Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Vaccinium macrocarpon
Species name
American cranberry (Vaccinium macrocarpon) is a species of eudicot in the family Ericaceae (heath family).
Species info
Gene sequence info
Vaccinium_macrocarpon.4CL.fa
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>vmacro01055-RA_Vaccinium_macrocarpon_Stevens_v1
MTTLVQNQAQNEDHIFKSPYAQVWVPENVTLPEFVLQGFELYADKVAFVESESGKEYTHGEVVRDTKRFAKALRSLGLRNGRVVVVLLPNVAEYAIVALGIMAAGGVFSGANPTGHASEIKKQVEAADAKLIVTNGPNYEKVKCLGVPIIILGEQRVESAIYWAELLEAADRAGTGTNNEPIAQTDLCALPFSSGTTGTSKGVMLTHRNLISNLCSTLFDVRPELIGKVTTLGLMPFFHIYGITGICCATLKNKGKVVVMGRYKIDTYLNALIDHEVTFAPIVPAIISDMVKNPAVDDFDLGKLKLYAVMTAAAPLAPEVLSAFERKFPGVGVQEAYGMTEHSCITLTHGGDPEKGHRISKKNSVGFVLPNLEVKFIDPNTGRSLPKNTRGEICVRSQCVMLGYYKNNEETAQTIDENGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAHLENIILTHPSVADVAVIPFPDEEAGEIPAACVVMNSNAKASEEEIMNYVGKNVANYERVRVVQFVDAIPRSASGKILRRLLKEELVKNMINNNPKRVQHN
>vmacro01079-RA_Vaccinium_macrocarpon_Stevens_v1
MAHSNRSLLLPPPSADPSSGFCSQTKTYFSLRPHPPLPPQSLSLSLTDYVFSLLRQNSPSPSSSSTSAALIDAANGRRIPYTELVTLTQTLATSLHRQLGLARGDSTFVLSPNSSRIPILYLALFSLGVVVSPSNPSSTMSDVSRQIELCKPVVAFVTSDANDKIISLFSRTIRLDSVEFESMMTTRCDEFVRFDVGQNDTAAILYSSGTDGSLSTTGKFKGVELTHQNLICSIAGVQAVRPVRQSLAVTLCPVPYFHIYGFLYCVRTVAMGESLVSVRKIDLLQMIRAIERFRVTHVAVAPPVIFSMVNNHNWTDSHDLRSLEVVVSSGAPLSKVLFKKFKERFPRVQLPQAYGLTETTAGVSRMVGPNESQKFGASGRLVAYCQAKIVDIETGMGLPPFKQGELWVRGPLVMKGYVGDPKATSTILDSEGWLRTGDMCYFDSEGFLYVVDRLKELIKYKGYQVAPVELENLLQTHPDIVDVAVVPLSINACFPSIEGLIFFFFSVACQYPDEEAGQVPMAFVVRRPESIVDESNIKDFVARQVAPYKKIRRVSFINSIPKNASGKVLRRELIKLALLGASSKL
>vmacro19091-RA_Vaccinium_macrocarpon_Stevens_v1
MEITKPPPPQKQQEDIIFRSKLPDIYIPNHLPLHSYVFQNISDHRSNPCLINGATGEIHTYAEVELTARRVAVGLSKHGIKQHDTILLLLPNSPEFVFSFLAASYLGATSTMANPFFTPAEVLKQAKASKAKLIVTQNSYVDKVLTHALEHDIEIACIDSLPPSPAKNVFHFSELAQSDENELPEVEIDPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPHLYMNSDDVSMCVLPLFHIYAMNSILLCSLRVGAAILLVQKYEILSFLGLMQRFKVTYGPFVPPIVLAIAKSEKVDDYDLSSVRMVQSGAAPLGKDVEEAVSAKFPNATLGQGYGMTEAGPVLALCLAFAKEPFEVKSGACGTVVRNAEMKIVDPETENSLPRNQPGEICIRGDQIMKGYLNDPEATERTIDKGGWLHTGDIGYIDDDDELFIVDRLKEIIKYNGFQVAPAEIEALLLNHPNISDAAVVGMTDESAGEVPVAFVVKSNGSQITEEEIKQYISKQVVYYKRIKRVFFTDSIPKAPSGKILRKDLRARLAAGLAN
