Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Theobroma cacao
Species name
Cacao (Theobroma cacao) is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Theobroma_cacao.HIDH.fa
Download
>rna-XM_018116398.1
MASNTTEIAREFVNSFPLFRVYKDGRIERLRETETVPPSNDPQTGVQSKDTIVSPESSLSARLFLPKITDPTAKIPLVIYIHGGAFCIESPFSPLYHNYLTSLVNKANVIAVAIQYRKAPEYPLPIAYDDAWTAIKWVASHANRDGPEPWLNDHADFERVFFAGDSAGANIAHNMTMKAGADGLIGVKLVGMLLMNPFFRNNEPDELIEYIFPSSSGCNDPRMNPASAIKELAGLACSRVLVCVSEKDFLKDRGVTYYEAVRKSGWDGVIDIVETPGEKHVFYLFDPSSQKAMDLMDQVSSFLNR
>rna-XM_018114696.1
MATIAVDHQSLGMQIGRGSNQHGAVVEEIPGLIKVSKDGHVERPQIVPNVSTALAPELGVTSKDMVIDEFTNVWARFYVPKSNRKLPLVVYFHGGGFCVGSAAWSCYHEFLAKLAAKAGCLIMSVNYRLAPENPLPAAYEDGFKCLTWLKQEAWNGSGEWWSNHCNFSSVFLAGDSAGANIAHNVAARLGSHNPYPLTLNGTILIQPFVGGETRTNSERNMVQSPRSALSLAASDTYWRLALPCGSNRDHPWCNPLGKGSAKMEEMRLLPTLVCVSEMDILKDRNLEFCTALGRAGKKVEHVLYGGVGHAFQVLSKSQLSQTRTHEMIGHIKAFICQ
>rna-XM_007042321.2
MSSGDSEIAHEFRPYFRAYKDGRVERFFGSDIVPASIDPQDGVSSKDVTIVPETSVSARIFIPSSVKPSQKLPLVVYFHGGGFFMGSSFCSEYHNYVTSLVSEANVVAVSVDYRLAPEHLIPIAYEDSWAALRWVASHCSGEGPEAWLKDYANFERVFLVGDSAGGNIVHNMAVQASTEDLSGVKLLGICLIQPFFGRKDGHVDKCWLFVSPTSRFDDPRINPAVDSRLSRLGCGRVLTFLAEKDNLRERGLFFCETLKSSGWGGELVIVETEGEDHAFQLLNQKSERALALMNRLVSFINQDKAASM
>rna-XM_007042317.2
MDSFTDNEIIRDCPPFFKVYKDGRVERYTVTTPAPEGIDPKTGVQSKDVVVSPGVKARIFMPQTRSPGKKLPLLVHYHGGGFSIGSALDTVTQKLLTPLVVQANIIAISIDYRLAPEYLLPIAYDDSWAGLQWVASHANGQGPEPWLNENADLGRVFLMGESAGATIAHYVAVQAGATKLVGLKIIGTLIVHPFFGSKEPDDIYKYVCPTSPGFDQDPKLNPAVDPNLKQMASDRVIVMVAEKDGLRSRGELYYETLVKSGWGGSVEFDESKGEDHCFHVLHDNGKAEVLKKKIVDFIKKD
>rna-XM_018114579.1
MESTTSEIAIDCAPLLRVYKDGRVERLLGTQTVPPGLDPKTNVESKDVVFSQETGQYVRLYIPKAIRSSSQKLPLLVYFHGGGFCIETASSPTYHNYLNSLVSEANIVAVSVDYRRAPEHPIPVAYDDSWAALKWVASHFGGNGPEEWLNCHADFDKVYLSGDSAGANIAHHIAIKIGKEKLDGVNLAGIVLAHPYFWGKEPVGDEIQDPAVRAKLEQIWRLASPTTSGSDDPWINPVDDQSLESLGCTRVLVCVAEKDLLRHRGWYYYEKLKKSGWGGEAEIMEAQGEEHVFHLAKPTCENAVAKLNKVAAFMNQDKA
