Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Vaccinium macrocarpon
Species name
American cranberry (Vaccinium macrocarpon) is a species of eudicot in the family Ericaceae (heath family).
Species info
Gene sequence info
Vaccinium_macrocarpon.C4H.fa
Download
>vmacro06326-RA_Vaccinium_macrocarpon_Stevens_v1
MDLLLLEKALLGLFIAIVLAITISKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKYGEILLLRMGQRNLVVVSSPDLSKEVLHTQGVEFGSRTRNVVFDIFTGEGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAGQVVEDVKKNPEAATNGIVLRRRLQMMMYNNMYRIMFDRRFESEDDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLQLFKDNFVDERKKLASTKRMDNNSLKCAMDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPRIQTKLRHELDTVLGPGTQITEPDVQKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPETWKKPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQSKLDTSEKGGQFSLHILKHSTIVLKPRSF
>vmacro14642-RA_Vaccinium_macrocarpon_Stevens_v1
MDLLLLEKALLGLFIAIVLAITISKLRGKRFKLPPGPIPVPIFGNWLQVGDDLNHRNLTDLAKKYGEILLLRMGQRNLVVVSSPDLSKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAGRVVEDVRKNPEAATNGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICREVKERRLQLFKDYFVDERKKLASTKRMDNNSLKCAMDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQKKLRHELDTVLGPGTQITEPDVQKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGSYDIPAESKILVNAWWLANNPETWKKPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQSKLDTSEKGGQFSLHILKHSTIVLKPRSF
>vmacro02872-RA_Vaccinium_macrocarpon_Stevens_v1
MDLLLLEKTLVALFFTTLVAITVSKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGQILLLRMGQRNLVVVSSPNLAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAGRVVEDVRRNKEAATDGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPVLRPFLRGYLKVCKDVKERRLQLFKDYFVDERKKLGSRKSVDNNTSLKCAMDHILEAQEKGEINEDNVLYIVENINVAAIETTLWSIEWGVAELVNHPRIQNKLRNELDTALGSGVQVTEPDIEKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDNWKNPEDFRPERFFEEESNVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPTGQSKIDTAEKAGQFSLHIMKHSTIVLKPRSF
MDLLLLEKALLGLFIAIVLAITISKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKYGEILLLRMGQRNLVVVSSPDLSKEVLHTQGVEFGSRTRNVVFDIFTGEGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAGQVVEDVKKNPEAATNGIVLRRRLQMMMYNNMYRIMFDRRFESEDDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLQLFKDNFVDERKKLASTKRMDNNSLKCAMDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPRIQTKLRHELDTVLGPGTQITEPDVQKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPETWKKPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQSKLDTSEKGGQFSLHILKHSTIVLKPRSF
>vmacro14642-RA_Vaccinium_macrocarpon_Stevens_v1
MDLLLLEKALLGLFIAIVLAITISKLRGKRFKLPPGPIPVPIFGNWLQVGDDLNHRNLTDLAKKYGEILLLRMGQRNLVVVSSPDLSKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRTGWEDEAGRVVEDVRKNPEAATNGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICREVKERRLQLFKDYFVDERKKLASTKRMDNNSLKCAMDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQKKLRHELDTVLGPGTQITEPDVQKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGSYDIPAESKILVNAWWLANNPETWKKPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQSKLDTSEKGGQFSLHILKHSTIVLKPRSF
>vmacro02872-RA_Vaccinium_macrocarpon_Stevens_v1
MDLLLLEKTLVALFFTTLVAITVSKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGQILLLRMGQRNLVVVSSPNLAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAGRVVEDVRRNKEAATDGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPVLRPFLRGYLKVCKDVKERRLQLFKDYFVDERKKLGSRKSVDNNTSLKCAMDHILEAQEKGEINEDNVLYIVENINVAAIETTLWSIEWGVAELVNHPRIQNKLRNELDTALGSGVQVTEPDIEKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPDNWKNPEDFRPERFFEEESNVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPTGQSKIDTAEKAGQFSLHIMKHSTIVLKPRSF
Sheng jun & Dong yang Teams, Yunnan agriculture University