Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Welwitschia mirabilis
Species name
Welwitschia mirabilis is a species of seed plant in the family Welwitschiaceae.
Species info
Gene sequence info
Welwitschia_mirabilis.COMT.fa
Download
>W.mirabilis.16598
MAHWHLLHHCVLNGELPFRKAHGMNIFEYAAVHADFNCAMSSTSATFIKPFLAAYKQRISALSSLVDVGGGSGSTLRPSSENARTSLAPSTLISLTSFPLPLRSQACILSLDFASSDLR
>W.mirabilis.16988
MLANNEVMMAPWLLLYHCELNGELPFRKAHGMNIFEYAAVHADFNALFNCAMSSTSATFIEPFLAAYKHRLSAISSLVDVGGGLGNTLAAIVRECPNIICALNFDLPHELSALEEIDTA
>W.mirabilis.18384
MANDESFLKALLLTSATCLPMAVKAALDLNVFQIIADEGAGAALTPRQIMKKVAQAENVSNPTAHVALDRILSLLASHSVLTCRPAAGGGAGERVYGLSDLSVHLVSNSNDVSLGPLLLMNHDKVFMDTWQFLKCAVTEGAQPFVKAHGVGAFEYPAHDERFNALFNRAMSQHSGLMMAKILDVYRGFEHVSELVDVGGGVGLTSSMIVTRHPHIKATNFDMPHVVSTAPAHPGVVHVGGDMFDSVPPAQAILMKWILHDWSDELCIRLLKNCHKALPENGKVIVIEHMLPTIPEASTCAQESYQVDLLMLAYNPGGKERTEQDFRDLAHQSGFKGGLKPICCVSGIWVMELYK
>W.mirabilis.18385
MAENANANANANANGEIKVANDESFLKALLLTSATCLPMAVKAALDLNVFQIIADEGAGAALTPRQIMKKVAQAENVSNPTAHVALDRILSLLASHSVLTCRPAAGGGAGERVYGLSDLSVHLVSNSNDVSLGPLLLMNHDKVFMDTWH
>W.mirabilis.17297
MQESQARLQMMELANMLSVPMALNAAVRLQVPDIIWQNGANTPLSCAQIASSVLGRPASEVAPNAANLQRIMRMLSSYNVFSETLTESGERFYSLTEVGRTLAKDESGHSFGEYVLQHHQKPMLNAWEQLECAVIDPSEEPFVKANGKPAYAFYGDGEEYNQLMIFFFLTFSSKTSLLNILDVA
>W.mirabilis.17298
MQESQARLQMMELANMLSVPMALNAAVRLQVPDIIWQNGANTPLSCAQIASSVLGRPASEVAPNAANLQRIMRMLSSYNVFSETLTESGERFYSLTEVGRTLAKDESGHSFGEYVLQHHQKPMLNAWEQLECAVIDPSEEPFVKANGKPAYAFYGDGEEYNQLMKDAMTGVSVPFMRCLLQNYRGFQGIRTLVDVGGSSGFCLHMILQEYPEIKGINFDLPYVVGNAPSYPGISHVGGNMFEAIPSGDAIFMKWILTTWSDDKCIELLKRCHESLPEGGKVIACEPVLPKKTDTSNRSRALLEGDVFVMTVYSNGGKERTHDEFKQLGTTAGFSRFHVFEVDPFYATLEFSK
>W.mirabilis.04061
GIITRHCQENDIVIVIEHMLSTIPKQSTYAQASHQVDILMLAYNPNGKECIKQDFRA
>W.mirabilis.24016
SLTVKCTLLFRIPEIIAKSGPNAFSFSKITKRLLIELSYTELLHSVMDYMVTICFFTKNNYGRGERRCGLTTTLKHMEKDTTSKELLTPIFMLVKNEVMMVPWHLLHHCVLNRELPFRKLYEMNNFEYASKNGYYMTSRRRTV
>W.mirabilis.17031
