Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Vaccinium macrocarpon
Species name
American cranberry (Vaccinium macrocarpon) is a species of eudicot in the family Ericaceae (heath family).
Species info
Gene sequence info
Vaccinium_macrocarpon.HIDH.fa
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>vmacro02186-RA_Vaccinium_macrocarpon_Stevens_v1
MRSNITKLWPYVCPNNSGLSDPRINTAVDPNLNKLGCKRVLVCLAKRDPLIDVGERRRQDVELKVSGRPCDGPRDVRELLSMQTSKMVAAVDEVGDVRVMVGVVVVEKCRWCSSCGSGSCGECGGGGVVVVVVSVYCSGDRSGRVVVISVALVVVVVEMVVVEWWRQWWHRGGNVGVLVGVVVVEWWQ
>vmacro02189-RA_Vaccinium_macrocarpon_Stevens_v1
MASTADRQVTHDFPLIGIRAFKDGTVERLKGTEIVPPSTNPITGVQSKDVWATSHSKDGGDEEVWLNDYADFDRLFFAGDSAGGNIAHNMAVRVGLEGLGGATLVGIVLVHAWFGGKESIGAEGEKITGKAFSDKLWLFVCPSSSGSDDPLFNPVMDPDFSKLGCNKVLVCVAEKDMLRDRGLYYKEELEKSGWGRVVEVMEVAGEDHVFHLFNPDCENALAMLKRLAAFMNFEDKA
>vmacro02185-RA_Vaccinium_macrocarpon_Stevens_v1
LHPTALRKLISRLHLTAAIHNSWSRPFVCLQEVVSVLVGLVFMQLTPGIEYNKTATLRNSHGLKKRSHPLATTQSPASNPRTSSSPDLKIWTRVFLPRLPDPARKLPVLLYAHGDGFSTMSAFSPCYDAYVRTLAAEAHVIAVSVEYRLAPEHPIPACYNDIVLEGTSRDEAIRGGSGWDRVLVLVAEKDHLCGPVKVYYENLKKCVEGEGGACGK
>vmacro02188-RA_Vaccinium_macrocarpon_Stevens_v1
MASTTEKEVTHDFPLLGVRAFKDGTVERLLGTEIVPPSTNPITGVQSKDVWAASHSKDSGGVELWLNDYVDFDRLFFAGDSAGANLAHNMAVRVGLEGLGGVSLVGIVLVHPWFGGKEPIGAEGEKLSVKDFSDNLWLFVCPSSSGSDDPLFNPVMDPDFSKLGCNKVLVCVAEKDFLRDRGWYYKEELKKRFLTQGGQLPPLPLHGAAPESMGSPSDSELQNITP
>vmacro02190-RA_Vaccinium_macrocarpon_Stevens_v1
MASNTNDEIAYEFLPYFRAYKNGQVERFFGTDRVPPSTNPNSPVSSKDVIISPESTVSARLFKPTAVDPNLRLPLLVYFHGGAYSFGSPFCAEYHNHLTSLVAEANVIAISVDYRLAPEYPIPIAYEDSWAALKWVASHCNGQGPEDWINENADLQRVFVSGDSAGANIAHNTAMKAGEEELVGVKLIGACLVHPDFASKEGHVPKAWFFACPDTSGSSDPRINPAVDSRLVKIGCMRVLVCIAEKDGLKERGLFYYETLKKSGWGGVVQILETHGEGHVFHLFNPSCENAVDLVKSLASFINQE
>vmacro07519-RA_Vaccinium_macrocarpon_Stevens_v1
