Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Scutellaria baicalensis
Species name
Baikal skullcap (Scutellaria baicalensis) is a species of eudicot in the family Lamiaceae (mint family).
Species info
Gene sequence info
Scutellaria_baicalensis.4CL.fa
Download
>Sb01t11940.mRNA1
MGSDSARRGAAFLSVGDSMAGLGGTDDEPEVDIDPNDVVALAVFLRHNQAAERRHPDSQKPNHERRSTRRCRALRSALSRCGGSVDAEIRDRFAAGIDTEPLCLGGGGGVTAGAGAGLAKNPIVDNFDLSSIWMVLSGATSLEKELESALLSRLPQAIFGQSYMFISLYF
>Sb02t10650.mRNA1
MLSVASVETQNPELSSHVLPRDQTETDRVFVSKLPKISISNHLPLHTYCFQNLPHYSDRTCLFVGNSGKSYSFAETHLLCRKVAAGLSNLGIRKGDVVMVLLQNCAEFVFTFMGASMIGAVTTMANPFCTANEIFKQFRASKSKLIITQSQYVEKLRETGDESIVFGEDFSVITLDSPPGGCLHFSVLSDANEDDAPEVDIDPNDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLMMQKFEIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEGALLSRLPQAIFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGCSLPRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHSNIADAAVVPQKDEAAGEVPVAFVVPSIGSELTEEAVKEFISKQVVFYKRLQKVYFVHSIPKSPSGKILRKDLRSKLAATPPSSS
>Sb02t17140.mRNA1
MAPYGEAEEIIFRSKLPDIYIPNHLPLHSYCFENISKHRKKPCLINAAAAGTKEVYTYEEVELMARKVASGLSKLGIHQGHTIMLLLPNSPEFVLSFLGASYLGAITTTANPHFTPAEVAKQLRASNAALVITQACHADKVRGEGVPVACIDAPPEWCLSFADLRAADEAEMPAVKIQTEDVVALPYSSGTTGLPKGVMLTHKALVTNVAQQVDGENPNLYIHSDDVILCVLPMFHIYSLNTVLLCGLRVGAAILIVQRFEIVPLLEMIERYKVTIGPLVPPIVLSIVKSPFVGNYDLSSLRIVMSGAAPLGKDLEDALTIKLPNAKLGQGYGMTEAGPVMSIYMGFAKEKFEVKSGTCGCVVRNAEMKIIDPLTAASLGPNQSGEICIRGDQLMKGYLKDPESTNRTIDKDGWLHTGDIGFIDDDNDLFIVDRLKELIKYKGFQVAPAELEALLLNHPYISDAAVVSMRDEEAGEVPVAFVVKSNGSTINEDEIKQYISKQVVFYKRIKSVFFVDAIPKSPSGKILRKELRARQD
>Sb02t09100.mRNA1
MVGQQACSDVCDFYFDGKFVPAGFKTLALLSYPQLCNSVILQSCCYAVPLLWGIKVLSDANEDDPPEVDIDPNYAVALSFSSGTTRLSKGVILTHKSLITSVVQQVDDDVVLCVLPLFHIYFLNSVLLCSIKGSADSHRVSVTAVVSPLVLALAKNPMVDNFDLSSFRMVLSGVAPLGKELEVVLLSRLPQAIFEQNSSTI
>Sb02t19320.mRNA1
METVENHGDVIFRSKLPDIYIPKHLPLHSYCFENISEHRTKPCLINGATNEVHTYEEVELISRKVAAGLSHLGLHHGDTIMILLPNSPEFVFAFLGASYIGAVSTMANPFFTPAEVIKQAKASNAKLIITQACYVKKVWDYAVENGVRVMCVDSPPPEAAGECLEFSQLTSADEGDMPEVEINSEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSDDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQRYKVTIGPFVPPIVLAIVKSPVVGNYDLSSIRTVMSGAAPLGKELEEAVRIKFPNAKLGQGYGMTEAGPVLAMCLAFAKEGFEIKSGACGTVVRNAEMKIVDIETAASLGRNQPGEICIRGDQIMKGYLNDPESTARTIDKEGWLHTGDIGFIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPSISDAAVVSMKDEEAGEVPVAFVVKSNGSTITEDDIKQFISKQVIFYKRIHRVFFIDAIPKNPSGKILRKDLRAILPTKAATLSN
