Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Sorghum bicolor
Species name
Sorghum (Sorghum bicolor) is a species of monocot in the family Poaceae (grass family).
Species info
Gene sequence info
Sorghum_bicolor.COMT.fa
Download
>rna-XM_002465600.1
MACTTAASLQHDKANDDEACMYAQELLFSFIVPMTLKAVIELGLIDYLLAADGRSVTPEELAAEWPQSAEAAAAVDRMMRLLASHSVVRCTTEVGPDGKARRSYAAAPVCKWLATRNAGGQGSLAPMGLMNLNKAFMETWYFMKEAVTEGATPTEKAYGMPLFEHLGSDEASNTLFNQAMAGHSEMIIKKLLEVYRGFEGVDVLVDVGGGTGSTLRMVTAQYKHLRGVNYDLPHVIAQAPPVQGVEHVGGSMFEYIPSGNAILLKWILHLWRDDECVKILKNCHRALPANGKVIVVEYVLPASPEPTQVAQVSLLLDVAMLNRLRGAKERTEQEFAQLAAEAGFSGGCRATYVFASAWALEFTK
>rna-XM_002453029.2
MPPPSAAATSTTAAASAARDDMSPAEARLAMMELANMVSVPMALTAVIRLGVPAAIWAGGANAPRSAAELLPAGHPDPSVLERLLRLLASRGVFSESTSTSEDRTTTTRRFALTAVGRTLVPEGASGASYADYVLQHHQDALVAAWPRLHEAVLDPRGPEPFARANAGVPAYAYYGKDREANQVMLRAMTGVSEPFMHALLDGYGFDGGFHGVATLVDVGGSSGACLEMIMRRVPTIKEGINFDLPDVVADAPAIAGVRHVGGDMFKSIPSGDAIFMKWVLTTWTNDECTAILRNCHAALPDGGKLVACEPVVPEETDSSTRTRALLENDIFVMTTYRTQGRERSEEEFHHLGIAAGFTGFRAIYLDPFYAVLEYTK
>rna-XM_021465868.1
MASYTSSHAVGKAGNQDDETCMHAMKLLGGLAVPFTIKAVIKLGIMDRLLTAERAMSAQELTAGLPCRAPAPAAAMVDRMLRFLASHGVVRCAATESELGSDDGKSCRRYAAAPVCKWFARGSGVESVVPMLFWMTSKTAMEPWYNIKDGVLEGETPFDKAYGMPFFEFLGANGTKNTLFNEAMASHSMITTKRLLEVFRGFENYNVLVDVGGGKGTTMQMIRSQYENISGINYDLPHVIAQASPIEGVEHVGGNMFDKIPRGDAIILKWILHDWGDKDCVKILKNCYAALPVNGTMIILEYILPETPEETLAAQIAYDLDLGMVLMFGASGKERTEKELSELAREAGFSGDCTATYIFANVWALEFTK
>rna-XM_002443892.2
MGSYTTRVHAVEKAANNQDDETCMHALMLLGGLAVPCTIKAVIELGIMDLLLAADRAMTAEELTARLPCPAAATAAAMVDRMLRFLASHGVVRCAAATKESSELGSDGGKSCRRYAAAPVCRWFTRSGGVESVVPMGLWMTGKTVLETWYNIKEAVLEGETPFDRAYGQPFFEYLGENGTVNTLFDEAMANHSTIITKRLVEVFRGFENYSVLVDVGGNKGTTLQMIRSQYENISGINYDLPRVIAQAPPIEGVEHVGGNMFDNVPRGDAIILKWILHDWGDKDCVKILKNCYAALPVNGTMIILEYILPETPEETLTSQLAFNFDFGMMLMYGAKGKERTEKELSELAREAGFSGDCTATYIFASIWALEFTK
>rna-XM_021464526.1
