Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Thellungiella halophila
Species name
Eutrema halophilum is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Thellungiella_halophila.HIDH.fa
Download
>PAC:20206073
MAAISFSLNHQSSDNRRGGSHHHHRHGPVVEEIEGLIRVFNDGCVERPPIVPTVSPTVHPSAKVTAFDIKLCNDTWTRVYIPDVAASSPSFTLPLLVYFHGGGFCVGSASWSCYHDFLTSLAVKARCVVVSVDYRLAPEHRLPAAYDDGVSVVSWVLKQHHVSNGGYSSWVSKCNLSNVFLAGDSAGANIAYQVAVRITASGKSVNNLNLKGVILIHPFFGGESRTSSEKKQQQHSKSSALTLSASDTYWRLALPRGASRDHPWCNPLVSSSVGFLREARLPATMVFMAEFDILKDRNLEMCRVMRSLGKRVEGIVHGGVGHAFHILDNSLVSRDRIHDMMCRLRNFIHP
>PAC:20199804
MDSEIVFDNSPGYRVYKNGRIERLIGETIVPPSLNPQNGVVSKDTLYSPGNNLSVRIYLPEKTSETGEKLPVLVYFHGGGFIIESAFSPTYHNFLTSAVAAADCLAISVDYRRAPEFPIPIPYEDSWNSLKWVFSHIDGSGPENWINKHADFGKVLLAGDSAGGNIAHHLAIRARKEKLESLISGIILIHPYFWGKTPIDEMETRDETKRKRIERSWGIASPNSENGADDPLINVVGSESSDLSGLGCGRVLVIVAGDDAFVRQGLVYAAKVEKSGWEGEVEVMEIKEEGHVHHLKNPFTDNARLVVEKLAEFVNK
>PAC:20184268
MESEIASEHLPFIRIYKDGRVERLSGTEIIPPSLDAATNDVVSKDVVYSPEHNLSVRIFLPHKSTAGENKKKLPLLIYIHGGAWIIESPFSPIYHNFLTEIVKSGNFLAVSVQYRRAPENPIPAAYDDSWSAVKWVFSHSDGSGPEDWVNEFADFGKVFIAGDSAGGNMSHHMAIRAGKEKLEPRIKGIAIVHPAFWGRDPVDEKDVQDREMRNGIAEVWEKIASPNSVDGTDDPLFNVVGSGSDFSELACEKVLVAVAGKDVFVRQGLGYAAKLEKSGWVGDVEVVVEEDEGHVFHLQNPNSKNAEKFLKKLVGFIIG
>PAC:20185071
MDSTTKQVSLELFPWLIVHSDGRLERLAGTEVCPPGLDPETGVVSKDIIIDHKTGLSARIYRPDLIQPGQKLPLVLYFHGGAFLIASASFPSYHTSVNKLVDQANIIAVSVNYR
>PAC:20184549
MNSDLTTDHLPFIRIHENGSVERLSGNDIVPASLNPQNNLPLLIYFHGGAYIVESPFSPVYHNYLTEVVKTSNCLAASVQYRRAPENPIPAAYDDSWSAIQWIFSHSNGSGEEDWINEFADFDRVFVAGDSAGANISHHMAIRAGKEKIKPRIKGVVMKDVQDEGIRRGIKEIWEKIVSPNSVDGVDDPWLNVVGSGSDISGLGCERVLVAVAGKDVFGRQGLAYAAKLEKSGWEGDLEVVEEEGEGHCFHLRNLNCENALKLMKTFREFIIYR
>PAC:20184971
LAPEHPLPTAYEDSWNALQAIQAGNEPWINDYVDFHRFFLVGDSAGANISHHLAFRTKQSDHMTLKIKGIGMIHPYFWGTKPIGSEVTDEARKQMVDGWWRFVCPSEKGSDDPWINPFADGSPDLEGLGCERVMVTVAEKDILRERGKMYYERLVKSEWRGEAEIMETKGKDHVFHIFEPDCDEAMDMLRRLALRDLYITSSVLSYDDSNYSL
>PAC:20184710
