Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Vitis vinifera
Species name
Wine grape (Vitis vinifera) is a species of eudicot in the family Vitaceae (grape family).
Species info
Gene sequence info
Vitis_vinifera.4CL.fa
Download
>rna-XM_010657675.2
MGTHLQASAQDNEHIFRSQHQAVPVPDNMTLPDFVLQDAELYAEKVAFVEAVTGKEYTYGEVVRDVRRFAKALRSIGLRKGRVVVVVLPNVAEYAIVALGIMAAGGVFSGANPAGHASEIKKQVEAADAKLVVTNGAMYEKVKSLELPVIVMGEEHVAGAINWGELLEAADRANTDTISEDVHQNDLCALPFSSGTTGISKGVMLTHRNLVANLCSTLFSVGPEMVGQITILGLMPFFHIYGITGICCATLRNKGKVVVIGRYELRTFLNALITHEITFAPIVPPIILALVKNPIVEEFDLSRLKLRAVMTAAAPLAPELLSAFEKKFPSVQVQEAYGLTEHSCITLTHGDPTKGHATAKKNSVGFILPNMELKFIDPETGISLPKNTPGEICVRSQCVMQGYYKNEEETARTIDNNGWLHTGDIGYIDDDGDVFVVDRIKELIKYKGFQVAPAELEAILLSHPSVEDTAVVSLPDEEAGEIPAACVVLNPEAKETEEEIVKYVASNVAQYKRVRVVHFVETIPKSPSGKIMRRLLREKMLEKMKNNTKSGAILP
>rna-XM_002276317.4
MEKSGYGRDGIYRSLSPPLVLPKDPNLSLVSFLFRKASSYPRRPALIEAHSGETVNFAQFKSMVIKVSHGLTRLGLKKNDVVLIFAPNSIQYPLCFFGVIAIGAIATTANPLYTVAEIQKQVKDSNAKLVITIPQLWEKVKALNLPAVILDSADTSKDTIQSPLKITYFSDLVKMAGEVSHFPKVSITQGDTAALLYSSGTTGASKGVILTHGNFVAAALMVTMDEELMGEMHNVFLCFLPMFHVFGLAVVMCAQLQMGYTIVSMPKFDLDVALKSIEKYRVTHMWLVPPVMLALVKQGKLDRYDISSLKHIGSGAAPLGKELMEECAKSLPHVAVGQGYGMTETCGIVSKEIPKIGIQHTGSTGPLVSGVEAQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKLTIDKKGWVHTGDVGYFDEQGKLFVVDRIKELIKYKGFQVAPAELEALLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVKTFIANQVAPFKKLRRVSFINTVPKSASGKILRRELIEKVRAKL
>rna-XM_010656030.2
MATSIVYRSPRPHVDIPNDPSISMLSFLFRKTSSFSTRLALVDSDSGETLTFFQLKSTVSRLAHSFAQLGITKNDVVLIFAPNSVRFPVCFLAIVALGAIATTANPLYTISELSKQVKDSNPKFVINVLRIRRT
>rna-XM_019221548.1
MQEAGRQSMQEFQSRISQDATLQHNVHELWDKVKNFDLTFVILSSSASQRLPSSNSRVWYYSDLIKTPEDRDLDFPPASVVQTDTVALLYSSGTTGTSKGVILTHRNFIAAGVMVTADQAYYGESSNVFLCFLPMFHIFGLSVILYAQLVRGNTVVTVAKFEIEKVLRSVEKYRVTHMFVVHPVMIALAKQSVVRKYDLSSLRQICSGAAPLGKDVMDDCAKNVPQAAVIQVFKPRIGIYLQLLLINCCKFCSLAYVLLLGIVGIDPGKLNICAPGSNVSAYTLARVVETPRAATRLIQGMRGDNKTVFVIKLHHDSKCTMWYSSSRHSGSTGILVPRVESQIVSEDTLKPLPPNQLGEIWVQGANMMQGYFNNPQATKLTIDEQGWVRTGDLGYFDEGGQLFVVDRIKELIKFKGFQVAPAELEGLLLSHPEILDSVVIPLPDVEAGEVPIAYVVRSPRSSLTEEDVQKFIAKQVGYCFKRYQQCVKDYTQVVTERIPPSSSRLHHSKDYEE
>rna-XM_002269909.3
MEATQEFIYRSKLPDINIPSHLPLHSYCFQHISKFSSNPCLINAGNGNIYTYADVHLTARKVAAGLNRLGIRQGDAIMLLLQNCPEFVFSFLGASYLGATSTTANPFYTPAEIEKQATASSARIIITQACFAEKVKKFAEENDVKIICIDEPVAGCLHFSELSQADENDIPDVNISPDDVVALPYSSGTVGLPKGVMLTHKSMITSVAQQVDGENPNLYFHLDDVILCVLPMFHIYSLSSVVLCGLRVGAAILIMQKFEINTLMELVQKHKVTIAPFVPPILLAIAKSPVAHQYDLSSIRTVISGAAPMGKELEDSLGSKLPNAVIGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIINPETGASLPPNQAGEICIRGDQIMKGYLNDIEATKEAIDEEKWLHTGDIGYIDDNDELFIVDRLKEIIKNRGFQVAPAELEAILIAHPNIVDAAVVPMKDEAAGEVPIAFIVRSNGFEITEDEIKEYIAKQVVYYKRIKRVFFIETIPKAPSGKILRKDLKAKLAAGFSN
