Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Thalictrum thalictroides
Species name
Rue-anemone (Thalictrum thalictroides) is a species of flowering plant in the family Ranunculaceae (buttercup family).
Species info
Gene sequence info
Thalictrum_thalictroides.CHS.fa
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>rna-gnl|WGS:JABWDY|TTHA_TU.07313.mRNA
MVDVNAFRRAQRAFGPATVMAIGTANPPNSIDQSTYPDYYFRITNSDHMTELKDKFKRICARSMIKTRYFHITEDLLKLNPNLGAYKAPSLNARQDILVEEIPKLGKEAALKAIQEWGQPKSKITHLIFCSTGGVDTPGADFQLTKLLGLQLSVKRYMMYQQGCFSGGMVLRLAKDLAENNRGARVLVVCSEITVVTFHGPSDTNLDSLLGQAIFGDGAAAVIVGADPVIGVEKPLFEIVSASQTIIPDCGGAIDGHLREEGLIFHLQKTVPELVSMNIKKSLEEAFEPLGISDWNSLFWIVHPGGPKILNQIELKLNLEPNKLALSRQVLSEYGNMSGASVLFVLDKMRTKSAQGRLKTTGDGLDWGVLFGFGPGLTVETTVLHSMPT
>rna-gnl|WGS:JABWDY|TTHA_TU.10955.mRNA
MVVSVDGSRRVQISNGLAMVMAIGTATPPNCVDQSTYPDYYFRVTNSEHKTELKEKFRRICERTTVKKRYIHLTEDILKKNPNMCAFNAPSLDARQAMAVVAVPNLAKEAATKAIEEWGQPKSMITHLVFCNSTCGGDIPGADVQLMKLLNLKPSVKRYMMYSQGCFGGGMVLRLAKDIAENNRGARVLAVCCETIHLSFRGPSADHLDSLVNQALFGDGAAALIIGADPVTGIEKPIFEVVSTAQTILPDSDGAIKGHLKEEGLTFNLVKDVPGLISKNIESCLEEAFEPLGISDWNSLFWIAHPGGPAIIDKIQNKLNLEPKKLRATRQVLSDYGNLSSACVLFIMEEMRKNSVQEGFKTTGEGLEWGVLFGIGAGLTVDTVVLRSMLI
>rna-gnl|WGS:JABWDY|TTHA_TU.17175.mRNA
MVDIDAFRRVQKADGQATVMAIGTATPPNCVDQSTYPDYYFRITNSEHMTDLKEKFKRICKNLNSFYTNLFLSFDLLNVSY
>rna-gnl|WGS:JABWDY|TTHA_TU.17176.mRNA
MSCVRAGERTTVKKRYIHLTEEILKENPNMCAYKAPSLDARQDMAVVDVPKLAKEAAVKAIEEWGQTKSKITHLIFCNSTCGGDIPGADVRLIKLLGLKLSVKRYMMYQQGCFGGGMVLRLAKDLAENNRGARVLVICCETIHLSFRGPSDDHLASLVNQALFGDGAAALIVGADPIIGIEKPLFEVISAVQTLVPDSDGAIQGHLKEEGLTFNLVKNVPELISKNIEKCLKEAFEPLGISDWNSLFWIAHPGGPAILDKVQDILCLEPQKLRATRQVLSDY
>rna-gnl|WGS:JABWDY|TTHA_TU.22095.mRNA
MPHKSLLSKLSIFQAITRMSKMNLNGNNKNRSHTPGKATVLALGKAFPSQLIPQECLVEGYCRDTKCEDPVMKAKLERLCKNTTVKTRYTVMSKEILDKYPELATEGSATIKQRLEIANEAVVEMAMEASLSCIKEWGRSAEDITHLVYVTSSEVRLPGGDLYLSSQLGLRNTVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSMDRPYDLVGAALFGDGAAAVIIGTDPVIGIEKPFMELNYAVQQFLPGTQHTIDGRLTEEGIIFKLGRDLPQKIEDNIQAFCNSLMAKADVKDYNDLFWAVHPGGPAILNKIENNLKLRAEKLQCSRRALMDYGNASSNTIFYVFDYIREELKKSGEEWGLALAFGPGITFEGILMRNLQYNGR
