Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Welwitschia mirabilis
Species name
Welwitschia mirabilis is a species of seed plant in the family Welwitschiaceae.
Species info
Gene sequence info
Welwitschia_mirabilis.HIDH.fa
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>W.mirabilis.17561
MNMGKSGDEGDEDAEALLIVDVPGFLQIYGDGFISRFDHRPQPPSAHSSSPLGVRTKDVAFEHREKNVEGVDEKTALEYHDTFWRLALPAHVDRDHPACNPRAAGAPDLKKVVLPPALVVVAELDLLLPRGTLYYEMLRECGKVAEMEVEGKVGHAHFLYDPTSSKSVQLIQRITRFLHERGGDRRAC
>W.mirabilis.07800
MNIVSCSDKKPDAGVAANDAANPKPAKHIKDEIQGLVRLYSDGTAERLSAVVSEVPPLQSCSKDVIIDPSKGIWARIHISKAVLSDKKTAKVPILLYFHGGGFLMGSPAWSVYNNFLNRLVSHGVIEGGFIVVSVAYRLAPEHRLPAAYDDGFQVLMWLISGATCDWISRHGDTRRCVIAGDSAGGNIVHHVALRAMKEPKMKKVVKGMVCIQPFFGTGGRNFDAGLPHEWINIFWRWSLPFPHGETKNHPWCNPLAEDRSAWATLPPVLVCVSDCDTLKDADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCLFVRYCCVLPEAIAFRHAFGRLSIC
>W.mirabilis.07802
MSIVGCSDEKPNSGIAANQAGNPKPPKHIKDEIQGLIRLYSDGTAERLSEVVSEVPPSQSCSKDVTISSSKGIWARIHIPKSALSDKKPFFGTGGRNFDAGLPHEWIDIFWRWSLPFQHGETKNHPWCNPLAERDRSAWATLPPVLVCVSECDTLREADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCLFMRYCCCGA
>W.mirabilis.07804
MKIVDYSDKKSNEGIAANHAGNPKPAKHMKDEIQGLIRLYSDGTAERLSGVVSEVPPSQSCSKDVTIDSCKGIWARIHISKSVVSDKKAPKPFFGTGGRNFDAGLPHEWIDIFWKWSLPFQHGETKSHPWCNLLAETDRSAWVTLPPVLVCVSECDTLMEADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCVFVRYCCCGA
>W.mirabilis.15215
MISRPYVCRQRVFRTEARTCPAALENFLTSSTRARLFNTINIPSLLSSPHPSPLHHFSKQPARTRLDMTPSSAKDETVVHVDGHRLFTYNADGTIRRLFGTEMTEPSPNRVRNGVKSKDVMVDPTTGVFVRIYMPTAVSGSKLPLLFYVHGGAFCVASAASAVYHAYLNNLVKHANVVAVSVDYRRAPEHRLPAAFDDCFAALRWLLAGDGRVDPWIASAADFRRVFLAGDSSGATVVHELGIRGGTVEWPADVSFGGGISFEPFFNPSQELKIGTSEESAEMATKRHEFMATVCLPQGEDEEYPPFNPVGPRSPPLSGSVLKRILVVVAEKDVLCEIGVSYFRQLVKAGVEGELEFSEGQIHVYQILDLFSPASAALMQRVSGFIHAVAADS
>W.mirabilis.15216
MVDPTTGVFVRIYMPTAVSGSKLPLLFYVHGGAFCVASAASAVYHAYLNNLVKHANVVAVSVDYRRAPEHRLPAAFDDCFAALRWLLAGDGRVDPWIASAADFRRVFLAGDSSGATVVHELGIRGGTVEWPADVSFGGGISFEPFFNPSQELKIGTSEESAEMATKRHEFMATVCLPQGEDEEYPPFNPVGPRSPPLSGSVLKRILVVVAEKDVLCEIGVSYFRQLVKAGVEGELEFSEGQIHVYQILDLFSPASAALMQRVSGFIHAVAADS
>W.mirabilis.15223
