Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Vitis vinifera
Species name
Wine grape (Vitis vinifera) is a species of eudicot in the family Vitaceae (grape family).
Species info
Gene sequence info
Vitis_vinifera.COMT.fa
Download
>rna-XM_010662020.2
MEKRQMVSSTEEEEDSHREYAMQLVSASVLPMVLKAALELGVLDIIGRAGPGALLSPSEIASHIPTHNPDAPFALDRILRLLASHSILTYSLDTHRDGKVHRLYGLAPVAKYFVPNQDGVSLAIYLRTIQDKVTVDIWHHLKDAVLEGGLPFKRSYGMDAIDYVGKDARFFEMLKASNRDYIPMFMNKILETYKGFEGLKSLVDVAGGNGSVLNFIVSRYPSIKGINFDLAPVIEKLPSYPGIEHVAGDMFTSVPKGDAIFMKNILHSWSDEHCVKLLRNCYHALPDNGKVIVVDAVIPDAPEPSAQVKSTYQLDLFMMNLNPDGKERTEKEFAELAKEAGFFSTKVAGCAYSFSLVEFHKKM
>rna-XM_002264530.3
MEDETLESRNQARLAILELTNMISVPMCLHAIVRLNVPDAIWQGGSNAPLSASQILTRVLPSGDPHNLQRILRLLTTYGVFAEHLLTDPSSDQVLRKYSLTDIGKTLVTDADGLSYGAYVLQHYQEELMTAWPLVHEAVVDSTTEPFVKANGEPAYSYYGKKPEMNDLMQRAMSGVSVPFMKAILNGYNGFDGVQRLVDVGGSAGDCLRMILQKHTNIKEGINFDLPEVVAKAPNIPGVTHVGGDMFKSVPDGDAIFMKWVLTTWTDEECKLIMKNCYNALPVGGKMIACEPVLPKESDNSLRTRALLEGDIFVMTIYRAKGKHRTEEEFRQLGLSAGFPHLRAFYIDHFYTVLEFQK
>rna-XM_019221570.1
MSNHTKLIMKRILQIYKGFEGLKVLVDVGGGIGVTLSIITSKYPHIKGINYDLPHALANAPSYPGVEHVGGDMFESVHKGDAIFMKWILHDRSDEHCLKLLTNCFEALPDNEKVIIVESILHMAPKNTVSTNIPFEQDLLMLAQNPGGKERTQKEYETLAIKSGFFGCMVICSVYNSWVMEFPKTAHP
>rna-XM_019222517.1
MLESRDQFFEGLSSLVDVGGGTGLTARTISEAFPRLKCRVFDLPHVVANLPEYRNLEFVGGDMFQSGPTADATLMKVFISRSPCLNADVAPEINAWSGISKIASWSGTPTPLENKSKGKNTMAFEKAHLDLLLVPSALLIMFAYHLFLLYRYLTAPHTTVIGFENNDKRAWVERIMQVDKRDVGIALNVIASNTSAATFLASVSLTLSSIIGAWIGSSSNNVFQSELIYGDTRPSTISIKYISLLTCFILAFSCFVQSARCFVHANYLISTPDSDIPVKNVEMVVIRAGEFWSLGLRAIYFAIDLLLWFFGPIPMFVCSVVLVILLYHLDCNSNPLHRHRSLASRSVKRVGEQVTAAAMTIEDHVA
>rna-XM_019222574.1
MILSDIGLVEKRIYHATLNGWGLSMIAVQMALKAAMELNVFNIIANAGPNAQLSCVEIVSKIPTTNPNAAVALDRILRTLTFNSILTASLRPCKDGTTIKQERTYGLTPKSCSLVTDNVEVSSTPTVNFCTERVVVESFYMLKYAVLEADCHPFHKAHGVNVFEYLSKDPRLSREFNEAMTMNSKIVLDMVLKAYRGGFEETKEIMDVGGSIGTSVVKLVSVYPHIRGINFDLPHVIADAPEQPGVTHVAGDMFESLPNAETILLKFVLHDWGDDGCKKVLRNCWKALPENGKVIVVEYAIPQVLGNDPPSLNATVADLYMMILNTGGKERTLAEFEHLAKAAGFAQTKVFPIAHGIHVIEFLKSC