>rna-XM_007034623.2
MDSLDKEVAIEILPFIRIYKGGSVERLAGSPNVPPSTEDPETGVSSKDITISDNPPISARIYLPKQVEQHQKVPLLVYFHGGGFCFESAFSFVETKYMNSLAYYAKVVVISIEYRLAPEHPLPIAYDDCWAGLQWVVSHSVDCGVDNKEPWLSTYVDFDRVYVAGDSAGANLAHNILMRAGSEALNGGVKITGAFVTHPYFWGSKPVGSEPKSIDKREKCAMYTIWHLIYPEAPGGIDNPMINPVSPGAPSLAGLGCSRLLVSVAEKDALRDRGIFYYNAVKESGWKGELVLVQVEREDHAFQILNYESENAKKLIKRLASFLV
>rna-XM_007033234.2
MRTKRMATISFDPRLNVQVGQKNHGVVVEEIEGLIRVYKNGHVERPPIIPIVPSTVTGGVISKDVVIDKFTSSWTRIYAPSYSSKMPLLVYFHGGGFCVGSAAWSCYHEFLSALASKAGCIIFSVNYRQAPENRLPAAYDDGINTLMWLKQQALNGSSEHKWWLSQCDFSSLFLGGDSAGANIAYNVATRLGSYGTSDSSFKPLVLKGTILIQPFFGGEARTASEMQATQPASSALTLSAYDTYWRLSLPLGANRDHPWCNPLAKGAAKLRQLRLPATMVCISEMDILKDRNLEFCNALASAGKRVETKMYKSVGHAFQILHNSPFSQVRTQELMSHLKTFINP
>rna-XM_018118765.1
MDSTAKEVVKELPGLIKLYKDGSVERLFGSPYVPPSPEPDPETGVSSKDITISDNPLISARLYLPKLTQPHEKLPILAYFHAGGFCLESAFSFFDQRYLNALVSEARVVAVSVEYRLAPEHPLPAAYEDCWAALQWVASHSLDNEIKKDSWLLNHGDFDRIFIGGDSAGGNIVHNIALQAGAEGLKGRVKLLGAFLSHPYFWGSESSTDHDKSMPTLAWEFVYPSAPGGIDNALINPLGPGKPSLAGLGCSRLLVCVAEKDQLRDFGVLYYDAVKESGWQGEIELFEVKGEDHAFHILDFGKENSKIMIKRLASFLAVS
>rna-XM_007030971.2
MGSLPHVVEDCFGLLKLYSDGSISRNPEIPSATPLLNDASVLYKDFLFDSKENLHLRLYKPTSSTTDAKLPILFYFHGGGFCFGSRSFPHFHNLSIRLAAAFNMLVIAPDHRLAPENRLPAAVDDACQALKWLQGQAMHGNDEDMDTLLTGVDFDRVFVLGDSSGGNLAHHLAVRFKAGSIELAPVRVRGYVLLAPFFGGIVRTRSEEERPCEAFWNLEMYERFWRLSIPAGSTLDHPLVNPFGPSGQNLAEVPLDPILVVVGGGEILRDRVEDYATRLKHLGKKTEFVEFEGQQHGFLTDHPFSEVAEKVIQRIRDFILENSN
>rna-XM_007017236.2
MDSSSKPELVTEFPGIIRVYKDGHVERLIETGFVPPSTDPQTGVSSKDITMIPESNVSARLFLPKLTSPHQKLPLLVYFHGGAFCVSSPFTPKYNSYLNALVAEANVIAVSVNYRKAPEHPIPTAYEDSWAALQWVVSHCNSKGPEAWLNDHADFQRVFLGGESAGANIAHNLAIIAGNPEFGLNVQLRGIALVHPFFWGSDPIGSEALMDPGKKSVLDRVWPFICPSNPDNNDPRFNPVAMDAPSLVGLGCTRVLVCVAEKDGVRDRGRLYFEALGRSGWMGVVEIMETEGEDHGFHLSDLESEKAKDLIKRLAAFYNGDMPSSL