>vmacro14404-RA_Vaccinium_macrocarpon_Stevens_v1
MEKSGYGQDGIYRSLRPPLLLPTDPNLSMVSFLFRNSSSFSHKPALIDSESGQILTFSHSNPPSPNSTIAIGAIGTTVNPAYTVREISNQVEDCKPKVIVTVPELWDKVKGFGLKYVMIGSEEKSNLIGNSSNLKVTWLNDLVKNSGNVSDWFPEAEIKSNDTAALLYSSGTTGLSKGVVLSHRNFMAAALMITSDAESVGERDNLFLCVLPMYHVFGLAVIMYAQLQRGVGIVSMAKFNLEMVLRAVEKYRVTDLWVVPPIVLAMAKNSIVKKYDVSSVRQILSGAAPLVKDLMVECAKNFPQAAIMQGFGMTETCGIVSIENPRVGSRHSGSAGMLVPGVEGQIVGVDTLKPLPPKQSGEIWVRGANMMQGYLNNSEATRLTIDKEGWVHTGDLGYFDEEGQLFIVDRLKELIKYKAFQIAPAELEGLLVSHPEILDAGVFGLPDAEAGEIPVANVVRSPTSSLTEKDVQIFIADQVAHFKRLHQVTFAESIPRSPSGKILRRELKEKVRSKI
>vmacro14403-RA_Vaccinium_macrocarpon_Stevens_v1
MEKSGYGKDGIYRSLRPPLLLPDDQNLSMVSFLFRNSSSYSDKPALIDADSGKTLTFSQFKSTVAKLSHAFLHQLGIKKNDVVLIFSPNSIQFPICFFAIVAIGAIATTVNPVYTVSEISKQVKDCKPKVIITVPELWDKVKGFGLKSIIIGSKQKSSLIGTPNSKVTWFDDLVENAGSVSDFSSVADIKSSDTAALLYSSGTTGLSKGVVLNHRNFVAAALMVTADQELAGEMDRLYLCVLPMFHVFGLAVILYAQLQRGDAIVSMAKFDLEMFSRVVEKYRVTHLWAVPPIVLALFKSNAARKYDLSSLRQIGSGAAPLGKDLMAESAKAFPHAVVMQGYGMTETCGIISIENPRLGPRHSGSAGTLVSGVECKIVGVGTLNPLPPKQLGEIWVRGANMMQGYYNNPQETKLTIDEQGWVHTGDLGYVDEEGHLFVVDRLKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDVEAGEVPVAYVIRSPNSSLTEKDVQKFIADQVAPFKRLRRVTFINSVPKTASGKILRRVLIENVQSKI
>vmacro14405-RA_Vaccinium_macrocarpon_Stevens_v1
MMFTRYKFESESWDQYVERIDLESTAHLLWVLLYCFTVVFVYLSIKTPPRFRLKWILTVTVTLAAIIKEYENRRHQAFQDIECLVFVRYCKLASTANIEAFGDPKLQRTQMEKSGYGRDGIYRSLRPPLRLPKDPNLSMVSFLFRNSSSYSDKPALIDADSGQTLTFSQFKSTVAKLSHAFINQLGIKKNDVVLIFARNSIQFPICFFAVVAIGAIATTVNPLYTVAEISKQVKDCKPKVIVTVSELWEKVKGFGLDYVIMGNEKNSSLIGNSSNSKITWLIDLVKNSGSTTDSFPAAEISSSDTAALLYSSGTTGVSKGVVLTHRNFVASALMVTADLELAGEMHNLFLCVLPMFHVFGLAVIMCGHLQRGDGIVSMAKFDFEMLLRAVEKYRVTHLWVVPPIVLALAKNSMVKKYDFSSLRQIGSGAAPLGKDLMAECAKNFPQATVLQGYGMTETCGIVSVENPRLGPRHSGSAGMLSPGVESKIVGVDTLKPLPPKQLGEIWVRGPNMMQGYLNNPEATRQTIDKQGWVHTGDLGYFDDEGQLFVVDRLKELIKYKGFQVAPAEIEGLLVSHPELLDAVVIPFPDAEAGEVPVAYVVRSPTSSLTEGDVKKFIAEQVAPFKRLHRVTFVNSVPKSASGKILRRELIEKVWSNL
>vmacro22175-RA_Vaccinium_macrocarpon_Stevens_v1
