Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Spinacia oleracea
Species name
Spinach (Spinacia oleracea) is a species of eudicot in the family Chenopodiaceae.
Species info
Gene sequence info
Spinacia_oleracea.COMT.fa
Download
>rna-XM_021990235.1
MVLNATIELGVLQIIHNDPNSNGLLPTELAARIQARNPEAPIMLDRMLRVLATYSVVSCITKPTSDGGVQRRYGPAPVTKCFVPDQDGVSLAPMLNLVVDKVFLLSWSKLKEAVLEGGIPFNKVHEMHAFEYPSVDPRFNEIFNKAMYDQSTYTIKKILQKYKGFEKIQQLVDVGGGLGHTINAITSQYPSIKGINFDLPHVIQHAPPIPGVEHVGGDMFGSVPEGDAIFMKWILHNWSDDRYLMLLKNCYKALPDNGKVIVVETNITDEPETTALAKAISQLDVSMMTQNPGGKERTSKEFEALAKATGFSGVKFDCYVSNFWVMEFYK
>rna-XM_021990259.1
MTDTECSTPLVEEQQHHRQDLEEKEEEEEENNFGYALQIVDSMAFPMVMNAVIELDILGIIARAGPGNKLLASEIAASLPEVKNPMAASMLDRMLWLLATYNVVTCEIFVAKDGGVVRKYGLAPVAKFFVPDHDGVSLAPLMSLSQDKVFVDCWSKLKDAVLEGGIPFNMVHGMHAFEYPSVDSRFNEVFNKAMAQSIIFVKKIFNKYKGLEDSNVKQLVDVGGGLGHSIGFITSKYPSIKGINFDLPHVIGDAPPCPGVEHIGGDMFESVPNGDAIFLKWILHDWSDEHCLTLLKNCYKAMPEGGKVIVVEAIIPDEPETTTFARAISQVDLLMMTQNPGGKERSKREFEALAKGAGFAGINFHCCVHGFWVMEFYK
>rna-XM_022002712.1
MGSTSAEKTQMGEDEACSFAMTVTSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIVAQLPSKNPDAANMLDRMLRLLASYSILSYSLQTRADGRVERLYGLAPVCQFLTKNEDGVTLGALSLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNNGMSNHSTITMKRILDTYKGFEGLSTLVDVGGGTGATLNMILSKHTTIKGINFDLPHVIEDAPAYNGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCLKFLKNCFASLPDHGKVIVCEYILPVAPETSHAARTVFHVDAIMLAHNPGGKERTEQEFEALAKGSGFEGFRVACSAYDTKVMEFLKKSS
>rna-XM_022002704.1
MGSVTNGVGEMSSYWDLGEEEEEEASFFALSLLSDNIKFEVLKAVKDLDVFETIKKCGPLAQLSAAEIVAKLPTENLVVATVNLGRLLDFLVSHSILTVTPTTLPGGKVERRYGLAPVCKFLTANEDGVSLGSFSNTLMYNALKQSCLCIKDAILEGEEPFKKAHGMTFYEYIGKNTEYRKGFHKAMSDHSTLIMRKILRTYKGFEGLSSLVDVGGGNGAILNMILSQYPTIKGINFDQPHVVADALTYPGVEHVGGDMFVNIPKGGDAIFLKWILHCFGDEACTKILKNCYAALPEDRGKVVICEYLLPDPDVTTNDIAANSVVQFDVMMMVLPGGKERTENEFKDLALAAGFHGFEVVCSAYNVKIIELLKIN
>rna-XM_021988484.1