>rna-gnl|WGS:JABWDY|TTHA_TU.24708.mRNA
MGSLIEITRGELQRTANPGKTTILALGKAFPHQLVMQELLVDGYFRNTQCDDPELKQKLARLCKSTTVKTRYVVMSEEILKEYPELGVEGLPTLRQRLEISNKAVTEMATEASVVCIKNWGRPASNITHLVYVSSSEARLPGGDLYLAKALGLNPDVSRVMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPNVDRPYDLVGAALFGDGAGAMILGSNPIQGVERPLFELYTAIQHFLPDTEKTIDGQLTEEGIGFKLGRDLPQIIEDNIEGFCTKLMKVVGFSNEEYNKLFWAVHPGGPAILNRLEKRFDLLPEKLTASRRALMDYGNASSNTIVYVLEYMMEEALKNDKKDDSEWGLILAFGPGVTFEGILARKLI
>rna-gnl|WGS:JABWDY|TTHA_TU.26882.mRNA
MVSVEEIRNAQRAKGPATVLAIGTATPSNCVYQADYPDYYFRITDSEHLTDLKEKFKRMCDKSQIKKRYMHLNEEILKENPSMCAYEAPSLDARQDMVVVEVPKLGKEAASKAIKEWGQPKSKITHVVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIIGADPDMAIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIQKSLVEAFTPIGITDWNSLFWIAHPGGPAILDQKVKREVD
>rna-gnl|WGS:JABWDY|TTHA_TU.31138.mRNA
MVDVNAFRRAQRACGPATVMAIGTANPPNCVDQSTYPDYYFRITNSDHMTELKEKFKRICAKSMIQTRYSHITEDLLKLNPNLGAYKAPSLNARQDILVEEIPKLGKEAALKAIQEWGQPKSKITHLIFSSTGGVDTPGADFQLTKLLGLQLSVKRYMMYQQGCFSGGMVLRLAKDLAENNRGARVLVVCSEITVVAFRGPSDTNLDYLLGQAIFGDGAAAVIVGADPVIGIEKPLFEIVSASQTIIPDSGGAIDGHLREEGLIFHLQQTVPELVSMNIKKSLEEAFEPLGISDWNSLFWIVHPGGPKILNQIELKLNLEPDKLALSRQVLSEYGNMSGASVLFVLDKMRTKSAQERLKTTGKGLDWGVLFGFGPGLTVETILLHSMPT
MVDVNAFRRAQRAFGPATVMAIGTANPPNSIDQSTYPDYYFRITNSDHMTELKDKFKRICARSMIKTRYFHITEDLLKLNPNLGAYKAPSLNARQDILVEEIPKLGKEAALKAIQEWGQPKSKITHLIFCSTGGVDTPGADFQLTKLLGLQLSVKRYMMYQQGCFSGGMVLRLAKDLAENNRGARVLVVCSEITVVTFHGPSDTNLDSLLGQAIFGDGAAAVIVGADPVIGVEKPLFEIVSASQTIIPDCGGAIDGHLREEGLIFHLQKTVPELVSMNIKKSLEEAFEPLGISDWNSLFWIVHPGGPKILNQIELKLNLEPNKLALSRQVLSEYGNMSGASVLFVLDKMRTKSAQGRLKTTGDGLDWGVLFGFGPGLTVETTVLHSMPT
>rna-gnl|WGS:JABWDY|TTHA_TU.10955.mRNA
MVVSVDGSRRVQISNGLAMVMAIGTATPPNCVDQSTYPDYYFRVTNSEHKTELKEKFRRICERTTVKKRYIHLTEDILKKNPNMCAFNAPSLDARQAMAVVAVPNLAKEAATKAIEEWGQPKSMITHLVFCNSTCGGDIPGADVQLMKLLNLKPSVKRYMMYSQGCFGGGMVLRLAKDIAENNRGARVLAVCCETIHLSFRGPSADHLDSLVNQALFGDGAAALIIGADPVTGIEKPIFEVVSTAQTILPDSDGAIKGHLKEEGLTFNLVKDVPGLISKNIESCLEEAFEPLGISDWNSLFWIAHPGGPAIIDKIQNKLNLEPKKLRATRQVLSDYGNLSSACVLFIMEEMRKNSVQEGFKTTGEGLEWGVLFGIGAGLTVDTVVLRSMLI
>rna-gnl|WGS:JABWDY|TTHA_TU.17175.mRNA