>rna-XM_007017238.2
MGSNASEVALDLFPYLKVYKDGTLERIAGVEVVSPGLDPETDVLSKDIVIVPETGVSARIYRPNLATTHEKLPLVVYFHGGAFCVASPAFPNYHTSLNKLVAEANIVALSVDYRLVPEFPLPTAYEDSWAALEWIASHKEGDSCQEAWIKDHADLDQVFLAGDSAGSNIAHHLALRLKDSDLGQKLKILGIGMIHPYFWGTNPIGSEFADQFRKELVDKWWLYVCPSDKGCDDPLINPFVDGSSDLSGLACDGILVIVAEKDILKDRGRLYYDKLVKSGWTGKAEIMETEGEDHVFHIFNPDCAKAKSLIKRLASFLNQGKAPVE
>rna-XM_007015568.2
MSNTAASATMTTPPFYEVDECRGVLRVYSDGSIWRSPKPSFNVPVDDDGSVVWKDILFDPVHNLQLRLYKPASSSSAKLPIFYYIHGGGFCIGSRAWPNCQNYCFRLSSELQAAVISPDYRLAPENRLPAAIEDGFMTVKWLQAQALAENPDPWLTDVGDFSRVFICGDSAGGNIAHNLAVQLGAGSSDLAPVRVRGYVLLAPFFGGTVRTRSEAEGPKDAFLNWELIDRFWRLSIPIGDTTDHPLINPFGPVSRSLEHLNLDPILVVVGGSDLLKDRAEEYAKRLKDWGKKIDYVEFEGQQHGFFTINPNSEPAKALMLIIKRFITENSS
>rna-XM_007011812.2
MHTHEPLKPQSSSSKFQGLNLSAPKMSIIAEAPGYFQVFSDGCVKRFAPEIAPASQESSGGYKSKDVILDPSKPITGRIFLPDIPGSCTSLPVLVYFHGGGFCIGSTTWLGYHHFLGDFSAASQSIVLSIDYRLAPEHRLPIAYDDCYSSLEWLCSQVTSEPWFKLADLSRVFLSGDSAGGNIVHQVAIRAMRNKALHVKIKGLLMIHPYFGSEERTDRERADGAAGDVAMNDMFWRLSIPDWSNRDYFGCNFEKQVVSEAEWREFPVVVVYVAGLDFLKERGVMYAEFLQRKGVKKLKLVEAERESHVFHVFYPESEATRLLQRQMSEFMKDN
>rna-XM_018129634.1
MVQEKKLVDEVSGWLRAYDDGSVDRTWTGPPEVKFMAEAVPPHEDFIEGVATRDVTIDSNSGLRVRIYLPEQVLTAKTKLPILLHFHGGGFCISQADWYMYYHIYARLARSVPAICVSVYLRLAPENKLPAACDDGYATLLWLKSLAKGESHEPWLNDHADFNRVFLIGDSSGGNIVHQVAVRAGNLDLSPLRLAGGIPIHPGFVRAERSKSELEQPESPFLTLDMVDKFLALALPIGSTKDHPITCPMGPSAPAMEGLNLPPFLFCVAEKDLIKDTEMEYYEAMRNANKEVELLISPGMGHSFYLNKIAVDMDPNYAAQTASLIAGIKEFVNNH
>rna-XM_018128990.1
MEQEKKLVDEVSGWVRAYDDGSVDRTWTGPPEVKFMTEAVPPHEEFIEGVATRDVTIDSDSSLRVRIYLPEQSLTTKTKLPIILHFHGGGFCISQADWYMHYIIYTRLARSVPAICVSVYLRLAPENKLPAACDDGYATLLWLKSLAKGESHEPWLNDHVDFNRVFLIGDSSGGNIMHQVAARAGNLDLSPLRLAGGIPIHPGFVRAERSKSELEQPESPFLTLDMVDKFLALALPVGSTKDHPITCPMGLAAPAMKGLNLPPFLFCVVEKDLIKDTEMEYYEAMKSQKHKFGKSSLSVKSFVVINLLWRHFFLLMGFYRSSMYCL
