Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Trochodendron aralioides
Species name
Trochodendron aralioides is a species of flowering plant in the family Trochodendraceae.
Species info
Gene sequence info
Trochodendron_aralioides.DFR.fa
Download
>evm.model.group0.3730
MEKSSKVCVTGGAGYLGSWLVKKLLERGHVVHATLRNLDDESKVGLLKSLPDADTRLLLFEADIYNPDEFERAIEGCEFVFHVATPKQHNNQSSQAYTSEAAVAGVKSIVGSCIRSGIVKRLIYTASVMAASPLKEDGTGFKDYIDESCWTPLNLSFPYSNDFSMGYIRSKTLAEKEVLSYKNNGNGGLEVVTLACGLVGGDTILHYLALSVEALLSQLTGSVSNYNNLCLLQEELGSVPLVHIDDVCEAHIFCIEKSSVQGRFLCATTYPTIAEIGNYYRDNYPEHGVAKEFVEGPGRGIKGSSRKLLDMGFEYKYDMKKILDGSVECARRLGVLK
>evm.model.group1.4717
MEENAVEETNFSRKLIHAIVGAIQTTHLSYAVPLFDAAGRFKDVDETLKIVSFSSKKLTDFGFQFKYSLENMFEGAIKSCKVKGLIPSPVKIMP
>evm.model.group3.1481
MERREQSGVGSKRDGTLTFCVTGATGFVGSWLVKSLLHRGYMVLATVRDPEKASRLLSIWRGDNRLKVFRADLQEDGSFDDAVKGCNGVFHVAASMEFSVLTESNIESYVQLNILDPAIKGTLNLLKACSRSKSVKRVVYTSSISTISAKDNTEKWRTMVDESCQVHADHVWSTKASGWVYVLSKLQSEEAAFRFANDNQIDLVSIIPTTVAGPFLTSNVPASVRVLLSPITGDPEFYPILSAVNSRLGSISLVHIEDICNAHIFLMEQAAAKGRYICSAHSCVMSELENHLALEYPLNMERFCEEQNGSVTSEISSKKLRDLGFEYKYGLEEIIQQTVDSCVQHGFLDPSGGNGGFP
>evm.model.group4.2194
MGSEAETVCVTGAAGFIGSWLVMRLLEQGYVVKATVRDPENMKKVKHLIELPNAKERLTLWKADLADEGSFDQAIQGCTGVFHVATPMDFESKDPEID
>evm.model.group11.1181
MGSEAVTVCVTGAAGFIGSWLVMRLLERGYIVKATVRDPENKKKVNHLLELRNAKERLTLWKADLSDHGSFDEAIQGCSGVFHVATPMDFDSKDPENEVIKPTINGMLSIMRSCAKAKTVRRLVFTSSAGTVCVEEERQPEYNESSWSDVDFCRVKKMTGWFKYSLEDMFEGAIKTCREKGLLPLSHSSENCANGKS
>evm.model.group14.1512
MKSFEASVQIRIRVNILVYERRDVFRVKNVAEQAAWEFTKENNIDIIIPMLVMGPFIMFGMPPSMITSLALITASQGRWKMIYSSHDTSIIELSKMLRERYPDYNIPTRFKEIDNSIKRVHFSSKKLTGLGFQYTKEDMYDGAICSCDEKKLIPIKSEEKPCDEERINGVEEKISVAIEKKLPVAVAEENPH
>evm.model.group15.1451
MEKNSNCKVCVTGGASYLGSSLVKKLLENGYTVHATLRNLGLSLSLILFAMVVTADDPLKVGLLKCLPDAETRLRLFAADIYKAEAFKPAIEGCHFVFHMATPLQHNTNSSQFKDTCEAAVAGVKSIVVSCIRSGTVKRLIYTAFVVAASPLIEDGTSFKETMDESCWTTLNLSAPYCTESLMAYAHSKTLAEKEVLSYCEKDNGGLEVVSLACGLVGGDTLVSCIPESMGVLIS
>evm.model.contig611.2
MGSEAVTVCVTGAAGFIGSWLVMRLLKQGYIVKATVRDPENKKKVNHLLELQNTKERLTLWKADLLDDGSFDEAIQDCSGVFHVATPMDFESKDPENEVIKPTINGMLSIMRSCAKAKTVRRLVFTSSAGTVCVEEERQPEYNESSWSDVDFCRVKKMTGWMYFVSKTLAEKAAWEFAKEKNIDLISIIPTLVVGPFIMPSMPPSLITALAPITGNEAHYSILKQCQYVHLDDLCIAHIYLFEHPDAKGRYICSSHNASILGLSKMLREKFPEYNVPTKPKFGADSNPLLIIYSIIFLLLEFRSGKHRYKDVDETLKIVSFSSKKLTDMGFQFKYSLEDMFEGAIKTCREKGLLPLSHSSENCANGKS
>evm.model.contig836.8
