Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Theobroma cacao
Species name
Cacao (Theobroma cacao) is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Theobroma_cacao.COMT.fa
Download
>rna-XM_007039153.2
MGSTGETQMTPNQVSDEELNLFAMQLTSASVLPMVLTSAIELDLFEIMAKAGPGAFLSPKELASQLPTKNPDAPVMLDRILRLLASYSVLNCSLRTLPDGKVERLYSLGPVCKFLTKNEDGVTLSSLSLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMNDHSTTTMRKILETYDGFEGVKTLVDVGGGIGASLSMIISKHPSIKGINFDLPHVIEDAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYQALPDNGKVIVAECNLPDYPDPSLATKLVVHIDCIMLAHNPGGKERTAKEFEALAKGAGFQGFQVKCCAFGTYIMEFLKTV
>rna-XM_007039259.2
MNSKESQARISTDEEDKRAQQYAMQLVSASVMPMVLKAAIQLGVFEIIQRSGPGALLSLSQIASQLPTQNNPDAPLILDRILRLLASYSILTFSLVADHQDGQVVRLYGLAPVAKYFIRSQGGGSLSSMLDLFQDRASIDIWYHLKDAVVEGGCPFNREHGMSSIEYMGKDARFGEIFKGSMIDFNGMFVEEMLKTYKGFEGLNSLVDVGGGNGSILHRIVSKYPAIKAINFDLPQIIENSPSYHGIEHVAGDMFESVPKGDAIFMKWVIHCLDDKKCLELLKNCYEALPAKGRVIIVDLVIPESPDSSRVVKSVYQFELFMMNFTGTLKERTEKEFESLAKGAGFSRVQVACCACSFSVVELYKNT
>rna-XM_007032584.2
MASSVENQFHGNNNAEQDQESFSYAMQIVSSSVLPMSMHAAIQLELFDIIAKAGPNAKFSPKEIAAQLPCKNPEAPSMLDRILRVLASHGIVGCSVVDEEGNNPQRLYSLTPVSKFFVRNEDGVSFGPLMALIQDKVSLDSWSHLKDAVLEGGVPFDRVHGTHAFEYFGKDPRLNQVFNTAMINHATIIVKKILETYKGFKQLNRVVDVAGGLGVTLSLITSKCPYIKGINFDLPHVIQHAPTCPGVEHVGGDMFESIPKGDAIFMKSVLHNWSDEQCLKLLKNCYNAIPDDGKVIVVDTVLPILPETNAFGRSTSQTDIIMMTHLPRGKERNKLEFEALATNAGFRGIRYECFVYDLWVMEFFK
>rna-XM_018120822.1
MENCALSFETYIAKPFYKHLCKSRYLQIEEINIMSTSLPDQQQFISKEEEDCLQAIQFATSTVLPFALKTAIDLDLLEIIAKAGPGCTLSPAEIVSNLPAKNPDAPAIIDRILRVLTAHSILACHLVTDKDGHTKRTYGIASIGRYFLQNEDGISVTPLLNMTLDKRLIDSWNFFKEATLEGGLSIVKGFGMNLFEMAAKDNNFFNTFNQAMSNHTNIVMKKILEIYKGFEGVSQVVDVGGGLGTNLKLIVSKYPQIKGINFDLPLVVKDAPNFPGVEHVGGDMFTQVPHGEVIFMKWVLHDWGDDQCLKLLKNCYDAISESGKVIILESILPELPMTDLVTTTTLNLDLGLVHLLPGAKERTKKEFETLARDAGFPTLKLVCRAYNYWVIELSKL
>rna-XM_018121419.1
MDSLPDQQKMSQNEMDFLLALRIATAPTLPLVLKAAIDLDLLEIMAAATASNSMLSPTEIASRLPTQNPDAPTIVDRLLRLLASHSILTCKLVAGRDEHAQRLYGLGPVGKYFVRNQEGNSLVPTLRVSLEKFYMECWYHLKEAALEGVLPFMKVHGMHLFELAANDDKVSSMFNASMSNLTSLVMKKVLETYKGFEGLSQVVDVGGGVGANLNLLVSKYPQIKGTNFDLPHVIRDAPLIPGVEHVGGDMFSKVPKGEVIFMKWILHDWGDEQCLKLLKNCFEALPENGKVVIVESLTPEFPMTDIVTKITFELDVSVLHMLPGAKERTKQEFEALAREAGFKTLNVVCRIYSYWVMELCKNVNIAN