>Sb03t41150.mRNA1
MGTDAKDMAHEEIIFRSKYPPVEVPEDMTLPEFVLANAELYLDKVAVVDSVTGKGYTYKEVRRDVGRFSKALRSLGLRKGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPNGHSSEIKKQVEAADAKLIVTDGSTYHKVKDLGVPVIIQSEDLIDGTINWDELLEAADKANTDFIDEKVKQTDLCALPFSSGTTGVSKGVMLTHQNLVANLCSTLFSVGPELIGQITVLGLIPFFHIYGLTGICCATMRNKGKVVVMQRYELRLFLSVLITHQVTFAPIVPPIILGLVKNPIVDEFDLGKLNLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGNVNHGVAKRNSVGFILPNLEVKFVDPETGISLPNNTPGEICVRSKCVMKGYYKNEYETTLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLGHPSIEDAAVVGIPDKEAGEIPAACVVIKREAKENEEDIIKYVSTNVASYKKVRLVQFVDVIPKSPSGKIMRRVMREDMVKNL
>Sb03t28470.mRNA1
MFIYILSDASEDDEPEVDIDPNDAVTLPFSSGTSKLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSIRAGAAVLPM
>Sb04t00940.mRNA1
MSTLPNIYGKDEIYRSPRPPISLPNNNISMIPFLFRNLSSTSNTTALIDAQTAQTLTFSHLKAHVLNLSHALINLNISKNDVVLILSPNSVLFPVAFFAVVAVGAIATTANPVYTTAELSKQIKDSNPKLIITTHQLHHKIKQFNLPCMMLTKDLIEQSSPNTTLELPSNVDQTDPAAILYSSGTAGTSKGVVLTHKNFIASALMMTSDQESKGESKTKNVFLCFLPMFHIFGLSALMYAQLQRGNTVVVMEKHEIRKTLMAIEKHKITHIFVVPIVIRELVKNEELVKKYDVSSLREILSGAAPLGKDVIQECTRVFPHLVIYQAYGMTETTGVISVDDPNTCSPHLGTTTGVLAPSVEAQILNLDTMKPLPPFQRGEIWVRGPLVMKGYLNNMKATMDTIDEGGWLHTGDIGYFDDKGRLYVVDRVKELIKYKGFQVAPAELEELLLTHPQILDAAVIGVPDAEAGEITVAFVVTSTITSLTKQQVHDFIAKQVAPFKRLKRVIFTQAIPKSPSGKILRRVLKQNLQSKL
>Sb04t00500.mRNA1
MVEIGFGYSKHCEQQLDNRCWDDVVLCVLPLFHIYSLNSVLLCSIRADATILLMQKFEIGSLLELIQSHRVSVAAVVSPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEAALLSRLPQAIFGQLVLLSPSPSYFHHFRTSSTFTFTFIINELKLEISQVCNHVCIFREKDNIALYEMRARHVS
>Sb04t23270.mRNA1
MLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLSVRCWLIQSLRVSVAAVVSLLVLAKNPMVDNFDLSSIRMVLSGATPLGKELEAALLSHLPQAIFGQVLLSPSPSYFHHFRTGSTFTFTFIINELKLEISQVCNHVCIFRAKDNIALNERRARHVS
>Sb07t04590.mRNA1
MELKHETEHIFRSKLPDIYIPNHLPIHTYCFQNISTHCSRPFLINAATGEVFTHADTELASRRVAVGLHNLCIRKSDVIMLLLHNSPEFAFSFLAASFIGATSTTANPHYTAAEIMLQVGVSKPKLIITHACHVDKVKHCGAIIVSVDPPPSPQIIHFKELMKSDETLLPKVEIYADDTAALPFSSGTTGLPKGVMLSHKNLVTCVSQQIDGENPANHTDSDDLLICVLPLFHVFSLLSVMLCSLRAGAAILIMPKFEINELMNLIQKYRVTIAPFVPPILLAIAKSPAAAKYDLSSVRRVLCGAAPMDQRLEVSLKAKLPNATIGQGYGMTEAGVVSMCLGFAKKPFKFKAGACGTVIRNARMKIVDPSTGTSLPRNRTGEICIRGDAVMKGYYNDPEATKRTIDKEGWLHSGDIGYVDSSDEVFIVDRLKELIKYKGFHIAPAELEALLISHPSISKAAVISMVDEDAGEVPVAFVVRANGSDINEQEIKKYISEHVVFYKRIHRVFFTDHIPISPSGKILRKNLRARI
>Sb07t01470.mRNA1
MLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYFLNSVLLCSIKGFADAEI
>Sb09t15340.mRNA1
