Enzyme
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
ANR
Enzyme
Anthocyanidin reductase
Enzyme name
EC:1.3.1.77
Entry
Oxidoreductases;Acting on the CH-CH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Sysname
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction
anthocyanidin with a 3-hydroxy group [CPD:C21381];NADH [CPD:C00004];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Arabis alpina
Species name
Gray rockcress (Arabis alpina) is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Arabis_alpina.ANR.fa
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>rna-gnl|WGS:JNGA|AALP_mrnaAA2G025700
MDQTVLTTGSKKACVIGGTGNLASILMKHLLQNGYKVNTTVRDPENENKMSHLRLLQELGDLKIFKADLTDEESFDSPFSGCEYVFHVATPINFTSEDPEKDMINPAIQGVINVLKSCLKSKSIKRVIYTSSAAAVSINNLSGPGLVMNEENWTDIDFLTKEKPFNWGYPISKTLAEKAACKFAEEHKIDLVTVIPALIAGNSLLSVPPPSSLSLSMSLITGKEMHLIGLKEMQKLSGSISFVHVDDLARAHLFLAEKETASGRYICCAYNTCVPKIADFLRQRYPKYNVISEFEECLSIAKLTLSSEKLVSEGFRFEYGINEMYDEMIEYFESKGLIEAKQS
>rna-gnl|WGS:JNGA|AALP_mrnaAA2G207000
MEENQRVCVTGSGGYIASWLVKFLLSRGYTVHGTVRDPCDGKNEHLKKLDYAAENLKLFKADLFDYEALSSAFSGPRLQSKLNSSSLGLLKFIKGGINSFLSEQLYLVDVRDVADALLLVYENQEAKGRYICNSHSLDNNGLMEKLKKMYPNHNFPESSAEEKGKEEVKEDRLRLSSEKLQSLGWKFRSLEETIDDSVVSFEVAGGYIASWLVKFLLSRGYTVHGTVRDPCDEKNEHLKKLDNAAKNLKLFKADLFDYEALSSAVFGCYGVFHVACPVPFEGVPLTEEELIKPALTGTKNVLEACSEAKVKKVVVVSSAAAVVYNPKWPKDVAKDEDCWSDTQYLRSLEGYWRYYDLAKTLMEREALEWSKNSLADVVTVCPSITIGPRLQYKLNSSSMGLLKFITGGMKTLLNDQVYLVDVRADALLLVYENQEAKGRYICNSHSLQSNALMEKLKNMYPNRNFPESFTEWKGKEEVKEERLRLSSEKLQNLGWKFRSLEETIDDSMVSFEVAGDLPKP
MDQTVLTTGSKKACVIGGTGNLASILMKHLLQNGYKVNTTVRDPENENKMSHLRLLQELGDLKIFKADLTDEESFDSPFSGCEYVFHVATPINFTSEDPEKDMINPAIQGVINVLKSCLKSKSIKRVIYTSSAAAVSINNLSGPGLVMNEENWTDIDFLTKEKPFNWGYPISKTLAEKAACKFAEEHKIDLVTVIPALIAGNSLLSVPPPSSLSLSMSLITGKEMHLIGLKEMQKLSGSISFVHVDDLARAHLFLAEKETASGRYICCAYNTCVPKIADFLRQRYPKYNVISEFEECLSIAKLTLSSEKLVSEGFRFEYGINEMYDEMIEYFESKGLIEAKQS
>rna-gnl|WGS:JNGA|AALP_mrnaAA2G207000
MEENQRVCVTGSGGYIASWLVKFLLSRGYTVHGTVRDPCDGKNEHLKKLDYAAENLKLFKADLFDYEALSSAFSGPRLQSKLNSSSLGLLKFIKGGINSFLSEQLYLVDVRDVADALLLVYENQEAKGRYICNSHSLDNNGLMEKLKKMYPNHNFPESSAEEKGKEEVKEDRLRLSSEKLQSLGWKFRSLEETIDDSVVSFEVAGGYIASWLVKFLLSRGYTVHGTVRDPCDEKNEHLKKLDNAAKNLKLFKADLFDYEALSSAVFGCYGVFHVACPVPFEGVPLTEEELIKPALTGTKNVLEACSEAKVKKVVVVSSAAAVVYNPKWPKDVAKDEDCWSDTQYLRSLEGYWRYYDLAKTLMEREALEWSKNSLADVVTVCPSITIGPRLQYKLNSSSMGLLKFITGGMKTLLNDQVYLVDVRADALLLVYENQEAKGRYICNSHSLQSNALMEKLKNMYPNRNFPESFTEWKGKEEVKEERLRLSSEKLQNLGWKFRSLEETIDDSMVSFEVAGDLPKP
Sheng jun & Dong yang Teams, Yunnan agriculture University