Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Vanilla planifolia
Species name
Cultivated vanilla (Vanilla planifolia) is a species of monocot in the family Orchidaceae (orchid family).
Species info
Gene sequence info
Vanilla_planifolia.4CL.fa
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>rna-gnl|WGS:JADCNL|Vpl01Ag03337.1
MEGAIPGRIIIPASHPSWFSPETGIYGSRHPPRSLPQDPFQDLVSFLFSRPHRGETALVDSLSGISISYPDLLSMVNLWPPACTTLEFPQAAFSWLDRRGYEEGYGMTESTAVDSPADLEALLISHAEILDAAVTSAFDEEAGEIPVAFVVRKLGSNLCSNAIMEFVAKQMLEILFPTFASLRLG
>rna-gnl|WGS:JADCNL|Vpl05Ag10805.1
MVKSPIVSEFDLEKLKLRSVMTAAAPLSPELRTAFEVKFPGVEIQEAYGLTEHSCITLTHCDPRKGHANAKKASVGFILPNIEVKFIDPESGRSLPKNTTGELCVKSQCVMQGYFKNKEETERTVDQDGWLHTGDIGFIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLAHPSVVDAAVFAVPDEEAGEVPTACVVKKVGAVEDEEEIIEIRGLNVASYKKIRMLKFVDSIPKSHSGKIMRRVLKDGFVKR
>rna-gnl|WGS:JADCNL|Vpl05Ag10484.1
MRSNSLHAEHIFRSKLPDINIPDHLPIHDHCFEKFPSVADRPCLIHGETGIIYTYADINNRQHKVIIHFPGFPHMNINLHLLT
>rna-gnl|WGS:JADCNL|Vpl05Ag10806.1
MEEDKQLQQEEEHIFRSKLSSVPVPENLTLPEFVLSGAEDYADKVALVETDTGKTLTYGEVVLNTRRFAWALRSLGLRNGHVVVVALPNLAIYPVVALGVMACGGVFSGVNPLSTPAEMKKQVDDSEAKLIVANAFSYEKVKDFMIPIILVGEDELPGAIPWNELLTAADLTEPTAMVDEGARKVQQSDICALPYSSGTTGSSKGVMLTHRNLIANLCSSLSNFPPEMVGQVTTLGLIPFFHIYGITGICCAVLRNKGKVVVLPGTTSEASSVL
>rna-gnl|WGS:JADCNL|Vpl05Ag10485.1
MGSISQEAEHVFRSKLPDINIPDHLPIHEYCFEKLPSVTDRPCLINSETGIIYTYADVHRLSRRTAAGMHRLGVRQGDVIMILLPNSPEFAFVFLGASMLGAISTTANPFYTPAEVNKQAKASATRLVVTESCYIHKVKDLGVQIVCIDEASFAEILATNEEELPEVEIKPTDVVALPYSSGTTGLPKGVMLTHRGLVTGAAQLVDGENPNQFFDMDDILLCVLPLFHIYCLNSVLLSGLRSGSAIVVVRKFELAKVLELVERYRVTVTPFVPPIFVEIAKSATSDAYDLSSVRMVMSGAAPLGKELQDKVMAKLPNAKLGQGYGMTEALVSMCLAFAKEPLDYKSGSCGTVVRNAELKFIHPETGASLPRNQPGEICIRGKHIMKGYLNDPEATERTIDKDGWLHTGDIGYVDEDDQIFIVDRLKELIKYKGFQVAPAEIEALLITHPGISSAAVVSMKDELCGELPIAFVVRSDNYEVNEDEIKQYISKQVIFYKRIHNVFFVESIPKSPSGKILRKDLRGRVASGV
>rna-gnl|WGS:JADCNL|Vpl07Ag14699.1
