Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Welwitschia mirabilis
Species name
Welwitschia mirabilis is a species of seed plant in the family Welwitschiaceae.
Species info
Gene sequence info
Welwitschia_mirabilis.4CL.fa
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>W.mirabilis.11351
MEKSGYCKDGIFRSLRPPITFPKDENVHLVSFLFRNMSLYPQNLALVDADSGEEWNFLELQNKVRLIGRGLYQLGIRKGDVILLFSPNSIYFPSCFLGILSIGAIVTTVNPLYTPSELEKQVKDSKAKVVLAVSELWDKVENLGLPIILIGNGSKKEAVFSSVATLTELLSMGKKGDLPVMNIKQSDTAALLYSSGTTGVNKGVILTHRNFIASALMMTKDEEGSDPSTWLVLIPMFHVYGLTVTFSELQRGSTVITLGKFNFVKMLETVQRYRVTHMPLVPPIIIALVKEAIVKKYDLSSLKKIVSGAAPLGKDVQENCEKKLPSARVLQGYGLTESSSIATLDFLEGGCGGVGSAGALVAGLEAKIVDAETGKAFPPNKPGEICLRGPNVMKGYLNNPQATRITLDSGGWLHTGDLGYFDENGYLFIVDRIKELIKYKGFQVAPAELEALMLTHPQILDAGVVGIPDEAAGEVPVGYVVRVPGSSVSEHEVMEYVANQVAPFKRLQRITFVNAIPKSPSGKILRRQLIDMSKSKL
>W.mirabilis.03821
MMRLPKEVMLTHQSLVASVAQQKFNMGVMLDHIQKYGITVLPLVPPIVLEITKTPSLDAFDISFIWIIMCEMSPLGKDLKNALHDKFPKAIFGQGQFWQ
>W.mirabilis.16970
MEKSGYCKDRIFRSLRPPLMLPKDQNLHIVSFLFRNSSSYLQNLALADAETAETLDFLEFQNQVNLIGRGLFHLGIRKNDVVLLFSPNSIYFPVCFFGILSIGGIVTTANPVYTTAELEKQVKDSKPKMVITVSKLVVKVESLGLPIIQIGDNENKANHDTSVVGFRDLLRLGEGRDVPHICIKQSDTAALLYSSGTTGINKGVILTHRNFMASAVMLTSDHDLRGEGPSTVLILIPMFHVYGLTLTFAQLQRGSAIATLGKFNFVKMLDAIEKYRVSHLPIVPPIMTALAKEEIVKRYDLSSLRQIASGAAPLGKEVQETCASKLPHTSVLQGYGLTESCGIAAVDFPTGRARVGSAGLLVQGLEGKIINIETGKSLPPNQSGEICLRGPNIMKGYLNNRQATKNALDAEGWLHTGDMGFFDENGYLFIVDRIKELIKYKGLQVAPAELEALLISHPQILDAAVIPQPDAAAGEVPVGYVVRVSGSSPTEDEIMEYVAQQVAPYKRLHRITFVNAIPKSASGKILRRELSTLAKSKL
>W.mirabilis.12535
MKAHLLRQFNSQIGMCTAHACATPRVGDSSVTCIIRFAMASQRGEVCDPGAGGSPAHRQRNRVRGGREEEGRKGEEEWVFRSRLPDIEIDDHMLLHEYCLLHRIDDLRDRPCLIEGVSGKVLSYGDVESMSRKVCRGLAHKMGLSKGDVMMILLSNSVEFVISFLGASMAGLAVTTANPFYTSSDILKQSLASGTRLIITSSACVPKLTSLTVEALI
>W.mirabilis.12536