>rna-XM_007027452.2
MEDETADSRNKARLAILELANMMSVPMSLNAVVRLNVPDAIWQGGANTPLSAAQILSRVLPSGGGDPENLQRILRMLTSYGVFAEHLDSECPERRYSLTDIGKTLVTDADGLSCAPYVLQHHQDALMRVWPLMHEAVLDPTSEPFVKVNGEAAYSYYGKKPEMNRLMQKAMSGVSVPFMRAILNSYDGFKGVKRLVDVGGSVGECLRMILQKHPHVEEGINFDLPEVVAKAPTIPGVSHVGGDMFKSIPSGDGIFMKWVLVAWTDDECKLIMENCYKALPVGGKLIACEPVLPKDSDDSHLTRALLEGDIFVMTIYRTKGKHRTEEEFKQLGLSAGFPHFRAFCFDDFYSVLEFQK
>rna-XM_018120813.1
MSSKLDNQNITANEEEEAFHQAMQLAMSTILPMVLKAAIDLDLLEIIAKAGPAGCKLSPIEIASHLPTKNPDASSIIDRILRLLASHSILTCDLATNEDGHVQRLYGLAPVAKYFLHNDDGISLIPTLTTSTDKYLLGAWYHLTEATLEGGAIPLVKAYGMDLFELAAKNDEISGKFNNTMGNQTAIIMKKVLEIYKGFEGINQLVDVGGGLGINLKLIVSKYPQIKGINFDLPHVVKDAPHFLGVDHVGGDMFIEVPQGEVIFMKWILHDWGDDRCLKLLKNCYNALPKFGKVVVVELVVPESPMTDIVTKNTLTLDAGLFIVVPGAKERTKEEYEALAKKAGFSTFRLVCRAYSYWVMEFHKSIIV
>rna-XM_007099622.2
MESSTKQDQESFLYAIQIVSSSVLPMSMHAAIQLQLFEIIAKAGPDAKLSPNEIAAQLRTNNPEAPSMLDRILRVLASHSIIGCSVADNEQGNNPRRLYSLTPVSKFFVPNDDGVSLGPLMALNQEKVILDSWSQLKDAIVEGGTPFDRVHGTHIFEGQCRDPRFNQVFHTAMINHTTIVVKNILGTYKGFEQLNRVVDVGGGLGAALSIITSKYPSIKGINFDLPHVIQHAPAYAGVEHVGGDMFESIPKGDAIFMKWILHDWNDEHCLKLLKNCYNAIPDDGKVIVVDAVLPVALDTNAFMRYASQMDVLMMTQCPGGKERTKPEFEALATKVGFSGIRYECFVCNFWVMEFFK
>rna-XM_007019028.2
MSQEDQDQELGKLAVRLANAVVLPMVLKSALELNIIDTISAAGDGTYLSPSQIASGLPTKNPEASLLLDRMLRLLASYSILKCSVRTKESGEVERLYGAGPLCKFIVKNQDEGSVAPLFLLHHDNVFMESWYHLNDVILEGGNPFNRAYGMTAFEYPGTDLRFNRVCNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALGIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSYEHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQSPGGKERTRKEYEALALRTGFSGCEVICCVYNSWVMEFHKRENL
>rna-XM_018126333.1
MTQEDQDQELGKLAVRLANAVILPMVLKSALELNIIDTISAAGDGTFLSPSQIASGLPTKNPEASVLLDRMLRLLASYSILKCSVRTKESGEVERLYGAGPLCKFLVKNQDEGSVAPLFLLHHDKVFMESWYHLNDVILEGGIPFNRAYGMTAFEYPGTDLRFNRVFNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALSIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQNPGGKERTRKEYEALALRTGFSGCEVVCCAYNSWVVEFHRRENL
>rna-XM_018127044.1