MSSIIGSNETQIHPTTEEEASCMAMCLATWSVPSMVFKTMLELNVIDIIYNSGPTAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGPDGQPKRLYGLGPVCQFLAKNDDEVSYAAYANLMHDKIIMDTWKHLKDAVLEGSVPFKKTYGTGIYDYLGTDSRFYRVFYDGMDHHSTIVLKKILETYKGFEGISTLVDVGGGSGVTLKMIVSKYPSIKAINFDQPHIIKDAPSYPGVEHVGGDMYASVPKADAIFMKWTFQSGTDEQCVKLLKNFHEALPEDGKVVICEYLVPDSPKTSYQAHTAFIWDIIMMTYPGGKARTKQEYEALGKEAGFEDFRLVCFACDTWVMEYLKKKKSGN
>rna-XM_021988632.1
MMGSNFTQKSPTTEEEALSMAMCLATSHVPSMAFKAVLELNIIDIINDVGPEAQLSPAEIAAQLATANPDAAVVLDRLLRLLANFTILTFSYRDGPSGQPERVYGLGPVCQFLAKNGGGSAIFWLPSVNKEVSLFVEGSESMLMVKEVKNEDEAYDLYNEYAFSKGFGIRVGKGRKRQNSEFYTMKRFLCSCEGVKDEKRKRTRSYARLDTRTGCTAFVQFSIGKDGVWTVVNHNMIHNHAMVPLNKRHLIRSQRKVSKEALYFMSTLKASGVKVSDTLRVLRKEVGGSPMVGFTASDAYNALSRAKANKLEGICGGSSYTAFANFMYDKVMMDSWKHLKDAVLEGGIPFQKAHGMSIFEYLSKDSRFHNVFYEGMDNHSIMVSKKILDNYKGFEGISSLVDVGGATGVTLNMIISKYPSIKGINFDLPHVIKNAPSFPGVEHVGGDMYVSVPKGDAIFMKWTFFTGNDEKCIKLLKNCHEALPEDGKVIICEHVVSDELDQTTYQAHTGFIFDAIMLTFPGGRTRTKHEYEALGKQAGFETFRFVCFACDTWVMEFLKMPV
>rna-XM_021988613.1
MSSIIGSNESQIHPTTEEEASCMAMCLATWSVPSMVFKTVLELNVLDIIYFTGPEAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGDDGHPKRLYGLGPVCQFLAKNDDEVSYAAFANLMHDKVIMDTWKHLKDAVLVGGSPFKNTYGTGIFDYLGTDSRFYKVFYDGMDHHSTIVMKKLLDTYQGFEGISTIVDVGGATGLTLKMILDKYPSIKAINFDLPHIIKDAPSYPGVEHVGGDMYESVPKGDAIFMKWTFQSGTDEQCVTLLKNCHESLPEDGKVIICEYVVPESPKTSYQAHTAFIWDAIMLTFPGGKSRTKKEYEALGKEAGFEDFQLVCFACDTWVMEYLKKKSVN
>rna-XM_021993199.1
MSPEKPTTTAPQAEIDETSESRNQARLAIMELANMISIPMALNAVVRLKVPTAIWSSGANTPLTAAEIIPLILPNNPHADADNLGRLLRLLTTYGVFSEHPPISGENMRRFSLTEVGRTLVEGDGDGLSYGEYVLQHHQDALVRGWTLVDHAVKGPTSKTPFEVANGEPAYDYYGRSEEMNVLMQRAMAGVSVPFMKAVVGGGYDGFDGVKRLVDVGGSAGDCVKMIMSKYECIKEGINFDLPEVVAQAPLITGVTHVGGDMFKSIPCGDAIFMKWVLTTWSDNEVKQIMKKCNEALPAGGKLIACEPVLPERSDDSHRTRALLSGDIFVMTIYGAKGRHRMEEEYRQLGISVGFPHFRAVHIDYFFTILEFQK
>rna-XM_022002732.1
MEEETTIYQAMQLTTAIALPMALKTAMDLGLLEIMDKAGPSTHLSPSDIAARVDPNTNDHTRMVQMVDRILRLLSSHSVVYCSVVEDEHNQNDGQVQRLYTLAPLSRYFLQSKDDQGSLAPMFSTINDKFMTNVWYYMKDAILEGEVAVVKAYGKDPKEAIEKDERFASIFYDAMREFNPLFINKVLKEYKGFEGLNSVVDVGGGNGQILKAIISKYPTITGINFDLPIVIEKQPIHPGIEHVAGDMLTSNPTGDAIFMKWVLKNLDDKQCLNVLKNCYTALPEGGKLMLVELVIPDIPDSSITSRSVFQFDVYLTNMNAGGKERTSRRISGTCQSSRLFRHQSHGSGLRYDSSGIS