MGSLPHIVEDCEGILQLYSDGSINRSDINLDNFFNNANPLNDVVSSAVLWKDLLFHKPHHLYLRLYKPKQNPPSPSSLPVLLFLHGGGFCIGSRSWPNFHNYCLRLSSALQAVVVSPDYRLAPEHRLPAPIDDAISAIEWVRAQATCENPDPWLGSGVMDYGRVFVLGDSSGGNIAHHLAVRFGLGFDDLGPLRVRGFVLMAPFFGGSTRTKSEAEGPPEPLLNLEILDSHGHSRTIPFYVVTEL
>vmacro15325-RA_Vaccinium_macrocarpon_Stevens_v1
MFFHGQFIWHQSRSYIISVLRQKPPIHQNSMASATNEIAHDFSPFFLIYKDSAVETLNAPPPHAPPSPSDPTTASKDITISPSTTARIYLPKPTTTQNKLPILLYFHGGGFCVGSAFAADTHRFTTTLSSLSNCIAVSVEYRLAPKHFLPAAYDDCWSALQWVASHSSSVAKEGGGGEPWLSDHGDFTRVFIAGDSAGGNIAHNMAMKAGRENLPNGIRILGAIASHPYFWNSSPIGSDPVVGHDNRVGSRLWKFIHPSCPGGLDDPVINPWGPGAPSLAGLGCSRLLVCVAEKDPLRERNLRYYEAVKESGWRGEAELYEAKGEGHVDSLFYRRATFKSFSGVPELALLNPNPSGKPGQLASAEPPVWKRLGDQAGSPPPGHS
>vmacro19492-RA_Vaccinium_macrocarpon_Stevens_v1
MDSTTSEITHHFPPFFQVHKDGQVHRFMPSVFAPPTLDPQTGVESKDVLISPETGVKARIFLPKMNDPDQKKLPLVVHYHGGAFCFGSALDTATTQFLTRLVSEANVVAVSVDYRLAPEHKLPIAFDDSWSALQWIGAHFNGNGPELWLNQYVDFGRVFLTGESAGATIAHHVAVRVGTTTGFPDGPRVRGAVMVHPYFADTKPNDVMRFMYPGSSGTDSDPRLNPKADPDTDKMGCEKVVVFVAENDEFGLKPLGVEYCETLKKSGWKGNVELVENKGEGHVFHLINPTCENALLLVQKFASFVNDVS
>vmacro19491-RA_Vaccinium_macrocarpon_Stevens_v1
MESTASEIVTHEFPPYFRVYKGGRIERFKKFTPVPMTIEPKTGVEIKDVSISPNIKARIFKPKMDGPDQKLPLVVHYHGGAFCVGSPFDATTLVFLSSLASEAKVIALSVDYRLAPENKLPIAFDDSWSALQWISTHSKGDGPNPWLNDYVDFNRVFLMGESAGATIAHQVAVRAGSVGLDGFCIHGLILAHPYFADHEPDKLILFLYPESCGTEADPRLNPKSDPDLVKMVCSKVLVCVADKDWFKSRGVTYCGTLKSIWKGDVEFVETEGSHCFHVFNPTSEEAGLLRQRSSLIFAKLTTSLMDFDLRALKLFLKLIYLIFFNFVEKDDKLVIIDLKAVELLLKSVFEIFFNLVEGDC
>vmacro19493-RA_Vaccinium_macrocarpon_Stevens_v1
MNSVFVPPTLDPQTGVESKDVLISPETGVKARIFLPKINGPDPIKKLPLLVHYHGGGFCIASALSATTAKFLTRLVTEANVIAVSVEYRLAPEHPLPIAFEDSWSAFQWIGTHRNGDGPELWLNRYVDFGRVFLAGESAGATIAHYVAVRAGSTTAGFEGTLVRGVIIAHPYFAINVPDQMIRYMYPGSSGTDSDPKLNPKADPDLGKMGCEKVLVLVAEKDWLKPRGVEYCETLRNSDWKGTVELVENEGEDHCFHMFNPACENALLLVQKLASFVNQASE
>vmacro13775-RA_Vaccinium_macrocarpon_Stevens_v1