MLEVASAESQKPDLSPQSLVVVGGGGGGGGVDTPPNITTCTRNHQSSSETTTLTTNNNVFRSKLPDIPISNHLPLHTYCFENLSHFSDNTCLILGSTNKTYSFAETHLISQKVGAGLSNLGVRKGHVIMLLLQNCAEFVFSFMGASMIGAVTTTANPFYTAAEVFKQFNASKPKLIITHAQYVDKLRDAGGGGDNNLPKLGEDYTLITIDDPPENCLHFSVLSEANETDIPTVSIDPNDAVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGDNPNLFLKTEDVVLCVLPLFHIFSLNSVLLCSLRAGSRVLLMQKFEIGTLLELIQRYRVSVAAVVPPLVLALAKNPMVESFDLSSIRTVLSGAAPLGKELEQALRSRVPQAVFGQGYGMTEAGPVLSMSLAFAKQPFQTKSGSCGTVVRNAELKVIDSETGCSLPRNQQGEICIRGLQIMKGYLNDVDATATTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQAFKHLSISRLILFYIDYALRYLQQSLRPFLLAIHPLRMPLLYRAFNKYSKATLNTTLGREQALVPRPGPKEASLEARARGSSRRTQKDDVAGEVPIAFVVRSHGFELTEEAVKEYIAKQVVFYKKLHRVYFAHAIPKSPSGKILRKDLRAKLATASHNVPS
>vmacro13117-RA_Vaccinium_macrocarpon_Stevens_v1
MMEHQNHQRQDDHHPEFIFRSKLPDIYIPKHLPLHTYCFENISQFSSKPCIINGATGETHTYADVELTARRVASGLHKIGIHQGDVIMLLLHNSPEFVFAFLGASYAGATATTANPFYTTAEIEKQARAAKAKLIITQACYAEKVTEFGRENGVKVMCTDKDVEGCFHFSELTGADERELPAVKISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVIVCLLPLFHIYSLNSVLLCGLRVGATILIMQKFEINALLELVHKYKVTIAPFVPPIVLAIAKSPVVDNYDLSSIRMVMSGAAPMGKELEDKVRDKLPNAALGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGHSLPHNQAGEICIRGDQIMKVCTQ
MTTLVQNQAQNEDHIFKSPYAQVWVPENVTLPEFVLQGFELYADKVAFVESESGKEYTHGEVVRDTKRFAKALRSLGLRNGRVVVVLLPNVAEYAIVALGIMAAGGVFSGANPTGHASEIKKQVEAADAKLIVTNGPNYEKVKCLGVPIIILGEQRVESAIYWAELLEAADRAGTGTNNEPIAQTDLCALPFSSGTTGTSKGVMLTHRNLISNLCSTLFDVRPELIGKVTTLGLMPFFHIYGITGICCATLKNKGKVVVMGRYKIDTYLNALIDHEVTFAPIVPAIISDMVKNPAVDDFDLGKLKLYAVMTAAAPLAPEVLSAFERKFPGVGVQEAYGMTEHSCITLTHGGDPEKGHRISKKNSVGFVLPNLEVKFIDPNTGRSLPKNTRGEICVRSQCVMLGYYKNNEETAQTIDENGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAHLENIILTHPSVADVAVIPFPDEEAGEIPAACVVMNSNAKASEEEIMNYVGKNVANYERVRVVQFVDAIPRSASGKILRRLLKEELVKNMINNNPKRVQHN
>vmacro01079-RA_Vaccinium_macrocarpon_Stevens_v1
