Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Spinacia oleracea
Species name
Spinach (Spinacia oleracea) is a species of eudicot in the family Chenopodiaceae.
Species info
Gene sequence info
Spinacia_oleracea.CHS.fa
Download
>rna-XM_021988956.1
MASVQEIRNAQRAHGPATILAIGTANPQNEMIQAEYPDFYFRVTDTEHMTGLKKKFERMCEKSMIKKRYMHVTEELLKQNPHMCDYNASSLDTRQDILATEVPKLGKEAAIKAIKEWGQPRSKITHVIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMLYQQGCYAGGTVLRLAKDIAENNRGSRVLVVCSEITVICFRGPTETHLDSMIGQALFGDGAGSVIVGADPIESVERPIFQLVSAAQTILPDSEGAIDGHLREVGLAFHLLKDVPGLISKNIEKSLVEAFKPIGIDDWNSLFWVAHPGGPAILDQVEAKLELNQDKLGITRHVLSEFGNMSSACVLFILDEMRKRSLKEGKTTTGYGLDWGVLFGFGPGLTVETVVLHSVPLTD
>rna-XM_021988955.1
MASIRDNRNAQRADGPATILAIGTANPPNEMSQDDFPDFYFRVTKSQHMVDLKDKFNNMCKKSTVKKRYMYITEELLKQNQNMCDYNSSSLDVRQDILATEVPKLGKEAAVKAIKEWGQPRSNITHLIFCTVSGVSMPGADYHLTKLLGLSPSVNRFMLYQQGCYGGGTVLRLAKDIAENNRGARVLVVCAEMTVVGFRGPTETHLDSMIGQALFTDGAGAVIVGADPDESINERPIFELVWASQTFLPGCERAIAGQLRQVGLTIHLSKDVPKLISNNLEKVLVEAFEPIGINDWNSIFWVAHPGGPAILDEVEVKLGLEEDKLSATRHVLSEFGNMSSASVLFILDETRKRSFNEGKATTGGGLDWGVLFGFGPGITIETVVLHSVPTKLA
>rna-XM_021989500.1
MIGTMASIQEIREAQRANGPATILAIGTANPPNVMYQSNYPDFYFRITNTDHLTHLKAKFNRICEKSMMKKRHLHVTEELLIENPEMSDDNASSLKSRQVILAKEVPKLGKEAAEIAIKEWGQPKSKITHLVFGTNCDVDLPGSDHELVKLLGLHPSVKRFMLRQGGCHGGGTLLRIAKDIAENNRGARVLVICSESTVICFHAPTDMNLVPHAIFGDGAGAIIMGADFDEPTERPIFQLVSTGQTTLPDSQGDIQARLSEIGMTVQLSQQVPKIIAKNIENCLDVSFKYVGINDWNSIFWIAHPGGPAILDQVEAKLGLEKNKLSTSRHVLSEYGNMWGATVIFILDQMRKRSLNEGKSTTGEGFDWGVLFAFGPGITVETILLHSVPIN
>rna-XM_021991039.1
MGIQEIKVDAMSKKATPGKATILALGKGFPHQLVMQEFLVDGYFRNTNCDDPELKEKLNRLCKTTTVKTRYVVMSDEILDKYPELAIEGKPTVTQRLDICNEAVTQMALEASQACISNWGRPISDITHLVYVSSSEARLPGGDIYLAKGLGLKPETNRVMLYFAGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSATRPYDLVGVALFGDGAGAMLIGSDPDTSIERPLFELHTAIQHFLPDTEKIIDGRLTEEGISFKLDRALPQIIEDNIEGFCGKLMDTIGMSDKDYNKIFWAVHPGGPAILNRLEKRLDLSPEKLIASRRALADYGNASSNTIVYVMEYMMEESKKLNKEVMNGIGDEWGLILAFGPGVTFEGIVAKNLIM
>rna-XM_022004738.1
