Enzyme

A cytochrome P-450 (heme thiolate) protein found in plants. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.

IFS2

Enzyme

2-hydroxyisoflavanone synthase

Enzyme name

EC:1.14.14.87

Entry

Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Class

liquiritigenin, [reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating, aryl migration)

Sysname

(1) liquiritigenin + O2 + [reduced NADPH---hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R07777];(2) (2S)-naringenin + O2 + [reduced NADPH---hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R07778]

Reaction

2,4',7-trihydroxyisoflavanone [CPD:C15567];H2O [CPD:C00001];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];2,4',5,7-tetrahydroxyisoflavanone [CPD:C12631]

Product

Species information

Trifolium pratense

Species name

Peavine clover (Trifolium pratense) is a species of eudicot in the family Fabaceae (pea family).

Species info

Gene sequence info

Trifolium_pratense.IFS2.fa

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>Tp57577_TGAC_v2_mRNA35760.v2
SIHCRHSDFSRSYAMGNGSAEAMQWAMAELLNHPEAFHKVRNEIESVTQNVRLVEESDIPNLPYLQAVVKETLRLYPPGPVTTRECNQDCKINGFDIPAKTAVAINLYAIMRDPEIWEDPNEFHPERFLKEKDDQSSDYDYQNDDKRMEFNFVPFGAGRRGCPGTALAF
>Tp57577_TGAC_v2_mRNA8281.v2
MLVEIAIALLVIALFIHLRPKPTAKSKALRHLPNPPTPKPRLPFIGHLHLLNSPLPHHSLLHLAESYG
>Tp57577_TGAC_v2_mRNA21507.v2
DFFTAATDTTAISTEWALVELMNNPSLLQKAREEINKVVGKNKLVDESDSPNLPYLQAIVMEAYRLHPPVPMVARRCIKDCKIENYMIPKNSLIFVNTWSICRNPKYWDNPLKFDPERFLQNSTDSYIDVRGQNFSLLPFGSGARMCPGINLTMRLVPALLGAIIQCFDFHVLDSKGQIMKGGDIAIDVNERPGLTAPRAHDLVCIPVERIGYRGPLETLGC
>Tp57577_TGAC_v2_mRNA21082.v2
LQNQIMEHLLLAFTFFLSSLICYIIFRPMLSRHKNLPPSPFFKLPLIGHMHILSPHLHQSFDRLSRKYGPLFSVDFGSVPCVVASTPHFAKLILQTNEQSFNCRYESVAIKRLTYDASLAFSPYGDYWRFVKKLSMSELLSSRNINNFQQLRLQENHVILKLFANKAKSYETVNVTQEFLKVTNSVISKMMLGEAEEARDVIRDVTEMFGEFNVSDFIWLFKKLDIQGLGKRIEDLFVRFDTLVE
>Tp57577_TGAC_v2_mRNA14503.v2
MILQDIFIAGTDTSALTIEWALAELINNPHIMAKARQEINDVVGNNRIVEEQDIVNLPYLQAIVKETLRIHPTGPLIVRESSEKCTIQGYEIPAKTQLFINIWSIGRDPNYWDNPLEFKPERFTSEVGNLDVRGQHFHLIPFGSGRRGCPGTSLALHVVQTNLAAMIQCFEWKVNGSVDMEEKPGLTLSRAHPLICVPVPRLNPFPSM
>Tp57577_TGAC_v2_mRNA21645.v2