MGSYDSSSSSSNDSSARNEEDESCMFALKLLGGFAVPFTIKAVIELGVMDQLLTAERAMSAEELVAAAVAAQLPRPEVACTMVDRLLRFLASHSVVRCTTEVVVGTDDATTTTCCRRSYAASPVCKWFARNGVEDSVLPLGMMILNKTFLDSWQNITDAVLEGAAPFEKTYGMPMFEYLSTNGPLNTVFHEAMANHSMIITKKLLKFFRGFEGLDVLVDVGGGNGTTLQMIRGQYKNMRGINYDLPHVIAQAAPVEGVEHVGGSMFDNIPRGNAVLLKWILHDWDDKACIKILKNCYTALHVRGKVIVLEYVVPDEPEPTLAAQGAFELDLTMLVTFGSGKERTQREFSELAMEAGFSREFKATYIFANVWALEFTK
>rna-XM_002445038.2
MGSTAEDVAAVADEEACMYAMQLASSSILPMTLKNALELGLLEVLQKDAGKALAAEEVVARLPVAPTNPAAADMVDRMLRLLASYDVVKCQMEDKDGKYERRYSAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFDESVSTLVDVGGGIGATLHAITSHHSHIRGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATLLKNCYDALPEKGGKVIVVECVLPVTTDAVPKAQGVFHVDMIMLAHNPGGRERYEREFRDLAKAAGFSGFKATYIYANAWAIEFIK
>rna-XM_002445091.2
MASYTSTSGQFAVGKVAAANQDDETCMHALKLLGGLAVPFTIKAVIELGIMDLLLAADRAMTAEALTAALLCPAPAPAAAAAMVDRMLRFLASHGVVRCATESEELGSDDGKSCRRYAAAPVCKWFARGGGVESVVPMGFWMTSTTNMETWHNIKDGVLAGETPFDKAYGMPVFEYLGANGTMNTLFNEAMASHSMIITKRLLEVFRGFENYSVLVDVGGGNGTTMQMIRSQYENISGINYDLPHVIAQASPIEGVEHVAGNMFDNIPRGDAIILKWILHNWGDKECVKILKNCYTALPVNGTVIILEYILPETPEETLASQLAFDFDLGMMLFFGASGKERTEKELLELAREAGFSGDYTATYIFANVWAHEFTK
MACTTAASLQHDKANDDEACMYAQELLFSFIVPMTLKAVIELGLIDYLLAADGRSVTPEELAAEWPQSAEAAAAVDRMMRLLASHSVVRCTTEVGPDGKARRSYAAAPVCKWLATRNAGGQGSLAPMGLMNLNKAFMETWYFMKEAVTEGATPTEKAYGMPLFEHLGSDEASNTLFNQAMAGHSEMIIKKLLEVYRGFEGVDVLVDVGGGTGSTLRMVTAQYKHLRGVNYDLPHVIAQAPPVQGVEHVGGSMFEYIPSGNAILLKWILHLWRDDECVKILKNCHRALPANGKVIVVEYVLPASPEPTQVAQVSLLLDVAMLNRLRGAKERTEQEFAQLAAEAGFSGGCRATYVFASAWALEFTK
>rna-XM_002453029.2
MPPPSAAATSTTAAASAARDDMSPAEARLAMMELANMVSVPMALTAVIRLGVPAAIWAGGANAPRSAAELLPAGHPDPSVLERLLRLLASRGVFSESTSTSEDRTTTTRRFALTAVGRTLVPEGASGASYADYVLQHHQDALVAAWPRLHEAVLDPRGPEPFARANAGVPAYAYYGKDREANQVMLRAMTGVSEPFMHALLDGYGFDGGFHGVATLVDVGGSSGACLEMIMRRVPTIKEGINFDLPDVVADAPAIAGVRHVGGDMFKSIPSGDAIFMKWVLTTWTNDECTAILRNCHAALPDGGKLVACEPVVPEETDSSTRTRALLENDIFVMTTYRTQGRERSEEEFHHLGIAAGFTGFRAIYLDPFYAVLEYTK
>rna-XM_021465868.1