MISIASPDLHQHDASPGTVETTPETTIFRSRLPDIPIPNHLPLHTYCFENLAELADKPCLIAGSTGQIYTFAETNLLCRRVAAGLAGLGIQQGDVILLLLQNCPEFVFSFMAVSYLGAAATTANPFCTPSEILKQFKASGAKLVITQSIYLDKLGNGLTVITIDDPPAGCLPFSVLSAADEATIPEEPIDAGRAVALPFSSGTTGLPKGVVLTHRSLVTSVAQQVDGENPNLYLKTEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVMIMPKFEIGAMLGLIEKHKVTVAPIVPPLVLALAKNPVVESYDLGSIRIVISGAAPLGKELEEALRRRLPQASFGQGYGMTEAGPVLSMCPAFAKQPTAVKSGSCGTVVRNAEMKVIDPETGFSLGRNKPGEICIRGAQIMKGYLNDQEATLATVDVEGWLHTGDIGYVDDDGEVFIVDRLKELIKFKGFQVPPAELEALLISHPSVADAAVVPQNDVVAGEVPVAFIVRSDIELTEEAVKEFIAKQVVFYKRLYKVYFIHAIPKSPSGKIFRKDLKARLANAAA
>rna-gnl|WGS:JADCNL|Vpl07Ag15230.1
MLTYADVQVSSLRVARGLRRLGIRRGDVIMLLLPNCPEFVLAFLAASACGAAATTANPFFTAAEIRKQAAASGARLIVTDAAGVEKSRGVVPTLVCVGDEVDGCVSFTELLETEDGWTPEEEEEKFQPDDVVALPYSSGTTGLPKGVMLTHKGTVTSISQQVDGENVHLYYHSGDVMLCVLPMYHIYSLVTVLCCALRAKAAVVVMRKFDMRGMMELIQRHRITVAPLVPPIAVEIAKTSATDAYDLSSVRMVISGAAPLSKELEDAIRAKMPNAVLGQGYGMTEAGPVISFCTSFSKEPIPSKAGSCGMVVRNAELKVVDPSTGASLRRNQRGEICLRAENVMKGYLNDAKATQGTIDEEGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVAPAEIEALLLAHDHVIDAAVVPLEDEAAGEVPVAFVVRTKGSEMTADELKRYIAKQVVFYKRISKVFFVDVIPKLPSGKILRKVLKQRLQVGLPLFQNH
>rna-gnl|WGS:JADCNL|Vpl08Ag17411.1
MGSMFSPNTEHIFRSKLPDIHIPDHLPIHDYCFEKLPDIADRPCLIDGATDTIYTYSDVHRLSRSTASGLHRIGVRQGDVIMILLPNSPEFAFAFLGASLLGAVSTTANPFYTPAEIHKQAKASSTRLVITESCHHHKVKELGVDVLCIDDGSFAELLTAEEEDLPTVEIKPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFNEEDVLLCVLPMFHIYSLNSVLLCGLRAGSAIVIMRRFELVKMLELLEKYKVTVAPFVPPIVVEMAKSTAVDAYDVSSVRMVMSGAAPMGKELQDKLMTKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPLEYKSGSCGTVVRNAQLKIIDPETGASLPYNQPGEICIRGNQIMKGYLKDSEATARTIDEEGWLHTGDVGYVDEDDQIFIVDRLKELIKYKGFQVAPAELEALLIAHPFISSAAVVPMKDDLCGELPIAFVVRADGREIGEDEIKQYISKQVVFYKRIHKVFFVEAIPKSPSGKILRKDLRARLANGQTH
>rna-gnl|WGS:JADCNL|Vpl11Ag20893.1
MVLSLVKNPLVEICNLSSIRIIISGAAPLGEELVAALQRLLPQAILGQFNNFEGLRHDRGGSRVSMCPAFAKRPMAAKSGSCGTVVRNAELKVIDPSTGYLNEPNATSATTDMDGWLHTGTLVMWTSMMRQKDEVAGEVPIAFVVRSDLKLNEVVVREFISKQVVYYKRLHKVYFVDVIQRSSAGKILKKDLRARPNSQNERVILTNSVLLFCFANPSVYGLVIHDLRLLRLSLVAKTYLPFVSDDGALRCIKVEYGGNPTFFEVLHGYSWILKLIRMKENWVEINRK
