Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Trema orientalis
Species name
Trema orientale is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Trema_orientalis.COMT.fa
Download
>rna-gnl|WGS:JXTC|TorRG33x02_013030.1
MGSTAMAPTSEEEACLNAMQLSSAWVLPIVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSLLTYSLRDLPDGKVEWLYGLSPVSKFFLNNEDDYTFAPHCLLGLDKVVIESWHQLKDTVLEGGIPFKRAYGMSIFEYQATDPRFGKVWDMAMRTHSTITMKKMLETYKGFEGLNSVVDVGGGSGAIISVIVSTYPSVKGINYDLPHIVKAAPQYPGVEHVGGDMFASVPKADAVFMKAILHNWSDERCLTLLKNCYAALPENGKVIAADCIVPVSLDSSSITKGVVHTDIIMLAQTPSGKERTEKEFEALAKGAGFRGFQVICRVLNTYIMEFLKN
>rna-gnl|WGS:JXTC|TorRG33x02_026030.1
MGDETSQSRNQARLRILELANMISVPMSLNAVARLNVPDAIWQGGSNSPLSASQILTRVLPSGGGDAENLQRVLRMLTSYGVFEEHLSSGAASDERKYSLTDVGKTLVTDPDGLSYAPYVLQHHQDALVSAWPLVHEAVVDPTTEPFARANGEPAYDYYGKKPEMNGLMQKAMSGVSVPFMRAILEGYDGFEGVKTLVDVGGSAGDCLRMILRKHPNVLRGINFDLPEVVARAPRIPGVTHVGGDMFKSIPEADAIFMKWVLTTWTDDECKTIMENSFKALPEGGKLIACEPVLPNESDDSHRTRALLEGDIFVMTIYRAKGKHRTEEEFRELGLSAGFPHFRAIYIDYFYTVLEFQK
>rna-gnl|WGS:JXTC|TorRG33x02_040210.1
MDSQETLAQSSLSTKEDEACLNAMIFTNSQVLPLVLNAAIELDLFGIIAKAGPDAQLSPSEIASQLPFTQNSNANPSLLDRMLRLFASHSLLTCSTSTSEDGEIQRLYGLTPTSEFFVCNRNPNESSLASLVALHCHAAPLKDNILDGRTSSQFERVHGMPVYKYMDSNPSFSNIFHDAMVNRSTIIMKKVLNVYKGFEGLSSLVDVGGGTGHCLNMIISQYPSILGTNLDLPHVTENAPSYAGIKHVPGDMFSSIPKADQAIMIKEILHNWSDEHCRKLVKNCYEALPQDGKLIVIEIIMPEKPDSSMVSKFISELDNTMLTQPGGRERTRREFQALCYESGFSSFSIACFALSVWAVMEFQK
>rna-gnl|WGS:JXTC|TorRG33x02_069510.1
MASSLELENGGPPKVVLDESDERKEVEESFSYAAQLVNSAVLSMSLQSTIELGVFDIIAKAGEGAKLSASEIVAQMPSNNPDAPRMLDRILRMLASHSVLTCSVVADDQRVYGLNDVTKLFVTNEDGVSLGPLVSLLQDKVFLDSWSELKGAILEGGIPFNRVYGMHAFEYPVLDSRFNQVFNKAMYNQTTLVIKKILEVYKGFEDLKQLVDVGGGLGVTLSQITSKYPHIKGINFDLPHVIEHAPSYPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCLKLLKNCYKAIPENGKIIVMEAILPTVPETTSGDKAISEMDVLMMTQNPGGKERNEKEFLALATGAGFSGIRFECFVCNFWIMELYK
>rna-gnl|WGS:JXTC|TorRG33x02_069500.1
MVIVVEAILPAMPETTCADKSTSQLDVLMLTQNPGGKERSQQVFLALANSSGFSGIPFESFLCNFKMEFFKWMAYGILLK
>rna-gnl|WGS:JXTC|TorRG33x02_069490.1
MAPSRELDNQHSKLVESKTVEEEEEESFCYAVQLVMSSVLPMSLHAAVELGVFEIIAKAGDGAKLSPDEIAAQMAANNNPDAAVMLDRVLRLLASHSVLACSVINANDHDGRSFRRVYSLAPVSKYFVTNEDGVSLRPFMALIQDKMHVYYCTRQYCCTEYYLIRSQLKDAILEGGLPFNRAHGIHAFKYTELNPKFNQLYNTAMYNVTTIVVKKILESYKGFEHLTHLVDVGGNLGITLNLIISKYPHIKAINFDLPQVIEHAPSYPGVEHVGGDMFENVPTGDAILLKSILHDWSDEPCLKILNNCYKAIPENGKVIVVEEILPVKPETKTSVKSTSQTDVLMMTKNPGGKERSQEEYLALATAAGFTGVKFESCGCNFWVLEFFK