MASNTTEIAREFVNSFPLFRVYKDGRIERLRETETVPPSNDPQTGVQSKDTIVSPESSLSARLFLPKITDPTAKIPLVIYIHGGAFCIESPFSPLYHNYLTSLVNKANVIAVAIQYRKAPEYPLPIAYDDAWTAIKWVASHANRDGPEPWLNDHADFERVFFAGDSAGANIAHNMTMKAGADGLIGVKLVGMLLMNPFFRNNEPDELIEYIFPSSSGCNDPRMNPASAIKELAGLACSRVLVCVSEKDFLKDRGVTYYEAVRKSGWDGVIDIVETPGEKHVFYLFDPSSQKAMDLMDQVSSFLNR
>rna-XM_018114696.1
MATIAVDHQSLGMQIGRGSNQHGAVVEEIPGLIKVSKDGHVERPQIVPNVSTALAPELGVTSKDMVIDEFTNVWARFYVPKSNRKLPLVVYFHGGGFCVGSAAWSCYHEFLAKLAAKAGCLIMSVNYRLAPENPLPAAYEDGFKCLTWLKQEAWNGSGEWWSNHCNFSSVFLAGDSAGANIAHNVAARLGSHNPYPLTLNGTILIQPFVGGETRTNSERNMVQSPRSALSLAASDTYWRLALPCGSNRDHPWCNPLGKGSAKMEEMRLLPTLVCVSEMDILKDRNLEFCTALGRAGKKVEHVLYGGVGHAFQVLSKSQLSQTRTHEMIGHIKAFICQ
>rna-XM_007042321.2
MSSGDSEIAHEFRPYFRAYKDGRVERFFGSDIVPASIDPQDGVSSKDVTIVPETSVSARIFIPSSVKPSQKLPLVVYFHGGGFFMGSSFCSEYHNYVTSLVSEANVVAVSVDYRLAPEHLIPIAYEDSWAALRWVASHCSGEGPEAWLKDYANFERVFLVGDSAGGNIVHNMAVQASTEDLSGVKLLGICLIQPFFGRKDGHVDKCWLFVSPTSRFDDPRINPAVDSRLSRLGCGRVLTFLAEKDNLRERGLFFCETLKSSGWGGELVIVETEGEDHAFQLLNQKSERALALMNRLVSFINQDKAASM
>rna-XM_007042317.2
MDSFTDNEIIRDCPPFFKVYKDGRVERYTVTTPAPEGIDPKTGVQSKDVVVSPGVKARIFMPQTRSPGKKLPLLVHYHGGGFSIGSALDTVTQKLLTPLVVQANIIAISIDYRLAPEYLLPIAYDDSWAGLQWVASHANGQGPEPWLNENADLGRVFLMGESAGATIAHYVAVQAGATKLVGLKIIGTLIVHPFFGSKEPDDIYKYVCPTSPGFDQDPKLNPAVDPNLKQMASDRVIVMVAEKDGLRSRGELYYETLVKSGWGGSVEFDESKGEDHCFHVLHDNGKAEVLKKKIVDFIKKD
>rna-XM_018114579.1
MESTTSEIAIDCAPLLRVYKDGRVERLLGTQTVPPGLDPKTNVESKDVVFSQETGQYVRLYIPKAIRSSSQKLPLLVYFHGGGFCIETASSPTYHNYLNSLVSEANIVAVSVDYRRAPEHPIPVAYDDSWAALKWVASHFGGNGPEEWLNCHADFDKVYLSGDSAGANIAHHIAIKIGKEKLDGVNLAGIVLAHPYFWGKEPVGDEIQDPAVRAKLEQIWRLASPTTSGSDDPWINPVDDQSLESLGCTRVLVCVAEKDLLRHRGWYYYEKLKKSGWGGEAEIMEAQGEEHVFHLAKPTCENAVAKLNKVAAFMNQDKA
>rna-XM_007034623.2