>rna-gnl|WGS:JADCNL|Vpl11Ag20892.1
MAASFLGAATTAANPLCTPAEILKQLKSSGAKLVVTQSIYADKLGGGLKVITVDDPPLGCLSFSVLSAADEAAIPESSSNTDDAVALPFSSGTTGLPKGVVLTHRNLVSSVAQQVDGENPNFHLRKDDVVLCVLPCFIYFSQLRTALFPESRCGGAYHAPIRDGSHVGFDREA
>rna-gnl|WGS:JADCNL|Vpl14Ag26019.1
MAASGKVLYSVDEGIHRSPLQPVTFPTEPCLSLITFLFRNIASYPDRLAIADADSGESLTFAQLFSAIRSTSAGLSRLGIQKGTVVLICAPNSIHFAVSFFAIIAAGAVATTVNPLYTASELSKQAIDSGSKVVITVTSLWDKVKFLRLPTVFIGPKAAPSVAADSKVPILYLSDLMSVPEAEYSPPVVHQSDICTLLYSSGTTGTSKGVMLSHRNFICTSLMATHDQDLRRHPQNICLCVLPMFHVFGLSVITYAQLQRGNSLVVMGRFEMDLVLRSIEKYRVTYFFVVPPIMITLAKQGRVVRYDLSSLKYLASGAAPLGKDLMEEVAKNYPEKMVLQGYGLTEACGFISIEYPEKSVGKFGSVGFLAVGIDGKVLNVDTQEPLPPNQLGELCFRGPNIMQGYFNNPQATELTLDKEGWLHTGDLGYFDENGQIFVVDRIKELIKYKGLQVAPAELEGLLLSHPDIVDAVVIPFPDDEAGEIPIGYVVRSPNSSITEDEVLKFIANQVAPYKKLRRVTFVNSVPKSPSGKILRRELIQKAKSNL
>rna-gnl|WGS:JADCNL|Vpl_s283Ag27740.1
MVLQGYGLTEACGFISIEYPEKSVGKYGSVGFLAVGIDGKVLNVDTQEPLPPNQLGELCFRGPNIMQGYFNNPQATELTLDKEGWLHTGDLGYFDENGQIFVVDRIKELIKYKGLQVAPAELEGLLLSHPDIVDAVVIPFPDDEAGEIPIGYVVRSPNSSITEDEVLKFIAKQVAPYKKLRRVTFVNSVPKSPSGKILRRELIQKVKSNL
MEGAIPGRIIIPASHPSWFSPETGIYGSRHPPRSLPQDPFQDLVSFLFSRPHRGETALVDSLSGISISYPDLLSMVNLWPPACTTLEFPQAAFSWLDRRGYEEGYGMTESTAVDSPADLEALLISHAEILDAAVTSAFDEEAGEIPVAFVVRKLGSNLCSNAIMEFVAKQMLEILFPTFASLRLG
>rna-gnl|WGS:JADCNL|Vpl05Ag10805.1
MVKSPIVSEFDLEKLKLRSVMTAAAPLSPELRTAFEVKFPGVEIQEAYGLTEHSCITLTHCDPRKGHANAKKASVGFILPNIEVKFIDPESGRSLPKNTTGELCVKSQCVMQGYFKNKEETERTVDQDGWLHTGDIGFIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLAHPSVVDAAVFAVPDEEAGEVPTACVVKKVGAVEDEEEIIEIRGLNVASYKKIRMLKFVDSIPKSHSGKIMRRVLKDGFVKR
>rna-gnl|WGS:JADCNL|Vpl05Ag10484.1
MRSNSLHAEHIFRSKLPDINIPDHLPIHDHCFEKFPSVADRPCLIHGETGIIYTYADINNRQHKVIIHFPGFPHMNINLHLLT
>rna-gnl|WGS:JADCNL|Vpl05Ag10806.1
MEEDKQLQQEEEHIFRSKLSSVPVPENLTLPEFVLSGAEDYADKVALVETDTGKTLTYGEVVLNTRRFAWALRSLGLRNGHVVVVALPNLAIYPVVALGVMACGGVFSGVNPLSTPAEMKKQVDDSEAKLIVANAFSYEKVKDFMIPIILVGEDELPGAIPWNELLTAADLTEPTAMVDEGARKVQQSDICALPYSSGTTGSSKGVMLTHRNLIANLCSSLSNFPPEMVGQVTTLGLIPFFHIYGITGICCAVLRNKGKVVVLPGTTSEASSVL
