Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Trema orientalis
Species name
Trema orientale is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Trema_orientalis.C4H.fa
Download
>rna-gnl|WGS:JXTC|TorRG33x02_146090.1
MDLLLLEKALLALFFAATVAVAISRLRRKRFKLPPGPIPVPVFGNWLQVGDNLNHRVLAKLAKKYGDIFVLRMGQQNLVIVSSPELAKEVLKTQGVEFGSRTRSVVFDIFSGDGQDMTFAAYGDHWRKMRRIMTVPFFTSKVVPQYSRSWEEEAASMVEEFRKNPQASTNGIGVRIRLQLLMHNNIYRIMFDKTFEGENDPLFVNLHDLNIKRAVLAHSLAYNYGDFIPIFRPFLRGYLNICKETNEKRLQVFDFFIQERKNVIASSTIKRRDNQGLRFPGIDHILEAQEKGEINEENVRYIVENVNIGGIDTVTRSLEWAIAELANNPEVQKKLQLELDTVLERGLQITEPDTHKLPYLLAVIKETLRLRMALPLLVPHMNINDAKLDGYDIPAESRISVNAWWLANNPAHWKDPEQFRPDRFLEEESHVQVNGNDFRYIPFGVGRRSCPGIVMALPIFCITLGRLVQNFDILVPPGQSEIDTAERAGQFSLHILKPYKVVFKPRSI
>rna-gnl|WGS:JXTC|TorRG33x02_228600.1
MGHLGLKSIIFPILLTITLVSTLTTKLSILLVVPLVFHVLLRSISKRSSNNLPPGPLSLPIVGNWLQVGNDLNHRFLASLSQTYGSVFLLKLGSRNLTVVSDPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHLYSSMWEQEMDLVVDDLNRDERVRSEGIVIRRRLQLMLYNIMYRMMFDTKFESLEDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQSRRLAFFNNYFVNKRREIMAANGEKHKISCAIDHIIDAEKKGEISKENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQSKVREEIRAVLKGEPVTESNLNELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPRESKVVVNAWWLANNPAWWKKPEEFRPERFLEEEGSTEAVAGGKVDFRFLPFGVGRRSCPGIILALPILASVIAKLVSSFEMKAPKGVEKVDVSEKGGQFSLHLANHSTVVFHPIRA
>rna-gnl|WGS:JXTC|TorRG33x02_313490.1
MALVAYLGAGPKRSPQLASTNRIGSQRLQLLMHNNLYMIIFDKRGVLAQSLGYNYGDFIPILRPFLRGYLNINREACEKRLSTKLITNTNKSKNKEKLGFAGIGHILEAQQMGEITKDNVHYLIENMNVAAKNSHFIVDCTLAGAKAIIIKAPSLEWAIADVANHPEVQKRIQIELDTVLGPGIQITERDIQKLLYLQAVIEEVLKARHGGSSPGPSSEHKRRKDRIIRHPSREQDNDKYVVVGQQPDPLEEPGRVSTPEIRGGGVPCGGQRQ
>rna-gnl|WGS:JXTC|TorRG33x02_313560.1
MDLLLLMEKTLLALFFAAAIAVAISKLRRKLFKLPPGPITVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFQIGQRNIGVISSPELAKE
>rna-gnl|WGS:JXTC|TorRG33x02_313460.1
MDLLLLEKTLIALFVAVVLAIAIAKLRGRKFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRFGWEAEAASVVEDVKKNPESARNGIVLRRRLQLMMYNNMYRIMFDRRFDSEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLQLFKEYFVDERKKLGSTKSSTDHDGLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRQELDTVLGPGVQVTEPDMQKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPANWKKPEEFRPERFLQEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQSQIDTAEKGGQFSLHILKHSTIVLKPRSF
>rna-gnl|WGS:JXTC|TorRG33x02_315420.1
MDLLFLEKLLLSLFFSLLAAIAVSKLRGRRFKLPPGPLPVPVFGNWLQVGDDLNHRNLSDLARRFGEIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRIGWEDEITRVVDDVRADPGASGSGIVLRRRLQLMMYNNMYRIMFDRRFESEADPLFVRLKTLNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLKLFKDYFLEERKKVASTTRTDNNALKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQQKLRDELDTVLGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPAHWKNPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQQKLDTSEKGGQFSLHILKHSTIVAKPRVF
>rna-gnl|WGS:JXTC|TorRG33x02_349350.1