MAQGAVQEGSLEIEVDAFPFFTAFKGGVVRRYSGTETVPPSLEKSTDGVKSKDSVVNQDNGVYVRMFLPTAPADERMPVLFYVHGGGFCIESPSSPTYHGYMTSVAAHVRALCVSVHYRRTPEHRLPAAYEDCFAALRWLLHGKGRDDPWVAGFGNLGQLFVAGDSCGANIVHELGLRARRVDWGPGVRFCGAVSVHPGFCGEVADDNLDEIGRHILRLTANGVIFKSALPEGEEDLSKYPPFNPTAPISPSPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFEPDEGH
>W.mirabilis.15224
MTKKKDLSKYPPFNPTSPISPPPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFELDEGHVFHLFSPQSAVAASFMQRVCKFIHDTCSET
>W.mirabilis.15225
MSQGAAQEGSMEIEVDAFPFFTAFKGGFVRRYNGTETVPPSPEKSSDGVKSKDSVVNQDNGIYVRMFLPTAPADARMPVLFYVHGGGFCIESPSSPTYHGYMTSVAAHVRALCVSVHYRRTPEHRLPAAYEDCFEALQWLLLGNGRDDPWVAACGNLSQLFVAGDSCGANIVHELGLRARRVEWGTGVRFCGAVSVHPAFCGEVAEDNLDEIGRHLLRLTANGVMFKSALPEGEKDLSKYPPFNPTSPISPPPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFELDEGHVFHLFSPQSAVAASFMQRVCKFIHDTCSET
>W.mirabilis.15226
MDSESSGNQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIEPSTGVFVRLYLPEHSQKAKLPLLFYVHGGGFCIGSAASTLYHKYLNKVAKELRLLCVSVDYRRAPEERLPAAYDDCFLALRWLLAGAGREDQWIASAGNVGRVFVAGDSAGGNIVHELGIRAGKVEWPSNVKFEGAVYFHPFFHKKPEGDGYITDPAGNRGSLTYDGLVSLVLPPGEKPEEYPPFNPVGPRSPPLSGIVYERALVAVADKDNIKEGGLQYYRHLVEAGRKAELEVTLGKDHVFHLFDLPGAAAVALMQRVYAFIHGHSSAG
>W.mirabilis.15227
MDSESSGNQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIEPSTGVFVRLYLPEHSQKAKLPLLFYVHGGGFCIGSAASTLYHKYLNKVAKELRLLCVSVDYRRAPEERLPPPTTIVLALRWLLAGAGREDQWIASAGNVGRVFVAGDSAGGNIVHELGIRAGKVEWPSNVKFEGAVYFHPFFHKKPEGDGYITDPAGNRGSLTYDGLVSLVLPPGEKPEEYPPFNPVGPRSPPLSGIVYESSGCCGPTHCRNCPF
>W.mirabilis.15228
MDSESSAKQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIDPSTGVFVRLYLPEHSQIARLPLLFYVHGGAFCIGSAASTLYQKYLNKVAKELRLLCVSVDYRRAPEDRLPAAYDDCFLALRWLLAGTGREDPWIASAGDVGRVFVAGDSAGGNIVHELGIRASKVEWPSDVKFEGAVYFHPFFHKTPEGDGYIRDPAGNRGGLTYDGLVSLVLPPGEKAEEYPPFNPVGPRSPPLSGIVYERALVAVAEKDSIKEGGLGYYRHLVEAGRKAEVEVTPEKDHVFHLFDLTGAAAVALMRRVYAFIHGHSFSG
>W.mirabilis.15229
MDSESSAKQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDISFAFSASPSITAERRRTVSRPPTTIVLALRWLLAGTGREDPWIASAGDVGRVFVAGDSAGGNIVHELGIRASKVEWPSDVKFEGAVYFHPFFHKTPEGDGYIRDPAGNRGGLTYDGLVSLVLPPGEKAEEYPPFNPVGPRSPPLSGIVYESR
>W.mirabilis.15230
MSSHGGAVFRQYSCVEGRKPRNQDLHFKIRGGERELQKSWRALRRRTMANEKVEINGLPYFKKFADGTVVRFLNTELSQANPHDYSEGAKSKDLLIDPSTDVFVRLYLPEMRSCQKLPILFYIHGGGFCVGSAASTLYYKYLNKVANELNLLCVAVNYRKAPEHRFPAAYDDCFTGLRWLLAGGGREDPWIASAADFGAYFAGDSAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFMT
