Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Welwitschia mirabilis
Species name
Welwitschia mirabilis is a species of seed plant in the family Welwitschiaceae.
Species info
Gene sequence info
Welwitschia_mirabilis.DFR.fa
Download
>W.mirabilis.07225
MPGANDRLRLFRADLLVEDSFDSAIDNSEGVFRIMSPVTIDPKDPQNEVIKLAVRRMLRIPEAYQKVKNCQTSGHYFICVGTFMKEAVIDESSWSDVQFCRRKHPPRWAYIGPSKPRLNTASKMTCKLSSDSDCGCGTCSSFSE
>W.mirabilis.07226
MIGKQIVWTRGSGFIASSLLKRLLELGNFVHAIVRDQENASKVQHFLNLLGANNRLRLFRADLLVAGSFDSTIDDCEGVFHMVSPVTIDPEDLKNEVIKLTVRRMLSILEACEKVKNGQTSGHFFIYVGTFMEGSSDR
>W.mirabilis.18036
MLVMHLVYSSRVLIRPEKTLCNCEAENTPKTQHLMKLPGADRRLRIFKADLCEEGSFDVAVGSCEGLSRDVGPVDSNLNDPENE
>W.mirabilis.08765
MDDVFKAYVLLHEMPSCTSRYVCCSGAIKLDELYPMISCDAINLSDVEAPFKICILSKRLMDLGFKYKHCYMDSMLDDM
>W.mirabilis.16675
MDATTTLELESKPIVCVTGISGYIASSPVSMLLLLGYSIHGTICNPENTSKTQHLMKLPEADKRLYIFKEDLYEEGSTEQQQRESQRAMRKKVERENRRRQYLQSRHPIDPM
>W.mirabilis.25044
DESKTRHLKGLGGAAERLSLWKADLNDEGSFDAVFDGCHGVFHCATHLDFESAHPEEEVIKPTVEGVLNVMRSCAKAKSVKTVMYTSSAGSVQFNEHSKPPFDETCWTDVDVCRKRKMTGWMYFVGKTLAERAAWEFAEKHNVHLITVIPTLVVGPFISPDMPPSIVTALAPLTSICLRRPTPL
MPGANDRLRLFRADLLVEDSFDSAIDNSEGVFRIMSPVTIDPKDPQNEVIKLAVRRMLRIPEAYQKVKNCQTSGHYFICVGTFMKEAVIDESSWSDVQFCRRKHPPRWAYIGPSKPRLNTASKMTCKLSSDSDCGCGTCSSFSE
>W.mirabilis.07226
MIGKQIVWTRGSGFIASSLLKRLLELGNFVHAIVRDQENASKVQHFLNLLGANNRLRLFRADLLVAGSFDSTIDDCEGVFHMVSPVTIDPEDLKNEVIKLTVRRMLSILEACEKVKNGQTSGHFFIYVGTFMEGSSDR
>W.mirabilis.18036
MLVMHLVYSSRVLIRPEKTLCNCEAENTPKTQHLMKLPGADRRLRIFKADLCEEGSFDVAVGSCEGLSRDVGPVDSNLNDPENE
>W.mirabilis.08765
MDDVFKAYVLLHEMPSCTSRYVCCSGAIKLDELYPMISCDAINLSDVEAPFKICILSKRLMDLGFKYKHCYMDSMLDDM
>W.mirabilis.16675
MDATTTLELESKPIVCVTGISGYIASSPVSMLLLLGYSIHGTICNPENTSKTQHLMKLPEADKRLYIFKEDLYEEGSTEQQQRESQRAMRKKVERENRRRQYLQSRHPIDPM
>W.mirabilis.25044
DESKTRHLKGLGGAAERLSLWKADLNDEGSFDAVFDGCHGVFHCATHLDFESAHPEEEVIKPTVEGVLNVMRSCAKAKSVKTVMYTSSAGSVQFNEHSKPPFDETCWTDVDVCRKRKMTGWMYFVGKTLAERAAWEFAEKHNVHLITVIPTLVVGPFISPDMPPSIVTALAPLTSICLRRPTPL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University