>rna-gnl|WGS:JXTC|TorRG33x02_204940.1
MLAIYRYHLKDAILEGGIPFNRAYGMTAFEYHGTDLRFNKIFNRGMSDHSTITMKKILETYKGFEGLNTVVDVGGGTGAVLSMIVAKYPSIKGINFDLPHVIHDAPPYPGVEHVGGDMFESVPKGDAIFMKWICHDWSDEHCSKFLKNCYDALPENGKVILAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFQVHCNAFNTYVIELLKKP
>rna-gnl|WGS:JXTC|TorRG33x02_204950.1
MGSTGSETQITPTQVSDEEANLFAMQLASASVLPMVLKTAIELDLLEIIAKAGPGAYLSPSDIASQLPTTNPDAPVMLDRILRLLASYSILTYSLRELPHGKVERLYGLASVSKYLIKNEDGVSIAPLCLMNQDKVLMESW
>rna-gnl|WGS:JXTC|TorRG33x02_282630.1
MIISMYPSIKGFNFDLATILDKSPCHPGIEHCSGDMFASIPKGDAIFMKPIPDHGKVIVVDMVILEAPETSLAARSLFQFDLFMMNTNITGKERTAREFEGLAKEAGFSQIYLACSAYNFSVVELFKRA
>rna-gnl|WGS:JXTC|TorRG33x02_294370.1
MASDSAILHSVVKDYKHVFEGLNSLVDVGGGTGKTSRIITEAFPHLQCTVLPHMVANLPETENLKFVGGDMFRHITPADSVLLEL
>rna-gnl|WGS:JXTC|TorRG33x02_341160.1
MASTAMAPTSEEEACLNAMQLSSAWVLPMVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSLLTYSLRDLPDGKVESLYGLSPVSKFFLNNEHDCTFAPQCLLVLDKVVIESWHQLKDTVLEGGVPFKRAYGMSIFEYQATDPRFGKVWDRAMRTHSTITMKRMLEIYKGFEGLNSVVDVGGGSGASISVIISTYPSIKGINYDLPHIVKAAPQYPGVEHVGGDMFASVPKADAVFMKAILHNWSDERCLTLLKNCYAALPENGKVIAADCIVPVSLDSSSITKGVVHSDIIMLAQTPSGKERTEEEFEALVKGAGFRGFQVICRVLNTYVMEFLKN
MGSTAMAPTSEEEACLNAMQLSSAWVLPIVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSLLTYSLRDLPDGKVEWLYGLSPVSKFFLNNEDDYTFAPHCLLGLDKVVIESWHQLKDTVLEGGIPFKRAYGMSIFEYQATDPRFGKVWDMAMRTHSTITMKKMLETYKGFEGLNSVVDVGGGSGAIISVIVSTYPSVKGINYDLPHIVKAAPQYPGVEHVGGDMFASVPKADAVFMKAILHNWSDERCLTLLKNCYAALPENGKVIAADCIVPVSLDSSSITKGVVHTDIIMLAQTPSGKERTEKEFEALAKGAGFRGFQVICRVLNTYIMEFLKN
>rna-gnl|WGS:JXTC|TorRG33x02_026030.1
MGDETSQSRNQARLRILELANMISVPMSLNAVARLNVPDAIWQGGSNSPLSASQILTRVLPSGGGDAENLQRVLRMLTSYGVFEEHLSSGAASDERKYSLTDVGKTLVTDPDGLSYAPYVLQHHQDALVSAWPLVHEAVVDPTTEPFARANGEPAYDYYGKKPEMNGLMQKAMSGVSVPFMRAILEGYDGFEGVKTLVDVGGSAGDCLRMILRKHPNVLRGINFDLPEVVARAPRIPGVTHVGGDMFKSIPEADAIFMKWVLTTWTDDECKTIMENSFKALPEGGKLIACEPVLPNESDDSHRTRALLEGDIFVMTIYRAKGKHRTEEEFRELGLSAGFPHFRAIYIDYFYTVLEFQK
>rna-gnl|WGS:JXTC|TorRG33x02_040210.1
MDSQETLAQSSLSTKEDEACLNAMIFTNSQVLPLVLNAAIELDLFGIIAKAGPDAQLSPSEIASQLPFTQNSNANPSLLDRMLRLFASHSLLTCSTSTSEDGEIQRLYGLTPTSEFFVCNRNPNESSLASLVALHCHAAPLKDNILDGRTSSQFERVHGMPVYKYMDSNPSFSNIFHDAMVNRSTIIMKKVLNVYKGFEGLSSLVDVGGGTGHCLNMIISQYPSILGTNLDLPHVTENAPSYAGIKHVPGDMFSSIPKADQAIMIKEILHNWSDEHCRKLVKNCYEALPQDGKLIVIEIIMPEKPDSSMVSKFISELDNTMLTQPGGRERTRREFQALCYESGFSSFSIACFALSVWAVMEFQK
