Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product

Species information
Tripterygium wilfordii
Species name
Tripterygium wilfordii is a species of eudicot in the family Celastraceae (bittersweet family).
Species info

Gene sequence info
Tripterygium_wilfordii.DFR.fa
Download
>rna-XM_038841509.1
MGGEAETVCVTGAAGFIGSWLVMRLLEAGYTVRATVRDPDNMKKVKHLLELTNAKTHLSLWKADLAVEGSFDEAIRGCTGVFHVATPMDFESKDPENEVIKPTINGVISIMKACAEAKTVRRLVFTSSAGTVDVREQQQSEYDESCWSDLEFVRSVKMTGWMYFVSKTLAEQAAWKYAKENNIDFISIIPTLVVGPFLMPSMPPSLITALSPITGNESHYHIIKQGQFVHLDDLCNAHIFLFENPKAEGRYICSSHEATILELAKMLKHKYPEYNIPTKFKDVDENVKNIVFSSKKLRDLGFQFKYSLQDMFTDAIEACRAKGLLLPLSNVDSAADKNCVHGTS
>rna-XM_038859368.1
MGTVVAPQTQTVCVTGAAGYIGSWLVMKLLERDYVVRATVRDPENMKKVKHLLDLPKAKTNLTLWRADLAVDGSFDEAIQGCNGVFHVATPMDFESKDPENEVIKPTIDGVISIMKACVKAKTVRRLVFTSSAGTVNVEEKQRPVYDENCWSDLEFVRAIKMTGWMYFVSKTLAEQAAWKFAEENKLDFISIIPTLVVGPFIMPSMPPSLITALSLLTGNEAHYSIIKQGQFVHLDDLCESHIYLFEHPQAKGRYICSSHEATIVELAKLLSEKYPEYNIPKKFKDVDENLKRIVFSSKKLTDAGFQFKYSLEDMFVEAIETCQAKGLLPSP
>rna-XM_038863337.1
MGGEGETVCVTGAAGFIGSWLVMRLLETGYVVRATVRDPENMKKVKHLLDLPNAKTHLSLWKADLAVEGSFDEAIRGCTGVFHVATPMDFESKDPENEVIKPTINGVLSIMKACAEAKTVRRLVFTSSAGTVDVGEQQQSEYDESCWSDLEFVKSVKMTGWMYFVSKTLAEQAAWKYAKENNIDFISIIPTLVVGPFLMPSMPPSLITGLSPITGNESHYHIIKQGQFVHLDDLCNAHIFLFENPKAEGRYICSSHEATILELAKMLKNKYPEYNVPTQFKDVDENVKNIVFSSKKLRDLGFQFKYSLEDMFTDAIEACRAKGLLPLSNVDPVADKNNVNETI
>rna-XM_038826587.1
MDEIYWTNIDFINANVQAGKSYVISKTSTEKASIEFAEETGLDLVTVVNPSLVVFSFFCPLSSAPVRMMLALVSE
>rna-XM_038835764.1
MQEMEVKGEVAPTYCVTGATGFVGSWLVKVLLERGYMVHATIRDPAKSLHLLSLWTGTDRLRLFQADLEQEGSFDEAVKGCHGVFHVAASMEFDIIHTEKVEDYVQSNIIDPGIKGTLNLLKSCLKSKSIKRVVFTSSISTMTAKDSNGDWRPVVDESCKTRVDHVWNMKASGWVYVLSKLLSEEAAFRFANENGIDLVSVITTTVAGPFLTPSVPSSIQVLFSPITGDCKFFSILSAVNTRMGSLALVHIEDICNAHIFLMENARAEGEYICCTGSCVMSELLDLLAQEYPSSNLQSIEGKFQASKPPEISSKKLRDLGFSYKYGIKEIIRHTVAACSDLGFLPPTRK
MGGEAETVCVTGAAGFIGSWLVMRLLEAGYTVRATVRDPDNMKKVKHLLELTNAKTHLSLWKADLAVEGSFDEAIRGCTGVFHVATPMDFESKDPENEVIKPTINGVISIMKACAEAKTVRRLVFTSSAGTVDVREQQQSEYDESCWSDLEFVRSVKMTGWMYFVSKTLAEQAAWKYAKENNIDFISIIPTLVVGPFLMPSMPPSLITALSPITGNESHYHIIKQGQFVHLDDLCNAHIFLFENPKAEGRYICSSHEATILELAKMLKHKYPEYNIPTKFKDVDENVKNIVFSSKKLRDLGFQFKYSLQDMFTDAIEACRAKGLLLPLSNVDSAADKNCVHGTS
>rna-XM_038859368.1
MGTVVAPQTQTVCVTGAAGYIGSWLVMKLLERDYVVRATVRDPENMKKVKHLLDLPKAKTNLTLWRADLAVDGSFDEAIQGCNGVFHVATPMDFESKDPENEVIKPTIDGVISIMKACVKAKTVRRLVFTSSAGTVNVEEKQRPVYDENCWSDLEFVRAIKMTGWMYFVSKTLAEQAAWKFAEENKLDFISIIPTLVVGPFIMPSMPPSLITALSLLTGNEAHYSIIKQGQFVHLDDLCESHIYLFEHPQAKGRYICSSHEATIVELAKLLSEKYPEYNIPKKFKDVDENLKRIVFSSKKLTDAGFQFKYSLEDMFVEAIETCQAKGLLPSP
>rna-XM_038863337.1
MGGEGETVCVTGAAGFIGSWLVMRLLETGYVVRATVRDPENMKKVKHLLDLPNAKTHLSLWKADLAVEGSFDEAIRGCTGVFHVATPMDFESKDPENEVIKPTINGVLSIMKACAEAKTVRRLVFTSSAGTVDVGEQQQSEYDESCWSDLEFVKSVKMTGWMYFVSKTLAEQAAWKYAKENNIDFISIIPTLVVGPFLMPSMPPSLITGLSPITGNESHYHIIKQGQFVHLDDLCNAHIFLFENPKAEGRYICSSHEATILELAKMLKNKYPEYNVPTQFKDVDENVKNIVFSSKKLRDLGFQFKYSLEDMFTDAIEACRAKGLLPLSNVDPVADKNNVNETI
>rna-XM_038826587.1
MDEIYWTNIDFINANVQAGKSYVISKTSTEKASIEFAEETGLDLVTVVNPSLVVFSFFCPLSSAPVRMMLALVSE
>rna-XM_038835764.1
MQEMEVKGEVAPTYCVTGATGFVGSWLVKVLLERGYMVHATIRDPAKSLHLLSLWTGTDRLRLFQADLEQEGSFDEAVKGCHGVFHVAASMEFDIIHTEKVEDYVQSNIIDPGIKGTLNLLKSCLKSKSIKRVVFTSSISTMTAKDSNGDWRPVVDESCKTRVDHVWNMKASGWVYVLSKLLSEEAAFRFANENGIDLVSVITTTVAGPFLTPSVPSSIQVLFSPITGDCKFFSILSAVNTRMGSLALVHIEDICNAHIFLMENARAEGEYICCTGSCVMSELLDLLAQEYPSSNLQSIEGKFQASKPPEISSKKLRDLGFSYKYGIKEIIRHTVAACSDLGFLPPTRK
Gene tree
Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University