MLRIFTCSSALRSPSPFFRFLRQFPRSYSSPTSVTISGRNLRRKPTQTTLRLICSHSSSDLVSEHPPFVKIYKDGRIERLSGTETVPASLNPQNGVVSKDVVYSPELNLSVRLFLPQKATELAAGDKIPLLIYIHGGAWIIGSPFSPTYHNFLTEVVKSANCLAVSIQYRRAPEDPIPAAYEDSWSAIQWVFSHSHGSGPVDWINEVADFDRVFLAGDSAGANMSHHMAIRAGKEKLNPRIKGTAIVHPAFWGKDPVDEHDVQDREARRRIAEVWEKLASPNSVDGVDDPLFNVIGSGSDFSEMGCEKVLVAVAGKDVFVRQGLGYAAKLMKSGWKGDVEVMEEEDEDHCFHLLNPDSENAPKFMKKFVEFIAS
>PAC:20192477
MGATTLTHETTINPNNTNIDHGPVVDELDGLIRVYTDGHVERPQFEPCVGPSLPLELGVACSDVHIDKLTNVWARLYVPMLTKTSVSKLPLLVYFHGGGFCIGSASWSCYHQFLARLSASSRCLVMSVNYRLAPENPLPAAYEDGVNAVLWLNKTRNDNLWSKLCDFGKIFLAGDSAGGNIANHVAARLAASDDLIKPLKIEGTILIQPFFGGEARTESERRVENNMKSSVLTLEGSDAWWRLALPRGANREHPYCKPVKTMIKMVRTLVCVAEMDVLMDREMEMCDGNEEVIKRVVYKGVGHAFQILGKSQLAHTMTLQMLCHIDAFIHHYHPFN
>PAC:20190006
MSINPVDEHDLQDREARRRIAVAGKDVFVRQGLGYAVKLMKSGWKGDVEVMEEEDEDHCFHFLNSDSENAPKF
>PAC:20206844
MDSEIAVDVSPVFKIYKSGRIERLMGETTVPPSSDPENGVVSKDVVYSPDDNLSVRIYLPEKAAAESGEKLPLLVYFHGGGFVIETAFSPTYHTFLTAATSASDCVAVSVDYRRAPEHPIPISYDDSWTALKWVFSHIAGSGSEDWLNKHADFGKVFLAGDSAGANIAHHMATRAAKEKLCSDLDGGDSGISGIILVHPYFWSRTPIDDKETRDATMRSKIEAFWMMASPNNKDGADDPWINVVKSESVDLSGLGCGKVLVMVAEKDALVRQGLGYAAKLEKSGWKGRVELVESEGEDHVFHLMKPDCDKALEAMQRFSGFIKGDDK
MAAISFSLNHQSSDNRRGGSHHHHRHGPVVEEIEGLIRVFNDGCVERPPIVPTVSPTVHPSAKVTAFDIKLCNDTWTRVYIPDVAASSPSFTLPLLVYFHGGGFCVGSASWSCYHDFLTSLAVKARCVVVSVDYRLAPEHRLPAAYDDGVSVVSWVLKQHHVSNGGYSSWVSKCNLSNVFLAGDSAGANIAYQVAVRITASGKSVNNLNLKGVILIHPFFGGESRTSSEKKQQQHSKSSALTLSASDTYWRLALPRGASRDHPWCNPLVSSSVGFLREARLPATMVFMAEFDILKDRNLEMCRVMRSLGKRVEGIVHGGVGHAFHILDNSLVSRDRIHDMMCRLRNFIHP
>PAC:20199804
MDSEIVFDNSPGYRVYKNGRIERLIGETIVPPSLNPQNGVVSKDTLYSPGNNLSVRIYLPEKTSETGEKLPVLVYFHGGGFIIESAFSPTYHNFLTSAVAAADCLAISVDYRRAPEFPIPIPYEDSWNSLKWVFSHIDGSGPENWINKHADFGKVLLAGDSAGGNIAHHLAIRARKEKLESLISGIILIHPYFWGKTPIDEMETRDETKRKRIERSWGIASPNSENGADDPLINVVGSESSDLSGLGCGRVLVIVAGDDAFVRQGLVYAAKVEKSGWEGEVEVMEIKEEGHVHHLKNPFTDNARLVVEKLAEFVNK
>PAC:20184268
MESEIASEHLPFIRIYKDGRVERLSGTEIIPPSLDAATNDVVSKDVVYSPEHNLSVRIFLPHKSTAGENKKKLPLLIYIHGGAWIIESPFSPIYHNFLTEIVKSGNFLAVSVQYRRAPENPIPAAYDDSWSAVKWVFSHSDGSGPEDWVNEFADFGKVFIAGDSAGGNMSHHMAIRAGKEKLEPRIKGIAIVHPAFWGRDPVDEKDVQDREMRNGIAEVWEKIASPNSVDGTDDPLFNVVGSGSDFSELACEKVLVAVAGKDVFVRQGLGYAAKLEKSGWVGDVEVVVEEDEGHVFHLQNPNSKNAEKFLKKLVGFIIG