>rna-XM_022006744.1
MSPPNSMQTQNEGRVYDEEEEEEEEDACSMFALSLLNSSITPIVLQAVLELNVLEIIKKLGPFGSHFSAKEVVAHLPAKNPEAPTMLDRMLRLLASHSVLSCTTRSLPDGPVERLYGLTPVCKFMIKDNNGVSLAPLASISKPVIDSSYQLKASILEGGHPFERAHGVTHYVYNGQNPDMNAKFNFAMASHSTITMDKILRTYKGFDGLSTLVDVGGGNGATLKKIVSKYHNIRGINFDLPHVINDAPICPGVEHVGGDMFASVPRADAVFMKWICHAWSDEECIKFLKNCYDAIPEDGKVIVCEYFLPEEVELSHAAKFMFQFDTTMMVIPNGKERTEKEFQALAKAAGFQGFSVACSAFHTKVMEFLKNK
>rna-XM_021982642.1
MNNTTYVDLQYTRYLSLSMGDHSSMSSKANNVNEASSDAFDNTVRVLIDVDDNDDEAENFVLAAQLVQSSVLPWVLHTAMELDLFGIIARAGRQLSATEISAQLPTTTNNHDAPLMLDRILRLLANYSVISCTMCSTSANAESERRYGLSRLTKFFHPDQQGASLGPLLALFLDKVVQDSWTKLKDAVLEGEIPFNMVHGAHAFEYPSLDPRFNQVFNKAMSNYPNILIKKILQKYKGFEGVKQLVDVGGGH
>rna-XM_021984665.1
MSSIIGSNESQIHPTTEEEASCMAMCLATWSVPSMVFKTVLELNVLDIIYFTGPEAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGDDGQPKRLYGLGPVCQFLAKNDDEVSYAAFANLMHDKVIMDTWKHLKEAVLVGGSAFRNSNGTSFFDYLGTDSRFYKVFYEGMDHHSTIVMKKLLDTYQGFKGISTIIDVGGATGLTLKMILDKYPSIKAINFDLPHIIKDAPSYPGVEHVGGDMYDSVPKGDAIFMKVSFNFDCDANLPMWIE
>rna-XM_021985360.1
WILHCFGDEACTKILKNCYAALPEDRGKVVICEYLLPDPDVTTNDIAANSVVQFDVMMMVLPGGKERTENEFKDLALAAGFHGFEVVCSAYNVKIIELLKIN
MVLNATIELGVLQIIHNDPNSNGLLPTELAARIQARNPEAPIMLDRMLRVLATYSVVSCITKPTSDGGVQRRYGPAPVTKCFVPDQDGVSLAPMLNLVVDKVFLLSWSKLKEAVLEGGIPFNKVHEMHAFEYPSVDPRFNEIFNKAMYDQSTYTIKKILQKYKGFEKIQQLVDVGGGLGHTINAITSQYPSIKGINFDLPHVIQHAPPIPGVEHVGGDMFGSVPEGDAIFMKWILHNWSDDRYLMLLKNCYKALPDNGKVIVVETNITDEPETTALAKAISQLDVSMMTQNPGGKERTSKEFEALAKATGFSGVKFDCYVSNFWVMEFYK
>rna-XM_021990259.1
MTDTECSTPLVEEQQHHRQDLEEKEEEEEENNFGYALQIVDSMAFPMVMNAVIELDILGIIARAGPGNKLLASEIAASLPEVKNPMAASMLDRMLWLLATYNVVTCEIFVAKDGGVVRKYGLAPVAKFFVPDHDGVSLAPLMSLSQDKVFVDCWSKLKDAVLEGGIPFNMVHGMHAFEYPSVDSRFNEVFNKAMAQSIIFVKKIFNKYKGLEDSNVKQLVDVGGGLGHSIGFITSKYPSIKGINFDLPHVIGDAPPCPGVEHIGGDMFESVPNGDAIFLKWILHDWSDEHCLTLLKNCYKAMPEGGKVIVVEAIIPDEPETTTFARAISQVDLLMMTQNPGGKERSKREFEALAKGAGFAGINFHCCVHGFWVMEFYK
>rna-XM_022002712.1
