Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Theobroma cacao
Species name
Cacao (Theobroma cacao) is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Theobroma_cacao.CHS.fa
Download
>rna-XM_018118459.1
MFMFTGMTLSLRSHHRAGKQLFLYHSQLRSVLRCFSSRQSKTHSDGADEQKRGWDDKAKSSNKTKRAKSMARVINSTPWSSELESSLSSLSPSLSKTTVLQTLRLIKAPSKALQFFDWVQKMGFHHNAQSFFLILEILGKERNLNAARNLLLSIEKRSNGSVKLEDQFFNSLIRSYGKAGLFQESIKVFETMKGIGVSPSVVSFNNLLMILLKRGRTNMAKSVFDEMLSTYGVSPDVYTFNILIRGFCMNSMVDEGFRFFKEMERFKCDPDVVTYNIIVDGLCRAGKVGIARNVVRGMSKKSLDLNPNVVTYTTLVRGYCMKQEIDEALVVFKEMISRRLRPNRITYNTLIKGLSEVHEYEKIKEILEGMGEDGRFVPDTCTLNTLINAHCNAENMDEALNVFKRMSELNVLPDSATYSVIIRSLCQKGDFEKAEEFFDELAEKEILLSDVGCTPLVAAYNPMFEYLCGNGKTKKAEIVFRQLMKRGRQDPPAYKTLILGHCREGTFKDGYELLVLMLRRDFEPGFEIYDSLISGLLQKGEPLLAHLTLEKMLKSSHLPQTSSVHSILAELLKKSCAQEAASLVTLMLDTRIRQNVNLSTQTAKLLFARWLQDKAFQIIGLLYDNGYVVEMEELVGFLCQSGKLLEACKMLQFSLEKHKSVDIEMCSMVIEGLCNSKRLSEAFGLYYELVERGKHQQLRCLENLKIALEAGGRLDEAEFVSKRMPKPAALPEESEERFSPKLNYNSLSFLRMPKWKAFLKPNSLQEQANLSFIFSAHGNAYIKVFVKNLVSVFFVGLLKMSKTDSNGAPGHRLRRASTSGKATVLAMGKAFPSQLIPQECLVEGYIRDTKCEDASIKAKLERLCKTTTVKTRYTVMCKEILDKYPELATEGSSTIKQRLEIANPAVVEMALEASLACIKEWGRPATDITHIIYVSSSEIRLPGGDLYLASQLGLKNDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRILLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIIGTDPITNSESPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEDNIEEFCRKLVSKANLTEFNDLFWAVHPGGPAILNRLENTLKLNNGKLECSRRALMDYGNVSSNTIFYVMEYMREELKAEGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_007041882.2
MGEEAQEGFAKRANPGKATILALGKAFPHQLVMQDFLVDGYFKNTNCDDPELKQKLSRLCKTTTVKTRYVVMSDEILKKYPELAIEGLPTVKQRLDICNNAVTEMAIEASRACIKKWGRPMSDITHLVYVSSSEARLPGGDLFLAKGLGLSPETQRVMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSADRPYDLVGVALFGDGAGAMIIGSDPVLSIERPLFELHTAIQNFLPNTEKTIDGKLTEEGISFKLARELPQIIEDNVEGFCEKLMGIVGLTDKDYNNMFWAVHPGGPAILNRMEKRLDLFPEKLNASRRALMDYGNASSNTIVYVLEYMIEESLKRKTESREDSEWGLILAFGPGVTFEGILARNLTVE
>rna-XM_007031990.2
MAMASVEEIRKAQRAQGPATVLAIGTATPPNCVSQADYPDYYFRITNSEHLTELKEKFKRMCDKSMIKKRYMYLTEEILKENPNMCAYMASSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGADPDTKIERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNVEKSLVEAFSPIGINDWNSIFWIAHPGGPAILDQVEAKLGLKEEKLKATRHVLSEFGNMSSACVLFILDEMRKQSLEQGKPTTGEGLEWGVLFGFGPGLTVETVVLHSISTEATH