>rna-XM_002272746.4
MEVKKEEQPQQQQTEIIFRSKLPDIYIPDHLPLHSYCFENISKFSSRPCVIDGANGDIYTYADVELTARRVGAGLHKMGIKQGEVIMLLLQNCTEFVFAFLGASYIGATSTTANPFYMPAEIEKQAKASKCRLIITQACYSEKAMSFAEENDVKVMCIDTPPEGCLHFSELTNADEADLPTVKINPDDVVALPYSSGTTGLPKGVMLTHRGQVTSVAQQVDGDNPNLYFHSEDVILCVLPLFHVYSLNSVLLCGLRVGAAILIMQKFEIIKLLELINKYKVTIAPFVPPIVLAIAKSPVVDEYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGSCGTVVRNAQMKILDPDTGASLPRNQPGEICIRGHQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNVSDAAVVSMKDEAAGEVPVAFIVRSNGSKITEDEIKQYISKQVVFYKRIYRVFFVETIPKAPSGKILRKDLRARLAVGVPN
>rna-XM_002274958.4
MISIETQNPDVSNLDTSHSIPKMANRIDDHVFRSKLPEIPISNHLPLHTYCFENYSQFADRPCLIVGSTNKTYSFAETHLISRKVGAGFAHLGLKQGDVVMILLQNCAEFAFSFLGASMVGAVTTTANPFYTSAEIFKQLNASKAKIVVTQAQYVDKLRDYPDGQVAKIGEGFTVITIDDPPENCMHFSVVSEANESELPEVSINSDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLHLTPDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQRYRVSVAAVVPPLVLALAKNPMVESFDLSSIRVVLSGAAPLGKELEAALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGQQIMKGYLNDPEATASTIDVDGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDDVAGEVPVAFVVRSNGFELTEEAVKEFISKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAEKTPEPN
MGTHLQASAQDNEHIFRSQHQAVPVPDNMTLPDFVLQDAELYAEKVAFVEAVTGKEYTYGEVVRDVRRFAKALRSIGLRKGRVVVVVLPNVAEYAIVALGIMAAGGVFSGANPAGHASEIKKQVEAADAKLVVTNGAMYEKVKSLELPVIVMGEEHVAGAINWGELLEAADRANTDTISEDVHQNDLCALPFSSGTTGISKGVMLTHRNLVANLCSTLFSVGPEMVGQITILGLMPFFHIYGITGICCATLRNKGKVVVIGRYELRTFLNALITHEITFAPIVPPIILALVKNPIVEEFDLSRLKLRAVMTAAAPLAPELLSAFEKKFPSVQVQEAYGLTEHSCITLTHGDPTKGHATAKKNSVGFILPNMELKFIDPETGISLPKNTPGEICVRSQCVMQGYYKNEEETARTIDNNGWLHTGDIGYIDDDGDVFVVDRIKELIKYKGFQVAPAELEAILLSHPSVEDTAVVSLPDEEAGEIPAACVVLNPEAKETEEEIVKYVASNVAQYKRVRVVHFVETIPKSPSGKIMRRLLREKMLEKMKNNTKSGAILP
>rna-XM_002276317.4
MEKSGYGRDGIYRSLSPPLVLPKDPNLSLVSFLFRKASSYPRRPALIEAHSGETVNFAQFKSMVIKVSHGLTRLGLKKNDVVLIFAPNSIQYPLCFFGVIAIGAIATTANPLYTVAEIQKQVKDSNAKLVITIPQLWEKVKALNLPAVILDSADTSKDTIQSPLKITYFSDLVKMAGEVSHFPKVSITQGDTAALLYSSGTTGASKGVILTHGNFVAAALMVTMDEELMGEMHNVFLCFLPMFHVFGLAVVMCAQLQMGYTIVSMPKFDLDVALKSIEKYRVTHMWLVPPVMLALVKQGKLDRYDISSLKHIGSGAAPLGKELMEECAKSLPHVAVGQGYGMTETCGIVSKEIPKIGIQHTGSTGPLVSGVEAQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKLTIDKKGWVHTGDVGYFDEQGKLFVVDRIKELIKYKGFQVAPAELEALLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVKTFIANQVAPFKKLRRVSFINTVPKSASGKILRRELIEKVRAKL
