Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Scutellaria baicalensis
Species name
Baikal skullcap (Scutellaria baicalensis) is a species of eudicot in the family Lamiaceae (mint family).
Species info
Gene sequence info
Scutellaria_baicalensis.COMT.fa
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>Sb01t11100.mRNA1
MEGESPVVAIMELANMISVPMSLNAVVRLNVADAIWQGGSNAPLSAAEILSATAAGPAADPDILQRILRLLTSHGVFTEHVDQDQSLRRYSLTEVGKTLVTDENGLSYAPYVLQHHQDALVRAWPLVHEAVVDPSTEPFVKANGEAAYSYYGKKPEMNILMQRAMAGVSVPFMKTLLDCYDGFEGVGTLVDVGGSSGDCLRMIMDKNPSIKEGINFDLPEVVGKAPTFPGITHVGGDMLKFVPPGDAIFLKWVLTTWTDEECKQILRNCYNALPPGGKAIACEPVLPDQTDNSHRSRALLEGDIFVMTIYRAKGKHRTESAYKELGLSVGFPKFKAKIYMDQFYTVLEFQK
>Sb01t51040.mRNA1
MGSTTKSVATSTTNSDEEEAFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPGAFVSPAEIAAQLPTTNAEARVMLDRILRLLTTYSVLNCRLETLPDGGVERLYGLAPVCKFLTKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSGHSTITMKKILETYHGFDGLNTLVDVGGGIGATLNMIVSEHPSIKGINFDLPHVIEDAPSHSGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCIKFLKNCYDALPQNGKVILAECVLPEAPDSGLATKNVVHIDVIMLAHNPGGKERTEKEFHNLAKAAGFKEFQKVCCAYNTWIMELLK
>Sb01t51230.mRNA1
MGSTTKSVATSTTNSDEEEAFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPGAFVSPAEIAAQLPTTNAEARVMLDRILRLLTTYSVLNCRLETLPDGGVERLYGLAPVCKFLTKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSGHSTITMKKILETYHGFDGLNTLVDVGGGIGATLNMIVSEHPSIKGINFDLPHVIEDAPSHSGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCIKFLKNCYDALPQNGKVILAECVLPEAPDSGLATKNVVHIDVIMLAHNPGGKERTEKEFHNLAKAAGFKEFQKVCCAYNTWIMELLK
>Sb02t33990.mRNA1
MKNEGSGSMAALVMLESSPVMLAPWHRLTSRLLINNGTPPFEAAHGEDIWEYASENSAHSDLINDAMACHARRAIAAIVDQYPEAFKGIGSLVDVGGGNGTALRAIVKACPWIRGINFDLPHVVSKAPQCDGVEHVEGDMFKYVPKGDATFLMWTLHDWSDDECIKILKNCREAIPRETGKVIIAEAVITEGDEDRYSSCSIRFGHGDVGSYGEGKREDC
>Sb09t01810.mRNA1
MSHSTILFKNVIEIYKGFEGLKSLVDVGGGTGTALNMIVSKYPSIKGINFDLPHVISHAPSYPGIEHVGGDMFTSVPKGDAIFMKVDHKTSFKAIIHGIQ
>Sb09t02040.mRNA1
MKQFKVAEIKMEQKEEEACILAIQLAAGSVLPMVLKSAIELNLLELIKKADPPCISAKELAAQLSAANPNAPHMLDRILRFLTACSVLTCSGGEERRYSLAPLAKFLTKNEDGASLAPVSLMAQDKVFLASCYNIDKYIVSMTTLFIMRFKLRVNAGIEHVGGDMFTSVPKGDAIFMKWITHSWDDADCVKILRNCREALPENGKVIVVEHMIRETPNSGSTTYEFQVDVMMLALSPGARERTELEFNTLAKEAGFKEFRKVCSTYTLCLMEFYK