MASYTSSHAVGKAGNQDDETCMHAMKLLGGLAVPFTIKAVIKLGIMDRLLTAERAMSAQELTAGLPCRAPAPAAAMVDRMLRFLASHGVVRCAATESELGSDDGKSCRRYAAAPVCKWFARGSGVESVVPMLFWMTSKTAMEPWYNIKDGVLEGETPFDKAYGMPFFEFLGANGTKNTLFNEAMASHSMITTKRLLEVFRGFENYNVLVDVGGGKGTTMQMIRSQYENISGINYDLPHVIAQASPIEGVEHVGGNMFDKIPRGDAIILKWILHDWGDKDCVKILKNCYAALPVNGTMIILEYILPETPEETLAAQIAYDLDLGMVLMFGASGKERTEKELSELAREAGFSGDCTATYIFANVWALEFTK
>rna-XM_002443892.2
MGSYTTRVHAVEKAANNQDDETCMHALMLLGGLAVPCTIKAVIELGIMDLLLAADRAMTAEELTARLPCPAAATAAAMVDRMLRFLASHGVVRCAAATKESSELGSDGGKSCRRYAAAPVCRWFTRSGGVESVVPMGLWMTGKTVLETWYNIKEAVLEGETPFDRAYGQPFFEYLGENGTVNTLFDEAMANHSTIITKRLVEVFRGFENYSVLVDVGGNKGTTLQMIRSQYENISGINYDLPRVIAQAPPIEGVEHVGGNMFDNVPRGDAIILKWILHDWGDKDCVKILKNCYAALPVNGTMIILEYILPETPEETLTSQLAFNFDFGMMLMYGAKGKERTEKELSELAREAGFSGDCTATYIFASIWALEFTK
>rna-XM_021464526.1
MGSYDSSSSSSNDSSARNEEDESCMFALKLLGGFAVPFTIKAVIELGVMDQLLTAERAMSAEELVAAAVAAQLPRPEVACTMVDRLLRFLASHSVVRCTTEVVVGTDDATTTTCCRRSYAASPVCKWFARNGVEDSVLPLGMMILNKTFLDSWQNITDAVLEGAAPFEKTYGMPMFEYLSTNGPLNTVFHEAMANHSMIITKKLLKFFRGFEGLDVLVDVGGGNGTTLQMIRGQYKNMRGINYDLPHVIAQAAPVEGVEHVGGSMFDNIPRGNAVLLKWILHDWDDKACIKILKNCYTALHVRGKVIVLEYVVPDEPEPTLAAQGAFELDLTMLVTFGSGKERTQREFSELAMEAGFSREFKATYIFANVWALEFTK
>rna-XM_002445038.2
MGSTAEDVAAVADEEACMYAMQLASSSILPMTLKNALELGLLEVLQKDAGKALAAEEVVARLPVAPTNPAAADMVDRMLRLLASYDVVKCQMEDKDGKYERRYSAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFDESVSTLVDVGGGIGATLHAITSHHSHIRGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATLLKNCYDALPEKGGKVIVVECVLPVTTDAVPKAQGVFHVDMIMLAHNPGGRERYEREFRDLAKAAGFSGFKATYIYANAWAIEFIK
>rna-XM_002445091.2
MASYTSTSGQFAVGKVAAANQDDETCMHALKLLGGLAVPFTIKAVIELGIMDLLLAADRAMTAEALTAALLCPAPAPAAAAAMVDRMLRFLASHGVVRCATESEELGSDDGKSCRRYAAAPVCKWFARGGGVESVVPMGFWMTSTTNMETWHNIKDGVLAGETPFDKAYGMPVFEYLGANGTMNTLFNEAMASHSMIITKRLLEVFRGFENYSVLVDVGGGNGTTMQMIRSQYENISGINYDLPHVIAQASPIEGVEHVAGNMFDNIPRGDAIILKWILHNWGDKECVKILKNCYTALPVNGTVIILEYILPETPEETLASQLAFDFDLGMMLFFGASGKERTEKELLELAREAGFSGDYTATYIFANVWAHEFTK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University