>rna-XM_019225415.1
MGSSTEERQYSHGSTGEEEEVQEAEHYCNAMQLVASSLLPMVMQTAIELGLFHIIAKAGQASASEIASQLRANNPAAPIMLDRILYFLTSHSVLTCSALDADGGRLKRVYGITPVSKYFVPDQDGISLSPLLTLTQDKVFMDSWCHLNNSIIEGGIPFNRAHGVNAFEYPGKNPRFNQAFNTAMLNHTIMITNKIVESYKGFGNLKQVVDVGGGLGTTLGIITSKYPSIKAINFDLPHVIQHALPYPGVEHLGGDMFESVPNGEAMFLKWILHDWSDEHCLKLLKNCYKALPEHGKAIVVEGFLPEIPEGSASVQALCEGDLIMMTQNPGGRERTKQEFLDLAMAAGFAGIRFECLVYNYWIMEFFK
>rna-XM_002267143.4
MGSSAEEKQSSRLCHEDGDVEPCSYAMQLVTSSVLPMVMQTSIELGLFDIIAKLGQASASEIASRLPTKNPEAPIMLDRMLYLLTTHSVLSCSAIDGDERVYALTPVSKYFASNQDGVSFGPLLALIQDKVFMDSWSQLKNAIIEGGIPFNRVHGSHAFEYPGKDPRFNQVFNTAMFNHTTIIVNKILESYKGFEHLTRVVDVGGGLGTTLSIITSKYPHIEAINFDLPHVIEHAVAFPGVEHIGGDMFESVPKGDAIFMKWILHDWSDDHCLKLLKNCYKALPEHGKVIIVEGVLPEIPEKGSTVKAICQTDLIMLTQNPGGKERTRKEFLDLAIGAGFAGIRYECYVSCYWVMEIFM
>rna-XM_002267507.2
MQTHNGSDGKQEAAEHYSRAMQMATSSVVCMAMHVANELGLFDIIAKVGQASASQIASHLATNNPNAPTMLDRILYVLTAHSLLTCSVDDTDDGHSKRVYGLTPVSKLFARNEDGVSFAPLMALNQDKIFIGSWFEMTNAILEGGIPFDRAHGSNAFEYPRKDLRFNKVFNAAMHNYTTLFINETLESYKGFEHLKEVVDVGGGLGVTLGAITSKYPSIKGINFDLPHVIEHAPHYPGVEHVGGDMFESVPKGEAIFMKWILHDWSDEHCLKLLKNCYNALPEHGKVIVVEGVLPAAPETSAVVKAVSQTDLIMMAQNPGGKERTREEFLDLATGAGFAGIRFECFVLTYWVMEFFK
>rna-XM_002266863.3
MEPSAEEKQSSRLCHEDGDVEPCSYAMQLVTSSVLPMVMQTSIELGLFDIIANLGQASASEIASRLPTKNQEAPIILDRMLYLLTTHSVLSCSAIDGDERVYALTPVSKYFASNQGVSFGPLLALIQDKVFMDSWSQLKNAIIEGGIPFNRVHGSHAFEYPGKDPRFNQVFNTAMFNHTTVIVNKILESYKGFEHLTRVVDVGGGLGTTLSIITSKYPHIEAINFDLPHVIEHAVAYPGVKHIGGDMFVSVPKGDAIFMKWILHDWSDDHCLKLLKNCYKALPEHGKVIVVEGVLPEIPEKGSTVKAICQTDLIMLTQNPGGKERTRKEFLDLTIGAGFAGIRYECYVSCYWVMEIFK
>rna-NM_001281171.1