MAAPLLVPHTNANDAKVGPYDIPAGSRITVNAWWLANNPPHWKNPEVFRPERFLEEESHVNVSGNDFRYIPFGVGRRSCPGMMLTLPMLRITLGRLVQNFDLLLPPGQVKVDTSEDDEQFSLRLLNPLKIVFKPRSTL
>rna-gnl|WGS:JXTC|TorRG33x02_349360.1
MDAVARSMDWAIADLVNHREVQKKLQHELDAGLGPGTQITEPDIQKLPYLQAVIKEVLRLRMAAPLLIPHMNINDAKLWPYDIPAETKITVNAWWLANNPTHWTNPGEFRPERFLEEESHVEVNGNNYRYIPFGVGRRGCPGTMLAMPMFCITLGRSVQNFISSARSDRV
>rna-gnl|WGS:JXTC|TorRG33x02_351650.1
MDLLLMEKTLLALFFAAAIAVAISKLRRKRFKLPPGPIPVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFRIGQRNIGVISSPELAKEVLQTQGVDFSYRIRNAAFDIFTGNGQDLIFTDGDHWRKMRRVMTVPFFNNKAVQKYSRCWEEEAASMVEDIKKSYPQAMTTGICMRTRLKLLTHNNMFRMLFDKRFEGQNDPLFLDLQELNVKRDVLAQGHRYNYGDFNPILRPFLRGYLNTCKETCEKRLRIFDHFIQNRKKLITSTNDQEKLVFAGIDHILEAQQMGVINEDNVRYIVDNMNNAGIDTIVRSLEWAIVHLVNQPEVQRKLQHELDTVLGPGIQLTEPDTHKLPYLEAVLKE
>rna-gnl|WGS:JXTC|TorRG33x02_351640.1
MAAPLLVPHTNANDAKVGPYDIPAGSRITVNAWWLANNPPHWKNPEVFRPERFLEEEFHVNVNGNDFRYIPFGVGRRSCPGMMLTLPMLRITLGRLVQNFDLLLPPGQVKVDTSEDDEQFSLRLLNPLKIVFKPRSTL
>rna-gnl|WGS:JXTC|TorRG33x02_351620.1
MDLLLMEKTLLALFFAAAIAVTISKLRRKRFKLPPGPIPVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFQIGQRNIGVISSPELAKEVLQTQGVDFS
>rna-gnl|WGS:JXTC|TorRG33x02_351630.1
MRRVMTVPFFNNKAVQKYSRCWEEEAASMVEDIKKSYPQAMTTGICMRTRLKLLTHNNMFRMLFDKRFEGQNDPLFLDLQELNVKRDVLAQSHRYNHGDFNPILRPFLRGYLNTCKETCEKRLRIFDHFIQNRKKLITSTNDQEKLAFAGIDHILEAQQMGVINEDNVRYIVDNMNNAGTN
>rna-gnl|WGS:JXTC|TorRG33x02_354490.1
FPIRHANKTIYHYSQHLYAQTVLIVSQNFLVVTAIETTLWSIEWGIAELVNHPEIQRRLRQELDTVLGPGVQVTEPDMQKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPANWKKPEEFRPERFLQEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQSQIDTAEKGGQFSLHILKHSTIVLKPRSF
MDLLLLEKALLALFFAATVAVAISRLRRKRFKLPPGPIPVPVFGNWLQVGDNLNHRVLAKLAKKYGDIFVLRMGQQNLVIVSSPELAKEVLKTQGVEFGSRTRSVVFDIFSGDGQDMTFAAYGDHWRKMRRIMTVPFFTSKVVPQYSRSWEEEAASMVEEFRKNPQASTNGIGVRIRLQLLMHNNIYRIMFDKTFEGENDPLFVNLHDLNIKRAVLAHSLAYNYGDFIPIFRPFLRGYLNICKETNEKRLQVFDFFIQERKNVIASSTIKRRDNQGLRFPGIDHILEAQEKGEINEENVRYIVENVNIGGIDTVTRSLEWAIAELANNPEVQKKLQLELDTVLERGLQITEPDTHKLPYLLAVIKETLRLRMALPLLVPHMNINDAKLDGYDIPAESRISVNAWWLANNPAHWKDPEQFRPDRFLEEESHVQVNGNDFRYIPFGVGRRSCPGIVMALPIFCITLGRLVQNFDILVPPGQSEIDTAERAGQFSLHILKPYKVVFKPRSI
>rna-gnl|WGS:JXTC|TorRG33x02_228600.1
MGHLGLKSIIFPILLTITLVSTLTTKLSILLVVPLVFHVLLRSISKRSSNNLPPGPLSLPIVGNWLQVGNDLNHRFLASLSQTYGSVFLLKLGSRNLTVVSDPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHLYSSMWEQEMDLVVDDLNRDERVRSEGIVIRRRLQLMLYNIMYRMMFDTKFESLEDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQSRRLAFFNNYFVNKRREIMAANGEKHKISCAIDHIIDAEKKGEISKENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQSKVREEIRAVLKGEPVTESNLNELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPRESKVVVNAWWLANNPAWWKKPEEFRPERFLEEEGSTEAVAGGKVDFRFLPFGVGRRSCPGIILALPILASVIAKLVSSFEMKAPKGVEKVDVSEKGGQFSLHLANHSTVVFHPIRA
>rna-gnl|WGS:JXTC|TorRG33x02_313490.1
MALVAYLGAGPKRSPQLASTNRIGSQRLQLLMHNNLYMIIFDKRGVLAQSLGYNYGDFIPILRPFLRGYLNINREACEKRLSTKLITNTNKSKNKEKLGFAGIGHILEAQQMGEITKDNVHYLIENMNVAAKNSHFIVDCTLAGAKAIIIKAPSLEWAIADVANHPEVQKRIQIELDTVLGPGIQITERDIQKLLYLQAVIEEVLKARHGGSSPGPSSEHKRRKDRIIRHPSREQDNDKYVVVGQQPDPLEEPGRVSTPEIRGGGVPCGGQRQ