MIEVKSAILAPEAPPPIANGTASAVVEKKKEEKGEEEWVFRSRLPDIEIDDHMLLHEYCLLHRIDDLRDRPCLIEGVSGKVLSYGDVESMSRKVCRGLAHKMGLSKGDVMMILLSNSVEFVISFLGASMAGLAVTTANPFYTSSDILKQSLASGTRLIITSSACVPKLTSLISEHKVNVLTVDTPAEGCLPFSDLLDGGDCPDDDKLARTLGVHVDDTVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGDNPNLHITPDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLLPKFEMGTLLSAVHRHRLTIAAVVPPIVLALAKSALLEAENGSDSYDLSSVRKVLSGAAPLSPELEQALRQRLPNATFGQGYGMTEAGPVLSMCLGFAKHPLPNKFGSCGAVVRNAQMKIVDLQSGASLPRNQAGEICIRGNQIMKGYLNDPEATARTIDADGWLHTGDVGYIDDDDEVFIVDRVKEIIKFKGFQVPPAELEALLVGHPAIRDAAVVPLRDEMAGELPVAFVVKAEGEEVTEEEVKQYIAKQVVYYKRLHRVHFASAIPKSPAGKILRRELRDGLNSCQARYLNDPEATARTIDADGWLHTGDVGYIDDDDEVFIVDRVKEIIKFKGFQVPPAELEALLVGHPAIRDAAVVPLRDEMAGELPVAFVVKAEGEEVTEEEVKQYIAKQVVYYKRLHRVHFASAIPKSPAGKILRRELRDGLNSCQARPSREGT
>W.mirabilis.13010
MAINGERQFIFKSKHPQATVPDYLSLPEFVLEKANDYADKPAIVDSHSDRKYSYGDLHRLSHNAAAAFHSHGLRKGDVVFVLLPNMPEYPMLILGIMLAGGVFTGANPASHRPRSTNRSTILAPK
>W.mirabilis.13011
MAINGERQFIFKSKHPQATVPDYLSLPEFVLEKANDYADKPAIVDSHSDRKYSYGDLHRLSHNAAAAFHSHGLRKGDVVFVLLPNMPEYPMLILGIMLAGGVFTGANPASHPAEINKQIDDSGAKMIVTEASLLGKLTRRTNISLIVAGKTDSSSDTISLDDIFGFEDGNFFPKAKISQDDLCALPYSSGTTGTPKGVMYTHRKLMAMLCSILSFHEMEPGALLGKSVTPGLTGLV
>W.mirabilis.13012
MPFFHMYGSIGICFSTLRQKAKLVVISRFDLRHFLRTVIEHQVELAPIVPTVVRSLLKSPSVNEFDLGNLRLKGVMTAATPLSPDLRRAFVSKFPGVQVQEAYGLTEHCGIAMRLRDSTKKKVGSILPNIEVKLVDPMTGKSLPENTAGELWVRSECVMKGNRW
>W.mirabilis.13013
MDRNDFVFRSDFPGVPVPDNLSLPEFVLENALDYADSVAIVDSHSAKQYSYGDVCRLCRNAAAGLVRRGLRKGDVVFVLLPNMPEYPILVLGIMLAGGVFSGANPAAHVSEIKKQIDDSGAKMIVIAEALLDKLPQTTNIPVIVAPGEKGADGMSLGRIFAEDSRGVVLEEARQNELCALPYSSGTTGMSKGVMLTHRNLIANLCSTLFNVDESLLGKATTLGLMPFFHIYGITGICCATLRQKGKVVVMSRFELRHFLKTLIEQQVNFAPIVPPIMLALVKSPITKFPGVEVQEAYGLTEHSCITLTHCAPDGVRGNAKKNSVGFILPNLEVKFVDPQTGASLPRNAVGELCVRSQCVMQGYLRKKDETQKTIDEEGWLHTGDLAYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAVLVSHPSVEDAAVVALPDEEAGEIPAACVVKAPGGTQTEDDLMKFVASQVAPYKKVRFLKFVSVILKTLIEQQVNFAPIVPPIMLALVKSPIVNEFDLQRLQLKAIMTAAAPLAPDLLRAFETKFPGVEVQEAYGLTEHSCITLTHCAPDGVRGNAKKNSVGFILPNLEVKFVDPQTGASLPRNAVGELCVRSQCVMQGYLRKKDETQKTIDEEGWLHTGDLAYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAVLVSHPSVEDAAVVALPDEEAGEIPAACVVKAPGGTQTEDDLMKFVASQVAPYKKVRFLKFVSVIPKSSSGKILRRQLRDELLQSKSALS