>W.mirabilis.15231
MANEKVEINGLPYFKKFADGTVVRFLNTELSQANPHDYSEGAKSKDLLIDPSTDVFVRLYLPEMRSCQKLPILFYIHGGGFCVGSAASTLYYKYLNKVANELNLLCVAVNYRKAPEHRFPAAYDDCFTGLRWLLAGGGREDPWIASAADFGRVFLAGDSAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFHDIEGGKEAYDKLSAAVVGSHASDLTYEKLLSILLPEGENVDYPPINPVGPRSPPLSRLAYERMLVAVAENDFVKEVGIKYHQQLVNAGCSAELECTAGQGHVFHLMDIACPAALALLRRFAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFHDIEGGKEAYDKLSAAVVGSHASDLTYEKLLSILLPEGENVDYPPINPVGPRSPPLSRLAYERMLVAVAENDFVKEVGIKYHQQLVNAGCSAELECTAGQGHVFHLMDIACPAALALLRRLSAFIYA
>W.mirabilis.23122
MADENRCVAAEIPGAVRLYTDGTIHRTPETTLFPSSGGRFIDGVATTDVQIDGQTGLWARVFQPETAPPNAKPPIVIFFHGGAFCTGNPSLPEYHRFCSIMAAETGAVWLSVAYRYILKLNISNMVPTARSCLAS
>W.mirabilis.23123
MADENRCVAAEIPGAVRLYTDGTIHRTPETTLFPSSGGRFIDGVATTDVQIDGQTGLWARVFRPETAPPNAKPPIVIFFHGGAFCTGNPSLPEYHRFCSIMAAETGAVWLSVAYRRSPEYRLPAAVEDAITAVLWIDGQKGPASLPFPADPARCFLVGLSAGAALVHQAVLSVSSRRLLKTRILGLVLLHPGFLKPEVSRSEVLGARGPGAPVTLGFIEDCLRMILPPNAGRDYFLLCPNIPAAADIAAGASCGWQARCFL
>W.mirabilis.02988
MAEVVDKIEGFITVYRNGYVIRTEDPKFYCPQEHKAQEGGLMFKDVVVDQNKVWVRIYVPEKALKRSQKIPVVLFFHGGGFCLASPGTPMIHASCVKWAQACYSVFISAHYRLCPDNRLPAAFEDAASVLAWLEGQAHVDEWLKANADFSRVFLMGDSAGGNIAHHLAFSGATKKSPAEMKLNVNGMILNGLGVPAVVVVVAGLDILRDRALEYCEILKRKCDCRVEVLMYENEDHGFASVKIGQESYMNFVESASRFIHSQSLHG
MNMGKSGDEGDEDAEALLIVDVPGFLQIYGDGFISRFDHRPQPPSAHSSSPLGVRTKDVAFEHREKNVEGVDEKTALEYHDTFWRLALPAHVDRDHPACNPRAAGAPDLKKVVLPPALVVVAELDLLLPRGTLYYEMLRECGKVAEMEVEGKVGHAHFLYDPTSSKSVQLIQRITRFLHERGGDRRAC
>W.mirabilis.07800
MNIVSCSDKKPDAGVAANDAANPKPAKHIKDEIQGLVRLYSDGTAERLSAVVSEVPPLQSCSKDVIIDPSKGIWARIHISKAVLSDKKTAKVPILLYFHGGGFLMGSPAWSVYNNFLNRLVSHGVIEGGFIVVSVAYRLAPEHRLPAAYDDGFQVLMWLISGATCDWISRHGDTRRCVIAGDSAGGNIVHHVALRAMKEPKMKKVVKGMVCIQPFFGTGGRNFDAGLPHEWINIFWRWSLPFPHGETKNHPWCNPLAEDRSAWATLPPVLVCVSDCDTLKDADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCLFVRYCCVLPEAIAFRHAFGRLSIC
>W.mirabilis.07802
MSIVGCSDEKPNSGIAANQAGNPKPPKHIKDEIQGLIRLYSDGTAERLSEVVSEVPPSQSCSKDVTISSSKGIWARIHIPKSALSDKKPFFGTGGRNFDAGLPHEWIDIFWRWSLPFQHGETKNHPWCNPLAERDRSAWATLPPVLVCVSECDTLREADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCLFMRYCCCGA
>W.mirabilis.07804
MKIVDYSDKKSNEGIAANHAGNPKPAKHMKDEIQGLIRLYSDGTAERLSGVVSEVPPSQSCSKDVTIDSCKGIWARIHISKSVVSDKKAPKPFFGTGGRNFDAGLPHEWIDIFWKWSLPFQHGETKSHPWCNLLAETDRSAWVTLPPVLVCVSECDTLMEADVEYYVALKEKAKDVRLVTLKGVGHAFQLLQTDSPRVVELLNATCVFVRYCCCGA