MGYSVETQFHGNNDHSEQDEESFSCAMQLVNSTALPMSLHAAIQLEIFEIIAKAGPDAKLSPQEIGAHLPTQNPDAPMMLDSILRLLASHSVLACSLAVVEQGDSPQRLYSLTPVTKFFIRNEDGVSLAPLVSLVQDKIFLDSWCQLKDAILEGGIPFNRVHGTHAFEYPGKDPRFNKIFNTAMMNQTTIVMKKILEAYKGFEHLSQLVDVGGGLGVTLRIITSKYPSIKGINFDQPHVIRHAPAYPAGVEHVGGDMFKSVPKGDTVFMKWILHDWSDDHCLKLLKNCYKAIPDDGKVIVIDSVLPVLPESNAASKANSELDVVMMTQNPGGKERTKPELEALATMAGFSGIRYECFVCNCWVMEFFK
>rna-XM_018126569.1
MESSAEQNQESFSYAIQIVTSNALPMSMHAAIQLQLFEIIAKAGPDAKLSPKEIAAQLRTKNPDAPSMLDRLLRVLASHNIVGCSVADDEQGNNPQRLYSLTPVSKFFVPNEDGVSLGPLMSLLQDKVFLDSWSQLKDAILEGGIPFDRVHGTNAFEYPGKDPRFNQVFNTAMINHTTIIVKKILETYKGFEQLNRVVDVGGGLGVTLSIITSKYPSIRGINFDLPHVIQHAPAYPGVEHVGGDMFKSVPKGDAIFMKWILHDWSDEHCLKLLKNCYNAIPDDGKVIVADAVLPIVPEANAFVRGTSMMDVLMMTQNPGGKERTKPEFEALATKAGFAGIRYECSVCNFWVMEFFK
>rna-XM_018128863.1
MSTSMSEEEEAFGYAWCLRSSDMFCFVLDAAIQLGLFDIIAKAGPGAHLSSSEIASQLNANNPEAPSLLDRVLRLLACYDLVTCITRNLDGDGKVERLYGLALPGKAFVPDESRGCLAGFAITKAKIEAYLYLKDMILDGGNVFERLHGAGMPVYQYMSLHPDMARKFDTTMTNLSKVVMNKVLDKYHGFQGIPCLVDVGGGYGISLNIIISKYPSIHGINYDMPHVIQDAPSFPGIQHIGGDMFSSVPKADAIMIKDVLHNWNDERCLKLLKNCYEALPERGKVIVVSYVMIDEPEASDGAKFVCQMDLLMALQGGAKQRTENQFKDLSKAAGFSDFQLNCRIFNAIGVMEFFK
MGSTGETQMTPNQVSDEELNLFAMQLTSASVLPMVLTSAIELDLFEIMAKAGPGAFLSPKELASQLPTKNPDAPVMLDRILRLLASYSVLNCSLRTLPDGKVERLYSLGPVCKFLTKNEDGVTLSSLSLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMNDHSTTTMRKILETYDGFEGVKTLVDVGGGIGASLSMIISKHPSIKGINFDLPHVIEDAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYQALPDNGKVIVAECNLPDYPDPSLATKLVVHIDCIMLAHNPGGKERTAKEFEALAKGAGFQGFQVKCCAFGTYIMEFLKTV
>rna-XM_007039259.2
MNSKESQARISTDEEDKRAQQYAMQLVSASVMPMVLKAAIQLGVFEIIQRSGPGALLSLSQIASQLPTQNNPDAPLILDRILRLLASYSILTFSLVADHQDGQVVRLYGLAPVAKYFIRSQGGGSLSSMLDLFQDRASIDIWYHLKDAVVEGGCPFNREHGMSSIEYMGKDARFGEIFKGSMIDFNGMFVEEMLKTYKGFEGLNSLVDVGGGNGSILHRIVSKYPAIKAINFDLPQIIENSPSYHGIEHVAGDMFESVPKGDAIFMKWVIHCLDDKKCLELLKNCYEALPAKGRVIIVDLVIPESPDSSRVVKSVYQFELFMMNFTGTLKERTEKEFESLAKGAGFSRVQVACCACSFSVVELYKNT
>rna-XM_007032584.2
