Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Simmondsia chinensis
Species name
Goatnut (Simmondsia chinensis) is a species of eudicot in the family Simmondsiaceae.
Species info
Gene sequence info
Simmondsia_chinensis.DFR.fa
Download
>Sc02g0005910.01
MVAEGEVVCVTGAAGFIGSWLVMRLLEHGYVVRATVRDPKNMKKVKHLLDLPKAETHLTLWKADLSEEGSFDEAIQGCTGVFHVATPMDFESKDPENEVIKPTINGMLDIMKSCVKAKVRRLVFTSSAGTIDVNETPKPFYDETCWSDVDFCRRVKMTGWMYFVSKTLAEQAAWKYAEENKLDFVSIIPPLVVGPFLMPTLPPSLITALSPITRTESHYHIIKQGQFVHLDDLCMAHIFLYEHPNAQGRYIACACDATIFDITKMLNQKYPEHNVPTEFKDFDKNMKSVSFSSKKLTDLGFEFKYTLEDMFTGAVETCKAKGLLPTPLANHENGTK
>Sc02g0002510.01
MVVPTGETVCVTGAAGYFGSWLVMRLLERGYTVRATVGDPGNMRKVKHLLDLPNAKTQLTLWKADLNDEGSFDTAIHGCSGVFHVATPTYFDATDPENKVIKPTVSGVLDIMKACAKAKVRRLVFTSSAAAVSIEENQKPMYDETCWTDVEFCRSNKMLGWMYLVSKTLAEKAAWSFAAECHVEFISVIPTLVVGPFLIPTMPPSLVAALCPLTRNEAYYSMIMRQGHFVHLDDVCMAHIFLYEHAGAHGRYIVSASNANVYDIGKMLKETYPEFNVPTKFKDCDENMKSIHLSSKKLTELGFEFKYDLKDMYIEAIEACQAKGFLSTSVENHANDSD
>Sc02g0002460.01
MVVPTGETVCVTGAAGYVGSWLVMRLLERGYTVRATVRDPGNMRKVKHLLDLPNAKTQLTLWKADLNDEGSFDTAIHGCSGVFHVATPTYFDATDPENKVIKPTVSGVLDIMKACAKAKVRRLVFTSSAGAVSIEENQKPMYDETCWTDVEFCRSNKMLGWMYLVSKTLAEKAAWSFAAECHVELISVIPTLVVGPFLIPTMPPSLVAALCPLTRNEAYYSMIMRQGHFVHLDDVCMAHIFLYEHAGAHGRYIVSASNANVYDIGKMLKETYPEFNVPTKFKDCDENMKSIHLSSKKLTELGFEFKYDLKDMYIEAIEACQAKGFLSTSVENHANDSD
>Sc16g0006600.01
MEENGRYCVTGATGYVGSWLVKLLLQRGCMVHATVRDPAKASYLMPKWNGDGRLKLFRADLHDEGSFDDAVKGCDGVFHVAASMEFNVLPQDNIESYVKSRIIEPAIEGTLSLLRSCSRSGSVRRVVLTSSISTITAKDSHGNWRSIADESCQTPIHQVWNARASGWVYVLSKLLTEEAAFQFANCNGVDLVSVITTTVGGPFLTSSVPSSIHVLLSPLTGDPEFAPIMSAVSARMGCIGVVHIEDICNAHIFLMEHPAANGRYLCCAHSASVSELVHLLARFYPLSHHLQRREGEGNGRIPCKISSKKLKDLGFEYKYGVVDIINDTIRCCVECGYLPFNECVRATHK
>Sc26g0003580.01
MDFVFFDVVGNMKKVKHLIELPNAKTHLTLWKADLNQEGSFDAAIVGCSGVFHVATPMDFDAKDPENEVIKPTINGVLDIMKACVKAKVRRLVFTSSAGTVNVEETPRSVYDETCWSNVEFCRTNKMTGWMYFVSKTLAEQAAWEYAKENKMDFISIIPPLVVGPFLMPSMPPSLVTALSPITRNEAHYSIIKQGQFVHLDDLCMAHIFLYEHPRAQGRYIASACEATIYDIGKMLRETYPEYDVPTKFKDYDEDMKHVHFSSKKLIDLGFEFKCSLKDMYTGAIETCRATGLLPTPNNVHVNGLNKEVRSTLDLV
>Sc26g0003530.01
MVVQNGETVCVTGAAGFIGSWLVMRLLEHGYTVRATVRDPSNMKKVKHLIELPNAKTHLTLWKADLNQEGSFDAAIVGCSGVFHVATPMDFDAKDPENEVIKPTINGVLDIMKACVKAKVRRLVFTSSAGTVNVEETPRSVYDETCWSNVEFCRTNKMTGWMYFVSKTLAEQAAWEYAKENKMDFISIIPPLVVGPFLMPSMPPSLVTALSPITRNEAHYSIIKQGQFVHLDDLCMAHIFLYEHPRAQGRYIASACEATIYDIGKMLRETYPEYDVPTKFKDYDEDMKHVHFSSKKLIDLGFEFKCSLKDMYTGAIETCRATGLLPTPNKVHVNGLNKEVRSTLDLV