>rna-XM_010656030.2
MATSIVYRSPRPHVDIPNDPSISMLSFLFRKTSSFSTRLALVDSDSGETLTFFQLKSTVSRLAHSFAQLGITKNDVVLIFAPNSVRFPVCFLAIVALGAIATTANPLYTISELSKQVKDSNPKFVINVLRIRRT
>rna-XM_019221548.1
MQEAGRQSMQEFQSRISQDATLQHNVHELWDKVKNFDLTFVILSSSASQRLPSSNSRVWYYSDLIKTPEDRDLDFPPASVVQTDTVALLYSSGTTGTSKGVILTHRNFIAAGVMVTADQAYYGESSNVFLCFLPMFHIFGLSVILYAQLVRGNTVVTVAKFEIEKVLRSVEKYRVTHMFVVHPVMIALAKQSVVRKYDLSSLRQICSGAAPLGKDVMDDCAKNVPQAAVIQVFKPRIGIYLQLLLINCCKFCSLAYVLLLGIVGIDPGKLNICAPGSNVSAYTLARVVETPRAATRLIQGMRGDNKTVFVIKLHHDSKCTMWYSSSRHSGSTGILVPRVESQIVSEDTLKPLPPNQLGEIWVQGANMMQGYFNNPQATKLTIDEQGWVRTGDLGYFDEGGQLFVVDRIKELIKFKGFQVAPAELEGLLLSHPEILDSVVIPLPDVEAGEVPIAYVVRSPRSSLTEEDVQKFIAKQVGYCFKRYQQCVKDYTQVVTERIPPSSSRLHHSKDYEE
>rna-XM_002269909.3
MEATQEFIYRSKLPDINIPSHLPLHSYCFQHISKFSSNPCLINAGNGNIYTYADVHLTARKVAAGLNRLGIRQGDAIMLLLQNCPEFVFSFLGASYLGATSTTANPFYTPAEIEKQATASSARIIITQACFAEKVKKFAEENDVKIICIDEPVAGCLHFSELSQADENDIPDVNISPDDVVALPYSSGTVGLPKGVMLTHKSMITSVAQQVDGENPNLYFHLDDVILCVLPMFHIYSLSSVVLCGLRVGAAILIMQKFEINTLMELVQKHKVTIAPFVPPILLAIAKSPVAHQYDLSSIRTVISGAAPMGKELEDSLGSKLPNAVIGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIINPETGASLPPNQAGEICIRGDQIMKGYLNDIEATKEAIDEEKWLHTGDIGYIDDNDELFIVDRLKEIIKNRGFQVAPAELEAILIAHPNIVDAAVVPMKDEAAGEVPIAFIVRSNGFEITEDEIKEYIAKQVVYYKRIKRVFFIETIPKAPSGKILRKDLKAKLAAGFSN
>rna-XM_002272746.4
MEVKKEEQPQQQQTEIIFRSKLPDIYIPDHLPLHSYCFENISKFSSRPCVIDGANGDIYTYADVELTARRVGAGLHKMGIKQGEVIMLLLQNCTEFVFAFLGASYIGATSTTANPFYMPAEIEKQAKASKCRLIITQACYSEKAMSFAEENDVKVMCIDTPPEGCLHFSELTNADEADLPTVKINPDDVVALPYSSGTTGLPKGVMLTHRGQVTSVAQQVDGDNPNLYFHSEDVILCVLPLFHVYSLNSVLLCGLRVGAAILIMQKFEIIKLLELINKYKVTIAPFVPPIVLAIAKSPVVDEYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGSCGTVVRNAQMKILDPDTGASLPRNQPGEICIRGHQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNVSDAAVVSMKDEAAGEVPVAFIVRSNGSKITEDEIKQYISKQVVFYKRIYRVFFVETIPKAPSGKILRKDLRARLAVGVPN
>rna-XM_002274958.4
MISIETQNPDVSNLDTSHSIPKMANRIDDHVFRSKLPEIPISNHLPLHTYCFENYSQFADRPCLIVGSTNKTYSFAETHLISRKVGAGFAHLGLKQGDVVMILLQNCAEFAFSFLGASMVGAVTTTANPFYTSAEIFKQLNASKAKIVVTQAQYVDKLRDYPDGQVAKIGEGFTVITIDDPPENCMHFSVVSEANESELPEVSINSDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLHLTPDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQRYRVSVAAVVPPLVLALAKNPMVESFDLSSIRVVLSGAAPLGKELEAALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGQQIMKGYLNDPEATASTIDVDGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDDVAGEVPVAFVVRSNGFELTEEAVKEFISKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAEKTPEPN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University