MAHSNRSLLLPPPSADPSSGFCSQTKTYFSLRPHPPLPPQSLSLSLTDYVFSLLRQNSPSPSSSSTSAALIDAANGRRIPYTELVTLTQTLATSLHRQLGLARGDSTFVLSPNSSRIPILYLALFSLGVVVSPSNPSSTMSDVSRQIELCKPVVAFVTSDANDKIISLFSRTIRLDSVEFESMMTTRCDEFVRFDVGQNDTAAILYSSGTDGSLSTTGKFKGVELTHQNLICSIAGVQAVRPVRQSLAVTLCPVPYFHIYGFLYCVRTVAMGESLVSVRKIDLLQMIRAIERFRVTHVAVAPPVIFSMVNNHNWTDSHDLRSLEVVVSSGAPLSKVLFKKFKERFPRVQLPQAYGLTETTAGVSRMVGPNESQKFGASGRLVAYCQAKIVDIETGMGLPPFKQGELWVRGPLVMKGYVGDPKATSTILDSEGWLRTGDMCYFDSEGFLYVVDRLKELIKYKGYQVAPVELENLLQTHPDIVDVAVVPLSINACFPSIEGLIFFFFSVACQYPDEEAGQVPMAFVVRRPESIVDESNIKDFVARQVAPYKKIRRVSFINSIPKNASGKVLRRELIKLALLGASSKL
>vmacro19091-RA_Vaccinium_macrocarpon_Stevens_v1
MEITKPPPPQKQQEDIIFRSKLPDIYIPNHLPLHSYVFQNISDHRSNPCLINGATGEIHTYAEVELTARRVAVGLSKHGIKQHDTILLLLPNSPEFVFSFLAASYLGATSTMANPFFTPAEVLKQAKASKAKLIVTQNSYVDKVLTHALEHDIEIACIDSLPPSPAKNVFHFSELAQSDENELPEVEIDPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPHLYMNSDDVSMCVLPLFHIYAMNSILLCSLRVGAAILLVQKYEILSFLGLMQRFKVTYGPFVPPIVLAIAKSEKVDDYDLSSVRMVQSGAAPLGKDVEEAVSAKFPNATLGQGYGMTEAGPVLALCLAFAKEPFEVKSGACGTVVRNAEMKIVDPETENSLPRNQPGEICIRGDQIMKGYLNDPEATERTIDKGGWLHTGDIGYIDDDDELFIVDRLKEIIKYNGFQVAPAEIEALLLNHPNISDAAVVGMTDESAGEVPVAFVVKSNGSQITEEEIKQYISKQVVYYKRIKRVFFTDSIPKAPSGKILRKDLRARLAAGLAN
>vmacro14404-RA_Vaccinium_macrocarpon_Stevens_v1
MEKSGYGQDGIYRSLRPPLLLPTDPNLSMVSFLFRNSSSFSHKPALIDSESGQILTFSHSNPPSPNSTIAIGAIGTTVNPAYTVREISNQVEDCKPKVIVTVPELWDKVKGFGLKYVMIGSEEKSNLIGNSSNLKVTWLNDLVKNSGNVSDWFPEAEIKSNDTAALLYSSGTTGLSKGVVLSHRNFMAAALMITSDAESVGERDNLFLCVLPMYHVFGLAVIMYAQLQRGVGIVSMAKFNLEMVLRAVEKYRVTDLWVVPPIVLAMAKNSIVKKYDVSSVRQILSGAAPLVKDLMVECAKNFPQAAIMQGFGMTETCGIVSIENPRVGSRHSGSAGMLVPGVEGQIVGVDTLKPLPPKQSGEIWVRGANMMQGYLNNSEATRLTIDKEGWVHTGDLGYFDEEGQLFIVDRLKELIKYKAFQIAPAELEGLLVSHPEILDAGVFGLPDAEAGEIPVANVVRSPTSSLTEKDVQIFIADQVAHFKRLHQVTFAESIPRSPSGKILRRELKEKVRSKI
>vmacro14403-RA_Vaccinium_macrocarpon_Stevens_v1
MEKSGYGKDGIYRSLRPPLLLPDDQNLSMVSFLFRNSSSYSDKPALIDADSGKTLTFSQFKSTVAKLSHAFLHQLGIKKNDVVLIFSPNSIQFPICFFAIVAIGAIATTVNPVYTVSEISKQVKDCKPKVIITVPELWDKVKGFGLKSIIIGSKQKSSLIGTPNSKVTWFDDLVENAGSVSDFSSVADIKSSDTAALLYSSGTTGLSKGVVLNHRNFVAAALMVTADQELAGEMDRLYLCVLPMFHVFGLAVILYAQLQRGDAIVSMAKFDLEMFSRVVEKYRVTHLWAVPPIVLALFKSNAARKYDLSSLRQIGSGAAPLGKDLMAESAKAFPHAVVMQGYGMTETCGIISIENPRLGPRHSGSAGTLVSGVECKIVGVGTLNPLPPKQLGEIWVRGANMMQGYYNNPQETKLTIDEQGWVHTGDLGYVDEEGHLFVVDRLKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDVEAGEVPVAYVIRSPNSSLTEKDVQKFIADQVAPFKRLRRVTFINSVPKTASGKILRRVLIENVQSKI