MVAEGEVVCVTGAAGFIGSWLVMRLLEHGYVVRATVRDPKNMKKVKHLLDLPKAETHLTLWKADLSEEGSFDEAIQGCTGVFHVATPMDFESKDPENEVIKPTINGMLDIMKSCVKAKVRRLVFTSSAGTIDVNETPKPFYDETCWSDVDFCRRVKMTGWMYFVSKTLAEQAAWKYAEENKLDFVSIIPPLVVGPFLMPTLPPSLITALSPITRTESHYHIIKQGQFVHLDDLCMAHIFLYEHPNAQGRYIACACDATIFDITKMLNQKYPEHNVPTEFKDFDKNMKSVSFSSKKLTDLGFEFKYTLEDMFTGAVETCKAKGLLPTPLANHENGTK
>Sc02g0002510.01
MVVPTGETVCVTGAAGYFGSWLVMRLLERGYTVRATVGDPGNMRKVKHLLDLPNAKTQLTLWKADLNDEGSFDTAIHGCSGVFHVATPTYFDATDPENKVIKPTVSGVLDIMKACAKAKVRRLVFTSSAAAVSIEENQKPMYDETCWTDVEFCRSNKMLGWMYLVSKTLAEKAAWSFAAECHVEFISVIPTLVVGPFLIPTMPPSLVAALCPLTRNEAYYSMIMRQGHFVHLDDVCMAHIFLYEHAGAHGRYIVSASNANVYDIGKMLKETYPEFNVPTKFKDCDENMKSIHLSSKKLTELGFEFKYDLKDMYIEAIEACQAKGFLSTSVENHANDSD
>Sc02g0002460.01
MVVPTGETVCVTGAAGYVGSWLVMRLLERGYTVRATVRDPGNMRKVKHLLDLPNAKTQLTLWKADLNDEGSFDTAIHGCSGVFHVATPTYFDATDPENKVIKPTVSGVLDIMKACAKAKVRRLVFTSSAGAVSIEENQKPMYDETCWTDVEFCRSNKMLGWMYLVSKTLAEKAAWSFAAECHVELISVIPTLVVGPFLIPTMPPSLVAALCPLTRNEAYYSMIMRQGHFVHLDDVCMAHIFLYEHAGAHGRYIVSASNANVYDIGKMLKETYPEFNVPTKFKDCDENMKSIHLSSKKLTELGFEFKYDLKDMYIEAIEACQAKGFLSTSVENHANDSD
>Sc16g0006600.01
MEENGRYCVTGATGYVGSWLVKLLLQRGCMVHATVRDPAKASYLMPKWNGDGRLKLFRADLHDEGSFDDAVKGCDGVFHVAASMEFNVLPQDNIESYVKSRIIEPAIEGTLSLLRSCSRSGSVRRVVLTSSISTITAKDSHGNWRSIADESCQTPIHQVWNARASGWVYVLSKLLTEEAAFQFANCNGVDLVSVITTTVGGPFLTSSVPSSIHVLLSPLTGDPEFAPIMSAVSARMGCIGVVHIEDICNAHIFLMEHPAANGRYLCCAHSASVSELVHLLARFYPLSHHLQRREGEGNGRIPCKISSKKLKDLGFEYKYGVVDIINDTIRCCVECGYLPFNECVRATHK
>Sc26g0003580.01
MDFVFFDVVGNMKKVKHLIELPNAKTHLTLWKADLNQEGSFDAAIVGCSGVFHVATPMDFDAKDPENEVIKPTINGVLDIMKACVKAKVRRLVFTSSAGTVNVEETPRSVYDETCWSNVEFCRTNKMTGWMYFVSKTLAEQAAWEYAKENKMDFISIIPPLVVGPFLMPSMPPSLVTALSPITRNEAHYSIIKQGQFVHLDDLCMAHIFLYEHPRAQGRYIASACEATIYDIGKMLRETYPEYDVPTKFKDYDEDMKHVHFSSKKLIDLGFEFKCSLKDMYTGAIETCRATGLLPTPNNVHVNGLNKEVRSTLDLV
>Sc26g0003530.01
MVVQNGETVCVTGAAGFIGSWLVMRLLEHGYTVRATVRDPSNMKKVKHLIELPNAKTHLTLWKADLNQEGSFDAAIVGCSGVFHVATPMDFDAKDPENEVIKPTINGVLDIMKACVKAKVRRLVFTSSAGTVNVEETPRSVYDETCWSNVEFCRTNKMTGWMYFVSKTLAEQAAWEYAKENKMDFISIIPPLVVGPFLMPSMPPSLVTALSPITRNEAHYSIIKQGQFVHLDDLCMAHIFLYEHPRAQGRYIASACEATIYDIGKMLRETYPEYDVPTKFKDYDEDMKHVHFSSKKLIDLGFEFKCSLKDMYTGAIETCRATGLLPTPNKVHVNGLNKEVRSTLDLV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University