>rna-gnl|WGS:JXTC|TorRG33x02_313560.1
MDLLLLMEKTLLALFFAAAIAVAISKLRRKLFKLPPGPITVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFQIGQRNIGVISSPELAKE
>rna-gnl|WGS:JXTC|TorRG33x02_313460.1
MDLLLLEKTLIALFVAVVLAIAIAKLRGRKFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRFGWEAEAASVVEDVKKNPESARNGIVLRRRLQLMMYNNMYRIMFDRRFDSEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLQLFKEYFVDERKKLGSTKSSTDHDGLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRQELDTVLGPGVQVTEPDMQKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPANWKKPEEFRPERFLQEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQSQIDTAEKGGQFSLHILKHSTIVLKPRSF
>rna-gnl|WGS:JXTC|TorRG33x02_315420.1
MDLLFLEKLLLSLFFSLLAAIAVSKLRGRRFKLPPGPLPVPVFGNWLQVGDDLNHRNLSDLARRFGEIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRIGWEDEITRVVDDVRADPGASGSGIVLRRRLQLMMYNNMYRIMFDRRFESEADPLFVRLKTLNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLKLFKDYFLEERKKVASTTRTDNNALKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQQKLRDELDTVLGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPAHWKNPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQQKLDTSEKGGQFSLHILKHSTIVAKPRVF
>rna-gnl|WGS:JXTC|TorRG33x02_349350.1
MAAPLLVPHTNANDAKVGPYDIPAGSRITVNAWWLANNPPHWKNPEVFRPERFLEEESHVNVSGNDFRYIPFGVGRRSCPGMMLTLPMLRITLGRLVQNFDLLLPPGQVKVDTSEDDEQFSLRLLNPLKIVFKPRSTL
>rna-gnl|WGS:JXTC|TorRG33x02_349360.1
MDAVARSMDWAIADLVNHREVQKKLQHELDAGLGPGTQITEPDIQKLPYLQAVIKEVLRLRMAAPLLIPHMNINDAKLWPYDIPAETKITVNAWWLANNPTHWTNPGEFRPERFLEEESHVEVNGNNYRYIPFGVGRRGCPGTMLAMPMFCITLGRSVQNFISSARSDRV
>rna-gnl|WGS:JXTC|TorRG33x02_351650.1
MDLLLMEKTLLALFFAAAIAVAISKLRRKRFKLPPGPIPVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFRIGQRNIGVISSPELAKEVLQTQGVDFSYRIRNAAFDIFTGNGQDLIFTDGDHWRKMRRVMTVPFFNNKAVQKYSRCWEEEAASMVEDIKKSYPQAMTTGICMRTRLKLLTHNNMFRMLFDKRFEGQNDPLFLDLQELNVKRDVLAQGHRYNYGDFNPILRPFLRGYLNTCKETCEKRLRIFDHFIQNRKKLITSTNDQEKLVFAGIDHILEAQQMGVINEDNVRYIVDNMNNAGIDTIVRSLEWAIVHLVNQPEVQRKLQHELDTVLGPGIQLTEPDTHKLPYLEAVLKE
>rna-gnl|WGS:JXTC|TorRG33x02_351640.1
MAAPLLVPHTNANDAKVGPYDIPAGSRITVNAWWLANNPPHWKNPEVFRPERFLEEEFHVNVNGNDFRYIPFGVGRRSCPGMMLTLPMLRITLGRLVQNFDLLLPPGQVKVDTSEDDEQFSLRLLNPLKIVFKPRSTL
>rna-gnl|WGS:JXTC|TorRG33x02_351620.1
MDLLLMEKTLLALFFAAAIAVTISKLRRKRFKLPPGPIPVPFFGNWLQVGHNLKHNQLPELAKKYGDIFMFQIGQRNIGVISSPELAKEVLQTQGVDFS
>rna-gnl|WGS:JXTC|TorRG33x02_351630.1
MRRVMTVPFFNNKAVQKYSRCWEEEAASMVEDIKKSYPQAMTTGICMRTRLKLLTHNNMFRMLFDKRFEGQNDPLFLDLQELNVKRDVLAQSHRYNHGDFNPILRPFLRGYLNTCKETCEKRLRIFDHFIQNRKKLITSTNDQEKLAFAGIDHILEAQQMGVINEDNVRYIVDNMNNAGTN
>rna-gnl|WGS:JXTC|TorRG33x02_354490.1
FPIRHANKTIYHYSQHLYAQTVLIVSQNFLVVTAIETTLWSIEWGIAELVNHPEIQRRLRQELDTVLGPGVQVTEPDMQKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPANWKKPEEFRPERFLQEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQSQIDTAEKGGQFSLHILKHSTIVLKPRSF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University