Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Setaria italica
Species name
Foxtail millet (Setaria italica) is a species of monocot in the family Poaceae (grass family).
Species info
Gene sequence info
Setaria_italica.COMT.fa
Download
>rna-XM_004954398.2
MMELANMISVPMALTAVIRLGVPSAVWAGGANAPLSAAELLPEGHPDPSVLERLLRLLASRGVFSEHGGGSAGSPRRFALTAVGRTLVPSGPSGASYADYVLQHHQDALVSAWPRLHEAVLDPAGPEPFARANAGVPAYAYYGRDREANEVMLRAMTGVSEPFMEALLDGYAAGFEGVATLVDVGGSSGACLEMIMRRVDTIREGINFDLPDVVAAAPPIVGVRHVGGDMFKSIPSGDAIFMKWVLTTWTNEECTAILGNCYSALPDGGKVIACEPVVPEETDGSTRTRALLENDIFVMTTYRTQGRERSEDEFRNLGIAAGFTGFRAIYLDPLYAVLEYTKNK
>rna-XM_004959904.2
MNRASMADSRFTMEVVIKEAGGYFKGLKTLTDVGGGHGAATAAIVATFPDMQCTVMDLQQVVNSARECGGTVKFVVGNMFESIPPADAVLLKLVLHSWDDASCIKILKCCKEAIPPMGGKVFNINTVLGHRGETSKHETEAQLLLDLYMMRGHGFERDERQWKTIFLEVGFANYTVIPLQDPLAMIVLHPSPLVVEMTVKVTGTGGAKEDSFLSTDEAEAAP
>rna-XM_004972743.4
MGSTAADVAAVADEEACMYALQLVSSSILPMTLKNAIELGLLEVLQKDPAAALSPEEVVARLPVAPANPDAPVMVDRMLRLLASYDVVRCQMEDKDGKYSRRYAAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFEGVGTLVDVGGGIGATLHAITSCHPQIKGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATILKNCYDALPANGKVIIVECVLPVNPEATPKAQGVFHVDMIMLAHNPGGKERYEREFRELAKGAGFTGFKATYIYANAWAIEFTK
>rna-XM_004975022.4
MSNPAAGAAVDGDEATCLHALELISSFAVSMTVKAAIELGLIDALSTAAGRAMTADELSAQLPTADKAEAAASVDRLLRLLASYNVVNCSTETGPSDEALQRRYTATPVCRWLTSNSGEGSLAPLAMFAVDEDYLPSWHHLGAAVAGGGPAAFERAHGVPMFRYMGMNTRLNRVFNQAMAQQTMMVIGKLLDRFKGFDGIGVLVDVGGGTGATLEMITSRYKHIKGINFDLPHALSEAPAIPGVQHVTGNMFEEVPYGDAIFLKSILHLQNDEDCMKILSNCHRALPERGKVIAVEIVLPAIPEATPVAQNPFRLDVIMLNNFRGGKERTEQEFVKLARDSGFEGEFGSTYIFANYWALEFSK
>rna-XM_012848119.1
MAMWTAPSSRLFVAASAIWYPGYSCLRYLVPRVQNSLFGTRAPERDPPAAAPVFSACANVASGSRLGRPSAPPVLVDRGRASVSFSAPWISSVSKSLRLPGHPPPPRANPVEIQRQLAAAATAADEMQGDQQQPGLSPFAMAYGGQTVWERAERDAAAFRFNDAMAADTAFLMPIVLRECAEVFRGLTSLVDVAGGLGGAAATIEAAFPDLKCTVLDLPQVVACKW
>rna-XM_004979731.2
MGSTGYANGAGVVVDDDDATCLHAQTLVYAYNVTMAVHAAVKLGLIDALGAADGRALTADELAAKVVKAEDKAESAALIGRILRFLASFDVVRCSAEKGPDGAVLWRYSPAPACRWLTMNNGEGSLGPMAVFDVDEDNFSSWHHIADAVAGGGKQTPFQIAHGGTPAYDYFGKNPRLSTLFDQAMAHQSLLVIRKLLEHPKVFDGVGVIVDVGGGTGATLALIRGRYKHIKGINMDLAHVISEAPSLEGVEHVAGDMFESVPSGDAVLMKWMLHMQSDEECMMILKNCHKALPANGKVIVIQSVLPETPESTPASRDSFTMDMIILVNFKGGKERTEQEYAKLGRDAGFTGGFQSTYIFCNIYALEFTK