MVDIDAFRRVQKADGQATVMAIGTATPPNCVDQSTYPDYYFRITNSEHMTDLKEKFKRICKNLNSFYTNLFLSFDLLNVSY
>rna-gnl|WGS:JABWDY|TTHA_TU.17176.mRNA
MSCVRAGERTTVKKRYIHLTEEILKENPNMCAYKAPSLDARQDMAVVDVPKLAKEAAVKAIEEWGQTKSKITHLIFCNSTCGGDIPGADVRLIKLLGLKLSVKRYMMYQQGCFGGGMVLRLAKDLAENNRGARVLVICCETIHLSFRGPSDDHLASLVNQALFGDGAAALIVGADPIIGIEKPLFEVISAVQTLVPDSDGAIQGHLKEEGLTFNLVKNVPELISKNIEKCLKEAFEPLGISDWNSLFWIAHPGGPAILDKVQDILCLEPQKLRATRQVLSDY
>rna-gnl|WGS:JABWDY|TTHA_TU.22095.mRNA
MPHKSLLSKLSIFQAITRMSKMNLNGNNKNRSHTPGKATVLALGKAFPSQLIPQECLVEGYCRDTKCEDPVMKAKLERLCKNTTVKTRYTVMSKEILDKYPELATEGSATIKQRLEIANEAVVEMAMEASLSCIKEWGRSAEDITHLVYVTSSEVRLPGGDLYLSSQLGLRNTVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSMDRPYDLVGAALFGDGAAAVIIGTDPVIGIEKPFMELNYAVQQFLPGTQHTIDGRLTEEGIIFKLGRDLPQKIEDNIQAFCNSLMAKADVKDYNDLFWAVHPGGPAILNKIENNLKLRAEKLQCSRRALMDYGNASSNTIFYVFDYIREELKKSGEEWGLALAFGPGITFEGILMRNLQYNGR
>rna-gnl|WGS:JABWDY|TTHA_TU.24708.mRNA
MGSLIEITRGELQRTANPGKTTILALGKAFPHQLVMQELLVDGYFRNTQCDDPELKQKLARLCKSTTVKTRYVVMSEEILKEYPELGVEGLPTLRQRLEISNKAVTEMATEASVVCIKNWGRPASNITHLVYVSSSEARLPGGDLYLAKALGLNPDVSRVMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPNVDRPYDLVGAALFGDGAGAMILGSNPIQGVERPLFELYTAIQHFLPDTEKTIDGQLTEEGIGFKLGRDLPQIIEDNIEGFCTKLMKVVGFSNEEYNKLFWAVHPGGPAILNRLEKRFDLLPEKLTASRRALMDYGNASSNTIVYVLEYMMEEALKNDKKDDSEWGLILAFGPGVTFEGILARKLI
>rna-gnl|WGS:JABWDY|TTHA_TU.26882.mRNA
MVSVEEIRNAQRAKGPATVLAIGTATPSNCVYQADYPDYYFRITDSEHLTDLKEKFKRMCDKSQIKKRYMHLNEEILKENPSMCAYEAPSLDARQDMVVVEVPKLGKEAASKAIKEWGQPKSKITHVVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIIGADPDMAIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIQKSLVEAFTPIGITDWNSLFWIAHPGGPAILDQKVKREVD
>rna-gnl|WGS:JABWDY|TTHA_TU.31138.mRNA
MVDVNAFRRAQRACGPATVMAIGTANPPNCVDQSTYPDYYFRITNSDHMTELKEKFKRICAKSMIQTRYSHITEDLLKLNPNLGAYKAPSLNARQDILVEEIPKLGKEAALKAIQEWGQPKSKITHLIFSSTGGVDTPGADFQLTKLLGLQLSVKRYMMYQQGCFSGGMVLRLAKDLAENNRGARVLVVCSEITVVAFRGPSDTNLDYLLGQAIFGDGAAAVIVGADPVIGIEKPLFEIVSASQTIIPDSGGAIDGHLREEGLIFHLQQTVPELVSMNIKKSLEEAFEPLGISDWNSLFWIVHPGGPKILNQIELKLNLEPDKLALSRQVLSEYGNMSGASVLFVLDKMRTKSAQERLKTTGKGLDWGVLFGFGPGLTVETILLHSMPT
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University