MVHEALSNQIQVSQKKIIEEVSGWLRVFDDGSVDRTWTGPPEVKFMSDQVQSHEDFVDGVATRDVITDSESGLRVRIYLPKIEVNEDEQKLPILLHFHGGGFCISKADWFMYYHVYTRLAREAKVICVSVFLPLAPENRLPAACDDSFSALLWLKSLATGSAFHEPWLETHADFSRVFLIGDSSGGNLVHEVAARAGEVDLSPVRLAGAIPIHPGFVRSTRSKSEQEQPESPFLTLDMVDKFLSLALPVGATKDHPITCPMGDRAPPIAAMKLPPILFCVAEMDLIRDTEMEYYEALKKGNKDVELMVNKGMGHSFYLNKIAVDMDPQTGIETEKLIAGIADFVKRH
>vmacro04055-RA_Vaccinium_macrocarpon_Stevens_v1
MSSTTPSPYEVDECRGVLRVFSDGSIIRSTKPSFDIPVHDDGSVLWKDVLFDSTHNLQLRLYKPASPSSHKLPIFYYIHGGGFCIGSRAWPNCQNYCFRLASDLQAVIIAPDYRLAPENRLPAAVDDGFAAVKWLQAQSESEEPDSWLADVADFSRVFISGDSAGGNIAHHLAVRLGPGSAELRLVRVRGYVLLAPFFGGTVLTRSEAEGPEDAFLNWELIDRFWRLSIPVGETTDHPLVNPFGPVSPPIEQLDLDPILVVVGGSDLLKDRAEEYAKKLKGWGKKVEYVEFKGKQHGFFTINPNSQAANELMLMIKHFITVNSS
>vmacro04458-RA_Vaccinium_macrocarpon_Stevens_v1
MDSSKREVSHDIPPYLRVYKDGTVERLLGYEIAPAAFDPLTGVVSKDTVITPETGVSARLYRPNLPPNDQKLPLVIYFHGGAFFISSTADPKYQHSLNVLVSKANIILVSVNYRKAPEHPLPAAFEDSWEALKWVASHVSGGGSEDWLRGKIDFSRVVLAGDSAGANIAQNLAIRVGSNPIGDLKLHGIIMIHPYFWGKEPIGEEKKDAVRKSMVDGWWRFVCRSDKGNDDPLINPFADGAPSLSGLACDRVIVCVAEKDILRDRGRLYYETLVKSGWNGKAEILEIEGVDHVFHIMDPSCEKALYMVKCLACFINQE
MRSNITKLWPYVCPNNSGLSDPRINTAVDPNLNKLGCKRVLVCLAKRDPLIDVGERRRQDVELKVSGRPCDGPRDVRELLSMQTSKMVAAVDEVGDVRVMVGVVVVEKCRWCSSCGSGSCGECGGGGVVVVVVSVYCSGDRSGRVVVISVALVVVVVEMVVVEWWRQWWHRGGNVGVLVGVVVVEWWQ
>vmacro02189-RA_Vaccinium_macrocarpon_Stevens_v1
MASTADRQVTHDFPLIGIRAFKDGTVERLKGTEIVPPSTNPITGVQSKDVWATSHSKDGGDEEVWLNDYADFDRLFFAGDSAGGNIAHNMAVRVGLEGLGGATLVGIVLVHAWFGGKESIGAEGEKITGKAFSDKLWLFVCPSSSGSDDPLFNPVMDPDFSKLGCNKVLVCVAEKDMLRDRGLYYKEELEKSGWGRVVEVMEVAGEDHVFHLFNPDCENALAMLKRLAAFMNFEDKA
>vmacro02185-RA_Vaccinium_macrocarpon_Stevens_v1
LHPTALRKLISRLHLTAAIHNSWSRPFVCLQEVVSVLVGLVFMQLTPGIEYNKTATLRNSHGLKKRSHPLATTQSPASNPRTSSSPDLKIWTRVFLPRLPDPARKLPVLLYAHGDGFSTMSAFSPCYDAYVRTLAAEAHVIAVSVEYRLAPEHPIPACYNDIVLEGTSRDEAIRGGSGWDRVLVLVAEKDHLCGPVKVYYENLKKCVEGEGGACGK