TMLLAGTDSSAVTLEWSMSNILNHPEVLKKLRDGLNTRVGQDRLVDESDLPKLTYLRNVINETFRLYTPAPLLVPHSTLDECFIEGYKIPRDTIVLINAWAIHRDPKTWSDATTFKPERFDKKGELEKMITFGMGRRACAGEALVMRAISMTLALLI
>Tp57577_TGAC_v2_mRNA28454.v2
LFISKLPHQSFHKLSTQYGPLMQILLGSKLCVVTSSPEIAKEFLKTNETYFSNHIINAAIVYLSYGLKGFLFAPYGNYWKFMKKMCMSKLLGGRTLDQLRPLRQQETLRFLRLLQKKGEACEVVDVGDELLTLTNNIITRMIMRKTCSDNDDDVEDIRKMVKDTTELTGKFNVSHFIWFCKNLDFQGMNKRLKGIMERFDTMMEKVIKEHQDEKKNRKEKGEGVAHVKDLLDILLEILEDESTEIKLSRENVKAFILDIFMAGTDTSAITMEWALAELINNPDVMDKARQEIDSIMLDKNRLIEESDIPNLPYLQAIVKETLRIHPTVPKLGRQSSESCLVYGYEIPANTNLFVNLWSMGRDPKLWENPHEFRPERFMNEDNKFDVRGRNFQFMPFGTGRRACPGASLALQVIPTNLANMIQCFEWKVGGDGVVNMEEKAAMTLPRAHPLICVPIPRFNSIPSSVN
>Tp57577_TGAC_v2_mRNA28451.v2
MALMVDYIQLFFLWLLSTIAIRAILTRKKNNNHLTPPSPPTLPIIGHLHLISKLPHKSFHKLSTQYGPLMQIYLGSMLCVVTSSPEIAKEFLKTNETYFSNRMITSAVEYLSYGSKGFLFAPYGDYWKFMKKMCMSELLGGRTLDQLRPLRQQETLRFLRLLQKKGEAREIVDVGDELLTLTNNIITRMIMRKTCSENDSDVEDIRKMVKDTAELAGKFNVSDFIWFCKSLDFQGMNKRLKGIIDKFDTMMERVIKEHEEEKKKRKENGEGVAHVKNLLDILLEILEDESTEIKLSRENVKAFILDIFMAGTDTSAITIEWCLAELINNPDVMDKARQEIDSIMLDMNRLIEESDIPNLPYLQAIVKETLRIHPTAPMLGRQSSESCLVYGYEIPANTNLFVNLWSMGRDPKLWENPLEFRPEXXXXXXXXXXXXXXXXXXXXCKGTKFSIYAIWNW
>Tp57577_TGAC_v2_mRNA1064.v2
MISNSFLLATNVLLILFLLQLFSYFKRNKKSHLPPHPPSPPSIPIIGHLHLLKPLIHHAFRDLSDQYGDLISLRLGSARFIVVNTPTLAKEVLKTHELAYSHRKMNIAINMVVYNDATFAFAPYGSYWKFIKKIATTELLGNRTIGQFQPIRTQELHQFIQTLAYKSKAEERVNLTQALIKLSNNIISRMMLSIETSGTDSQAEQARALVREVTQIFGEFNISDFIGIFKNFDLQGFKKRALDIHKRYDALLEKIISDREVLRKKTKIIEGGCENGEERLKDFLDMLLDVSEEKDREVNFTRNHIKSLILVHFKKVYIEYITYNIFSINYYSHIFQDYFTAATDTTAISVEWTISELFNNPKVLKKAQEEVERVIGKERLVSEEDFPNLPYIHAIIKETMRLHPPIPMIMRKGMEDCVVNGNTIPKGSLVCVNIWAMGRDEKIWENPLEFRPERFLEKNEGSNIDMKGHHFELLPFGSGRRGCPGMPLAMRQLPTVIGTLIQCFEWKMLDSNCKILDHGKKIDMDERPGLTAPRANDLICIPVARLNPIPLLQLQ
>Tp57577_TGAC_v2_mRNA15433.v2
MLLEIAVALLVIALFIYLRPTPTAKSKALRHLPNPPSPKPRLPFIGHLHLLDHPLLHISLIRLGERYGPLYSLYFGSMPTVVASTPDLFKLFLQTHEATSFNTRFQTSAIRRLTYDNSVAMVPFGPYWKFVRKLIMNDLLNATTVNKLRPLRSKEIRKVLNVMANSAETQQPLNITVELLKWTNSTISTMMLGEAEEVRDIARDVLKIFGEYSVTDFIGPLKIFKKFGNYEQRIDAIFNKYDPIIERVIKKRQGIVNKRKNGEVLVGEEENVVFLDTLLEFAQDETMEIKITKEQIKGLVVDFFSAGTDSTAVATEWTLAELINNPRVLKKAREEVESVVGKDRLVDESDIQNLPYIRAMVKEVFRLHPPLPVVKRKCTEECEINGYVIPEGALILFNVWQVGRDPKYWEKPLEFRPERFLENAGVGEGEASSIDLRGQHFTLLPFGSGRRMCPGVNLATAGMATLLSSIIQCFDLQVPGPNGQILKGSDAKVTMDERPGLSVPRAQNLVCVPLARAGAAKLLSS