>W.mirabilis.13774
MAPAAADTEQMIQAEAEYIYRSKLPDIYIPDKMPLHKYCFEKLADVADRPCLIDGASGKIWTYAEVELASRRVGAGLARFGIGRGDVVMLLLQNRAEFAFTFLGASMRGAVVTTANPFYTPGEVAKQASASGARVVVTQAAFAEKLSAIRQRLSHVFTIDEPVPEGCLPFSALAEADEAELDGLADDIDAEEVVALPYSSGTTGLPKGVMLTHRSLVASVAQQVDGENPNLNFRSDDVILCVLPLFHIYSLNSVMLCALRVGAAILLMQKFNMGAMLDHIQKYGITVLPLVPPIVLEITKTPSLDAFDISSVRIIMCGAAPLGKDLEDALRDKFPKAIFGQGYGMTEAGPVLAMNLAFAKEPFPVKSGSCGTVVRNAEIKIIDTETGVSLPHNQCGEICIRGPEIMKGYLNDPEATALTIDKHGWLHTGDVGYIDDDEELFIVDRVKEIIKYKGFQVAPAELEALLVKHPSIADAAVVPTERTFAKKRKQSIYTVKRHTVLRPYP
>W.mirabilis.19233
MAYYSQTLSIDPRRGFCSEIGIYYSKKKPAEFPSASLKLDIASYVFRHLQNPSKTAFIDAFSRILRLPVSHPQLQGSRYRNENRSVTLFTMPLFHVYGLSFLLRIEEKISVFLCKFNFAAMLHAVEKFQVKELPLSPLILVAFLKSPIVSSYDLSSLEYVIPAVVWAVTFRRVFTPSFHTIPPKLPSLTPFLVSFDYLSLIHNSRALATGLYSLGFRKGDVFSEFRDSSLHLSRNPFLGAIPTYANPLNSKREIFNQIRRSKAKVAFSLSSLPCKVAAAKIPVILIDSPYASFQVRNN
MEKSGYCKDGIFRSLRPPITFPKDENVHLVSFLFRNMSLYPQNLALVDADSGEEWNFLELQNKVRLIGRGLYQLGIRKGDVILLFSPNSIYFPSCFLGILSIGAIVTTVNPLYTPSELEKQVKDSKAKVVLAVSELWDKVENLGLPIILIGNGSKKEAVFSSVATLTELLSMGKKGDLPVMNIKQSDTAALLYSSGTTGVNKGVILTHRNFIASALMMTKDEEGSDPSTWLVLIPMFHVYGLTVTFSELQRGSTVITLGKFNFVKMLETVQRYRVTHMPLVPPIIIALVKEAIVKKYDLSSLKKIVSGAAPLGKDVQENCEKKLPSARVLQGYGLTESSSIATLDFLEGGCGGVGSAGALVAGLEAKIVDAETGKAFPPNKPGEICLRGPNVMKGYLNNPQATRITLDSGGWLHTGDLGYFDENGYLFIVDRIKELIKYKGFQVAPAELEALMLTHPQILDAGVVGIPDEAAGEVPVGYVVRVPGSSVSEHEVMEYVANQVAPFKRLQRITFVNAIPKSPSGKILRRQLIDMSKSKL
>W.mirabilis.03821
MMRLPKEVMLTHQSLVASVAQQKFNMGVMLDHIQKYGITVLPLVPPIVLEITKTPSLDAFDISFIWIIMCEMSPLGKDLKNALHDKFPKAIFGQGQFWQ
>W.mirabilis.16970