>vmacro02188-RA_Vaccinium_macrocarpon_Stevens_v1
MASTTEKEVTHDFPLLGVRAFKDGTVERLLGTEIVPPSTNPITGVQSKDVWAASHSKDSGGVELWLNDYVDFDRLFFAGDSAGANLAHNMAVRVGLEGLGGVSLVGIVLVHPWFGGKEPIGAEGEKLSVKDFSDNLWLFVCPSSSGSDDPLFNPVMDPDFSKLGCNKVLVCVAEKDFLRDRGWYYKEELKKRFLTQGGQLPPLPLHGAAPESMGSPSDSELQNITP
>vmacro02190-RA_Vaccinium_macrocarpon_Stevens_v1
MASNTNDEIAYEFLPYFRAYKNGQVERFFGTDRVPPSTNPNSPVSSKDVIISPESTVSARLFKPTAVDPNLRLPLLVYFHGGAYSFGSPFCAEYHNHLTSLVAEANVIAISVDYRLAPEYPIPIAYEDSWAALKWVASHCNGQGPEDWINENADLQRVFVSGDSAGANIAHNTAMKAGEEELVGVKLIGACLVHPDFASKEGHVPKAWFFACPDTSGSSDPRINPAVDSRLVKIGCMRVLVCIAEKDGLKERGLFYYETLKKSGWGGVVQILETHGEGHVFHLFNPSCENAVDLVKSLASFINQE
>vmacro07519-RA_Vaccinium_macrocarpon_Stevens_v1
MGSLPHIVEDCEGILQLYSDGSINRSDINLDNFFNNANPLNDVVSSAVLWKDLLFHKPHHLYLRLYKPKQNPPSPSSLPVLLFLHGGGFCIGSRSWPNFHNYCLRLSSALQAVVVSPDYRLAPEHRLPAPIDDAISAIEWVRAQATCENPDPWLGSGVMDYGRVFVLGDSSGGNIAHHLAVRFGLGFDDLGPLRVRGFVLMAPFFGGSTRTKSEAEGPPEPLLNLEILDSHGHSRTIPFYVVTEL
>vmacro15325-RA_Vaccinium_macrocarpon_Stevens_v1
MFFHGQFIWHQSRSYIISVLRQKPPIHQNSMASATNEIAHDFSPFFLIYKDSAVETLNAPPPHAPPSPSDPTTASKDITISPSTTARIYLPKPTTTQNKLPILLYFHGGGFCVGSAFAADTHRFTTTLSSLSNCIAVSVEYRLAPKHFLPAAYDDCWSALQWVASHSSSVAKEGGGGEPWLSDHGDFTRVFIAGDSAGGNIAHNMAMKAGRENLPNGIRILGAIASHPYFWNSSPIGSDPVVGHDNRVGSRLWKFIHPSCPGGLDDPVINPWGPGAPSLAGLGCSRLLVCVAEKDPLRERNLRYYEAVKESGWRGEAELYEAKGEGHVDSLFYRRATFKSFSGVPELALLNPNPSGKPGQLASAEPPVWKRLGDQAGSPPPGHS
>vmacro19492-RA_Vaccinium_macrocarpon_Stevens_v1
MDSTTSEITHHFPPFFQVHKDGQVHRFMPSVFAPPTLDPQTGVESKDVLISPETGVKARIFLPKMNDPDQKKLPLVVHYHGGAFCFGSALDTATTQFLTRLVSEANVVAVSVDYRLAPEHKLPIAFDDSWSALQWIGAHFNGNGPELWLNQYVDFGRVFLTGESAGATIAHHVAVRVGTTTGFPDGPRVRGAVMVHPYFADTKPNDVMRFMYPGSSGTDSDPRLNPKADPDTDKMGCEKVVVFVAENDEFGLKPLGVEYCETLKKSGWKGNVELVENKGEGHVFHLINPTCENALLLVQKFASFVNDVS
>vmacro19491-RA_Vaccinium_macrocarpon_Stevens_v1