SGSNSMNQGFSSSAEFNSPVPATIPKSEEDTFVFATLLTSASVLPMALKSALELDLLEIIAKAGPGAFVSTSEIAAKVTKRNPKAPVMLDRILRLLATYDVVKCSLRDSPDGGVERLYGLGPVCKYFTTNEDGVSVAPLLLMNQDKVPMQSKRYHLKDAVLDGGIPFNKAYGMTDFEYHGTEPRFNKVFNNGVSGHPTITMKKILEAYKGFEGLTSIVDVGGGTGATLNMIISKYPTIKGINFDLPHVIDDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCYEWDDAHCLKFLENCYQALPDNGKVIVAECILPVVPDTSLATKTAVHIDVIMLAYNTGGKARTEKEFEALAKGAGFQGFKVVCCAFNSWIMEFCKTA
>rna-XM_003634113.2
MGSTSMTPTTILESDEEASLFSMQLVSASVLPMVLKSALELDLLEIIAKAGPGAFVSTSEIAAQIPTHNPEAPVMLDRILRLLATYAVVKCSLRNLPDGGVERLYGLAPVCKYLTRNEDGVSVAPLLLMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSGHSTITMKKILEAYKGFEGLTSIVDVGGGTGATLNMIISKYPTIKGINFDLPHVIDDAPSYPGVENVGGDMFVSVPKGDAIFMKWICHDWSDAHCLKFLKNCYQALPDNGKVIVAECILPVAPDTSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFKVVCCAFNTWIMEFCKTA
>rna-XM_019216269.1
MSLKKDEAYRWMSEEDESCIQAMLFASSHVFPTILNTAVELNLFEIIARAGPGAYVSPSEIASQLPTQNPNAPCFMDRMLRLFASHGLLSYSLRTLEDGRVDRLYGLTPVCKFFLRSDDGSCLASLSTLGSHRAMREVWPHLKDAILKGGNQFQKVHGMSMFEYMDKDPTLNKAFNEAMVGRSTIIMKKIVETYQGFEGLASLVDVGGGTGANLNMIISKYPSIKGINFDLPHVVQTAPTYPGIEHVGGSMLVSIPKADAIMIKDTCHNWSDEHCLKFLRNCYESLPKNGKVIVIDIIMPEAPEPSIGSQYVARLDNVMLLLHGGKERTAREFEALCKGSGFSDFRVACCVYSCLSAVMEFQK
>rna-XM_003634380.3
MSSNRLDSYPMSKLQFEGEDEEELGKLAVRLANGIILPMALKSALELNLIEILAGAGDGAFLSPSEIAAYLPARNPDAPVLLDRVLRLLASYSILKCSLRTLDNGEVERLYGVGPICKFLTRNPDGGSIGPLFLLHHDKVFMESWYHLNDAILEGGIPFNRAYGMTAFEYPGTDQRFNRVFNEAMSNHTTLIMKRILQIYKGFEGLKVLVDVGGGIGVTLRIITSEYPQIKGINYDLPHVLADAPSYPGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLKLLTNCFEALPDNGKVIIVESILHVAPENTVSANIPFEQDLLMLAQNPGGKERTQKEYETLAIKSGFSCCKVICSVYNSWVMEFHKTAHP
>rna-XM_002268272.2
MSSNRRDSYPMSKLQFEGEDEEELGKLAVRLANSIILPMALKSALELNLIEIMAGAGDGALLSPSEIAAQLPARNPDAPVLLDRVLRLLASYSILRCSLRTLDNGEVERLYGVGPICKFLTRNPDGGSIGPLLLLHHDKVFMESWYHLNDAILEGGIPFNRAYGMTDFEYLGTDQRFNRVFNEAMSNHSTLIMKRILQIYKGFEGLQVLVDVGGGIGVTLRIITSEYPQIKGINYDLSHVLADAPSYPGVEHVGGDMFESVPKGDAIFMKWILHGWSDEHCLKLLTNCFEALPDNGKVIIVESILHVAPENTVSVNIPFEQDLLMLAQSPGGKERTQKEYETLAIKSGFSGCKVICSVYNSWVMEFHKTAHP