>rna-gnl|WGS:JADCNL|Vpl05Ag10485.1
MGSISQEAEHVFRSKLPDINIPDHLPIHEYCFEKLPSVTDRPCLINSETGIIYTYADVHRLSRRTAAGMHRLGVRQGDVIMILLPNSPEFAFVFLGASMLGAISTTANPFYTPAEVNKQAKASATRLVVTESCYIHKVKDLGVQIVCIDEASFAEILATNEEELPEVEIKPTDVVALPYSSGTTGLPKGVMLTHRGLVTGAAQLVDGENPNQFFDMDDILLCVLPLFHIYCLNSVLLSGLRSGSAIVVVRKFELAKVLELVERYRVTVTPFVPPIFVEIAKSATSDAYDLSSVRMVMSGAAPLGKELQDKVMAKLPNAKLGQGYGMTEALVSMCLAFAKEPLDYKSGSCGTVVRNAELKFIHPETGASLPRNQPGEICIRGKHIMKGYLNDPEATERTIDKDGWLHTGDIGYVDEDDQIFIVDRLKELIKYKGFQVAPAEIEALLITHPGISSAAVVSMKDELCGELPIAFVVRSDNYEVNEDEIKQYISKQVIFYKRIHNVFFVESIPKSPSGKILRKDLRGRVASGV
>rna-gnl|WGS:JADCNL|Vpl07Ag14699.1
MISIASPDLHQHDASPGTVETTPETTIFRSRLPDIPIPNHLPLHTYCFENLAELADKPCLIAGSTGQIYTFAETNLLCRRVAAGLAGLGIQQGDVILLLLQNCPEFVFSFMAVSYLGAAATTANPFCTPSEILKQFKASGAKLVITQSIYLDKLGNGLTVITIDDPPAGCLPFSVLSAADEATIPEEPIDAGRAVALPFSSGTTGLPKGVVLTHRSLVTSVAQQVDGENPNLYLKTEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVMIMPKFEIGAMLGLIEKHKVTVAPIVPPLVLALAKNPVVESYDLGSIRIVISGAAPLGKELEEALRRRLPQASFGQGYGMTEAGPVLSMCPAFAKQPTAVKSGSCGTVVRNAEMKVIDPETGFSLGRNKPGEICIRGAQIMKGYLNDQEATLATVDVEGWLHTGDIGYVDDDGEVFIVDRLKELIKFKGFQVPPAELEALLISHPSVADAAVVPQNDVVAGEVPVAFIVRSDIELTEEAVKEFIAKQVVFYKRLYKVYFIHAIPKSPSGKIFRKDLKARLANAAA
>rna-gnl|WGS:JADCNL|Vpl07Ag15230.1
MLTYADVQVSSLRVARGLRRLGIRRGDVIMLLLPNCPEFVLAFLAASACGAAATTANPFFTAAEIRKQAAASGARLIVTDAAGVEKSRGVVPTLVCVGDEVDGCVSFTELLETEDGWTPEEEEEKFQPDDVVALPYSSGTTGLPKGVMLTHKGTVTSISQQVDGENVHLYYHSGDVMLCVLPMYHIYSLVTVLCCALRAKAAVVVMRKFDMRGMMELIQRHRITVAPLVPPIAVEIAKTSATDAYDLSSVRMVISGAAPLSKELEDAIRAKMPNAVLGQGYGMTEAGPVISFCTSFSKEPIPSKAGSCGMVVRNAELKVVDPSTGASLRRNQRGEICLRAENVMKGYLNDAKATQGTIDEEGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVAPAEIEALLLAHDHVIDAAVVPLEDEAAGEVPVAFVVRTKGSEMTADELKRYIAKQVVFYKRISKVFFVDVIPKLPSGKILRKVLKQRLQVGLPLFQNH
>rna-gnl|WGS:JADCNL|Vpl08Ag17411.1
