Enzyme
Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
OMT
Enzyme
Xanthohumol 4-O-methyltransferase
Enzyme name
EC:2.1.1.338
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase
Sysname
S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol [RN:R08004]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];xanthohumol [CPD:C16417]
Product
Species information
Spatholobus suberectus
Species name
Spatholobus suberectus is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Spatholobus_suberectus.OMT.fa
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>rna-gnl|WGS:QUWT|mrna.E2542_SST00502
MQKMDAEELFQAQAHLYNYTYSFIGSMCLKSAVHLGIPDIIFKNGQPITVPELVLALQIHPTKSGYVYRLMRLLVHAGFFAATKVVKDDKEEVGYDLTPSSRLLVKDNVPTLSPFVRAMFHPALVHSSEFLAEWFHGNELTPFNTAFGTGYWDYLSQNQEFNGLFNEAMISDSGMMNLVIKNCKSVFEGLNSLVDVGGGKGAVGRIVSESLPNLQWTVLDLPHVVENLLDSTNLKFVGGDMFRSIPSADAILLKLVLHAYSDEECVKVLKKCREAISNKGKEGKVIIIDIVIGEKNENHVLTEAKLFFDMLMMVLVNGREREEKEWEKLFLEAGFSHYKITPIFGMRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST00501
MSSDGGFDNSCPVTGTIDAIFATICLNLKVLGELVLHILNDEECIKVLKKCREAISNKGKEGKVIIIDIVIGEKNENHEWTETKLFFYMLMMAQVNGREREEKEWEKLFLEAGFKHYKITPIFGLRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST09692
MTFWDYASREPKLNHLFNDAMTNDTRLISSVVIEKCKGVFKGLESLVDVGGGTGTMAKAIVKSFPQLKCIVFDLPHVVDGLHGTENIKYVEGDMFEAIPSADSIMLKCILHNWNDEECLKILKRCKEAFASKDKGKVIIIDVVIENEKGDELGQTKLFYDVEMMVLVTGRERNEKDWAKLIFSAGFCNYKITPVLGLRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST09695
MFESIPPADAILLKWILYDWNDEQCVKTLKKCKEAIIKSKGKEQKVIIIDIVLENEKGDDESIETQLFFDMFLMVCVLEKREMR
>rna-gnl|WGS:QUWT|mrna.E2542_SST09771
METVLSNHSPPLDFKGLSKEEEDSLLGQVEIWWYMTCFTDSVALKCVIELRIADIIDRYGKPLSLSQIVENIEDAPSPDASLLQRVMRVMVRRKIFSAEQSEAGETLYGLTRASKWILRDTKMTLAPMLLLENHPIHLNPAHYISEIIREGTKNGTAFFRCHGHEQFEMTGLDPEYNRLFNEGMVCTARVVSKAVITGYKDGFNQIKSLVDVGGGIGGSLSEIVRAYPHIKAINFDLPHVVATAPKYDGITHVGGDMFVSIPSADAIYMKWILHDWSDEHCIKILKNCRKAIPEKTGKVIIVDHVLRPEGNELFTDVGIAFDMMLLAHNAGGKERTEENWKWLFKETGFARYNIIKINSLPSIIEAFPI
>rna-gnl|WGS:QUWT|mrna.E2542_SST09736
MGEIQRAVWYREEEAEARVDIWKYIFGFVEVTMVKCAIELGIADAIESHRSTMTISEMSSTLECDPSLLNHIMRILIHQKIFKSVSTSHGYPGYAQTPLSRRFRPAKGKRCKWKNNNTESDIECFDCRRKRIHIPQRM