MEKSGYCKDRIFRSLRPPLMLPKDQNLHIVSFLFRNSSSYLQNLALADAETAETLDFLEFQNQVNLIGRGLFHLGIRKNDVVLLFSPNSIYFPVCFFGILSIGGIVTTANPVYTTAELEKQVKDSKPKMVITVSKLVVKVESLGLPIIQIGDNENKANHDTSVVGFRDLLRLGEGRDVPHICIKQSDTAALLYSSGTTGINKGVILTHRNFMASAVMLTSDHDLRGEGPSTVLILIPMFHVYGLTLTFAQLQRGSAIATLGKFNFVKMLDAIEKYRVSHLPIVPPIMTALAKEEIVKRYDLSSLRQIASGAAPLGKEVQETCASKLPHTSVLQGYGLTESCGIAAVDFPTGRARVGSAGLLVQGLEGKIINIETGKSLPPNQSGEICLRGPNIMKGYLNNRQATKNALDAEGWLHTGDMGFFDENGYLFIVDRIKELIKYKGLQVAPAELEALLISHPQILDAAVIPQPDAAAGEVPVGYVVRVSGSSPTEDEIMEYVAQQVAPYKRLHRITFVNAIPKSASGKILRRELSTLAKSKL
>W.mirabilis.12535
MKAHLLRQFNSQIGMCTAHACATPRVGDSSVTCIIRFAMASQRGEVCDPGAGGSPAHRQRNRVRGGREEEGRKGEEEWVFRSRLPDIEIDDHMLLHEYCLLHRIDDLRDRPCLIEGVSGKVLSYGDVESMSRKVCRGLAHKMGLSKGDVMMILLSNSVEFVISFLGASMAGLAVTTANPFYTSSDILKQSLASGTRLIITSSACVPKLTSLTVEALI
>W.mirabilis.12536
MIEVKSAILAPEAPPPIANGTASAVVEKKKEEKGEEEWVFRSRLPDIEIDDHMLLHEYCLLHRIDDLRDRPCLIEGVSGKVLSYGDVESMSRKVCRGLAHKMGLSKGDVMMILLSNSVEFVISFLGASMAGLAVTTANPFYTSSDILKQSLASGTRLIITSSACVPKLTSLISEHKVNVLTVDTPAEGCLPFSDLLDGGDCPDDDKLARTLGVHVDDTVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGDNPNLHITPDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLLPKFEMGTLLSAVHRHRLTIAAVVPPIVLALAKSALLEAENGSDSYDLSSVRKVLSGAAPLSPELEQALRQRLPNATFGQGYGMTEAGPVLSMCLGFAKHPLPNKFGSCGAVVRNAQMKIVDLQSGASLPRNQAGEICIRGNQIMKGYLNDPEATARTIDADGWLHTGDVGYIDDDDEVFIVDRVKEIIKFKGFQVPPAELEALLVGHPAIRDAAVVPLRDEMAGELPVAFVVKAEGEEVTEEEVKQYIAKQVVYYKRLHRVHFASAIPKSPAGKILRRELRDGLNSCQARYLNDPEATARTIDADGWLHTGDVGYIDDDDEVFIVDRVKEIIKFKGFQVPPAELEALLVGHPAIRDAAVVPLRDEMAGELPVAFVVKAEGEEVTEEEVKQYIAKQVVYYKRLHRVHFASAIPKSPAGKILRRELRDGLNSCQARPSREGT
>W.mirabilis.13010
MAINGERQFIFKSKHPQATVPDYLSLPEFVLEKANDYADKPAIVDSHSDRKYSYGDLHRLSHNAAAAFHSHGLRKGDVVFVLLPNMPEYPMLILGIMLAGGVFTGANPASHRPRSTNRSTILAPK
>W.mirabilis.13011
MAINGERQFIFKSKHPQATVPDYLSLPEFVLEKANDYADKPAIVDSHSDRKYSYGDLHRLSHNAAAAFHSHGLRKGDVVFVLLPNMPEYPMLILGIMLAGGVFTGANPASHPAEINKQIDDSGAKMIVTEASLLGKLTRRTNISLIVAGKTDSSSDTISLDDIFGFEDGNFFPKAKISQDDLCALPYSSGTTGTPKGVMYTHRKLMAMLCSILSFHEMEPGALLGKSVTPGLTGLV
>W.mirabilis.13012