>W.mirabilis.15215
MISRPYVCRQRVFRTEARTCPAALENFLTSSTRARLFNTINIPSLLSSPHPSPLHHFSKQPARTRLDMTPSSAKDETVVHVDGHRLFTYNADGTIRRLFGTEMTEPSPNRVRNGVKSKDVMVDPTTGVFVRIYMPTAVSGSKLPLLFYVHGGAFCVASAASAVYHAYLNNLVKHANVVAVSVDYRRAPEHRLPAAFDDCFAALRWLLAGDGRVDPWIASAADFRRVFLAGDSSGATVVHELGIRGGTVEWPADVSFGGGISFEPFFNPSQELKIGTSEESAEMATKRHEFMATVCLPQGEDEEYPPFNPVGPRSPPLSGSVLKRILVVVAEKDVLCEIGVSYFRQLVKAGVEGELEFSEGQIHVYQILDLFSPASAALMQRVSGFIHAVAADS
>W.mirabilis.15216
MVDPTTGVFVRIYMPTAVSGSKLPLLFYVHGGAFCVASAASAVYHAYLNNLVKHANVVAVSVDYRRAPEHRLPAAFDDCFAALRWLLAGDGRVDPWIASAADFRRVFLAGDSSGATVVHELGIRGGTVEWPADVSFGGGISFEPFFNPSQELKIGTSEESAEMATKRHEFMATVCLPQGEDEEYPPFNPVGPRSPPLSGSVLKRILVVVAEKDVLCEIGVSYFRQLVKAGVEGELEFSEGQIHVYQILDLFSPASAALMQRVSGFIHAVAADS
>W.mirabilis.15223
MAQGAVQEGSLEIEVDAFPFFTAFKGGVVRRYSGTETVPPSLEKSTDGVKSKDSVVNQDNGVYVRMFLPTAPADERMPVLFYVHGGGFCIESPSSPTYHGYMTSVAAHVRALCVSVHYRRTPEHRLPAAYEDCFAALRWLLHGKGRDDPWVAGFGNLGQLFVAGDSCGANIVHELGLRARRVDWGPGVRFCGAVSVHPGFCGEVADDNLDEIGRHILRLTANGVIFKSALPEGEEDLSKYPPFNPTAPISPSPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFEPDEGH
>W.mirabilis.15224
MTKKKDLSKYPPFNPTSPISPPPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFELDEGHVFHLFSPQSAVAASFMQRVCKFIHDTCSET
>W.mirabilis.15225
MSQGAAQEGSMEIEVDAFPFFTAFKGGFVRRYNGTETVPPSPEKSSDGVKSKDSVVNQDNGIYVRMFLPTAPADARMPVLFYVHGGGFCIESPSSPTYHGYMTSVAAHVRALCVSVHYRRTPEHRLPAAYEDCFEALQWLLLGNGRDDPWVAACGNLSQLFVAGDSCGANIVHELGLRARRVEWGTGVRFCGAVSVHPAFCGEVAEDNLDEIGRHLLRLTANGVMFKSALPEGEKDLSKYPPFNPTSPISPPPSELVYERMLVAVAGKDPLREIGRRYYRWLEAGGVDVELYFELDEGHVFHLFSPQSAVAASFMQRVCKFIHDTCSET
>W.mirabilis.15226
MDSESSGNQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIEPSTGVFVRLYLPEHSQKAKLPLLFYVHGGGFCIGSAASTLYHKYLNKVAKELRLLCVSVDYRRAPEERLPAAYDDCFLALRWLLAGAGREDQWIASAGNVGRVFVAGDSAGGNIVHELGIRAGKVEWPSNVKFEGAVYFHPFFHKKPEGDGYITDPAGNRGSLTYDGLVSLVLPPGEKPEEYPPFNPVGPRSPPLSGIVYERALVAVADKDNIKEGGLQYYRHLVEAGRKAELEVTLGKDHVFHLFDLPGAAAVALMQRVYAFIHGHSSAG
>W.mirabilis.15227
MDSESSGNQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIEPSTGVFVRLYLPEHSQKAKLPLLFYVHGGGFCIGSAASTLYHKYLNKVAKELRLLCVSVDYRRAPEERLPPPTTIVLALRWLLAGAGREDQWIASAGNVGRVFVAGDSAGGNIVHELGIRAGKVEWPSNVKFEGAVYFHPFFHKKPEGDGYITDPAGNRGSLTYDGLVSLVLPPGEKPEEYPPFNPVGPRSPPLSGIVYESSGCCGPTHCRNCPF
