Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Arabis alpina
Species name
Gray rockcress (Arabis alpina) is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Arabis_alpina.4CL.fa
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>rna-gnl|WGS:JNGA|AALP_mrnaAA2G069200
MITAALHEPQIHKPADTSTAVSGNADAVPPTPRIFRSKLPDIDIPNHLSLHTYCFEKLSSVSHKSCLIVGSTGKSYSYGETHLVCRRVAAGMYKMGIRKGDVIMILLQNSAEFVFSFMGASMIGAVSTTANPFYTCQEIYKQLKSSGAKLIITQSQYVDKIGQDVKVITTDGPPSENCLPFSTLIEEDETEPPPESVHVGGDDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLHSNDVVLCVLPLFHIYSLNSVLLNSIRSGATVLLMHKFEIGALLDLIQRHRVTIAALVPPLVIALAKNPAVNSYDLSSVRLVLSGAAPLGKDLQDNLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPIPTKSGSCGTVVRNAELKVVHLETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDTEGWLHTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHHSIADAAVVPQNDEVAGEVPVAFVVRSNGNKITEEDIKEYISKQVVFYKRLHKVFFVPSIPKSPSGKILRKDLKAKLC
>rna-gnl|WGS:JNGA|AALP_mrnaAA3G243900
MSPQETMITDQKQSDDVIFRSKLPDIYIPNHLPLHDYIFENISDFTDKPCLINAPTGEVYTYADVHATSRKIAAGFRNLGVNKHDVIMLLLPNSPEFVFTFFAASFLGAITTAANPFFTTAEITKQAKASAAKIIITQSQYAGKIKNLQKDGVSIICTDSSEDCLCFSELTQSGEETEQHTTEILPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYFHREDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEISLLLEQIQRCKVTVAMVVPPIVLAMVKSPETEKYDLSSVRVIKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLTMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLPRNKPGEICIRGQQIMKGYLNDPEATAVTIDKDGWLHSGDVGLVDDDDELFIVDRLKEIIKYKGFQVAPAELESLLISHSDINDVAVVGMKEEGVGEVPIAFVVRSKDSSISEDEIKQFVSKQVVFYKRINKVFFTDSIPKAPSGKILRKDLRAKLANGLIDELSLK
>rna-gnl|WGS:JNGA|AALP_mrnaAA3G243700
MVLQQQTLFLTKKKTSTDQQETSHDFIFRSKLPDISIPNHLPLIDYVFQRFSGDGDGDFSATCLIDGATGRIFTYADVLTNTRRIAAGIHRLGIRHGDVVMLLLPNSPEFALSFLAVAYLGGVSTTANPFYTQPEIEKQGKASNAKMIITKPCYVEKLTNLQNDGVLIVCVEDDGDVVSLPDGCVRFKELNEADETELPKPEISPEDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNVYLTGDDVILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLEFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKYPFKTKSGACGTVIRNAEMKVVDTITGISLPRNKSGEICIRGNQLMKGYLNDPEATARTIDKDGFLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEVLLISHPLIVDAAVVAMKDEVADEVPVAFVVRTEGSKLTEDDVKSYVNKQVVHYKRIKKVFFIEAIPKAVSGKILRKDLRAKLETEYAK
>rna-gnl|WGS:JNGA|AALP_mrnaAA4G042700