MDSLDKEVAIEILPFIRIYKGGSVERLAGSPNVPPSTEDPETGVSSKDITISDNPPISARIYLPKQVEQHQKVPLLVYFHGGGFCFESAFSFVETKYMNSLAYYAKVVVISIEYRLAPEHPLPIAYDDCWAGLQWVVSHSVDCGVDNKEPWLSTYVDFDRVYVAGDSAGANLAHNILMRAGSEALNGGVKITGAFVTHPYFWGSKPVGSEPKSIDKREKCAMYTIWHLIYPEAPGGIDNPMINPVSPGAPSLAGLGCSRLLVSVAEKDALRDRGIFYYNAVKESGWKGELVLVQVEREDHAFQILNYESENAKKLIKRLASFLV
>rna-XM_007033234.2
MRTKRMATISFDPRLNVQVGQKNHGVVVEEIEGLIRVYKNGHVERPPIIPIVPSTVTGGVISKDVVIDKFTSSWTRIYAPSYSSKMPLLVYFHGGGFCVGSAAWSCYHEFLSALASKAGCIIFSVNYRQAPENRLPAAYDDGINTLMWLKQQALNGSSEHKWWLSQCDFSSLFLGGDSAGANIAYNVATRLGSYGTSDSSFKPLVLKGTILIQPFFGGEARTASEMQATQPASSALTLSAYDTYWRLSLPLGANRDHPWCNPLAKGAAKLRQLRLPATMVCISEMDILKDRNLEFCNALASAGKRVETKMYKSVGHAFQILHNSPFSQVRTQELMSHLKTFINP
>rna-XM_018118765.1
MDSTAKEVVKELPGLIKLYKDGSVERLFGSPYVPPSPEPDPETGVSSKDITISDNPLISARLYLPKLTQPHEKLPILAYFHAGGFCLESAFSFFDQRYLNALVSEARVVAVSVEYRLAPEHPLPAAYEDCWAALQWVASHSLDNEIKKDSWLLNHGDFDRIFIGGDSAGGNIVHNIALQAGAEGLKGRVKLLGAFLSHPYFWGSESSTDHDKSMPTLAWEFVYPSAPGGIDNALINPLGPGKPSLAGLGCSRLLVCVAEKDQLRDFGVLYYDAVKESGWQGEIELFEVKGEDHAFHILDFGKENSKIMIKRLASFLAVS
>rna-XM_007030971.2
MGSLPHVVEDCFGLLKLYSDGSISRNPEIPSATPLLNDASVLYKDFLFDSKENLHLRLYKPTSSTTDAKLPILFYFHGGGFCFGSRSFPHFHNLSIRLAAAFNMLVIAPDHRLAPENRLPAAVDDACQALKWLQGQAMHGNDEDMDTLLTGVDFDRVFVLGDSSGGNLAHHLAVRFKAGSIELAPVRVRGYVLLAPFFGGIVRTRSEEERPCEAFWNLEMYERFWRLSIPAGSTLDHPLVNPFGPSGQNLAEVPLDPILVVVGGGEILRDRVEDYATRLKHLGKKTEFVEFEGQQHGFLTDHPFSEVAEKVIQRIRDFILENSN
>rna-XM_007017236.2
MDSSSKPELVTEFPGIIRVYKDGHVERLIETGFVPPSTDPQTGVSSKDITMIPESNVSARLFLPKLTSPHQKLPLLVYFHGGAFCVSSPFTPKYNSYLNALVAEANVIAVSVNYRKAPEHPIPTAYEDSWAALQWVVSHCNSKGPEAWLNDHADFQRVFLGGESAGANIAHNLAIIAGNPEFGLNVQLRGIALVHPFFWGSDPIGSEALMDPGKKSVLDRVWPFICPSNPDNNDPRFNPVAMDAPSLVGLGCTRVLVCVAEKDGVRDRGRLYFEALGRSGWMGVVEIMETEGEDHGFHLSDLESEKAKDLIKRLAAFYNGDMPSSL
>rna-XM_007017238.2