>rna-XM_004979773.3
MDKIGFVNGAGVDEDSTCLHAQTLVYAYNVSMAVKAAVKLGLIDALSAADGNGLTAEELARKLVQAEDKAESASLIGRILRFLASFDVVRCSADKAPDGTVLWRYSPAPACRWLTTNNGEGSLGPMAVFAVDEDNFSSWHHIADAVAGGGKKTPFELAHGGTPAFEYFGKNRRLSLLFDRAMAQQSLLVIKKLVEHPKVFDGVGVLVDVGGGTGETLALISDRYKHIRGINMDLAHVVSEAPSLEGVEHVAGDMFESVPSGDAILMKWMIHLQSDEESILILKNCHRALPDNGKVIVIQSILPETPESTPAARDSYTMDIIIYVNFKGGKERTEQEYAKLGAAAGFSGFQKTYIFCNIYALEFTK
>rna-XM_004979262.3
MENTAPFPGKKTHISNGAPDEEDQVCLQAQELMFAYNNSLVLRAAIQLGLLDALCAAPTALTAGELAEQIKAADKAEATASVDRILVYLACFNVVRCSTEMTGLGGAVRRRYTPAPLCRWLTKNDGKGSLGPFAVFLGDPDHVLPWHHIADTVVSGDPSSPFERTQGMPFFDYLGKNQRLGTMFDHAMAEHSVILVTKMVEYFRGFDDVRQLVDVGGGTGNTLEMITSRYKHIKGINFDLPHVISQAPSLPGVEHVAGNMYESVPFGDAVLLQWILLMQTDEQCLKILKNCYKALPEGGKVIVIDGLLPETPDAKSPAARDAFTLDMCMFVLFKGKERTEREFTKLARESGFTGAVRTTYIFLNFYAIEFTK
>rna-XM_022823245.1
MEGGLESERETTNRWRVASNRSGGWPSSARVWIPHLWRDEECVKILKNCHRALPANGKVIVIEYVLPASPEPTLAAQGAFHLDVVMLNRLAGAKERTERGVRRDRRRGRLLRRLQGHLHLRQRLGARVHQAAALAFAVHISAPPFGDIAALIFSQPAEYAQPTTGHTKPCDKKLKCHA
MMELANMISVPMALTAVIRLGVPSAVWAGGANAPLSAAELLPEGHPDPSVLERLLRLLASRGVFSEHGGGSAGSPRRFALTAVGRTLVPSGPSGASYADYVLQHHQDALVSAWPRLHEAVLDPAGPEPFARANAGVPAYAYYGRDREANEVMLRAMTGVSEPFMEALLDGYAAGFEGVATLVDVGGSSGACLEMIMRRVDTIREGINFDLPDVVAAAPPIVGVRHVGGDMFKSIPSGDAIFMKWVLTTWTNEECTAILGNCYSALPDGGKVIACEPVVPEETDGSTRTRALLENDIFVMTTYRTQGRERSEDEFRNLGIAAGFTGFRAIYLDPLYAVLEYTKNK
>rna-XM_004959904.2
MNRASMADSRFTMEVVIKEAGGYFKGLKTLTDVGGGHGAATAAIVATFPDMQCTVMDLQQVVNSARECGGTVKFVVGNMFESIPPADAVLLKLVLHSWDDASCIKILKCCKEAIPPMGGKVFNINTVLGHRGETSKHETEAQLLLDLYMMRGHGFERDERQWKTIFLEVGFANYTVIPLQDPLAMIVLHPSPLVVEMTVKVTGTGGAKEDSFLSTDEAEAAP
>rna-XM_004972743.4
MGSTAADVAAVADEEACMYALQLVSSSILPMTLKNAIELGLLEVLQKDPAAALSPEEVVARLPVAPANPDAPVMVDRMLRLLASYDVVRCQMEDKDGKYSRRYAAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFEGVGTLVDVGGGIGATLHAITSCHPQIKGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATILKNCYDALPANGKVIIVECVLPVNPEATPKAQGVFHVDMIMLAHNPGGKERYEREFRELAKGAGFTGFKATYIYANAWAIEFTK