MASSVENQFHGNNNAEQDQESFSYAMQIVSSSVLPMSMHAAIQLELFDIIAKAGPNAKFSPKEIAAQLPCKNPEAPSMLDRILRVLASHGIVGCSVVDEEGNNPQRLYSLTPVSKFFVRNEDGVSFGPLMALIQDKVSLDSWSHLKDAVLEGGVPFDRVHGTHAFEYFGKDPRLNQVFNTAMINHATIIVKKILETYKGFKQLNRVVDVAGGLGVTLSLITSKCPYIKGINFDLPHVIQHAPTCPGVEHVGGDMFESIPKGDAIFMKSVLHNWSDEQCLKLLKNCYNAIPDDGKVIVVDTVLPILPETNAFGRSTSQTDIIMMTHLPRGKERNKLEFEALATNAGFRGIRYECFVYDLWVMEFFK
>rna-XM_018120822.1
MENCALSFETYIAKPFYKHLCKSRYLQIEEINIMSTSLPDQQQFISKEEEDCLQAIQFATSTVLPFALKTAIDLDLLEIIAKAGPGCTLSPAEIVSNLPAKNPDAPAIIDRILRVLTAHSILACHLVTDKDGHTKRTYGIASIGRYFLQNEDGISVTPLLNMTLDKRLIDSWNFFKEATLEGGLSIVKGFGMNLFEMAAKDNNFFNTFNQAMSNHTNIVMKKILEIYKGFEGVSQVVDVGGGLGTNLKLIVSKYPQIKGINFDLPLVVKDAPNFPGVEHVGGDMFTQVPHGEVIFMKWVLHDWGDDQCLKLLKNCYDAISESGKVIILESILPELPMTDLVTTTTLNLDLGLVHLLPGAKERTKKEFETLARDAGFPTLKLVCRAYNYWVIELSKL
>rna-XM_018121419.1
MDSLPDQQKMSQNEMDFLLALRIATAPTLPLVLKAAIDLDLLEIMAAATASNSMLSPTEIASRLPTQNPDAPTIVDRLLRLLASHSILTCKLVAGRDEHAQRLYGLGPVGKYFVRNQEGNSLVPTLRVSLEKFYMECWYHLKEAALEGVLPFMKVHGMHLFELAANDDKVSSMFNASMSNLTSLVMKKVLETYKGFEGLSQVVDVGGGVGANLNLLVSKYPQIKGTNFDLPHVIRDAPLIPGVEHVGGDMFSKVPKGEVIFMKWILHDWGDEQCLKLLKNCFEALPENGKVVIVESLTPEFPMTDIVTKITFELDVSVLHMLPGAKERTKQEFEALAREAGFKTLNVVCRIYSYWVMELCKNVNIAN
>rna-XM_007027452.2
MEDETADSRNKARLAILELANMMSVPMSLNAVVRLNVPDAIWQGGANTPLSAAQILSRVLPSGGGDPENLQRILRMLTSYGVFAEHLDSECPERRYSLTDIGKTLVTDADGLSCAPYVLQHHQDALMRVWPLMHEAVLDPTSEPFVKVNGEAAYSYYGKKPEMNRLMQKAMSGVSVPFMRAILNSYDGFKGVKRLVDVGGSVGECLRMILQKHPHVEEGINFDLPEVVAKAPTIPGVSHVGGDMFKSIPSGDGIFMKWVLVAWTDDECKLIMENCYKALPVGGKLIACEPVLPKDSDDSHLTRALLEGDIFVMTIYRTKGKHRTEEEFKQLGLSAGFPHFRAFCFDDFYSVLEFQK
>rna-XM_018120813.1
MSSKLDNQNITANEEEEAFHQAMQLAMSTILPMVLKAAIDLDLLEIIAKAGPAGCKLSPIEIASHLPTKNPDASSIIDRILRLLASHSILTCDLATNEDGHVQRLYGLAPVAKYFLHNDDGISLIPTLTTSTDKYLLGAWYHLTEATLEGGAIPLVKAYGMDLFELAAKNDEISGKFNNTMGNQTAIIMKKVLEIYKGFEGINQLVDVGGGLGINLKLIVSKYPQIKGINFDLPHVVKDAPHFLGVDHVGGDMFIEVPQGEVIFMKWILHDWGDDRCLKLLKNCYNALPKFGKVVVVELVVPESPMTDIVTKNTLTLDAGLFIVVPGAKERTKEEYEALAKKAGFSTFRLVCRAYSYWVMEFHKSIIV
>rna-XM_007099622.2
MESSTKQDQESFLYAIQIVSSSVLPMSMHAAIQLQLFEIIAKAGPDAKLSPNEIAAQLRTNNPEAPSMLDRILRVLASHSIIGCSVADNEQGNNPRRLYSLTPVSKFFVPNDDGVSLGPLMALNQEKVILDSWSQLKDAIVEGGTPFDRVHGTHIFEGQCRDPRFNQVFHTAMINHTTIVVKNILGTYKGFEQLNRVVDVGGGLGAALSIITSKYPSIKGINFDLPHVIQHAPAYAGVEHVGGDMFESIPKGDAIFMKWILHDWNDEHCLKLLKNCYNAIPDDGKVIVVDAVLPVALDTNAFMRYASQMDVLMMTQCPGGKERTKPEFEALATKVGFSGIRYECFVCNFWVMEFFK