MGSNASEVALDLFPYLKVYKDGTLERIAGVEVVSPGLDPETDVLSKDIVIVPETGVSARIYRPNLATTHEKLPLVVYFHGGAFCVASPAFPNYHTSLNKLVAEANIVALSVDYRLVPEFPLPTAYEDSWAALEWIASHKEGDSCQEAWIKDHADLDQVFLAGDSAGSNIAHHLALRLKDSDLGQKLKILGIGMIHPYFWGTNPIGSEFADQFRKELVDKWWLYVCPSDKGCDDPLINPFVDGSSDLSGLACDGILVIVAEKDILKDRGRLYYDKLVKSGWTGKAEIMETEGEDHVFHIFNPDCAKAKSLIKRLASFLNQGKAPVE
>rna-XM_007015568.2
MSNTAASATMTTPPFYEVDECRGVLRVYSDGSIWRSPKPSFNVPVDDDGSVVWKDILFDPVHNLQLRLYKPASSSSAKLPIFYYIHGGGFCIGSRAWPNCQNYCFRLSSELQAAVISPDYRLAPENRLPAAIEDGFMTVKWLQAQALAENPDPWLTDVGDFSRVFICGDSAGGNIAHNLAVQLGAGSSDLAPVRVRGYVLLAPFFGGTVRTRSEAEGPKDAFLNWELIDRFWRLSIPIGDTTDHPLINPFGPVSRSLEHLNLDPILVVVGGSDLLKDRAEEYAKRLKDWGKKIDYVEFEGQQHGFFTINPNSEPAKALMLIIKRFITENSS
>rna-XM_007011812.2
MHTHEPLKPQSSSSKFQGLNLSAPKMSIIAEAPGYFQVFSDGCVKRFAPEIAPASQESSGGYKSKDVILDPSKPITGRIFLPDIPGSCTSLPVLVYFHGGGFCIGSTTWLGYHHFLGDFSAASQSIVLSIDYRLAPEHRLPIAYDDCYSSLEWLCSQVTSEPWFKLADLSRVFLSGDSAGGNIVHQVAIRAMRNKALHVKIKGLLMIHPYFGSEERTDRERADGAAGDVAMNDMFWRLSIPDWSNRDYFGCNFEKQVVSEAEWREFPVVVVYVAGLDFLKERGVMYAEFLQRKGVKKLKLVEAERESHVFHVFYPESEATRLLQRQMSEFMKDN
>rna-XM_018129634.1
MVQEKKLVDEVSGWLRAYDDGSVDRTWTGPPEVKFMAEAVPPHEDFIEGVATRDVTIDSNSGLRVRIYLPEQVLTAKTKLPILLHFHGGGFCISQADWYMYYHIYARLARSVPAICVSVYLRLAPENKLPAACDDGYATLLWLKSLAKGESHEPWLNDHADFNRVFLIGDSSGGNIVHQVAVRAGNLDLSPLRLAGGIPIHPGFVRAERSKSELEQPESPFLTLDMVDKFLALALPIGSTKDHPITCPMGPSAPAMEGLNLPPFLFCVAEKDLIKDTEMEYYEAMRNANKEVELLISPGMGHSFYLNKIAVDMDPNYAAQTASLIAGIKEFVNNH
>rna-XM_018128990.1
MEQEKKLVDEVSGWVRAYDDGSVDRTWTGPPEVKFMTEAVPPHEEFIEGVATRDVTIDSDSSLRVRIYLPEQSLTTKTKLPIILHFHGGGFCISQADWYMHYIIYTRLARSVPAICVSVYLRLAPENKLPAACDDGYATLLWLKSLAKGESHEPWLNDHVDFNRVFLIGDSSGGNIMHQVAARAGNLDLSPLRLAGGIPIHPGFVRAERSKSELEQPESPFLTLDMVDKFLALALPVGSTKDHPITCPMGLAAPAMKGLNLPPFLFCVVEKDLIKDTEMEYYEAMKSQKHKFGKSSLSVKSFVVINLLWRHFFLLMGFYRSSMYCL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University