IKGNLGKMLMIIVGKYLNITVALNFDLPHIISTALQILRVKHVGRDMFNILHINTLKLKNDIKGNLGKMLMIIVGKYLNITHALNFDLPHIISTALQILRVKHVGRDMF
MAHWHLLHHCVLNGELPFRKAHGMNIFEYAAVHADFNCAMSSTSATFIKPFLAAYKQRISALSSLVDVGGGSGSTLRPSSENARTSLAPSTLISLTSFPLPLRSQACILSLDFASSDLR
>W.mirabilis.16988
MLANNEVMMAPWLLLYHCELNGELPFRKAHGMNIFEYAAVHADFNALFNCAMSSTSATFIEPFLAAYKHRLSAISSLVDVGGGLGNTLAAIVRECPNIICALNFDLPHELSALEEIDTA
>W.mirabilis.18384
MANDESFLKALLLTSATCLPMAVKAALDLNVFQIIADEGAGAALTPRQIMKKVAQAENVSNPTAHVALDRILSLLASHSVLTCRPAAGGGAGERVYGLSDLSVHLVSNSNDVSLGPLLLMNHDKVFMDTWQFLKCAVTEGAQPFVKAHGVGAFEYPAHDERFNALFNRAMSQHSGLMMAKILDVYRGFEHVSELVDVGGGVGLTSSMIVTRHPHIKATNFDMPHVVSTAPAHPGVVHVGGDMFDSVPPAQAILMKWILHDWSDELCIRLLKNCHKALPENGKVIVIEHMLPTIPEASTCAQESYQVDLLMLAYNPGGKERTEQDFRDLAHQSGFKGGLKPICCVSGIWVMELYK
>W.mirabilis.18385
MAENANANANANANGEIKVANDESFLKALLLTSATCLPMAVKAALDLNVFQIIADEGAGAALTPRQIMKKVAQAENVSNPTAHVALDRILSLLASHSVLTCRPAAGGGAGERVYGLSDLSVHLVSNSNDVSLGPLLLMNHDKVFMDTWH
>W.mirabilis.17297
MQESQARLQMMELANMLSVPMALNAAVRLQVPDIIWQNGANTPLSCAQIASSVLGRPASEVAPNAANLQRIMRMLSSYNVFSETLTESGERFYSLTEVGRTLAKDESGHSFGEYVLQHHQKPMLNAWEQLECAVIDPSEEPFVKANGKPAYAFYGDGEEYNQLMIFFFLTFSSKTSLLNILDVA
>W.mirabilis.17298
MQESQARLQMMELANMLSVPMALNAAVRLQVPDIIWQNGANTPLSCAQIASSVLGRPASEVAPNAANLQRIMRMLSSYNVFSETLTESGERFYSLTEVGRTLAKDESGHSFGEYVLQHHQKPMLNAWEQLECAVIDPSEEPFVKANGKPAYAFYGDGEEYNQLMKDAMTGVSVPFMRCLLQNYRGFQGIRTLVDVGGSSGFCLHMILQEYPEIKGINFDLPYVVGNAPSYPGISHVGGNMFEAIPSGDAIFMKWILTTWSDDKCIELLKRCHESLPEGGKVIACEPVLPKKTDTSNRSRALLEGDVFVMTVYSNGGKERTHDEFKQLGTTAGFSRFHVFEVDPFYATLEFSK
>W.mirabilis.04061
GIITRHCQENDIVIVIEHMLSTIPKQSTYAQASHQVDILMLAYNPNGKECIKQDFRA
>W.mirabilis.24016
SLTVKCTLLFRIPEIIAKSGPNAFSFSKITKRLLIELSYTELLHSVMDYMVTICFFTKNNYGRGERRCGLTTTLKHMEKDTTSKELLTPIFMLVKNEVMMVPWHLLHHCVLNRELPFRKLYEMNNFEYASKNGYYMTSRRRTV
>W.mirabilis.17031
IKGNLGKMLMIIVGKYLNITVALNFDLPHIISTALQILRVKHVGRDMFNILHINTLKLKNDIKGNLGKMLMIIVGKYLNITHALNFDLPHIISTALQILRVKHVGRDMF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University