>rna-gnl|WGS:JXTC|TorRG33x02_069510.1
MASSLELENGGPPKVVLDESDERKEVEESFSYAAQLVNSAVLSMSLQSTIELGVFDIIAKAGEGAKLSASEIVAQMPSNNPDAPRMLDRILRMLASHSVLTCSVVADDQRVYGLNDVTKLFVTNEDGVSLGPLVSLLQDKVFLDSWSELKGAILEGGIPFNRVYGMHAFEYPVLDSRFNQVFNKAMYNQTTLVIKKILEVYKGFEDLKQLVDVGGGLGVTLSQITSKYPHIKGINFDLPHVIEHAPSYPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCLKLLKNCYKAIPENGKIIVMEAILPTVPETTSGDKAISEMDVLMMTQNPGGKERNEKEFLALATGAGFSGIRFECFVCNFWIMELYK
>rna-gnl|WGS:JXTC|TorRG33x02_069500.1
MVIVVEAILPAMPETTCADKSTSQLDVLMLTQNPGGKERSQQVFLALANSSGFSGIPFESFLCNFKMEFFKWMAYGILLK
>rna-gnl|WGS:JXTC|TorRG33x02_069490.1
MAPSRELDNQHSKLVESKTVEEEEEESFCYAVQLVMSSVLPMSLHAAVELGVFEIIAKAGDGAKLSPDEIAAQMAANNNPDAAVMLDRVLRLLASHSVLACSVINANDHDGRSFRRVYSLAPVSKYFVTNEDGVSLRPFMALIQDKMHVYYCTRQYCCTEYYLIRSQLKDAILEGGLPFNRAHGIHAFKYTELNPKFNQLYNTAMYNVTTIVVKKILESYKGFEHLTHLVDVGGNLGITLNLIISKYPHIKAINFDLPQVIEHAPSYPGVEHVGGDMFENVPTGDAILLKSILHDWSDEPCLKILNNCYKAIPENGKVIVVEEILPVKPETKTSVKSTSQTDVLMMTKNPGGKERSQEEYLALATAAGFTGVKFESCGCNFWVLEFFK
>rna-gnl|WGS:JXTC|TorRG33x02_204940.1
MLAIYRYHLKDAILEGGIPFNRAYGMTAFEYHGTDLRFNKIFNRGMSDHSTITMKKILETYKGFEGLNTVVDVGGGTGAVLSMIVAKYPSIKGINFDLPHVIHDAPPYPGVEHVGGDMFESVPKGDAIFMKWICHDWSDEHCSKFLKNCYDALPENGKVILAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFQVHCNAFNTYVIELLKKP
>rna-gnl|WGS:JXTC|TorRG33x02_204950.1
MGSTGSETQITPTQVSDEEANLFAMQLASASVLPMVLKTAIELDLLEIIAKAGPGAYLSPSDIASQLPTTNPDAPVMLDRILRLLASYSILTYSLRELPHGKVERLYGLASVSKYLIKNEDGVSIAPLCLMNQDKVLMESW
>rna-gnl|WGS:JXTC|TorRG33x02_282630.1
MIISMYPSIKGFNFDLATILDKSPCHPGIEHCSGDMFASIPKGDAIFMKPIPDHGKVIVVDMVILEAPETSLAARSLFQFDLFMMNTNITGKERTAREFEGLAKEAGFSQIYLACSAYNFSVVELFKRA
>rna-gnl|WGS:JXTC|TorRG33x02_294370.1
MASDSAILHSVVKDYKHVFEGLNSLVDVGGGTGKTSRIITEAFPHLQCTVLPHMVANLPETENLKFVGGDMFRHITPADSVLLEL
>rna-gnl|WGS:JXTC|TorRG33x02_341160.1
MASTAMAPTSEEEACLNAMQLSSAWVLPMVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSLLTYSLRDLPDGKVESLYGLSPVSKFFLNNEHDCTFAPQCLLVLDKVVIESWHQLKDTVLEGGVPFKRAYGMSIFEYQATDPRFGKVWDRAMRTHSTITMKRMLEIYKGFEGLNSVVDVGGGSGASISVIISTYPSIKGINYDLPHIVKAAPQYPGVEHVGGDMFASVPKADAVFMKAILHNWSDERCLTLLKNCYAALPENGKVIAADCIVPVSLDSSSITKGVVHSDIIMLAQTPSGKERTEEEFEALVKGAGFRGFQVICRVLNTYVMEFLKN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University