MQKQNNEKSDVIFRSKLPDIYIPNHLSLHDYIFQNITEHGSKPCLINGPTGHVYTYSDVHVTSRKIATGFRNLGVNRNDVVMILLPNCPEFVLSFFAASFLGVTATAANPFYTPAEISKQAKGSNSKLIITETRYVEKVKDLGVKIVCIDDDESVMLPEGCLRFSELTKSTEVDTVEVLPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEIHLLLELIQRCKITVAPIVPPIVLAIANSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLAQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTRVSLSRNQPGEICIRGHQIMKGYLNNPEATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGYQVAPAELEALLIGHQDITDVAVVGMKDVAAGEIPVAFVVKSKDSVLSEDEVKQFVSKQVVFYKRINKVFFVDSIPKAPSGKILRKDLRAKLANGLTH
>rna-gnl|WGS:JNGA|AALP_mrnaAA6G213500
MEKSGYGRDGIYRSLRPMLTLPKDPNTSLVSFLFRNSSSYSSNLALADSDSGHSFTFSDLKSAVSRLANGFLRLGIRKHDVVLIFAPNSYQFPLCFLAVTAIGGVFTTANPLYTVNEISKQIKDSNPKIIISVAQLFDTIKGFDLPVVLLGSGDSLQVPESKKIYSFDNVMNLSEAVSDLPLVDVKQSDTAALLYSSGTTGVSKGVELTHGNFIAASLMVTMDQDLMGWNHGVFLCFLPMFHVFGLAVITYSQLQRGNAVISMAKFELELVLKNIEKYRVTHLWVVPPVFIALTKYKNVKKFDLSSLKYLASGAAPLGKDLMEECARNMPNLVLTQGYGMTETTGIVSIEDTRFGKRNSGSAGMLAPGIEAQIVSVETGKYQPPNQLGEVWVRGPNMMKGYLNNPKATKETIDSKGWVHTGDLGYFNEDGNLFVVDRIKELIKYKGFQVAPAELEDLLVSHPEILDAAVIPFPDEEAGEVPIAFVVRSPNSSITEKDIQDFVAKQVAPYKRLRRVSFINSVPKSAAGKILRRELVQQVRSKM
>rna-gnl|WGS:JNGA|AALP_mrnaAA7G013900
MASTHHHLLHISTNAKTQTPSPLWFSPQTGIYTSKFTSINLPIDSNLDAVTALFSHRHNGDTAIIDSLTGFSISHIDLKVLVKSIASRVYHDLGIRQGHVVSLVLPNSVYFPVIFLSLISLGAIVTTMNPSSSLSEIKKQVSECSVGLVFTCSENVEKLSSLGIVVVKVPESYDFDLIRVENPRFYSIFKGGLDYGFVAKPVIKQDDVAAIMYSSGTTGGSKGVLLTHRNLIASMELFVRFEASQYEYSGSSNVYLAALPLCHIYGLSLFVMGLLSVGSTIVVMRRFDVSDVVDVIERFKVTHFPVVPPMLMALTKKAKGVCGDVFRSLKQVSSGAAPLSRKFIEDFLQTLPHVDLIQGYGMTESTAVGTRGFNSQKVRKYSSVGLLAPNMQAKVVDWSSGSFLPPGNRGELWIQGPGVMKGYLNNPKATQMTIVEDSWLRTGDIAYFDDDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTAAPNEECGEIPVAFVVRKQGTTLSEQDVISYVAAQVSPYRKVRKVVMVNSIPKSPAGKILRKELKRRLTNCVTTSKL
>rna-gnl|WGS:JNGA|AALP_mrnaAA7G135200
MFKFNRALATLRGLLPKNTFDELCVRSQCAMQGYFKNKEETEKTIDEEAILLTHPSVEDVAVLPLPDKDAI
>rna-gnl|WGS:JNGA|AALP_mrnaAA8G419500
MECQNQDNEYIFRSLYPSVPIPDKLTLPEFVLQGVEEYTEKVAFVEAVTGKSVTYGDVVRDTKRLAKALTSLGLRKGQVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALVSEIKKQVEASGAKGIITDATNYEKVKTLGLPVIVLGDEKIEGAVNWKDLLEAGDKCSDNNNKEEILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSTLFSIRSEMIGQIVTLGLIPFFHIYGIVGICCATMKNKGKVVAMSRYDLRIFLNAMITHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMTAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGLSLPKNTPGELCVRSQCVMQGYFENKEETDKTIDEEGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPVACVVINSKAKENEEDILNFVAANVAHYKKVRAVHFVDSIPKSLSGKIMRRLLRDKILSMNTK