>rna-XM_007034380.2
MVTVEEVRKAQRAEGPATVLAIGTSTPPNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCEKSMIKRRYMYLTEEILKENPNICAYMATSLDARQDMVVVEVPKLGKEAATRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEIEKPMFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLAEAFQPLGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRKKSREDGLKTTGEGLEWGVLFGFGPGLTVETVVLHSISA
>rna-XM_007028593.2
MALPENFGRQKQAQSAATILSIGTANPVFCISQIDYPDYYFRVTKSEHMTQLKGKFKQICEKSMIRKRHFVLTEEILKKNASISTYDDPSLDARREIAFAQVPKLAMEAASKAIQEWGQPKSQITHLIFSSLSGMDMPGADYHLTKLLGLPSSVKRIMLNFQPCYASGTILRMAKDIAENNAGARILVVSTEISIGAFHGPNEHDIASLIGQAIVGDGAAAMIVGADPDVLNERPLFQIVSTAQNIIPGSGGAIEGHVREAGYSIQLSKDVPKLIANNLESCLSEALSPISINDWNSFFWIVHPGGSAILDQIEIKLGLKKEKLLATRHVLSEFGNMSVACVLFILDEMRKKSLEKGKATTGEGLEWGLLIGFGSGITLETVVLRSFPITITHP
>rna-XM_018125403.1
MASEKNLETQQAEEQVTILAIGTANPPHCFYQADYPDFYFRVTKSEHKIELKDKFKRICERSSIKKRYMHLTEDIIKENPNLIIYKAPSFDARQDILVTEVPKLGQEAALKAIKEWGQPISKITHLIFCTSSGINMPSADNQLARLIGLEPSVQKFMIYQQGCFAAGTALRLSKDLAKNNAGARVLIVCSELMVECFQPPSETHLDILVGSALFSDGAAAAIVGANPDATINERPSFQIVSAHQTIIPDSADIIVAKIREMGMEYYLSRDLPKCIANNIEQCLIEALIPFGIGDWKTLFYIVHPGGPAVLRGVEEKLGLGREKLKASWHVLSEYGNMWSPSVLFILDEMRKMSILEGKASSGDGLEWGVLFGFGPGLTVETVVLRSFALNSCR
MFMFTGMTLSLRSHHRAGKQLFLYHSQLRSVLRCFSSRQSKTHSDGADEQKRGWDDKAKSSNKTKRAKSMARVINSTPWSSELESSLSSLSPSLSKTTVLQTLRLIKAPSKALQFFDWVQKMGFHHNAQSFFLILEILGKERNLNAARNLLLSIEKRSNGSVKLEDQFFNSLIRSYGKAGLFQESIKVFETMKGIGVSPSVVSFNNLLMILLKRGRTNMAKSVFDEMLSTYGVSPDVYTFNILIRGFCMNSMVDEGFRFFKEMERFKCDPDVVTYNIIVDGLCRAGKVGIARNVVRGMSKKSLDLNPNVVTYTTLVRGYCMKQEIDEALVVFKEMISRRLRPNRITYNTLIKGLSEVHEYEKIKEILEGMGEDGRFVPDTCTLNTLINAHCNAENMDEALNVFKRMSELNVLPDSATYSVIIRSLCQKGDFEKAEEFFDELAEKEILLSDVGCTPLVAAYNPMFEYLCGNGKTKKAEIVFRQLMKRGRQDPPAYKTLILGHCREGTFKDGYELLVLMLRRDFEPGFEIYDSLISGLLQKGEPLLAHLTLEKMLKSSHLPQTSSVHSILAELLKKSCAQEAASLVTLMLDTRIRQNVNLSTQTAKLLFARWLQDKAFQIIGLLYDNGYVVEMEELVGFLCQSGKLLEACKMLQFSLEKHKSVDIEMCSMVIEGLCNSKRLSEAFGLYYELVERGKHQQLRCLENLKIALEAGGRLDEAEFVSKRMPKPAALPEESEERFSPKLNYNSLSFLRMPKWKAFLKPNSLQEQANLSFIFSAHGNAYIKVFVKNLVSVFFVGLLKMSKTDSNGAPGHRLRRASTSGKATVLAMGKAFPSQLIPQECLVEGYIRDTKCEDASIKAKLERLCKTTTVKTRYTVMCKEILDKYPELATEGSSTIKQRLEIANPAVVEMALEASLACIKEWGRPATDITHIIYVSSSEIRLPGGDLYLASQLGLKNDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRILLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIIGTDPITNSESPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEDNIEEFCRKLVSKANLTEFNDLFWAVHPGGPAILNRLENTLKLNNGKLECSRRALMDYGNVSSNTIFYVMEYMREELKAEGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_007041882.2