MEKRQMVSSTEEEEDSHREYAMQLVSASVLPMVLKAALELGVLDIIGRAGPGALLSPSEIASHIPTHNPDAPFALDRILRLLASHSILTYSLDTHRDGKVHRLYGLAPVAKYFVPNQDGVSLAIYLRTIQDKVTVDIWHHLKDAVLEGGLPFKRSYGMDAIDYVGKDARFFEMLKASNRDYIPMFMNKILETYKGFEGLKSLVDVAGGNGSVLNFIVSRYPSIKGINFDLAPVIEKLPSYPGIEHVAGDMFTSVPKGDAIFMKNILHSWSDEHCVKLLRNCYHALPDNGKVIVVDAVIPDAPEPSAQVKSTYQLDLFMMNLNPDGKERTEKEFAELAKEAGFFSTKVAGCAYSFSLVEFHKKM
>rna-XM_002264530.3
MEDETLESRNQARLAILELTNMISVPMCLHAIVRLNVPDAIWQGGSNAPLSASQILTRVLPSGDPHNLQRILRLLTTYGVFAEHLLTDPSSDQVLRKYSLTDIGKTLVTDADGLSYGAYVLQHYQEELMTAWPLVHEAVVDSTTEPFVKANGEPAYSYYGKKPEMNDLMQRAMSGVSVPFMKAILNGYNGFDGVQRLVDVGGSAGDCLRMILQKHTNIKEGINFDLPEVVAKAPNIPGVTHVGGDMFKSVPDGDAIFMKWVLTTWTDEECKLIMKNCYNALPVGGKMIACEPVLPKESDNSLRTRALLEGDIFVMTIYRAKGKHRTEEEFRQLGLSAGFPHLRAFYIDHFYTVLEFQK
>rna-XM_019221570.1
MSNHTKLIMKRILQIYKGFEGLKVLVDVGGGIGVTLSIITSKYPHIKGINYDLPHALANAPSYPGVEHVGGDMFESVHKGDAIFMKWILHDRSDEHCLKLLTNCFEALPDNEKVIIVESILHMAPKNTVSTNIPFEQDLLMLAQNPGGKERTQKEYETLAIKSGFFGCMVICSVYNSWVMEFPKTAHP
>rna-XM_019222517.1
MLESRDQFFEGLSSLVDVGGGTGLTARTISEAFPRLKCRVFDLPHVVANLPEYRNLEFVGGDMFQSGPTADATLMKVFISRSPCLNADVAPEINAWSGISKIASWSGTPTPLENKSKGKNTMAFEKAHLDLLLVPSALLIMFAYHLFLLYRYLTAPHTTVIGFENNDKRAWVERIMQVDKRDVGIALNVIASNTSAATFLASVSLTLSSIIGAWIGSSSNNVFQSELIYGDTRPSTISIKYISLLTCFILAFSCFVQSARCFVHANYLISTPDSDIPVKNVEMVVIRAGEFWSLGLRAIYFAIDLLLWFFGPIPMFVCSVVLVILLYHLDCNSNPLHRHRSLASRSVKRVGEQVTAAAMTIEDHVA
>rna-XM_019222574.1
MILSDIGLVEKRIYHATLNGWGLSMIAVQMALKAAMELNVFNIIANAGPNAQLSCVEIVSKIPTTNPNAAVALDRILRTLTFNSILTASLRPCKDGTTIKQERTYGLTPKSCSLVTDNVEVSSTPTVNFCTERVVVESFYMLKYAVLEADCHPFHKAHGVNVFEYLSKDPRLSREFNEAMTMNSKIVLDMVLKAYRGGFEETKEIMDVGGSIGTSVVKLVSVYPHIRGINFDLPHVIADAPEQPGVTHVAGDMFESLPNAETILLKFVLHDWGDDGCKKVLRNCWKALPENGKVIVVEYAIPQVLGNDPPSLNATVADLYMMILNTGGKERTLAEFEHLAKAAGFAQTKVFPIAHGIHVIEFLKSC