MEKVNEIRNAQRAEGAACVLAIGRANPPNFILQSEYPDYYFRVTKSEHMVDVKEKFKRICDKTMIRKRHLFVTEEILKANPSMITYGEVSHDARRQMTVDYLPKLGKEAALKALKEWGQPKSRITHLIVYNTLALSMPGADYELAKALELDTTVHRTVMYLVGCHAGPHILRHAKDIAENNKGARILIVCAEITAVNFHGPSETQIDSLIGQALFGDGAAAIIVGAEPDYSIERPCFQLISGTQRTIPNTDGAAFSEIINMGQTFHLRKDLPCLISDYIEESLVNIFKPIGITDWNSIFWIAHNGGPAVLNGIESELKLDKEKLNVTRHVLSEYGNMSSIGVLFMMDEMRKRSFEQGKTTTGLGCEWGVMFGFGPGLTIEALALRSVPLLD
>rna-XM_022005028.1
MEKVNEIRNAQRAEGAASVLAIGRANPPNFILQSEYPDYYFRVTESEHMVDVKEKFKRICDKTMIRKRHFFLTDEILKANPSMLTYGDVSHDARREMTIEYLPKLGKEAGLKAIKEWGQPKSQITHLIVYNTLALSMPGADYELAKALELEPTVHRTVMYLVGCHAGPHILRHAKDIAENNKGSRILIVCAETTTVNFHGPSETHIDSLVGQALFGDGAAAVIVGAEPDYSIERPCFHIIMGTQNTIPNTGSAAGSEIINMGQTFCLNRNLPCLISKHVQESLSNLFKPIGITDWNSIFWIAHNGGPAVLNGVESELKLDKEKLKVSRHVLSEYGNMSSVGVLFMMDEMRKRSLVQGYKTTGLGYEWGIMFGFGPGLTIEALALRSVPLLE
>rna-XM_022005647.1
MLKNGGNGASSDRTATLGKATVLAIGKAFPKQLIPQEHLVEGYIRDTNCHDLVVKEKLERLCKTTTVKTRYTVMSREILDKYPELATEGTPTIRQKLEIANPAVVEMALEASIACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLSAELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKDRPYDLVGAALFGDGAAAVVIGSNPDLSRENPFMELNYAVQQFLPGTHNVIDGCLTEEGINFKLGRDLPIKIEDNIEEFCKKLMSKEGLKEFNELFWAVHPGGPAILNRVENTLKLTGDKLNCSRRALMDYGNVSSNTIFYVMEYMREELKNKENGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_022005699.1
MASVDISEIHNVERAKGQANVLAIGTANPPNVMYQADYPDFYFRLTNSEHMTDLKAKFKRICEKTTIKKRYMHISEDILKEKPDLCDYNASSLDIRQVILAKEVPKVGKDAAMKAIEEWGQAMSKITHLIFCTTSGVDIPGADYQLTMLLGLNPSVKRYMLCQQGCHAGGTVLRLAKDLAENNYGSRVLVVCSENTTVCFRGPTETHPDSMVAQALFADGAGAVIVGAYPDESLNERPIFQIVSTAQTILPNSQGAIEGHLRQIGLAIQLLPNVPDLISNNIDKCLVEAFNPIGINDWNSIFWIAHPGGPAILGQVESKLGLQESKLTTTWHVLREFGNMSSACVFFIMDETRKRSLKEGKTTTGDGFDWGVLFGFGPGLTVETVVLRSFPLNQ
>rna-XM_021979439.1
MTSSLEEIRKAQRANGPATILAIGTATPPNCVYQSDYPDYYFRVTKSEHMTELKEKFQRMCDKSMIKKRYMYLTEEFLKENPNMCTYMGASLDTRQDIVVAEVPRLGKEAAVKAIKEWGQPKSKITHVIMCTTSGVDMPGADYQLTKLLGLRPSVRRFMLYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAICFRGPTETYLDSMVGQALFGDGAGALIVGADPDESIERPLFKMVWAAQTLLPDSEGAIDGHLREVGLTFHLLKDVPGLISKNINKALEDAFTPLGISDWNSIFWVAHPGGPAILDQVEAKLGLKEEKLKATRNVLSEYGNMSSACVLFILDEMRKKSMKEGKSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLNC
>rna-XM_021979440.1
MASLDEIRQAQRADGPAAILAIGTATPPNCVYQADYPDYYFRVTKSEHMTDLKEKFKRMCDKSMIKKRYMYLTEEILKEKPNLCEYMGSSLDTRQDMVVGEVPRLGKEAAMKAIKEWGQPKSKITHVIMCTTSGIDMPGADYQLTKLLGLRPCVRRFMLYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAICFRGPTETHLDSMVGQALFGDGAGALIVGADPDESIERPLFKMVWTAQTLLPDSEGAIDGHVREVGLTFHLLKDVPGLISKNINKALEDAFTPLGISDWNSVFWIAHPGGPAILDQVEAKLGLGEEKLTATRNVLRDFGNMSSACVLFILDEMRNKSSKEGKSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLSY
>rna-XM_021981504.1
MASTPSVQEIRNAQRSDGPATILAIGTANPVNEMYQAEYPDFYFRVTKSEHMTQLKQKFKRMCERSMIKKRYMHVTEELLKENPHMCDYNASSLDTRQDILATEVPKLGKEAAVKAIKEWGQPRSKITHVIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMLYQQGCYAGGTVLRLAKDIAENNRGARVLVVCSEITVICFRGPTETHLDSMIGQALFGDGAGAVIVGADPVEYIERPIFQLVWAAQTILPDSEGAIDGHLREVGLAFHLLKDVPGLISKNIEKALVEAFNPIGIIDWNSIFWVAHPGGPAILDQVEAKLGLNQDKLSPTRHVLSEYGNMSSACVLFILDEMRKRSMKGEMSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLAN
MASVQEIRNAQRAHGPATILAIGTANPQNEMIQAEYPDFYFRVTDTEHMTGLKKKFERMCEKSMIKKRYMHVTEELLKQNPHMCDYNASSLDTRQDILATEVPKLGKEAAIKAIKEWGQPRSKITHVIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMLYQQGCYAGGTVLRLAKDIAENNRGSRVLVVCSEITVICFRGPTETHLDSMIGQALFGDGAGSVIVGADPIESVERPIFQLVSAAQTILPDSEGAIDGHLREVGLAFHLLKDVPGLISKNIEKSLVEAFKPIGIDDWNSLFWVAHPGGPAILDQVEAKLELNQDKLGITRHVLSEFGNMSSACVLFILDEMRKRSLKEGKTTTGYGLDWGVLFGFGPGLTVETVVLHSVPLTD
>rna-XM_021988955.1
MASIRDNRNAQRADGPATILAIGTANPPNEMSQDDFPDFYFRVTKSQHMVDLKDKFNNMCKKSTVKKRYMYITEELLKQNQNMCDYNSSSLDVRQDILATEVPKLGKEAAVKAIKEWGQPRSNITHLIFCTVSGVSMPGADYHLTKLLGLSPSVNRFMLYQQGCYGGGTVLRLAKDIAENNRGARVLVVCAEMTVVGFRGPTETHLDSMIGQALFTDGAGAVIVGADPDESINERPIFELVWASQTFLPGCERAIAGQLRQVGLTIHLSKDVPKLISNNLEKVLVEAFEPIGINDWNSIFWVAHPGGPAILDEVEVKLGLEEDKLSATRHVLSEFGNMSSASVLFILDETRKRSFNEGKATTGGGLDWGVLFGFGPGITIETVVLHSVPTKLA
>rna-XM_021989500.1