>W.mirabilis.15228
MDSESSAKQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDIVIDPSTGVFVRLYLPEHSQIARLPLLFYVHGGAFCIGSAASTLYQKYLNKVAKELRLLCVSVDYRRAPEDRLPAAYDDCFLALRWLLAGTGREDPWIASAGDVGRVFVAGDSAGGNIVHELGIRASKVEWPSDVKFEGAVYFHPFFHKTPEGDGYIRDPAGNRGGLTYDGLVSLVLPPGEKAEEYPPFNPVGPRSPPLSGIVYERALVAVAEKDSIKEGGLGYYRHLVEAGRKAEVEVTPEKDHVFHLFDLTGAAAVALMRRVYAFIHGHSFSG
>W.mirabilis.15229
MDSESSAKQVEIDAFPMFRTYKDGTVVRLGATELSEPNPNDFSEGAKSKDISFAFSASPSITAERRRTVSRPPTTIVLALRWLLAGTGREDPWIASAGDVGRVFVAGDSAGGNIVHELGIRASKVEWPSDVKFEGAVYFHPFFHKTPEGDGYIRDPAGNRGGLTYDGLVSLVLPPGEKAEEYPPFNPVGPRSPPLSGIVYESR
>W.mirabilis.15230
MSSHGGAVFRQYSCVEGRKPRNQDLHFKIRGGERELQKSWRALRRRTMANEKVEINGLPYFKKFADGTVVRFLNTELSQANPHDYSEGAKSKDLLIDPSTDVFVRLYLPEMRSCQKLPILFYIHGGGFCVGSAASTLYYKYLNKVANELNLLCVAVNYRKAPEHRFPAAYDDCFTGLRWLLAGGGREDPWIASAADFGAYFAGDSAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFMT
>W.mirabilis.15231
MANEKVEINGLPYFKKFADGTVVRFLNTELSQANPHDYSEGAKSKDLLIDPSTDVFVRLYLPEMRSCQKLPILFYIHGGGFCVGSAASTLYYKYLNKVANELNLLCVAVNYRKAPEHRFPAAYDDCFTGLRWLLAGGGREDPWIASAADFGRVFLAGDSAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFHDIEGGKEAYDKLSAAVVGSHASDLTYEKLLSILLPEGENVDYPPINPVGPRSPPLSRLAYERMLVAVAENDFVKEVGIKYHQQLVNAGCSAELECTAGQGHVFHLMDIACPAALALLRRFAGANIVHEVGLRAGAVEWPADVKLAGGVFFHPFFHDIEGGKEAYDKLSAAVVGSHASDLTYEKLLSILLPEGENVDYPPINPVGPRSPPLSRLAYERMLVAVAENDFVKEVGIKYHQQLVNAGCSAELECTAGQGHVFHLMDIACPAALALLRRLSAFIYA
>W.mirabilis.23122
MADENRCVAAEIPGAVRLYTDGTIHRTPETTLFPSSGGRFIDGVATTDVQIDGQTGLWARVFQPETAPPNAKPPIVIFFHGGAFCTGNPSLPEYHRFCSIMAAETGAVWLSVAYRYILKLNISNMVPTARSCLAS
>W.mirabilis.23123
MADENRCVAAEIPGAVRLYTDGTIHRTPETTLFPSSGGRFIDGVATTDVQIDGQTGLWARVFRPETAPPNAKPPIVIFFHGGAFCTGNPSLPEYHRFCSIMAAETGAVWLSVAYRRSPEYRLPAAVEDAITAVLWIDGQKGPASLPFPADPARCFLVGLSAGAALVHQAVLSVSSRRLLKTRILGLVLLHPGFLKPEVSRSEVLGARGPGAPVTLGFIEDCLRMILPPNAGRDYFLLCPNIPAAADIAAGASCGWQARCFL
>W.mirabilis.02988
MAEVVDKIEGFITVYRNGYVIRTEDPKFYCPQEHKAQEGGLMFKDVVVDQNKVWVRIYVPEKALKRSQKIPVVLFFHGGGFCLASPGTPMIHASCVKWAQACYSVFISAHYRLCPDNRLPAAFEDAASVLAWLEGQAHVDEWLKANADFSRVFLMGDSAGGNIAHHLAFSGATKKSPAEMKLNVNGMILNGLGVPAVVVVVAGLDILRDRALEYCEILKRKCDCRVEVLMYENEDHGFASVKIGQESYMNFVESASRFIHSQSLHG
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University