MEKSGYGRDGIYRSLRPPLYLPKNPNLSLVSFLFRNVSSFADNRALVDAHTGETLTFAQFKSTVSKVAHGLLQLGIKKNDVVLIFAPNSIEFPISFFGVIATGAVATTVNPMYTVSELSKQVQDSTAKLIVTVEGLLPKVKDFGLPVILLGNEKKSVLPIGRIPSITSFSELVNNEGLDLDSNFNGIKQDDTAALLYSSGTTGMSKGVILTHRNFIASSLMITADQESAGEMHNVFLCVLPMFHVFGLAVIMLSQLQRGNTIVSMSKFDFEMILKTVEKYGITHMWVVPPIILALAKNNVVKKYNLSSLQQIGSGAAPLGRELMQECAKNFPQAVVVQGYGMTETCGIVSVENVYAGPRHSGSAGTLVPGVECQIVSVDKLKPLPPGQLGEICVRGPNMMQGYFKNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPSAYVVRAPNSSLSEEDIKNFIAKQVAPFKRLGRVTFINSIPKSAAGKILRKELIEKVLY
MGSDSARRGAAFLSVGDSMAGLGGTDDEPEVDIDPNDVVALAVFLRHNQAAERRHPDSQKPNHERRSTRRCRALRSALSRCGGSVDAEIRDRFAAGIDTEPLCLGGGGGVTAGAGAGLAKNPIVDNFDLSSIWMVLSGATSLEKELESALLSRLPQAIFGQSYMFISLYF
>Sb02t10650.mRNA1
MLSVASVETQNPELSSHVLPRDQTETDRVFVSKLPKISISNHLPLHTYCFQNLPHYSDRTCLFVGNSGKSYSFAETHLLCRKVAAGLSNLGIRKGDVVMVLLQNCAEFVFTFMGASMIGAVTTMANPFCTANEIFKQFRASKSKLIITQSQYVEKLRETGDESIVFGEDFSVITLDSPPGGCLHFSVLSDANEDDAPEVDIDPNDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLMMQKFEIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEGALLSRLPQAIFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGCSLPRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHSNIADAAVVPQKDEAAGEVPVAFVVPSIGSELTEEAVKEFISKQVVFYKRLQKVYFVHSIPKSPSGKILRKDLRSKLAATPPSSS
>Sb02t17140.mRNA1
MAPYGEAEEIIFRSKLPDIYIPNHLPLHSYCFENISKHRKKPCLINAAAAGTKEVYTYEEVELMARKVASGLSKLGIHQGHTIMLLLPNSPEFVLSFLGASYLGAITTTANPHFTPAEVAKQLRASNAALVITQACHADKVRGEGVPVACIDAPPEWCLSFADLRAADEAEMPAVKIQTEDVVALPYSSGTTGLPKGVMLTHKALVTNVAQQVDGENPNLYIHSDDVILCVLPMFHIYSLNTVLLCGLRVGAAILIVQRFEIVPLLEMIERYKVTIGPLVPPIVLSIVKSPFVGNYDLSSLRIVMSGAAPLGKDLEDALTIKLPNAKLGQGYGMTEAGPVMSIYMGFAKEKFEVKSGTCGCVVRNAEMKIIDPLTAASLGPNQSGEICIRGDQLMKGYLKDPESTNRTIDKDGWLHTGDIGFIDDDNDLFIVDRLKELIKYKGFQVAPAELEALLLNHPYISDAAVVSMRDEEAGEVPVAFVVKSNGSTINEDEIKQYISKQVVFYKRIKSVFFVDAIPKSPSGKILRKELRARQD
>Sb02t09100.mRNA1
MVGQQACSDVCDFYFDGKFVPAGFKTLALLSYPQLCNSVILQSCCYAVPLLWGIKVLSDANEDDPPEVDIDPNYAVALSFSSGTTRLSKGVILTHKSLITSVVQQVDDDVVLCVLPLFHIYFLNSVLLCSIKGSADSHRVSVTAVVSPLVLALAKNPMVDNFDLSSFRMVLSGVAPLGKELEVVLLSRLPQAIFEQNSSTI
>Sb02t19320.mRNA1
METVENHGDVIFRSKLPDIYIPKHLPLHSYCFENISEHRTKPCLINGATNEVHTYEEVELISRKVAAGLSHLGLHHGDTIMILLPNSPEFVFAFLGASYIGAVSTMANPFFTPAEVIKQAKASNAKLIITQACYVKKVWDYAVENGVRVMCVDSPPPEAAGECLEFSQLTSADEGDMPEVEINSEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSDDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQRYKVTIGPFVPPIVLAIVKSPVVGNYDLSSIRTVMSGAAPLGKELEEAVRIKFPNAKLGQGYGMTEAGPVLAMCLAFAKEGFEIKSGACGTVVRNAEMKIVDIETAASLGRNQPGEICIRGDQIMKGYLNDPESTARTIDKEGWLHTGDIGFIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPSISDAAVVSMKDEEAGEVPVAFVVKSNGSTITEDDIKQFISKQVIFYKRIHRVFFIDAIPKNPSGKILRKDLRAILPTKAATLSN