>rna-XM_004975022.4
MSNPAAGAAVDGDEATCLHALELISSFAVSMTVKAAIELGLIDALSTAAGRAMTADELSAQLPTADKAEAAASVDRLLRLLASYNVVNCSTETGPSDEALQRRYTATPVCRWLTSNSGEGSLAPLAMFAVDEDYLPSWHHLGAAVAGGGPAAFERAHGVPMFRYMGMNTRLNRVFNQAMAQQTMMVIGKLLDRFKGFDGIGVLVDVGGGTGATLEMITSRYKHIKGINFDLPHALSEAPAIPGVQHVTGNMFEEVPYGDAIFLKSILHLQNDEDCMKILSNCHRALPERGKVIAVEIVLPAIPEATPVAQNPFRLDVIMLNNFRGGKERTEQEFVKLARDSGFEGEFGSTYIFANYWALEFSK
>rna-XM_012848119.1
MAMWTAPSSRLFVAASAIWYPGYSCLRYLVPRVQNSLFGTRAPERDPPAAAPVFSACANVASGSRLGRPSAPPVLVDRGRASVSFSAPWISSVSKSLRLPGHPPPPRANPVEIQRQLAAAATAADEMQGDQQQPGLSPFAMAYGGQTVWERAERDAAAFRFNDAMAADTAFLMPIVLRECAEVFRGLTSLVDVAGGLGGAAATIEAAFPDLKCTVLDLPQVVACKW
>rna-XM_004979731.2
MGSTGYANGAGVVVDDDDATCLHAQTLVYAYNVTMAVHAAVKLGLIDALGAADGRALTADELAAKVVKAEDKAESAALIGRILRFLASFDVVRCSAEKGPDGAVLWRYSPAPACRWLTMNNGEGSLGPMAVFDVDEDNFSSWHHIADAVAGGGKQTPFQIAHGGTPAYDYFGKNPRLSTLFDQAMAHQSLLVIRKLLEHPKVFDGVGVIVDVGGGTGATLALIRGRYKHIKGINMDLAHVISEAPSLEGVEHVAGDMFESVPSGDAVLMKWMLHMQSDEECMMILKNCHKALPANGKVIVIQSVLPETPESTPASRDSFTMDMIILVNFKGGKERTEQEYAKLGRDAGFTGGFQSTYIFCNIYALEFTK
>rna-XM_004979773.3
MDKIGFVNGAGVDEDSTCLHAQTLVYAYNVSMAVKAAVKLGLIDALSAADGNGLTAEELARKLVQAEDKAESASLIGRILRFLASFDVVRCSADKAPDGTVLWRYSPAPACRWLTTNNGEGSLGPMAVFAVDEDNFSSWHHIADAVAGGGKKTPFELAHGGTPAFEYFGKNRRLSLLFDRAMAQQSLLVIKKLVEHPKVFDGVGVLVDVGGGTGETLALISDRYKHIRGINMDLAHVVSEAPSLEGVEHVAGDMFESVPSGDAILMKWMIHLQSDEESILILKNCHRALPDNGKVIVIQSILPETPESTPAARDSYTMDIIIYVNFKGGKERTEQEYAKLGAAAGFSGFQKTYIFCNIYALEFTK
>rna-XM_004979262.3
MENTAPFPGKKTHISNGAPDEEDQVCLQAQELMFAYNNSLVLRAAIQLGLLDALCAAPTALTAGELAEQIKAADKAEATASVDRILVYLACFNVVRCSTEMTGLGGAVRRRYTPAPLCRWLTKNDGKGSLGPFAVFLGDPDHVLPWHHIADTVVSGDPSSPFERTQGMPFFDYLGKNQRLGTMFDHAMAEHSVILVTKMVEYFRGFDDVRQLVDVGGGTGNTLEMITSRYKHIKGINFDLPHVISQAPSLPGVEHVAGNMYESVPFGDAVLLQWILLMQTDEQCLKILKNCYKALPEGGKVIVIDGLLPETPDAKSPAARDAFTLDMCMFVLFKGKERTEREFTKLARESGFTGAVRTTYIFLNFYAIEFTK
>rna-XM_022823245.1
MEGGLESERETTNRWRVASNRSGGWPSSARVWIPHLWRDEECVKILKNCHRALPANGKVIVIEYVLPASPEPTLAAQGAFHLDVVMLNRLAGAKERTERGVRRDRRRGRLLRRLQGHLHLRQRLGARVHQAAALAFAVHISAPPFGDIAALIFSQPAEYAQPTTGHTKPCDKKLKCHA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University