>Tp57577_TGAC_v2_mRNA15442.v2
MLVEIAIALLVIALFIDLRPKPTAKSKALRHLPNPPTPKPRLPFIGHLHLLNSPLLHHSLLHLAESYGPLFSLYFGSMPTVVASTPELFKLFLQTHEAISFNTRFQTSAIKRLTYDNSVAMAPFGPYWKFIRKLIMNDLLNATTINKLRPLRSKEIRKFLMVMANNAETQQPLNVTEELLRWTNSTISTMMLGETEEVRNIARDVLEIFGEYSVTDFIWPMQIFKKFGDYEQRIDAIFNKYDPIIERVIKKRQGIVNKRKNGEVLVGEEEM
>Tp57577_TGAC_v2_mRNA15423.v2
MLLEVAVALLVIALFIHLRPTPTAKSKALRHLPNPPSPKPRLPFIGHLHLLDNPLLHHSLIRLGERYGPLYSLYFGSMPTVVASTPDLFKLFLQTHEASSFNTRFQTSAIRRLTYDNSVAMSAETQEPLNVTEELLKWTNSTISTMMLGEAEEVRDIARDVLKIFGEYSITDFIGPLKIFKKFGSYEQRIDAIFNKYDPIIEKVIKKRQEIVNKRRSGEIKEGEENVVFLDTLLEIAQDETMEIKITKEQIKGLVVDFFSAGTDSTAVATEWTLAELINNPRVLNKAREEVESVVGKDRLVEESDVQNLPYIRAIVKEAFRLHPPLPVVKRKCTEECEINGYVIPEGALILFNVWQVGRDPKYWEKPLEFRPERFLENSSEGEAASIDLRGQHFQLLPFGSGRRMCPGANLATAGMATLLASIIQCFDLQVPGAHGQILKGDDAKVSMEERPGLTVPRAHNLICVPLARAAKLISS
>Tp57577_TGAC_v2_mRNA26503.v2
MFTGGTDTTAVTLEWSLAELINHPTIVEKARKEIDSMIRKDRIVIESDISYLPYLQAIVKETLRLHPPSPFILRESTENCTISGYDIPTKTQIFTNIWAIGRDPKNWDNPLEFMPERFLISDENGNESPVVDVRGQNYELMPFGSGRRMCPGTSLALNVAHTTLANMIHCFEWKIEDGGNVCVDMNEGPSFILSRAQPLICFPTPRLLPFPSE
>Tp57577_TGAC_v2_mRNA8873.v2
LVQDMLIGGSDSSSLTMEWAFSELLKNPKALKRAQEEVRQAFGSRGYVDEMDLQELKFLKAVIKETLRLHPINPIYSRECIETCEINGYTIPAGTQVFVNAWAIGRDQKYWNEGEKFYPERFLDCPIDYKGSDFEFLPFGAGRRMCPGISFAMPNIELALAQLLYYFDWEFPFGTSHESFDMSEAVGAVVKRKSELTVIPTPYNP
>Tp57577_TGAC_v2_mRNA16127.v2
MGYMQCFIILDLNLCMQDMFLAGTDTSSTTIDWALAELINNSHVMEKARQEIDSLTRKSRLIQESDLPNLPYLRAILKETPRLHPTIPLMVRESSKSCNISGFEIPAKTILYVNFWSMGRSPKLWENPLEFKPERFVNEENKFDVRGQNFQFIPFGTGIRVCTGTSLALQVVPTNLAIDSMF
>Tp57577_TGAC_v2_mRNA16136.v2
LPYLSLDTFNFYPSYQFTKIFTNLSIQYGPIMKLFLGYVPCVVISSPEITKEFLKTHETSFSNRLINHVVHYLSYGSEDFMFAPYGDYWKFMKKLCMSELLGGRKNS
>Tp57577_TGAC_v2_mRNA10060.v2
LKMTYMQCFIILDFKLCLQDMFLAGTDTSSTTIDWALAELINNSHVMEKVRQEIDSLTRKSRLIQESDLPNLPYLRAILKETLRLHPTIPLMVRESSKSCNVSGFEIPAKTILYVNFWSMGRNPKLWENPLEFKPERFMSEENKFDVRGQNFQFIPFGTGIRFCTGTSLALQVVPTNLAALIQCFEWKVGGNGKVNMEEKPSTILRRAHPLMCVPIPRFNLFSFDE

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University