MESTASEIVTHEFPPYFRVYKGGRIERFKKFTPVPMTIEPKTGVEIKDVSISPNIKARIFKPKMDGPDQKLPLVVHYHGGAFCVGSPFDATTLVFLSSLASEAKVIALSVDYRLAPENKLPIAFDDSWSALQWISTHSKGDGPNPWLNDYVDFNRVFLMGESAGATIAHQVAVRAGSVGLDGFCIHGLILAHPYFADHEPDKLILFLYPESCGTEADPRLNPKSDPDLVKMVCSKVLVCVADKDWFKSRGVTYCGTLKSIWKGDVEFVETEGSHCFHVFNPTSEEAGLLRQRSSLIFAKLTTSLMDFDLRALKLFLKLIYLIFFNFVEKDDKLVIIDLKAVELLLKSVFEIFFNLVEGDC
>vmacro19493-RA_Vaccinium_macrocarpon_Stevens_v1
MNSVFVPPTLDPQTGVESKDVLISPETGVKARIFLPKINGPDPIKKLPLLVHYHGGGFCIASALSATTAKFLTRLVTEANVIAVSVEYRLAPEHPLPIAFEDSWSAFQWIGTHRNGDGPELWLNRYVDFGRVFLAGESAGATIAHYVAVRAGSTTAGFEGTLVRGVIIAHPYFAINVPDQMIRYMYPGSSGTDSDPKLNPKADPDLGKMGCEKVLVLVAEKDWLKPRGVEYCETLRNSDWKGTVELVENEGEDHCFHMFNPACENALLLVQKLASFVNQASE
>vmacro13775-RA_Vaccinium_macrocarpon_Stevens_v1
MVHEALSNQIQVSQKKIIEEVSGWLRVFDDGSVDRTWTGPPEVKFMSDQVQSHEDFVDGVATRDVITDSESGLRVRIYLPKIEVNEDEQKLPILLHFHGGGFCISKADWFMYYHVYTRLAREAKVICVSVFLPLAPENRLPAACDDSFSALLWLKSLATGSAFHEPWLETHADFSRVFLIGDSSGGNLVHEVAARAGEVDLSPVRLAGAIPIHPGFVRSTRSKSEQEQPESPFLTLDMVDKFLSLALPVGATKDHPITCPMGDRAPPIAAMKLPPILFCVAEMDLIRDTEMEYYEALKKGNKDVELMVNKGMGHSFYLNKIAVDMDPQTGIETEKLIAGIADFVKRH
>vmacro04055-RA_Vaccinium_macrocarpon_Stevens_v1
MSSTTPSPYEVDECRGVLRVFSDGSIIRSTKPSFDIPVHDDGSVLWKDVLFDSTHNLQLRLYKPASPSSHKLPIFYYIHGGGFCIGSRAWPNCQNYCFRLASDLQAVIIAPDYRLAPENRLPAAVDDGFAAVKWLQAQSESEEPDSWLADVADFSRVFISGDSAGGNIAHHLAVRLGPGSAELRLVRVRGYVLLAPFFGGTVLTRSEAEGPEDAFLNWELIDRFWRLSIPVGETTDHPLVNPFGPVSPPIEQLDLDPILVVVGGSDLLKDRAEEYAKKLKGWGKKVEYVEFKGKQHGFFTINPNSQAANELMLMIKHFITVNSS
>vmacro04458-RA_Vaccinium_macrocarpon_Stevens_v1
MDSSKREVSHDIPPYLRVYKDGTVERLLGYEIAPAAFDPLTGVVSKDTVITPETGVSARLYRPNLPPNDQKLPLVIYFHGGAFFISSTADPKYQHSLNVLVSKANIILVSVNYRKAPEHPLPAAFEDSWEALKWVASHVSGGGSEDWLRGKIDFSRVVLAGDSAGANIAQNLAIRVGSNPIGDLKLHGIIMIHPYFWGKEPIGEEKKDAVRKSMVDGWWRFVCRSDKGNDDPLINPFADGAPSLSGLACDRVIVCVAEKDILRDRGRLYYETLVKSGWNGKAEILEIEGVDHVFHIMDPSCEKALYMVKCLACFINQE
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University