>rna-gnl|WGS:QUWT|mrna.E2542_SST07943
MASNNGRKASEIFQVGVNSTIPPTKVSSVQSLLRFLAHNGFFEIVRIHDNIEEKEAYALTAASELLVKGNDLCLAPMIKGVLDPTVTGSWHQLKKWTYEDDLTLFGISFGSHLWDFLNNNPTYNKLFNEAMASDSQMMNVALRDCNWVFEGLESFVDVGGGTGIMAKIICEAFPKLKCIVLERPAIVENLSGSNNVTYVGGDMFESIPKANAILLKGADSGTNKVLSQQLTI
>rna-gnl|WGS:QUWT|mrna.E2542_SST07942
MASINGRKASDLFQGQALLYRHLFAFVDSMYLKLIIELRIPDIIHNHGQPITLPELVSILQVPLAKVGQVHRLMRYLAHNGFFERVRIHDNGEEKEAYALTAASELLVKSNELSLAPMVECILDPTLSGSYHQLKKWVYEDDLTLFDVSLGCHFWDFLTKNPAYNESFNEAMASDSQLSNLALRDCKLVFEGLESIVDVGGGTGTTARIICEAFPNLKCIVFDRPQVVEHLSGTNNLTFVGGDMFKSIPKADAVLLKWILHNWTDKDCIKILKNCKEAILNNSKRGKVIIIDVVINEKQEEHKVTELKLLMDVNMACVNGQERSEEEWMKLFVEAGFQDYKISPLTGYLSLIEIYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST16287
MRLLTHNGFFTKTTLPSQNVFEQPKVVANLTGTQDLNFVGGDMFKSIPSADAVVLKCVLHDWNDELSVKVLKNCKEAISSKGKEGNVIIIDIAIDEASDDRELTELKLDYDLVMLAMLNGK
>rna-gnl|WGS:QUWT|mrna.E2542_SST16288
MDFRNNGTEESELYHAQTHLYKHVYNFISSMALKSATELGTADAIHSHGKPMTLSELASALKLHPSKVGVLYRFMRLLTHNGFFTKATVASQNGKEETAYALTPPSKLLIRRGSTCLAPIVKGALHSSSLDMWHSSNKWFTEDKELSLFESTTGESYWDFLNSDFDLLRLFQEAMTADSQMFKLGLKRCKHVFEGLSSLVDVGVFDQPQVVANLTETDNSNLVGGDMFKSIPSADAVFLKWVQHDWNDEHPVKIFKNCKEAISRKGKNGKVIIIDIAIDEASDDRDLTELKLDFDLVMLTINGKEREQKEWEKLIYDAGFSSYKITPVFGFKSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST16285
MAFTSNGSTEESELYHAQIHLYKHVYNFVSSMALKSAVELGIADVIHSHGKPMTLSELASALKLHPSKVGILHRFLRLLTHNGFFAKTPVPNGGEGEGEGETAYALTPPSKLLIRRGSTCLASIVEGALHASSLDMWHSSKKWFTEDKVLTLYESATGESFWDFLNKTTEAETLSMFQDAMAADSAMFKLALRECKHVFEGLGSLVDVGGGTGGVSRLINEEFPHLKCTVFDQPQVVANLTGNENLNFVGGDMFKSIPSADAVLLKWVLHDWNDELSVKILKNCKEAISGKGKEGKVIIIDIAIDEASDDRELTELKLDYDLVMLTMFNGKEREKKEWEKLIYEAGFSSYKITPICGFKSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST23496
MSLLVDLVTFKLEAKIFGHLRTMCLKWAVELGIPNIICNHEKPITLPELVSTLEIPLAKAGFV
>rna-gnl|WGS:QUWT|mrna.E2542_SST23498
MASMNNQEAIELLEGQSLLYMQIFGHLRTMCLKWAVELGIPDIIYNHGKPITLPELVSTLEIPPAKAGFVQRLMRFLAHNGIFDIHERQEDHGLTYALTPASKLLVSASDHCLSPMVRCVTDPLLMSKYHHLGEWIRGEDLTVYETALGTSVWGLIEKQPTYLSLFAEGMASDSRMVDLALKNCTSVFEELDSIVDVGGGTGTTARIICKAFPRLKCVVLDLPQVVANLTGSDNLSFVGGDMFKFVPQADAVLLKWVLHDWNDENCIKILKKCKDSISSKGNRGKVIIIDTVIDEKLDERDMTQTKLCMDISMLAINGKERTEEEWKQLFIEAGFKQYKIFPVFGFRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST27743