MGSTSAEKTQMGEDEACSFAMTVTSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIVAQLPSKNPDAANMLDRMLRLLASYSILSYSLQTRADGRVERLYGLAPVCQFLTKNEDGVTLGALSLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNNGMSNHSTITMKRILDTYKGFEGLSTLVDVGGGTGATLNMILSKHTTIKGINFDLPHVIEDAPAYNGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCLKFLKNCFASLPDHGKVIVCEYILPVAPETSHAARTVFHVDAIMLAHNPGGKERTEQEFEALAKGSGFEGFRVACSAYDTKVMEFLKKSS
>rna-XM_022002704.1
MGSVTNGVGEMSSYWDLGEEEEEEASFFALSLLSDNIKFEVLKAVKDLDVFETIKKCGPLAQLSAAEIVAKLPTENLVVATVNLGRLLDFLVSHSILTVTPTTLPGGKVERRYGLAPVCKFLTANEDGVSLGSFSNTLMYNALKQSCLCIKDAILEGEEPFKKAHGMTFYEYIGKNTEYRKGFHKAMSDHSTLIMRKILRTYKGFEGLSSLVDVGGGNGAILNMILSQYPTIKGINFDQPHVVADALTYPGVEHVGGDMFVNIPKGGDAIFLKWILHCFGDEACTKILKNCYAALPEDRGKVVICEYLLPDPDVTTNDIAANSVVQFDVMMMVLPGGKERTENEFKDLALAAGFHGFEVVCSAYNVKIIELLKIN
>rna-XM_021988484.1
MSSIIGSNETQIHPTTEEEASCMAMCLATWSVPSMVFKTMLELNVIDIIYNSGPTAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGPDGQPKRLYGLGPVCQFLAKNDDEVSYAAYANLMHDKIIMDTWKHLKDAVLEGSVPFKKTYGTGIYDYLGTDSRFYRVFYDGMDHHSTIVLKKILETYKGFEGISTLVDVGGGSGVTLKMIVSKYPSIKAINFDQPHIIKDAPSYPGVEHVGGDMYASVPKADAIFMKWTFQSGTDEQCVKLLKNFHEALPEDGKVVICEYLVPDSPKTSYQAHTAFIWDIIMMTYPGGKARTKQEYEALGKEAGFEDFRLVCFACDTWVMEYLKKKKSGN
>rna-XM_021988632.1
MMGSNFTQKSPTTEEEALSMAMCLATSHVPSMAFKAVLELNIIDIINDVGPEAQLSPAEIAAQLATANPDAAVVLDRLLRLLANFTILTFSYRDGPSGQPERVYGLGPVCQFLAKNGGGSAIFWLPSVNKEVSLFVEGSESMLMVKEVKNEDEAYDLYNEYAFSKGFGIRVGKGRKRQNSEFYTMKRFLCSCEGVKDEKRKRTRSYARLDTRTGCTAFVQFSIGKDGVWTVVNHNMIHNHAMVPLNKRHLIRSQRKVSKEALYFMSTLKASGVKVSDTLRVLRKEVGGSPMVGFTASDAYNALSRAKANKLEGICGGSSYTAFANFMYDKVMMDSWKHLKDAVLEGGIPFQKAHGMSIFEYLSKDSRFHNVFYEGMDNHSIMVSKKILDNYKGFEGISSLVDVGGATGVTLNMIISKYPSIKGINFDLPHVIKNAPSFPGVEHVGGDMYVSVPKGDAIFMKWTFFTGNDEKCIKLLKNCHEALPEDGKVIICEHVVSDELDQTTYQAHTGFIFDAIMLTFPGGRTRTKHEYEALGKQAGFETFRFVCFACDTWVMEFLKMPV
>rna-XM_021988613.1
MSSIIGSNESQIHPTTEEEASCMAMCLATWSVPSMVFKTVLELNVLDIIYFTGPEAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGDDGHPKRLYGLGPVCQFLAKNDDEVSYAAFANLMHDKVIMDTWKHLKDAVLVGGSPFKNTYGTGIFDYLGTDSRFYKVFYDGMDHHSTIVMKKLLDTYQGFEGISTIVDVGGATGLTLKMILDKYPSIKAINFDLPHIIKDAPSYPGVEHVGGDMYESVPKGDAIFMKWTFQSGTDEQCVTLLKNCHESLPEDGKVIICEYVVPESPKTSYQAHTAFIWDAIMLTFPGGKSRTKKEYEALGKEAGFEDFQLVCFACDTWVMEYLKKKSVN