MGEEAQEGFAKRANPGKATILALGKAFPHQLVMQDFLVDGYFKNTNCDDPELKQKLSRLCKTTTVKTRYVVMSDEILKKYPELAIEGLPTVKQRLDICNNAVTEMAIEASRACIKKWGRPMSDITHLVYVSSSEARLPGGDLFLAKGLGLSPETQRVMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSADRPYDLVGVALFGDGAGAMIIGSDPVLSIERPLFELHTAIQNFLPNTEKTIDGKLTEEGISFKLARELPQIIEDNVEGFCEKLMGIVGLTDKDYNNMFWAVHPGGPAILNRMEKRLDLFPEKLNASRRALMDYGNASSNTIVYVLEYMIEESLKRKTESREDSEWGLILAFGPGVTFEGILARNLTVE
>rna-XM_007031990.2
MAMASVEEIRKAQRAQGPATVLAIGTATPPNCVSQADYPDYYFRITNSEHLTELKEKFKRMCDKSMIKKRYMYLTEEILKENPNMCAYMASSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGADPDTKIERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNVEKSLVEAFSPIGINDWNSIFWIAHPGGPAILDQVEAKLGLKEEKLKATRHVLSEFGNMSSACVLFILDEMRKQSLEQGKPTTGEGLEWGVLFGFGPGLTVETVVLHSISTEATH
>rna-XM_007034380.2
MVTVEEVRKAQRAEGPATVLAIGTSTPPNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCEKSMIKRRYMYLTEEILKENPNICAYMATSLDARQDMVVVEVPKLGKEAATRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEIEKPMFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLAEAFQPLGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRKKSREDGLKTTGEGLEWGVLFGFGPGLTVETVVLHSISA
>rna-XM_007028593.2
MALPENFGRQKQAQSAATILSIGTANPVFCISQIDYPDYYFRVTKSEHMTQLKGKFKQICEKSMIRKRHFVLTEEILKKNASISTYDDPSLDARREIAFAQVPKLAMEAASKAIQEWGQPKSQITHLIFSSLSGMDMPGADYHLTKLLGLPSSVKRIMLNFQPCYASGTILRMAKDIAENNAGARILVVSTEISIGAFHGPNEHDIASLIGQAIVGDGAAAMIVGADPDVLNERPLFQIVSTAQNIIPGSGGAIEGHVREAGYSIQLSKDVPKLIANNLESCLSEALSPISINDWNSFFWIVHPGGSAILDQIEIKLGLKKEKLLATRHVLSEFGNMSVACVLFILDEMRKKSLEKGKATTGEGLEWGLLIGFGSGITLETVVLRSFPITITHP
>rna-XM_018125403.1
MASEKNLETQQAEEQVTILAIGTANPPHCFYQADYPDFYFRVTKSEHKIELKDKFKRICERSSIKKRYMHLTEDIIKENPNLIIYKAPSFDARQDILVTEVPKLGQEAALKAIKEWGQPISKITHLIFCTSSGINMPSADNQLARLIGLEPSVQKFMIYQQGCFAAGTALRLSKDLAKNNAGARVLIVCSELMVECFQPPSETHLDILVGSALFSDGAAAAIVGANPDATINERPSFQIVSAHQTIIPDSADIIVAKIREMGMEYYLSRDLPKCIANNIEQCLIEALIPFGIGDWKTLFYIVHPGGPAVLRGVEEKLGLGREKLKASWHVLSEYGNMWSPSVLFILDEMRKMSILEGKASSGDGLEWGVLFGFGPGLTVETVVLRSFALNSCR
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University