>Sb0t01090.mRNA1
MQWITHSWDDADCVKILRNCREALPENGKVIVVEHMIRETPNSGSTTYEFQVDVMTLALSPGARERTELEFNTLAKEAGFKEFSKVCSTYTLCLMEFYK
MEGESPVVAIMELANMISVPMSLNAVVRLNVADAIWQGGSNAPLSAAEILSATAAGPAADPDILQRILRLLTSHGVFTEHVDQDQSLRRYSLTEVGKTLVTDENGLSYAPYVLQHHQDALVRAWPLVHEAVVDPSTEPFVKANGEAAYSYYGKKPEMNILMQRAMAGVSVPFMKTLLDCYDGFEGVGTLVDVGGSSGDCLRMIMDKNPSIKEGINFDLPEVVGKAPTFPGITHVGGDMLKFVPPGDAIFLKWVLTTWTDEECKQILRNCYNALPPGGKAIACEPVLPDQTDNSHRSRALLEGDIFVMTIYRAKGKHRTESAYKELGLSVGFPKFKAKIYMDQFYTVLEFQK
>Sb01t51040.mRNA1
MGSTTKSVATSTTNSDEEEAFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPGAFVSPAEIAAQLPTTNAEARVMLDRILRLLTTYSVLNCRLETLPDGGVERLYGLAPVCKFLTKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSGHSTITMKKILETYHGFDGLNTLVDVGGGIGATLNMIVSEHPSIKGINFDLPHVIEDAPSHSGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCIKFLKNCYDALPQNGKVILAECVLPEAPDSGLATKNVVHIDVIMLAHNPGGKERTEKEFHNLAKAAGFKEFQKVCCAYNTWIMELLK
>Sb01t51230.mRNA1
MGSTTKSVATSTTNSDEEEAFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPGAFVSPAEIAAQLPTTNAEARVMLDRILRLLTTYSVLNCRLETLPDGGVERLYGLAPVCKFLTKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSGHSTITMKKILETYHGFDGLNTLVDVGGGIGATLNMIVSEHPSIKGINFDLPHVIEDAPSHSGVEHVGGDMFASVPKGDAIFMKWICHDWSDEHCIKFLKNCYDALPQNGKVILAECVLPEAPDSGLATKNVVHIDVIMLAHNPGGKERTEKEFHNLAKAAGFKEFQKVCCAYNTWIMELLK
>Sb02t33990.mRNA1
MKNEGSGSMAALVMLESSPVMLAPWHRLTSRLLINNGTPPFEAAHGEDIWEYASENSAHSDLINDAMACHARRAIAAIVDQYPEAFKGIGSLVDVGGGNGTALRAIVKACPWIRGINFDLPHVVSKAPQCDGVEHVEGDMFKYVPKGDATFLMWTLHDWSDDECIKILKNCREAIPRETGKVIIAEAVITEGDEDRYSSCSIRFGHGDVGSYGEGKREDC
>Sb09t01810.mRNA1
MSHSTILFKNVIEIYKGFEGLKSLVDVGGGTGTALNMIVSKYPSIKGINFDLPHVISHAPSYPGIEHVGGDMFTSVPKGDAIFMKVDHKTSFKAIIHGIQ
>Sb09t02040.mRNA1
MKQFKVAEIKMEQKEEEACILAIQLAAGSVLPMVLKSAIELNLLELIKKADPPCISAKELAAQLSAANPNAPHMLDRILRFLTACSVLTCSGGEERRYSLAPLAKFLTKNEDGASLAPVSLMAQDKVFLASCYNIDKYIVSMTTLFIMRFKLRVNAGIEHVGGDMFTSVPKGDAIFMKWITHSWDDADCVKILRNCREALPENGKVIVVEHMIRETPNSGSTTYEFQVDVMMLALSPGARERTELEFNTLAKEAGFKEFRKVCSTYTLCLMEFYK
>Sb0t01090.mRNA1
MQWITHSWDDADCVKILRNCREALPENGKVIVVEHMIRETPNSGSTTYEFQVDVMTLALSPGARERTELEFNTLAKEAGFKEFSKVCSTYTLCLMEFYK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University