>rna-XM_019225415.1
MGSSTEERQYSHGSTGEEEEVQEAEHYCNAMQLVASSLLPMVMQTAIELGLFHIIAKAGQASASEIASQLRANNPAAPIMLDRILYFLTSHSVLTCSALDADGGRLKRVYGITPVSKYFVPDQDGISLSPLLTLTQDKVFMDSWCHLNNSIIEGGIPFNRAHGVNAFEYPGKNPRFNQAFNTAMLNHTIMITNKIVESYKGFGNLKQVVDVGGGLGTTLGIITSKYPSIKAINFDLPHVIQHALPYPGVEHLGGDMFESVPNGEAMFLKWILHDWSDEHCLKLLKNCYKALPEHGKAIVVEGFLPEIPEGSASVQALCEGDLIMMTQNPGGRERTKQEFLDLAMAAGFAGIRFECLVYNYWIMEFFK
>rna-XM_002267143.4
MGSSAEEKQSSRLCHEDGDVEPCSYAMQLVTSSVLPMVMQTSIELGLFDIIAKLGQASASEIASRLPTKNPEAPIMLDRMLYLLTTHSVLSCSAIDGDERVYALTPVSKYFASNQDGVSFGPLLALIQDKVFMDSWSQLKNAIIEGGIPFNRVHGSHAFEYPGKDPRFNQVFNTAMFNHTTIIVNKILESYKGFEHLTRVVDVGGGLGTTLSIITSKYPHIEAINFDLPHVIEHAVAFPGVEHIGGDMFESVPKGDAIFMKWILHDWSDDHCLKLLKNCYKALPEHGKVIIVEGVLPEIPEKGSTVKAICQTDLIMLTQNPGGKERTRKEFLDLAIGAGFAGIRYECYVSCYWVMEIFM
>rna-XM_002267507.2
MQTHNGSDGKQEAAEHYSRAMQMATSSVVCMAMHVANELGLFDIIAKVGQASASQIASHLATNNPNAPTMLDRILYVLTAHSLLTCSVDDTDDGHSKRVYGLTPVSKLFARNEDGVSFAPLMALNQDKIFIGSWFEMTNAILEGGIPFDRAHGSNAFEYPRKDLRFNKVFNAAMHNYTTLFINETLESYKGFEHLKEVVDVGGGLGVTLGAITSKYPSIKGINFDLPHVIEHAPHYPGVEHVGGDMFESVPKGEAIFMKWILHDWSDEHCLKLLKNCYNALPEHGKVIVVEGVLPAAPETSAVVKAVSQTDLIMMAQNPGGKERTREEFLDLATGAGFAGIRFECFVLTYWVMEFFK
>rna-XM_002266863.3
MEPSAEEKQSSRLCHEDGDVEPCSYAMQLVTSSVLPMVMQTSIELGLFDIIANLGQASASEIASRLPTKNQEAPIILDRMLYLLTTHSVLSCSAIDGDERVYALTPVSKYFASNQGVSFGPLLALIQDKVFMDSWSQLKNAIIEGGIPFNRVHGSHAFEYPGKDPRFNQVFNTAMFNHTTVIVNKILESYKGFEHLTRVVDVGGGLGTTLSIITSKYPHIEAINFDLPHVIEHAVAYPGVKHIGGDMFVSVPKGDAIFMKWILHDWSDDHCLKLLKNCYKALPEHGKVIVVEGVLPEIPEKGSTVKAICQTDLIMLTQNPGGKERTRKEFLDLTIGAGFAGIRYECYVSCYWVMEIFK
>rna-NM_001281171.1
SGSNSMNQGFSSSAEFNSPVPATIPKSEEDTFVFATLLTSASVLPMALKSALELDLLEIIAKAGPGAFVSTSEIAAKVTKRNPKAPVMLDRILRLLATYDVVKCSLRDSPDGGVERLYGLGPVCKYFTTNEDGVSVAPLLLMNQDKVPMQSKRYHLKDAVLDGGIPFNKAYGMTDFEYHGTEPRFNKVFNNGVSGHPTITMKKILEAYKGFEGLTSIVDVGGGTGATLNMIISKYPTIKGINFDLPHVIDDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCYEWDDAHCLKFLENCYQALPDNGKVIVAECILPVVPDTSLATKTAVHIDVIMLAYNTGGKARTEKEFEALAKGAGFQGFKVVCCAFNSWIMEFCKTA