MSIKWAIDLGIPDIIHKHGQPITLPELVSALKVPQAKATCVQRLMRLLAHNDYFASSTLMMIAMKPTPQLGEWTCGEDLTIIETALGPGCYWDFIHQDAT
>rna-gnl|WGS:QUWT|mrna.E2542_SST27745
MASKNGYKASELLQAQAHLYRVLYSFLNPMSIKWAIDLGIPDIIHKHGQPITLPELVSALKVPQAKATCVQRLMRLLAHNDFFAIINTDDGSNEAYALTPPSQVLVNDTDHCLSSMVKLLNNPTLVGSYHQLGEWTCGEDLTIIETALGPGCYWDFIHQDATQMKMFNEAMESDSHIVRLALRDCKSVFEGLDSIVDVGGGTGNTAKIIGEAFPKLKYIVLDLPQVVAGITGSNNLSFVGGNMFKSVPQADAVLLKWVLHNWSDDDCIKILKNCKEAIAGKGEGGKVIIIDIVINEKQDEHKMTEMKLLFDIVMMTYHNGKERSEKDWKRLFVEAGFKSYKLFPAFGFRSLIELYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST29906
MGEIQRKAMSRWEKEEEEEEAQAQMDIWKYIFGFVEMAVVKCAIELGIAEAIEKHGSPMTLSEISSTLACDPSLLNRIMRFLVHRKIFKATPTSHGCSGYSQTPLSRRLMRNGEHSMAALLLLESSPVMLAPWHGLSARILANGNPSFEKAHGEDVWRYAAANLDHSNLINEAMACDAKLVMPVIIESCSETFDGLKSLVDVGGGNGTTMSILVKACPWIRGINFDLPHVIAESHQCDGVEHAAGDMFLNVPKADAAFLMWVLHDWSDEECIQILKKCREAIPKENGRVIIVEAVIEEEGKHNGLKDVGLMLDMVMMAHTNFGKERTLKEWEYVIKMAGFSAYTVKAIHAVQSVILAFY
>rna-gnl|WGS:QUWT|mrna.E2542_SST31491
MMRRLQSKAKYARAHGGQRRRGYIARKKRSRRTVLTADKEVYNGRERLSDELGRGYWDFIHQNATHLKTFNEAMESDYHVWVLHNWSDDDCIKILKNCKDAISGKGKGGKVIIIDIVINEKQDEHEMTEGKLLLDIAMMTSLNGKERDEKEWKQLFMKAGFKHYKILPYAHIRF
MQKMDAEELFQAQAHLYNYTYSFIGSMCLKSAVHLGIPDIIFKNGQPITVPELVLALQIHPTKSGYVYRLMRLLVHAGFFAATKVVKDDKEEVGYDLTPSSRLLVKDNVPTLSPFVRAMFHPALVHSSEFLAEWFHGNELTPFNTAFGTGYWDYLSQNQEFNGLFNEAMISDSGMMNLVIKNCKSVFEGLNSLVDVGGGKGAVGRIVSESLPNLQWTVLDLPHVVENLLDSTNLKFVGGDMFRSIPSADAILLKLVLHAYSDEECVKVLKKCREAISNKGKEGKVIIIDIVIGEKNENHVLTEAKLFFDMLMMVLVNGREREEKEWEKLFLEAGFSHYKITPIFGMRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST00501
MSSDGGFDNSCPVTGTIDAIFATICLNLKVLGELVLHILNDEECIKVLKKCREAISNKGKEGKVIIIDIVIGEKNENHEWTETKLFFYMLMMAQVNGREREEKEWEKLFLEAGFKHYKITPIFGLRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST09692
MTFWDYASREPKLNHLFNDAMTNDTRLISSVVIEKCKGVFKGLESLVDVGGGTGTMAKAIVKSFPQLKCIVFDLPHVVDGLHGTENIKYVEGDMFEAIPSADSIMLKCILHNWNDEECLKILKRCKEAFASKDKGKVIIIDVVIENEKGDELGQTKLFYDVEMMVLVTGRERNEKDWAKLIFSAGFCNYKITPVLGLRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST09695