>vmacro14405-RA_Vaccinium_macrocarpon_Stevens_v1
MMFTRYKFESESWDQYVERIDLESTAHLLWVLLYCFTVVFVYLSIKTPPRFRLKWILTVTVTLAAIIKEYENRRHQAFQDIECLVFVRYCKLASTANIEAFGDPKLQRTQMEKSGYGRDGIYRSLRPPLRLPKDPNLSMVSFLFRNSSSYSDKPALIDADSGQTLTFSQFKSTVAKLSHAFINQLGIKKNDVVLIFARNSIQFPICFFAVVAIGAIATTVNPLYTVAEISKQVKDCKPKVIVTVSELWEKVKGFGLDYVIMGNEKNSSLIGNSSNSKITWLIDLVKNSGSTTDSFPAAEISSSDTAALLYSSGTTGVSKGVVLTHRNFVASALMVTADLELAGEMHNLFLCVLPMFHVFGLAVIMCGHLQRGDGIVSMAKFDFEMLLRAVEKYRVTHLWVVPPIVLALAKNSMVKKYDFSSLRQIGSGAAPLGKDLMAECAKNFPQATVLQGYGMTETCGIVSVENPRLGPRHSGSAGMLSPGVESKIVGVDTLKPLPPKQLGEIWVRGPNMMQGYLNNPEATRQTIDKQGWVHTGDLGYFDDEGQLFVVDRLKELIKYKGFQVAPAEIEGLLVSHPELLDAVVIPFPDAEAGEVPVAYVVRSPTSSLTEGDVKKFIAEQVAPFKRLHRVTFVNSVPKSASGKILRRELIEKVWSNL
>vmacro22175-RA_Vaccinium_macrocarpon_Stevens_v1
MLEVASAESQKPDLSPQSLVVVGGGGGGGGVDTPPNITTCTRNHQSSSETTTLTTNNNVFRSKLPDIPISNHLPLHTYCFENLSHFSDNTCLILGSTNKTYSFAETHLISQKVGAGLSNLGVRKGHVIMLLLQNCAEFVFSFMGASMIGAVTTTANPFYTAAEVFKQFNASKPKLIITHAQYVDKLRDAGGGGDNNLPKLGEDYTLITIDDPPENCLHFSVLSEANETDIPTVSIDPNDAVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGDNPNLFLKTEDVVLCVLPLFHIFSLNSVLLCSLRAGSRVLLMQKFEIGTLLELIQRYRVSVAAVVPPLVLALAKNPMVESFDLSSIRTVLSGAAPLGKELEQALRSRVPQAVFGQGYGMTEAGPVLSMSLAFAKQPFQTKSGSCGTVVRNAELKVIDSETGCSLPRNQQGEICIRGLQIMKGYLNDVDATATTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQAFKHLSISRLILFYIDYALRYLQQSLRPFLLAIHPLRMPLLYRAFNKYSKATLNTTLGREQALVPRPGPKEASLEARARGSSRRTQKDDVAGEVPIAFVVRSHGFELTEEAVKEYIAKQVVFYKKLHRVYFAHAIPKSPSGKILRKDLRAKLATASHNVPS
>vmacro13117-RA_Vaccinium_macrocarpon_Stevens_v1
MMEHQNHQRQDDHHPEFIFRSKLPDIYIPKHLPLHTYCFENISQFSSKPCIINGATGETHTYADVELTARRVASGLHKIGIHQGDVIMLLLHNSPEFVFAFLGASYAGATATTANPFYTTAEIEKQARAAKAKLIITQACYAEKVTEFGRENGVKVMCTDKDVEGCFHFSELTGADERELPAVKISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVIVCLLPLFHIYSLNSVLLCGLRVGATILIMQKFEINALLELVHKYKVTIAPFVPPIVLAIAKSPVVDNYDLSSIRMVMSGAAPMGKELEDKVRDKLPNAALGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGHSLPHNQAGEICIRGDQIMKVCTQ
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University