MIGTMASIQEIREAQRANGPATILAIGTANPPNVMYQSNYPDFYFRITNTDHLTHLKAKFNRICEKSMMKKRHLHVTEELLIENPEMSDDNASSLKSRQVILAKEVPKLGKEAAEIAIKEWGQPKSKITHLVFGTNCDVDLPGSDHELVKLLGLHPSVKRFMLRQGGCHGGGTLLRIAKDIAENNRGARVLVICSESTVICFHAPTDMNLVPHAIFGDGAGAIIMGADFDEPTERPIFQLVSTGQTTLPDSQGDIQARLSEIGMTVQLSQQVPKIIAKNIENCLDVSFKYVGINDWNSIFWIAHPGGPAILDQVEAKLGLEKNKLSTSRHVLSEYGNMWGATVIFILDQMRKRSLNEGKSTTGEGFDWGVLFAFGPGITVETILLHSVPIN
>rna-XM_021991039.1
MGIQEIKVDAMSKKATPGKATILALGKGFPHQLVMQEFLVDGYFRNTNCDDPELKEKLNRLCKTTTVKTRYVVMSDEILDKYPELAIEGKPTVTQRLDICNEAVTQMALEASQACISNWGRPISDITHLVYVSSSEARLPGGDIYLAKGLGLKPETNRVMLYFAGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSATRPYDLVGVALFGDGAGAMLIGSDPDTSIERPLFELHTAIQHFLPDTEKIIDGRLTEEGISFKLDRALPQIIEDNIEGFCGKLMDTIGMSDKDYNKIFWAVHPGGPAILNRLEKRLDLSPEKLIASRRALADYGNASSNTIVYVMEYMMEESKKLNKEVMNGIGDEWGLILAFGPGVTFEGIVAKNLIM
>rna-XM_022004738.1
MEKVNEIRNAQRAEGAACVLAIGRANPPNFILQSEYPDYYFRVTKSEHMVDVKEKFKRICDKTMIRKRHLFVTEEILKANPSMITYGEVSHDARRQMTVDYLPKLGKEAALKALKEWGQPKSRITHLIVYNTLALSMPGADYELAKALELDTTVHRTVMYLVGCHAGPHILRHAKDIAENNKGARILIVCAEITAVNFHGPSETQIDSLIGQALFGDGAAAIIVGAEPDYSIERPCFQLISGTQRTIPNTDGAAFSEIINMGQTFHLRKDLPCLISDYIEESLVNIFKPIGITDWNSIFWIAHNGGPAVLNGIESELKLDKEKLNVTRHVLSEYGNMSSIGVLFMMDEMRKRSFEQGKTTTGLGCEWGVMFGFGPGLTIEALALRSVPLLD
>rna-XM_022005028.1
MEKVNEIRNAQRAEGAASVLAIGRANPPNFILQSEYPDYYFRVTESEHMVDVKEKFKRICDKTMIRKRHFFLTDEILKANPSMLTYGDVSHDARREMTIEYLPKLGKEAGLKAIKEWGQPKSQITHLIVYNTLALSMPGADYELAKALELEPTVHRTVMYLVGCHAGPHILRHAKDIAENNKGSRILIVCAETTTVNFHGPSETHIDSLVGQALFGDGAAAVIVGAEPDYSIERPCFHIIMGTQNTIPNTGSAAGSEIINMGQTFCLNRNLPCLISKHVQESLSNLFKPIGITDWNSIFWIAHNGGPAVLNGVESELKLDKEKLKVSRHVLSEYGNMSSVGVLFMMDEMRKRSLVQGYKTTGLGYEWGIMFGFGPGLTIEALALRSVPLLE
>rna-XM_022005647.1
MLKNGGNGASSDRTATLGKATVLAIGKAFPKQLIPQEHLVEGYIRDTNCHDLVVKEKLERLCKTTTVKTRYTVMSREILDKYPELATEGTPTIRQKLEIANPAVVEMALEASIACIKEWGRPAQDITHIVYVSSSEIRLPGGDLYLSAELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKDRPYDLVGAALFGDGAAAVVIGSNPDLSRENPFMELNYAVQQFLPGTHNVIDGCLTEEGINFKLGRDLPIKIEDNIEEFCKKLMSKEGLKEFNELFWAVHPGGPAILNRVENTLKLTGDKLNCSRRALMDYGNVSSNTIFYVMEYMREELKNKENGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_022005699.1