MFESIPPADAILLKWILYDWNDEQCVKTLKKCKEAIIKSKGKEQKVIIIDIVLENEKGDDESIETQLFFDMFLMVCVLEKREMR
>rna-gnl|WGS:QUWT|mrna.E2542_SST09771
METVLSNHSPPLDFKGLSKEEEDSLLGQVEIWWYMTCFTDSVALKCVIELRIADIIDRYGKPLSLSQIVENIEDAPSPDASLLQRVMRVMVRRKIFSAEQSEAGETLYGLTRASKWILRDTKMTLAPMLLLENHPIHLNPAHYISEIIREGTKNGTAFFRCHGHEQFEMTGLDPEYNRLFNEGMVCTARVVSKAVITGYKDGFNQIKSLVDVGGGIGGSLSEIVRAYPHIKAINFDLPHVVATAPKYDGITHVGGDMFVSIPSADAIYMKWILHDWSDEHCIKILKNCRKAIPEKTGKVIIVDHVLRPEGNELFTDVGIAFDMMLLAHNAGGKERTEENWKWLFKETGFARYNIIKINSLPSIIEAFPI
>rna-gnl|WGS:QUWT|mrna.E2542_SST09736
MGEIQRAVWYREEEAEARVDIWKYIFGFVEVTMVKCAIELGIADAIESHRSTMTISEMSSTLECDPSLLNHIMRILIHQKIFKSVSTSHGYPGYAQTPLSRRFRPAKGKRCKWKNNNTESDIECFDCRRKRIHIPQRM
>rna-gnl|WGS:QUWT|mrna.E2542_SST07943
MASNNGRKASEIFQVGVNSTIPPTKVSSVQSLLRFLAHNGFFEIVRIHDNIEEKEAYALTAASELLVKGNDLCLAPMIKGVLDPTVTGSWHQLKKWTYEDDLTLFGISFGSHLWDFLNNNPTYNKLFNEAMASDSQMMNVALRDCNWVFEGLESFVDVGGGTGIMAKIICEAFPKLKCIVLERPAIVENLSGSNNVTYVGGDMFESIPKANAILLKGADSGTNKVLSQQLTI
>rna-gnl|WGS:QUWT|mrna.E2542_SST07942
MASINGRKASDLFQGQALLYRHLFAFVDSMYLKLIIELRIPDIIHNHGQPITLPELVSILQVPLAKVGQVHRLMRYLAHNGFFERVRIHDNGEEKEAYALTAASELLVKSNELSLAPMVECILDPTLSGSYHQLKKWVYEDDLTLFDVSLGCHFWDFLTKNPAYNESFNEAMASDSQLSNLALRDCKLVFEGLESIVDVGGGTGTTARIICEAFPNLKCIVFDRPQVVEHLSGTNNLTFVGGDMFKSIPKADAVLLKWILHNWTDKDCIKILKNCKEAILNNSKRGKVIIIDVVINEKQEEHKVTELKLLMDVNMACVNGQERSEEEWMKLFVEAGFQDYKISPLTGYLSLIEIYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST16287
MRLLTHNGFFTKTTLPSQNVFEQPKVVANLTGTQDLNFVGGDMFKSIPSADAVVLKCVLHDWNDELSVKVLKNCKEAISSKGKEGNVIIIDIAIDEASDDRELTELKLDYDLVMLAMLNGK
>rna-gnl|WGS:QUWT|mrna.E2542_SST16288
MDFRNNGTEESELYHAQTHLYKHVYNFISSMALKSATELGTADAIHSHGKPMTLSELASALKLHPSKVGVLYRFMRLLTHNGFFTKATVASQNGKEETAYALTPPSKLLIRRGSTCLAPIVKGALHSSSLDMWHSSNKWFTEDKELSLFESTTGESYWDFLNSDFDLLRLFQEAMTADSQMFKLGLKRCKHVFEGLSSLVDVGVFDQPQVVANLTETDNSNLVGGDMFKSIPSADAVFLKWVQHDWNDEHPVKIFKNCKEAISRKGKNGKVIIIDIAIDEASDDRDLTELKLDFDLVMLTINGKEREQKEWEKLIYDAGFSSYKITPVFGFKSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST16285