MITAALHEPQIHKPADTSTAVSGNADAVPPTPRIFRSKLPDIDIPNHLSLHTYCFEKLSSVSHKSCLIVGSTGKSYSYGETHLVCRRVAAGMYKMGIRKGDVIMILLQNSAEFVFSFMGASMIGAVSTTANPFYTCQEIYKQLKSSGAKLIITQSQYVDKIGQDVKVITTDGPPSENCLPFSTLIEEDETEPPPESVHVGGDDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLHSNDVVLCVLPLFHIYSLNSVLLNSIRSGATVLLMHKFEIGALLDLIQRHRVTIAALVPPLVIALAKNPAVNSYDLSSVRLVLSGAAPLGKDLQDNLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPIPTKSGSCGTVVRNAELKVVHLETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDTEGWLHTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHHSIADAAVVPQNDEVAGEVPVAFVVRSNGNKITEEDIKEYISKQVVFYKRLHKVFFVPSIPKSPSGKILRKDLKAKLC
>rna-gnl|WGS:JNGA|AALP_mrnaAA3G243900
MSPQETMITDQKQSDDVIFRSKLPDIYIPNHLPLHDYIFENISDFTDKPCLINAPTGEVYTYADVHATSRKIAAGFRNLGVNKHDVIMLLLPNSPEFVFTFFAASFLGAITTAANPFFTTAEITKQAKASAAKIIITQSQYAGKIKNLQKDGVSIICTDSSEDCLCFSELTQSGEETEQHTTEILPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYFHREDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEISLLLEQIQRCKVTVAMVVPPIVLAMVKSPETEKYDLSSVRVIKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLTMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLPRNKPGEICIRGQQIMKGYLNDPEATAVTIDKDGWLHSGDVGLVDDDDELFIVDRLKEIIKYKGFQVAPAELESLLISHSDINDVAVVGMKEEGVGEVPIAFVVRSKDSSISEDEIKQFVSKQVVFYKRINKVFFTDSIPKAPSGKILRKDLRAKLANGLIDELSLK
>rna-gnl|WGS:JNGA|AALP_mrnaAA3G243700
MVLQQQTLFLTKKKTSTDQQETSHDFIFRSKLPDISIPNHLPLIDYVFQRFSGDGDGDFSATCLIDGATGRIFTYADVLTNTRRIAAGIHRLGIRHGDVVMLLLPNSPEFALSFLAVAYLGGVSTTANPFYTQPEIEKQGKASNAKMIITKPCYVEKLTNLQNDGVLIVCVEDDGDVVSLPDGCVRFKELNEADETELPKPEISPEDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNVYLTGDDVILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLEFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKYPFKTKSGACGTVIRNAEMKVVDTITGISLPRNKSGEICIRGNQLMKGYLNDPEATARTIDKDGFLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEVLLISHPLIVDAAVVAMKDEVADEVPVAFVVRTEGSKLTEDDVKSYVNKQVVHYKRIKKVFFIEAIPKAVSGKILRKDLRAKLETEYAK
>rna-gnl|WGS:JNGA|AALP_mrnaAA4G042700