MEKNSNCKVCVTGGASYLGSSLVKKLLENGYTVHATLRNFGLSLSSCSLSLSLSLILFAMVVTADDPLKVGLLKSLPDAETRLRLFAADIYKADEFKPAIEGCHFVFHMATPLQHNTNSSQRSLDEAGYPTLQRQHGKMSDSKVSPPETALLSSIADKEDQE
MEKSSKVCVTGGAGYLGSWLVKKLLERGHVVHATLRNLDDESKVGLLKSLPDADTRLLLFEADIYNPDEFERAIEGCEFVFHVATPKQHNNQSSQAYTSEAAVAGVKSIVGSCIRSGIVKRLIYTASVMAASPLKEDGTGFKDYIDESCWTPLNLSFPYSNDFSMGYIRSKTLAEKEVLSYKNNGNGGLEVVTLACGLVGGDTILHYLALSVEALLSQLTGSVSNYNNLCLLQEELGSVPLVHIDDVCEAHIFCIEKSSVQGRFLCATTYPTIAEIGNYYRDNYPEHGVAKEFVEGPGRGIKGSSRKLLDMGFEYKYDMKKILDGSVECARRLGVLK
>evm.model.group1.4717
MEENAVEETNFSRKLIHAIVGAIQTTHLSYAVPLFDAAGRFKDVDETLKIVSFSSKKLTDFGFQFKYSLENMFEGAIKSCKVKGLIPSPVKIMP
>evm.model.group3.1481
MERREQSGVGSKRDGTLTFCVTGATGFVGSWLVKSLLHRGYMVLATVRDPEKASRLLSIWRGDNRLKVFRADLQEDGSFDDAVKGCNGVFHVAASMEFSVLTESNIESYVQLNILDPAIKGTLNLLKACSRSKSVKRVVYTSSISTISAKDNTEKWRTMVDESCQVHADHVWSTKASGWVYVLSKLQSEEAAFRFANDNQIDLVSIIPTTVAGPFLTSNVPASVRVLLSPITGDPEFYPILSAVNSRLGSISLVHIEDICNAHIFLMEQAAAKGRYICSAHSCVMSELENHLALEYPLNMERFCEEQNGSVTSEISSKKLRDLGFEYKYGLEEIIQQTVDSCVQHGFLDPSGGNGGFP
>evm.model.group4.2194
MGSEAETVCVTGAAGFIGSWLVMRLLEQGYVVKATVRDPENMKKVKHLIELPNAKERLTLWKADLADEGSFDQAIQGCTGVFHVATPMDFESKDPEID
>evm.model.group11.1181
MGSEAVTVCVTGAAGFIGSWLVMRLLERGYIVKATVRDPENKKKVNHLLELRNAKERLTLWKADLSDHGSFDEAIQGCSGVFHVATPMDFDSKDPENEVIKPTINGMLSIMRSCAKAKTVRRLVFTSSAGTVCVEEERQPEYNESSWSDVDFCRVKKMTGWFKYSLEDMFEGAIKTCREKGLLPLSHSSENCANGKS
>evm.model.group14.1512
MKSFEASVQIRIRVNILVYERRDVFRVKNVAEQAAWEFTKENNIDIIIPMLVMGPFIMFGMPPSMITSLALITASQGRWKMIYSSHDTSIIELSKMLRERYPDYNIPTRFKEIDNSIKRVHFSSKKLTGLGFQYTKEDMYDGAICSCDEKKLIPIKSEEKPCDEERINGVEEKISVAIEKKLPVAVAEENPH
>evm.model.group15.1451
MEKNSNCKVCVTGGASYLGSSLVKKLLENGYTVHATLRNLGLSLSLILFAMVVTADDPLKVGLLKCLPDAETRLRLFAADIYKAEAFKPAIEGCHFVFHMATPLQHNTNSSQFKDTCEAAVAGVKSIVVSCIRSGTVKRLIYTAFVVAASPLIEDGTSFKETMDESCWTTLNLSAPYCTESLMAYAHSKTLAEKEVLSYCEKDNGGLEVVSLACGLVGGDTLVSCIPESMGVLIS
>evm.model.contig611.2
MGSEAVTVCVTGAAGFIGSWLVMRLLKQGYIVKATVRDPENKKKVNHLLELQNTKERLTLWKADLLDDGSFDEAIQDCSGVFHVATPMDFESKDPENEVIKPTINGMLSIMRSCAKAKTVRRLVFTSSAGTVCVEEERQPEYNESSWSDVDFCRVKKMTGWMYFVSKTLAEKAAWEFAKEKNIDLISIIPTLVVGPFIMPSMPPSLITALAPITGNEAHYSILKQCQYVHLDDLCIAHIYLFEHPDAKGRYICSSHNASILGLSKMLREKFPEYNVPTKPKFGADSNPLLIIYSIIFLLLEFRSGKHRYKDVDETLKIVSFSSKKLTDMGFQFKYSLEDMFEGAIKTCREKGLLPLSHSSENCANGKS
>evm.model.contig836.8
MEKNSNCKVCVTGGASYLGSSLVKKLLENGYTVHATLRNFGLSLSSCSLSLSLSLILFAMVVTADDPLKVGLLKSLPDAETRLRLFAADIYKADEFKPAIEGCHFVFHMATPLQHNTNSSQRSLDEAGYPTLQRQHGKMSDSKVSPPETALLSSIADKEDQE
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University