MASVDISEIHNVERAKGQANVLAIGTANPPNVMYQADYPDFYFRLTNSEHMTDLKAKFKRICEKTTIKKRYMHISEDILKEKPDLCDYNASSLDIRQVILAKEVPKVGKDAAMKAIEEWGQAMSKITHLIFCTTSGVDIPGADYQLTMLLGLNPSVKRYMLCQQGCHAGGTVLRLAKDLAENNYGSRVLVVCSENTTVCFRGPTETHPDSMVAQALFADGAGAVIVGAYPDESLNERPIFQIVSTAQTILPNSQGAIEGHLRQIGLAIQLLPNVPDLISNNIDKCLVEAFNPIGINDWNSIFWIAHPGGPAILGQVESKLGLQESKLTTTWHVLREFGNMSSACVFFIMDETRKRSLKEGKTTTGDGFDWGVLFGFGPGLTVETVVLRSFPLNQ
>rna-XM_021979439.1
MTSSLEEIRKAQRANGPATILAIGTATPPNCVYQSDYPDYYFRVTKSEHMTELKEKFQRMCDKSMIKKRYMYLTEEFLKENPNMCTYMGASLDTRQDIVVAEVPRLGKEAAVKAIKEWGQPKSKITHVIMCTTSGVDMPGADYQLTKLLGLRPSVRRFMLYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAICFRGPTETYLDSMVGQALFGDGAGALIVGADPDESIERPLFKMVWAAQTLLPDSEGAIDGHLREVGLTFHLLKDVPGLISKNINKALEDAFTPLGISDWNSIFWVAHPGGPAILDQVEAKLGLKEEKLKATRNVLSEYGNMSSACVLFILDEMRKKSMKEGKSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLNC
>rna-XM_021979440.1
MASLDEIRQAQRADGPAAILAIGTATPPNCVYQADYPDYYFRVTKSEHMTDLKEKFKRMCDKSMIKKRYMYLTEEILKEKPNLCEYMGSSLDTRQDMVVGEVPRLGKEAAMKAIKEWGQPKSKITHVIMCTTSGIDMPGADYQLTKLLGLRPCVRRFMLYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAICFRGPTETHLDSMVGQALFGDGAGALIVGADPDESIERPLFKMVWTAQTLLPDSEGAIDGHVREVGLTFHLLKDVPGLISKNINKALEDAFTPLGISDWNSVFWIAHPGGPAILDQVEAKLGLGEEKLTATRNVLRDFGNMSSACVLFILDEMRNKSSKEGKSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLSY
>rna-XM_021981504.1
MASTPSVQEIRNAQRSDGPATILAIGTANPVNEMYQAEYPDFYFRVTKSEHMTQLKQKFKRMCERSMIKKRYMHVTEELLKENPHMCDYNASSLDTRQDILATEVPKLGKEAAVKAIKEWGQPRSKITHVIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMLYQQGCYAGGTVLRLAKDIAENNRGARVLVVCSEITVICFRGPTETHLDSMIGQALFGDGAGAVIVGADPVEYIERPIFQLVWAAQTILPDSEGAIDGHLREVGLAFHLLKDVPGLISKNIEKALVEAFNPIGIIDWNSIFWVAHPGGPAILDQVEAKLGLNQDKLSPTRHVLSEYGNMSSACVLFILDEMRKRSMKGEMSTTGEGLDWGVLFGFGPGLTVETVVLHSVPLAN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University