNGRPRTPDCVVDETWFSSVEFCEQEKLWYPLSKTLAEEAARKFSKDNSIDMVTIHPAVVLGPLLQPTLNGSATTILKLINGSSTYPNTTYGWVSVKDVAMAHILAFEVPSASGRYNLVGKVAHYSEIVKILHEQYPTFKLPEKCEDDKPFAPIYQVYKEKATSLGIDYIPLETSIREIVESNKLRYRLYSLETSIREIVESLKEKDLLLIQGKSEHLRALEGANERLYLFKANLLEEGSFDLAVEGCEGVFHTASPLIIAIDPQAELIDPAVKGTLNVLSSCIKTPSVKRVVITSSMATVSYNERPRTPDVVVDETWFSSIEFCKQSKLWYHLSKIFAEEAAWKFSKDNSLDMVTIHPAGIIGPLLQPTLNASAGEFLKLINGSSTYANAAYGLVNVKDVAMAHILAFEVPSASGRYCLAERVAHYSDMVKILHEQYPTLKLPEKCADDKPFVPIYQISKKKAASLGIDYIPLETSIKETIESLKEKGFVSL
>Acat_1g002340
LIRKKPSNCVPWKEPMRDCPCLKQTCWKRAFLIQWLRGVRAELINPAVKGTLNVFSSCIKTPVKRVVMLSEEAAWKFLKDNSIGMVTINPAMVIGPLLQPTLNTSAAAIRNLIN
>Acat_1g019820
MTGKGKLACVTGGTGFLASVLIKQLLEKGYAVNTTARDPEKSEKLSHLKEMQNLAPVNLNADDPENELIKPAVQGILNVMKSCLKAKSVKRFVLTSSAVSVSIKKLRENGLVLDEESWSDMEFLTAEKPPTWGYSVSKMLTEREASRFAQQNNINLLTIIPPISIGPSPVAKDVPGNALALSLITGNEMLLNGLKIVQSLNGVISLSHIEDVCRAHIFVAENESASGRYICCSINTTLPEVASFLSKRYPQYEVPTDFGELPEKAELILSSEKLIKAGFEFKYKKLEEIYDPAVKYAKAIGLLPSK
>Acat_1g019860
MERTGLRGGFPTERQGLGVPRWRCSFSVHLQSTDEIISEYFGFSCPFFTPAARGMGNAATYESHGCGASCPGGIFGDEYSRHLREAEGAWRRNEMLLNGLKIVQSLNGAFSLSHIEDGHIFVAGNESASGHYICCSINITLPEVSSFLFGELPEKAELILSSEKLIKAGFEFKYKKLEEIYDPAIKYAKAIGLLPSK
>Acat_1g019890
NELIKPAVQGVLNVMKSCQKAKSVKRFLVSIKKLRENGLVLGDESWSDMEFLTAENSPTWGYGVSKMLTERKASRFAQEKNINLLTIIPTLSIGPAPVARDAPSISMTLSLLTGEEQDLQGNEMLLNGLKIMQSLNGSISIVHIEDICNAHIFVAKNEPASDRYICWSINITLLELTSSLSKKYSHFSELPKKAELILSSEKLIKARFEYKQLEKICDPAIKYAKAIRLPPPK
>Acat_1g019940
MLPRCWVPCSISSMIPVDYLSHRPAAMMFTHCLSTGSLISPMKPYRQIFQIMFMLAEPSSDAIAGQGLTQLRQHYPDLDDPALAQVAHPPPLLRLTGHLLAPDRAPKGVMFLVEHYLEVPPNVERGLTQVQAKRFSGRHRSSTSDGNALHRLMTSSPLASTHPLLEGGGLGHDGILLLAPILLIFWHKDGGVSSTYFSGSSATGFLGFSITSRVGGEGTSVTATFTSTSSSILRIGFVALKHPKMTKLACVTGGTGYMASVIIKQLLEKGYAVNTTNELIKPAVQGVLNVMKSCLKAKSVKRFVLTSSAISVSVKKLRENGLVLDEESWSDMEFLTAEKPPTWGYGVSKMLTEREASRFAQENNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGFKIMQSLNGSISIVHIEDVSRAHIFVAENESASGRYICCSINTTLPELASFLSKRYPQYKVPTDFGELPEKAELMLSSEKLIKAGFEFKYKQLEEIYDPAVKYAKAIGLLPSK
>Acat_1g019920
MASAVINQMLEKGYAVNSTNELIKPAVQGVLNVMKSCLKAKSVKRFVLTSSAISVSVKKLRENGLVLDEESWSDMEFLTAEKPPTWGYGVSKMLTEREASRFAQENNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGFKIMQSLNGSISIVHIEDVSRAHIFVAENESASGRYICCSINTTLPELASFLSKRYPQYKVPTE
>Acat_1g019910
MASAVINQMLEKGYAVNSTVRGSCPNSVGAEKSEKLSYLKEMQNLGPLKTFRADLTDEGSFDEAVAGCDYVFHVAAPNELIKPAVQGVLNVMKSCQRQTSAVSVSIKKLRENGLVLDEESWSDMEFLTAENSPTWGYGVSKMLTERKASRFAQEKNINLLTIIPTLSIGPAPIARDASSISMALSLLTGNEMLLNGLKIMQSLNGSISIVHIEDIYSAHIFVTKNESTSSHYICCAIITTLPELASFLSKQYPRYK