>PAC:20185071
MDSTTKQVSLELFPWLIVHSDGRLERLAGTEVCPPGLDPETGVVSKDIIIDHKTGLSARIYRPDLIQPGQKLPLVLYFHGGAFLIASASFPSYHTSVNKLVDQANIIAVSVNYR
>PAC:20184549
MNSDLTTDHLPFIRIHENGSVERLSGNDIVPASLNPQNNLPLLIYFHGGAYIVESPFSPVYHNYLTEVVKTSNCLAASVQYRRAPENPIPAAYDDSWSAIQWIFSHSNGSGEEDWINEFADFDRVFVAGDSAGANISHHMAIRAGKEKIKPRIKGVVMKDVQDEGIRRGIKEIWEKIVSPNSVDGVDDPWLNVVGSGSDISGLGCERVLVAVAGKDVFGRQGLAYAAKLEKSGWEGDLEVVEEEGEGHCFHLRNLNCENALKLMKTFREFIIYR
>PAC:20184971
LAPEHPLPTAYEDSWNALQAIQAGNEPWINDYVDFHRFFLVGDSAGANISHHLAFRTKQSDHMTLKIKGIGMIHPYFWGTKPIGSEVTDEARKQMVDGWWRFVCPSEKGSDDPWINPFADGSPDLEGLGCERVMVTVAEKDILRERGKMYYERLVKSEWRGEAEIMETKGKDHVFHIFEPDCDEAMDMLRRLALRDLYITSSVLSYDDSNYSL
>PAC:20184710
MLRIFTCSSALRSPSPFFRFLRQFPRSYSSPTSVTISGRNLRRKPTQTTLRLICSHSSSDLVSEHPPFVKIYKDGRIERLSGTETVPASLNPQNGVVSKDVVYSPELNLSVRLFLPQKATELAAGDKIPLLIYIHGGAWIIGSPFSPTYHNFLTEVVKSANCLAVSIQYRRAPEDPIPAAYEDSWSAIQWVFSHSHGSGPVDWINEVADFDRVFLAGDSAGANMSHHMAIRAGKEKLNPRIKGTAIVHPAFWGKDPVDEHDVQDREARRRIAEVWEKLASPNSVDGVDDPLFNVIGSGSDFSEMGCEKVLVAVAGKDVFVRQGLGYAAKLMKSGWKGDVEVMEEEDEDHCFHLLNPDSENAPKFMKKFVEFIAS
>PAC:20192477
MGATTLTHETTINPNNTNIDHGPVVDELDGLIRVYTDGHVERPQFEPCVGPSLPLELGVACSDVHIDKLTNVWARLYVPMLTKTSVSKLPLLVYFHGGGFCIGSASWSCYHQFLARLSASSRCLVMSVNYRLAPENPLPAAYEDGVNAVLWLNKTRNDNLWSKLCDFGKIFLAGDSAGGNIANHVAARLAASDDLIKPLKIEGTILIQPFFGGEARTESERRVENNMKSSVLTLEGSDAWWRLALPRGANREHPYCKPVKTMIKMVRTLVCVAEMDVLMDREMEMCDGNEEVIKRVVYKGVGHAFQILGKSQLAHTMTLQMLCHIDAFIHHYHPFN
>PAC:20190006
MSINPVDEHDLQDREARRRIAVAGKDVFVRQGLGYAVKLMKSGWKGDVEVMEEEDEDHCFHFLNSDSENAPKF
>PAC:20206844
MDSEIAVDVSPVFKIYKSGRIERLMGETTVPPSSDPENGVVSKDVVYSPDDNLSVRIYLPEKAAAESGEKLPLLVYFHGGGFVIETAFSPTYHTFLTAATSASDCVAVSVDYRRAPEHPIPISYDDSWTALKWVFSHIAGSGSEDWLNKHADFGKVFLAGDSAGANIAHHMATRAAKEKLCSDLDGGDSGISGIILVHPYFWSRTPIDDKETRDATMRSKIEAFWMMASPNNKDGADDPWINVVKSESVDLSGLGCGKVLVMVAEKDALVRQGLGYAAKLEKSGWKGRVELVESEGEDHVFHLMKPDCDKALEAMQRFSGFIKGDDK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University