MPFFHMYGSIGICFSTLRQKAKLVVISRFDLRHFLRTVIEHQVELAPIVPTVVRSLLKSPSVNEFDLGNLRLKGVMTAATPLSPDLRRAFVSKFPGVQVQEAYGLTEHCGIAMRLRDSTKKKVGSILPNIEVKLVDPMTGKSLPENTAGELWVRSECVMKGNRW
>W.mirabilis.13013
MDRNDFVFRSDFPGVPVPDNLSLPEFVLENALDYADSVAIVDSHSAKQYSYGDVCRLCRNAAAGLVRRGLRKGDVVFVLLPNMPEYPILVLGIMLAGGVFSGANPAAHVSEIKKQIDDSGAKMIVIAEALLDKLPQTTNIPVIVAPGEKGADGMSLGRIFAEDSRGVVLEEARQNELCALPYSSGTTGMSKGVMLTHRNLIANLCSTLFNVDESLLGKATTLGLMPFFHIYGITGICCATLRQKGKVVVMSRFELRHFLKTLIEQQVNFAPIVPPIMLALVKSPITKFPGVEVQEAYGLTEHSCITLTHCAPDGVRGNAKKNSVGFILPNLEVKFVDPQTGASLPRNAVGELCVRSQCVMQGYLRKKDETQKTIDEEGWLHTGDLAYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAVLVSHPSVEDAAVVALPDEEAGEIPAACVVKAPGGTQTEDDLMKFVASQVAPYKKVRFLKFVSVILKTLIEQQVNFAPIVPPIMLALVKSPIVNEFDLQRLQLKAIMTAAAPLAPDLLRAFETKFPGVEVQEAYGLTEHSCITLTHCAPDGVRGNAKKNSVGFILPNLEVKFVDPQTGASLPRNAVGELCVRSQCVMQGYLRKKDETQKTIDEEGWLHTGDLAYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAVLVSHPSVEDAAVVALPDEEAGEIPAACVVKAPGGTQTEDDLMKFVASQVAPYKKVRFLKFVSVIPKSSSGKILRRQLRDELLQSKSALS
>W.mirabilis.13774
MAPAAADTEQMIQAEAEYIYRSKLPDIYIPDKMPLHKYCFEKLADVADRPCLIDGASGKIWTYAEVELASRRVGAGLARFGIGRGDVVMLLLQNRAEFAFTFLGASMRGAVVTTANPFYTPGEVAKQASASGARVVVTQAAFAEKLSAIRQRLSHVFTIDEPVPEGCLPFSALAEADEAELDGLADDIDAEEVVALPYSSGTTGLPKGVMLTHRSLVASVAQQVDGENPNLNFRSDDVILCVLPLFHIYSLNSVMLCALRVGAAILLMQKFNMGAMLDHIQKYGITVLPLVPPIVLEITKTPSLDAFDISSVRIIMCGAAPLGKDLEDALRDKFPKAIFGQGYGMTEAGPVLAMNLAFAKEPFPVKSGSCGTVVRNAEIKIIDTETGVSLPHNQCGEICIRGPEIMKGYLNDPEATALTIDKHGWLHTGDVGYIDDDEELFIVDRVKEIIKYKGFQVAPAELEALLVKHPSIADAAVVPTERTFAKKRKQSIYTVKRHTVLRPYP
>W.mirabilis.19233
MAYYSQTLSIDPRRGFCSEIGIYYSKKKPAEFPSASLKLDIASYVFRHLQNPSKTAFIDAFSRILRLPVSHPQLQGSRYRNENRSVTLFTMPLFHVYGLSFLLRIEEKISVFLCKFNFAAMLHAVEKFQVKELPLSPLILVAFLKSPIVSSYDLSSLEYVIPAVVWAVTFRRVFTPSFHTIPPKLPSLTPFLVSFDYLSLIHNSRALATGLYSLGFRKGDVFSEFRDSSLHLSRNPFLGAIPTYANPLNSKREIFNQIRRSKAKVAFSLSSLPCKVAAAKIPVILIDSPYASFQVRNN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University