>rna-XM_007019028.2
MSQEDQDQELGKLAVRLANAVVLPMVLKSALELNIIDTISAAGDGTYLSPSQIASGLPTKNPEASLLLDRMLRLLASYSILKCSVRTKESGEVERLYGAGPLCKFIVKNQDEGSVAPLFLLHHDNVFMESWYHLNDVILEGGNPFNRAYGMTAFEYPGTDLRFNRVCNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALGIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSYEHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQSPGGKERTRKEYEALALRTGFSGCEVICCVYNSWVMEFHKRENL
>rna-XM_018126333.1
MTQEDQDQELGKLAVRLANAVILPMVLKSALELNIIDTISAAGDGTFLSPSQIASGLPTKNPEASVLLDRMLRLLASYSILKCSVRTKESGEVERLYGAGPLCKFLVKNQDEGSVAPLFLLHHDKVFMESWYHLNDVILEGGIPFNRAYGMTAFEYPGTDLRFNRVFNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALSIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQNPGGKERTRKEYEALALRTGFSGCEVVCCAYNSWVVEFHRRENL
>rna-XM_018127044.1
MGYSVETQFHGNNDHSEQDEESFSCAMQLVNSTALPMSLHAAIQLEIFEIIAKAGPDAKLSPQEIGAHLPTQNPDAPMMLDSILRLLASHSVLACSLAVVEQGDSPQRLYSLTPVTKFFIRNEDGVSLAPLVSLVQDKIFLDSWCQLKDAILEGGIPFNRVHGTHAFEYPGKDPRFNKIFNTAMMNQTTIVMKKILEAYKGFEHLSQLVDVGGGLGVTLRIITSKYPSIKGINFDQPHVIRHAPAYPAGVEHVGGDMFKSVPKGDTVFMKWILHDWSDDHCLKLLKNCYKAIPDDGKVIVIDSVLPVLPESNAASKANSELDVVMMTQNPGGKERTKPELEALATMAGFSGIRYECFVCNCWVMEFFK
>rna-XM_018126569.1
MESSAEQNQESFSYAIQIVTSNALPMSMHAAIQLQLFEIIAKAGPDAKLSPKEIAAQLRTKNPDAPSMLDRLLRVLASHNIVGCSVADDEQGNNPQRLYSLTPVSKFFVPNEDGVSLGPLMSLLQDKVFLDSWSQLKDAILEGGIPFDRVHGTNAFEYPGKDPRFNQVFNTAMINHTTIIVKKILETYKGFEQLNRVVDVGGGLGVTLSIITSKYPSIRGINFDLPHVIQHAPAYPGVEHVGGDMFKSVPKGDAIFMKWILHDWSDEHCLKLLKNCYNAIPDDGKVIVADAVLPIVPEANAFVRGTSMMDVLMMTQNPGGKERTKPEFEALATKAGFAGIRYECSVCNFWVMEFFK
>rna-XM_018128863.1
MSTSMSEEEEAFGYAWCLRSSDMFCFVLDAAIQLGLFDIIAKAGPGAHLSSSEIASQLNANNPEAPSLLDRVLRLLACYDLVTCITRNLDGDGKVERLYGLALPGKAFVPDESRGCLAGFAITKAKIEAYLYLKDMILDGGNVFERLHGAGMPVYQYMSLHPDMARKFDTTMTNLSKVVMNKVLDKYHGFQGIPCLVDVGGGYGISLNIIISKYPSIHGINYDMPHVIQDAPSFPGIQHIGGDMFSSVPKADAIMIKDVLHNWNDERCLKLLKNCYEALPERGKVIVVSYVMIDEPEASDGAKFVCQMDLLMALQGGAKQRTENQFKDLSKAAGFSDFQLNCRIFNAIGVMEFFK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University