>rna-XM_003634113.2
MGSTSMTPTTILESDEEASLFSMQLVSASVLPMVLKSALELDLLEIIAKAGPGAFVSTSEIAAQIPTHNPEAPVMLDRILRLLATYAVVKCSLRNLPDGGVERLYGLAPVCKYLTRNEDGVSVAPLLLMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSGHSTITMKKILEAYKGFEGLTSIVDVGGGTGATLNMIISKYPTIKGINFDLPHVIDDAPSYPGVENVGGDMFVSVPKGDAIFMKWICHDWSDAHCLKFLKNCYQALPDNGKVIVAECILPVAPDTSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFKVVCCAFNTWIMEFCKTA
>rna-XM_019216269.1
MSLKKDEAYRWMSEEDESCIQAMLFASSHVFPTILNTAVELNLFEIIARAGPGAYVSPSEIASQLPTQNPNAPCFMDRMLRLFASHGLLSYSLRTLEDGRVDRLYGLTPVCKFFLRSDDGSCLASLSTLGSHRAMREVWPHLKDAILKGGNQFQKVHGMSMFEYMDKDPTLNKAFNEAMVGRSTIIMKKIVETYQGFEGLASLVDVGGGTGANLNMIISKYPSIKGINFDLPHVVQTAPTYPGIEHVGGSMLVSIPKADAIMIKDTCHNWSDEHCLKFLRNCYESLPKNGKVIVIDIIMPEAPEPSIGSQYVARLDNVMLLLHGGKERTAREFEALCKGSGFSDFRVACCVYSCLSAVMEFQK
>rna-XM_003634380.3
MSSNRLDSYPMSKLQFEGEDEEELGKLAVRLANGIILPMALKSALELNLIEILAGAGDGAFLSPSEIAAYLPARNPDAPVLLDRVLRLLASYSILKCSLRTLDNGEVERLYGVGPICKFLTRNPDGGSIGPLFLLHHDKVFMESWYHLNDAILEGGIPFNRAYGMTAFEYPGTDQRFNRVFNEAMSNHTTLIMKRILQIYKGFEGLKVLVDVGGGIGVTLRIITSEYPQIKGINYDLPHVLADAPSYPGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLKLLTNCFEALPDNGKVIIVESILHVAPENTVSANIPFEQDLLMLAQNPGGKERTQKEYETLAIKSGFSCCKVICSVYNSWVMEFHKTAHP
>rna-XM_002268272.2
MSSNRRDSYPMSKLQFEGEDEEELGKLAVRLANSIILPMALKSALELNLIEIMAGAGDGALLSPSEIAAQLPARNPDAPVLLDRVLRLLASYSILRCSLRTLDNGEVERLYGVGPICKFLTRNPDGGSIGPLLLLHHDKVFMESWYHLNDAILEGGIPFNRAYGMTDFEYLGTDQRFNRVFNEAMSNHSTLIMKRILQIYKGFEGLQVLVDVGGGIGVTLRIITSEYPQIKGINYDLSHVLADAPSYPGVEHVGGDMFESVPKGDAIFMKWILHGWSDEHCLKLLTNCFEALPDNGKVIIVESILHVAPENTVSVNIPFEQDLLMLAQSPGGKERTQKEYETLAIKSGFSGCKVICSVYNSWVMEFHKTAHP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University