MAFTSNGSTEESELYHAQIHLYKHVYNFVSSMALKSAVELGIADVIHSHGKPMTLSELASALKLHPSKVGILHRFLRLLTHNGFFAKTPVPNGGEGEGEGETAYALTPPSKLLIRRGSTCLASIVEGALHASSLDMWHSSKKWFTEDKVLTLYESATGESFWDFLNKTTEAETLSMFQDAMAADSAMFKLALRECKHVFEGLGSLVDVGGGTGGVSRLINEEFPHLKCTVFDQPQVVANLTGNENLNFVGGDMFKSIPSADAVLLKWVLHDWNDELSVKILKNCKEAISGKGKEGKVIIIDIAIDEASDDRELTELKLDYDLVMLTMFNGKEREKKEWEKLIYEAGFSSYKITPICGFKSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST23496
MSLLVDLVTFKLEAKIFGHLRTMCLKWAVELGIPNIICNHEKPITLPELVSTLEIPLAKAGFV
>rna-gnl|WGS:QUWT|mrna.E2542_SST23498
MASMNNQEAIELLEGQSLLYMQIFGHLRTMCLKWAVELGIPDIIYNHGKPITLPELVSTLEIPPAKAGFVQRLMRFLAHNGIFDIHERQEDHGLTYALTPASKLLVSASDHCLSPMVRCVTDPLLMSKYHHLGEWIRGEDLTVYETALGTSVWGLIEKQPTYLSLFAEGMASDSRMVDLALKNCTSVFEELDSIVDVGGGTGTTARIICKAFPRLKCVVLDLPQVVANLTGSDNLSFVGGDMFKFVPQADAVLLKWVLHDWNDENCIKILKKCKDSISSKGNRGKVIIIDTVIDEKLDERDMTQTKLCMDISMLAINGKERTEEEWKQLFIEAGFKQYKIFPVFGFRSLIEVYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST27743
MSIKWAIDLGIPDIIHKHGQPITLPELVSALKVPQAKATCVQRLMRLLAHNDYFASSTLMMIAMKPTPQLGEWTCGEDLTIIETALGPGCYWDFIHQDAT
>rna-gnl|WGS:QUWT|mrna.E2542_SST27745
MASKNGYKASELLQAQAHLYRVLYSFLNPMSIKWAIDLGIPDIIHKHGQPITLPELVSALKVPQAKATCVQRLMRLLAHNDFFAIINTDDGSNEAYALTPPSQVLVNDTDHCLSSMVKLLNNPTLVGSYHQLGEWTCGEDLTIIETALGPGCYWDFIHQDATQMKMFNEAMESDSHIVRLALRDCKSVFEGLDSIVDVGGGTGNTAKIIGEAFPKLKYIVLDLPQVVAGITGSNNLSFVGGNMFKSVPQADAVLLKWVLHNWSDDDCIKILKNCKEAIAGKGEGGKVIIIDIVINEKQDEHKMTEMKLLFDIVMMTYHNGKERSEKDWKRLFVEAGFKSYKLFPAFGFRSLIELYP
>rna-gnl|WGS:QUWT|mrna.E2542_SST29906
MGEIQRKAMSRWEKEEEEEEAQAQMDIWKYIFGFVEMAVVKCAIELGIAEAIEKHGSPMTLSEISSTLACDPSLLNRIMRFLVHRKIFKATPTSHGCSGYSQTPLSRRLMRNGEHSMAALLLLESSPVMLAPWHGLSARILANGNPSFEKAHGEDVWRYAAANLDHSNLINEAMACDAKLVMPVIIESCSETFDGLKSLVDVGGGNGTTMSILVKACPWIRGINFDLPHVIAESHQCDGVEHAAGDMFLNVPKADAAFLMWVLHDWSDEECIQILKKCREAIPKENGRVIIVEAVIEEEGKHNGLKDVGLMLDMVMMAHTNFGKERTLKEWEYVIKMAGFSAYTVKAIHAVQSVILAFY
>rna-gnl|WGS:QUWT|mrna.E2542_SST31491
MMRRLQSKAKYARAHGGQRRRGYIARKKRSRRTVLTADKEVYNGRERLSDELGRGYWDFIHQNATHLKTFNEAMESDYHVWVLHNWSDDDCIKILKNCKDAISGKGKGGKVIIIDIVINEKQDEHEMTEGKLLLDIAMMTSLNGKERDEKEWKQLFMKAGFKHYKILPYAHIRF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University