>rna-XM_021993199.1
MSPEKPTTTAPQAEIDETSESRNQARLAIMELANMISIPMALNAVVRLKVPTAIWSSGANTPLTAAEIIPLILPNNPHADADNLGRLLRLLTTYGVFSEHPPISGENMRRFSLTEVGRTLVEGDGDGLSYGEYVLQHHQDALVRGWTLVDHAVKGPTSKTPFEVANGEPAYDYYGRSEEMNVLMQRAMAGVSVPFMKAVVGGGYDGFDGVKRLVDVGGSAGDCVKMIMSKYECIKEGINFDLPEVVAQAPLITGVTHVGGDMFKSIPCGDAIFMKWVLTTWSDNEVKQIMKKCNEALPAGGKLIACEPVLPERSDDSHRTRALLSGDIFVMTIYGAKGRHRMEEEYRQLGISVGFPHFRAVHIDYFFTILEFQK
>rna-XM_022002732.1
MEEETTIYQAMQLTTAIALPMALKTAMDLGLLEIMDKAGPSTHLSPSDIAARVDPNTNDHTRMVQMVDRILRLLSSHSVVYCSVVEDEHNQNDGQVQRLYTLAPLSRYFLQSKDDQGSLAPMFSTINDKFMTNVWYYMKDAILEGEVAVVKAYGKDPKEAIEKDERFASIFYDAMREFNPLFINKVLKEYKGFEGLNSVVDVGGGNGQILKAIISKYPTITGINFDLPIVIEKQPIHPGIEHVAGDMLTSNPTGDAIFMKWVLKNLDDKQCLNVLKNCYTALPEGGKLMLVELVIPDIPDSSITSRSVFQFDVYLTNMNAGGKERTSRRISGTCQSSRLFRHQSHGSGLRYDSSGIS
>rna-XM_022006744.1
MSPPNSMQTQNEGRVYDEEEEEEEEDACSMFALSLLNSSITPIVLQAVLELNVLEIIKKLGPFGSHFSAKEVVAHLPAKNPEAPTMLDRMLRLLASHSVLSCTTRSLPDGPVERLYGLTPVCKFMIKDNNGVSLAPLASISKPVIDSSYQLKASILEGGHPFERAHGVTHYVYNGQNPDMNAKFNFAMASHSTITMDKILRTYKGFDGLSTLVDVGGGNGATLKKIVSKYHNIRGINFDLPHVINDAPICPGVEHVGGDMFASVPRADAVFMKWICHAWSDEECIKFLKNCYDAIPEDGKVIVCEYFLPEEVELSHAAKFMFQFDTTMMVIPNGKERTEKEFQALAKAAGFQGFSVACSAFHTKVMEFLKNK
>rna-XM_021982642.1
MNNTTYVDLQYTRYLSLSMGDHSSMSSKANNVNEASSDAFDNTVRVLIDVDDNDDEAENFVLAAQLVQSSVLPWVLHTAMELDLFGIIARAGRQLSATEISAQLPTTTNNHDAPLMLDRILRLLANYSVISCTMCSTSANAESERRYGLSRLTKFFHPDQQGASLGPLLALFLDKVVQDSWTKLKDAVLEGEIPFNMVHGAHAFEYPSLDPRFNQVFNKAMSNYPNILIKKILQKYKGFEGVKQLVDVGGGH
>rna-XM_021984665.1
MSSIIGSNESQIHPTTEEEASCMAMCLATWSVPSMVFKTVLELNVLDIIYFTGPEAQLSAEEIVAKLPATNPHAAVVLDRMLRLLASFTILTCTQQVGDDGQPKRLYGLGPVCQFLAKNDDEVSYAAFANLMHDKVIMDTWKHLKEAVLVGGSAFRNSNGTSFFDYLGTDSRFYKVFYEGMDHHSTIVMKKLLDTYQGFKGISTIIDVGGATGLTLKMILDKYPSIKAINFDLPHIIKDAPSYPGVEHVGGDMYDSVPKGDAIFMKVSFNFDCDANLPMWIE
>rna-XM_021985360.1
WILHCFGDEACTKILKNCYAALPEDRGKVVICEYLLPDPDVTTNDIAANSVVQFDVMMMVLPGGKERTENEFKDLALAAGFHGFEVVCSAYNVKIIELLKIN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University