MQKQNNEKSDVIFRSKLPDIYIPNHLSLHDYIFQNITEHGSKPCLINGPTGHVYTYSDVHVTSRKIATGFRNLGVNRNDVVMILLPNCPEFVLSFFAASFLGVTATAANPFYTPAEISKQAKGSNSKLIITETRYVEKVKDLGVKIVCIDDDESVMLPEGCLRFSELTKSTEVDTVEVLPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEIHLLLELIQRCKITVAPIVPPIVLAIANSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLAQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTRVSLSRNQPGEICIRGHQIMKGYLNNPEATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGYQVAPAELEALLIGHQDITDVAVVGMKDVAAGEIPVAFVVKSKDSVLSEDEVKQFVSKQVVFYKRINKVFFVDSIPKAPSGKILRKDLRAKLANGLTH
>rna-gnl|WGS:JNGA|AALP_mrnaAA6G213500
MEKSGYGRDGIYRSLRPMLTLPKDPNTSLVSFLFRNSSSYSSNLALADSDSGHSFTFSDLKSAVSRLANGFLRLGIRKHDVVLIFAPNSYQFPLCFLAVTAIGGVFTTANPLYTVNEISKQIKDSNPKIIISVAQLFDTIKGFDLPVVLLGSGDSLQVPESKKIYSFDNVMNLSEAVSDLPLVDVKQSDTAALLYSSGTTGVSKGVELTHGNFIAASLMVTMDQDLMGWNHGVFLCFLPMFHVFGLAVITYSQLQRGNAVISMAKFELELVLKNIEKYRVTHLWVVPPVFIALTKYKNVKKFDLSSLKYLASGAAPLGKDLMEECARNMPNLVLTQGYGMTETTGIVSIEDTRFGKRNSGSAGMLAPGIEAQIVSVETGKYQPPNQLGEVWVRGPNMMKGYLNNPKATKETIDSKGWVHTGDLGYFNEDGNLFVVDRIKELIKYKGFQVAPAELEDLLVSHPEILDAAVIPFPDEEAGEVPIAFVVRSPNSSITEKDIQDFVAKQVAPYKRLRRVSFINSVPKSAAGKILRRELVQQVRSKM
>rna-gnl|WGS:JNGA|AALP_mrnaAA7G013900
MASTHHHLLHISTNAKTQTPSPLWFSPQTGIYTSKFTSINLPIDSNLDAVTALFSHRHNGDTAIIDSLTGFSISHIDLKVLVKSIASRVYHDLGIRQGHVVSLVLPNSVYFPVIFLSLISLGAIVTTMNPSSSLSEIKKQVSECSVGLVFTCSENVEKLSSLGIVVVKVPESYDFDLIRVENPRFYSIFKGGLDYGFVAKPVIKQDDVAAIMYSSGTTGGSKGVLLTHRNLIASMELFVRFEASQYEYSGSSNVYLAALPLCHIYGLSLFVMGLLSVGSTIVVMRRFDVSDVVDVIERFKVTHFPVVPPMLMALTKKAKGVCGDVFRSLKQVSSGAAPLSRKFIEDFLQTLPHVDLIQGYGMTESTAVGTRGFNSQKVRKYSSVGLLAPNMQAKVVDWSSGSFLPPGNRGELWIQGPGVMKGYLNNPKATQMTIVEDSWLRTGDIAYFDDDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTAAPNEECGEIPVAFVVRKQGTTLSEQDVISYVAAQVSPYRKVRKVVMVNSIPKSPAGKILRKELKRRLTNCVTTSKL
>rna-gnl|WGS:JNGA|AALP_mrnaAA7G135200
MFKFNRALATLRGLLPKNTFDELCVRSQCAMQGYFKNKEETEKTIDEEAILLTHPSVEDVAVLPLPDKDAI
>rna-gnl|WGS:JNGA|AALP_mrnaAA8G419500
MECQNQDNEYIFRSLYPSVPIPDKLTLPEFVLQGVEEYTEKVAFVEAVTGKSVTYGDVVRDTKRLAKALTSLGLRKGQVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALVSEIKKQVEASGAKGIITDATNYEKVKTLGLPVIVLGDEKIEGAVNWKDLLEAGDKCSDNNNKEEILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSTLFSIRSEMIGQIVTLGLIPFFHIYGIVGICCATMKNKGKVVAMSRYDLRIFLNAMITHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMTAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGLSLPKNTPGELCVRSQCVMQGYFENKEETDKTIDEEGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPVACVVINSKAKENEEDILNFVAANVAHYKKVRAVHFVDSIPKSLSGKIMRRLLRDKILSMNTK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University