>Acat_8g005180
MDGPDSASLPSAVATTTVCVTGATGYIGSWLVRGNSQLKIFRSDLNEEGSFDEAVKGCLAVFHVAAPMEFNVYILSKLLTEEKAFQFVKEKGIDLVSIIPPTVAGPFLTTVVPSSVQVLLSPVTGDPNLYPILISVHSRLGSIPLVHIEDICNAHIFLMEQQGAEGRFICSVGSSTMPQLTDLLSLKYPSFSSKRFAKGFNDVVPPVISSKRLTNLGFKFKYGVEDIIEQSVACCIENGFLKQEIEITSSRHEADNAAITNENTQRFL
>Acat_8g009150
MQFHFYIMDMIPGNKGKVCVTGASGFIASWLVKRLLDSGYHVRGTVKDPGDYKKTSHLWELEGARERLQLMKADLMEEGSFDEAVMGCKGIFHIASPVLKGHSDPKACYSCPILLIRILVQKLTETPFSLGYIHMTCGRLLGILDPAINGTLNVLRSCKKNQALKRVVLTSSSSTVRIKEDIDPKVPLDETSWSSMELCKRLQEAGYVLLCPYNDFSFLFKLWYALAKILAEKAAWEFAKENNIDLVTVLPAFVIGPSLPRDLCLTASDVLGLLRGDNERFSLHGRMGYVHIDDVAHCHILAYEDTKAHGRYLCSSTVLDNHELAGIIAKRYPSLPIPKRFKNYYGKTPYYEFNTSKLQDLGFMFKGIEEMFDDCIRSLKEHGYHLDC
>Acat_8g011320
MSSEGGVCVTGGSGIIGSWVIRLLVERGYTVKAYHDEGETKHLPGLDGASQRLRLFQMDLPNCTSILAAVQGTTGGTVNVLRAAQESKVRRVVVTSSSAAIFPNPSWPAGVVYNEDSWTDVDYCKKLELWYPVSKTLAERAAWEFSAKEGLDVVAIHPGMVLGPILPPAIGVSATILLHLLEGNY
>Acat_10g010850
MEKLGEKRRVCVTGAGGFVASWLVKVLLDKGFMVHGTVRDPSDGKNAHLKKLDNASENLQLFKADLLDYNAVASAIAGCEGVFHVASPVEVITPAVTGTLNVLKACCEAKVKRVVVVSSSTAVMMIPNWPKDKVMDESCWSDKEYCRTIENWYRLSKTLAESEALEYAEKHGLDVVTVCPSVIIGPLLQPTVNSSSLCLIGLLKGGRELMENKCRTFVDVRDVVDALLLVYEKPEASGRYICASHMMKLRDLVEILRGMYPNYNYPKTFVEVDEVVLLSSEKLKMLGWECRRLEESLIDSRKRERGMERLGEKRRVCVTGAGGFVASWLVKLLLNKGFMVHGTVRDPSDEKNAHLKKLDDASENLQLFKADLLDYNAVASAVAGCEGVFHVASPVPAVKNWYCLSKTLAESEALEYAEKHGLDVVTVCPCMVIGPLLQPTVNSSSLFLISLLKGGRESVENKRRNLVDVRDVADALLLVYEKPEASGRYICASHMMKLRDLVDMLRGMYPNHDYPKTFVEVDEGVLVSSEKLKMLGWECRRLEESLIDSSERGMEKLREKTRVCVTGAGGFVASWLVKLLLNKGFMVHGTVRDPSDEKNAHLKKLENASENLQLFKADLLDYNAVASAIAGCEGVEVITPAVTGTLNVLKACCEAKVKRVVAVSSVAAVAMIPNWPKDKVMDESCWSDKEYCRTTENWYCLSKTLAESEALEYAEKHGLDVVTVCPSMVIGPLLQPTVNSSSLFFINILKGVPESMENRCWYFVDVRDVDALLLVYEKPEASGRYICAPHRMEVRDLADMLKSMYPNYNYPKTFVEVDEGVLVSSEKLKMLGWECRRLEESLIDGVECCRNAGLLSKD
>Acat_11g018180
MGHRLLKFLQALLGSVPLVHIEDVCEAHTFCMEKPSMAGRFLVAGRRIPDDARACGLLHETVEGDGHGIGCRTTKLADLGFEYRYDSQQILYESVEFWQEIGSSKNWQ
>Acat_11g018170
EDIYCQSRGSCGPEYIAVLRTIRDSEASHLHRFCHSCITIEGRRHRERRIRSGKPNLWPGWRRYNSSLGTIEVSSHYVATCRRRDELWQLKFLLACACPSMQEIVDYYATEYPDLDSKRRLYCLAFWSWRNFSYGYGNVVLDSDFRVEALREKGMQGIQSKRKLVDMGFKYGLRSKVCVTGASGFLGSWLVQKLLKKGHAVHVTLRNLGLSPTLTSPSFVLRFFFFPSEQSDVVNKISRRHKDTRLHLFEAELYDPFTFEAAIQGCEFVFLLATPMQHNNSYPEYKDTTQAAVAAVRSILQSCERSRTVKRSSRLHRTTGPVLKISLMNPAGRHFISRLLAAKILRRSSFSLAILLLIIVLLISTLA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University