MGSMFSPNTEHIFRSKLPDIHIPDHLPIHDYCFEKLPDIADRPCLIDGATDTIYTYSDVHRLSRSTASGLHRIGVRQGDVIMILLPNSPEFAFAFLGASLLGAVSTTANPFYTPAEIHKQAKASSTRLVITESCHHHKVKELGVDVLCIDDGSFAELLTAEEEDLPTVEIKPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFNEEDVLLCVLPMFHIYSLNSVLLCGLRAGSAIVIMRRFELVKMLELLEKYKVTVAPFVPPIVVEMAKSTAVDAYDVSSVRMVMSGAAPMGKELQDKLMTKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPLEYKSGSCGTVVRNAQLKIIDPETGASLPYNQPGEICIRGNQIMKGYLKDSEATARTIDEEGWLHTGDVGYVDEDDQIFIVDRLKELIKYKGFQVAPAELEALLIAHPFISSAAVVPMKDDLCGELPIAFVVRADGREIGEDEIKQYISKQVVFYKRIHKVFFVEAIPKSPSGKILRKDLRARLANGQTH
>rna-gnl|WGS:JADCNL|Vpl11Ag20893.1
MVLSLVKNPLVEICNLSSIRIIISGAAPLGEELVAALQRLLPQAILGQFNNFEGLRHDRGGSRVSMCPAFAKRPMAAKSGSCGTVVRNAELKVIDPSTGYLNEPNATSATTDMDGWLHTGTLVMWTSMMRQKDEVAGEVPIAFVVRSDLKLNEVVVREFISKQVVYYKRLHKVYFVDVIQRSSAGKILKKDLRARPNSQNERVILTNSVLLFCFANPSVYGLVIHDLRLLRLSLVAKTYLPFVSDDGALRCIKVEYGGNPTFFEVLHGYSWILKLIRMKENWVEINRK
>rna-gnl|WGS:JADCNL|Vpl11Ag20892.1
MAASFLGAATTAANPLCTPAEILKQLKSSGAKLVVTQSIYADKLGGGLKVITVDDPPLGCLSFSVLSAADEAAIPESSSNTDDAVALPFSSGTTGLPKGVVLTHRNLVSSVAQQVDGENPNFHLRKDDVVLCVLPCFIYFSQLRTALFPESRCGGAYHAPIRDGSHVGFDREA
>rna-gnl|WGS:JADCNL|Vpl14Ag26019.1
MAASGKVLYSVDEGIHRSPLQPVTFPTEPCLSLITFLFRNIASYPDRLAIADADSGESLTFAQLFSAIRSTSAGLSRLGIQKGTVVLICAPNSIHFAVSFFAIIAAGAVATTVNPLYTASELSKQAIDSGSKVVITVTSLWDKVKFLRLPTVFIGPKAAPSVAADSKVPILYLSDLMSVPEAEYSPPVVHQSDICTLLYSSGTTGTSKGVMLSHRNFICTSLMATHDQDLRRHPQNICLCVLPMFHVFGLSVITYAQLQRGNSLVVMGRFEMDLVLRSIEKYRVTYFFVVPPIMITLAKQGRVVRYDLSSLKYLASGAAPLGKDLMEEVAKNYPEKMVLQGYGLTEACGFISIEYPEKSVGKFGSVGFLAVGIDGKVLNVDTQEPLPPNQLGELCFRGPNIMQGYFNNPQATELTLDKEGWLHTGDLGYFDENGQIFVVDRIKELIKYKGLQVAPAELEGLLLSHPDIVDAVVIPFPDDEAGEIPIGYVVRSPNSSITEDEVLKFIANQVAPYKKLRRVTFVNSVPKSPSGKILRRELIQKAKSNL
>rna-gnl|WGS:JADCNL|Vpl_s283Ag27740.1
MVLQGYGLTEACGFISIEYPEKSVGKYGSVGFLAVGIDGKVLNVDTQEPLPPNQLGELCFRGPNIMQGYFNNPQATELTLDKEGWLHTGDLGYFDENGQIFVVDRIKELIKYKGLQVAPAELEGLLLSHPDIVDAVVIPFPDDEAGEIPIGYVVRSPNSSITEDEVLKFIAKQVAPYKKLRRVTFVNSVPKSPSGKILRRELIQKVKSNL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University