>Sb03t41150.mRNA1
MGTDAKDMAHEEIIFRSKYPPVEVPEDMTLPEFVLANAELYLDKVAVVDSVTGKGYTYKEVRRDVGRFSKALRSLGLRKGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPNGHSSEIKKQVEAADAKLIVTDGSTYHKVKDLGVPVIIQSEDLIDGTINWDELLEAADKANTDFIDEKVKQTDLCALPFSSGTTGVSKGVMLTHQNLVANLCSTLFSVGPELIGQITVLGLIPFFHIYGLTGICCATMRNKGKVVVMQRYELRLFLSVLITHQVTFAPIVPPIILGLVKNPIVDEFDLGKLNLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGNVNHGVAKRNSVGFILPNLEVKFVDPETGISLPNNTPGEICVRSKCVMKGYYKNEYETTLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLGHPSIEDAAVVGIPDKEAGEIPAACVVIKREAKENEEDIIKYVSTNVASYKKVRLVQFVDVIPKSPSGKIMRRVMREDMVKNL
>Sb03t28470.mRNA1
MFIYILSDASEDDEPEVDIDPNDAVTLPFSSGTSKLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSIRAGAAVLPM
>Sb04t00940.mRNA1
MSTLPNIYGKDEIYRSPRPPISLPNNNISMIPFLFRNLSSTSNTTALIDAQTAQTLTFSHLKAHVLNLSHALINLNISKNDVVLILSPNSVLFPVAFFAVVAVGAIATTANPVYTTAELSKQIKDSNPKLIITTHQLHHKIKQFNLPCMMLTKDLIEQSSPNTTLELPSNVDQTDPAAILYSSGTAGTSKGVVLTHKNFIASALMMTSDQESKGESKTKNVFLCFLPMFHIFGLSALMYAQLQRGNTVVVMEKHEIRKTLMAIEKHKITHIFVVPIVIRELVKNEELVKKYDVSSLREILSGAAPLGKDVIQECTRVFPHLVIYQAYGMTETTGVISVDDPNTCSPHLGTTTGVLAPSVEAQILNLDTMKPLPPFQRGEIWVRGPLVMKGYLNNMKATMDTIDEGGWLHTGDIGYFDDKGRLYVVDRVKELIKYKGFQVAPAELEELLLTHPQILDAAVIGVPDAEAGEITVAFVVTSTITSLTKQQVHDFIAKQVAPFKRLKRVIFTQAIPKSPSGKILRRVLKQNLQSKL
>Sb04t00500.mRNA1
MVEIGFGYSKHCEQQLDNRCWDDVVLCVLPLFHIYSLNSVLLCSIRADATILLMQKFEIGSLLELIQSHRVSVAAVVSPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEAALLSRLPQAIFGQLVLLSPSPSYFHHFRTSSTFTFTFIINELKLEISQVCNHVCIFREKDNIALYEMRARHVS
>Sb04t23270.mRNA1
MLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLSVRCWLIQSLRVSVAAVVSLLVLAKNPMVDNFDLSSIRMVLSGATPLGKELEAALLSHLPQAIFGQVLLSPSPSYFHHFRTGSTFTFTFIINELKLEISQVCNHVCIFRAKDNIALNERRARHVS
>Sb07t04590.mRNA1
MELKHETEHIFRSKLPDIYIPNHLPIHTYCFQNISTHCSRPFLINAATGEVFTHADTELASRRVAVGLHNLCIRKSDVIMLLLHNSPEFAFSFLAASFIGATSTTANPHYTAAEIMLQVGVSKPKLIITHACHVDKVKHCGAIIVSVDPPPSPQIIHFKELMKSDETLLPKVEIYADDTAALPFSSGTTGLPKGVMLSHKNLVTCVSQQIDGENPANHTDSDDLLICVLPLFHVFSLLSVMLCSLRAGAAILIMPKFEINELMNLIQKYRVTIAPFVPPILLAIAKSPAAAKYDLSSVRRVLCGAAPMDQRLEVSLKAKLPNATIGQGYGMTEAGVVSMCLGFAKKPFKFKAGACGTVIRNARMKIVDPSTGTSLPRNRTGEICIRGDAVMKGYYNDPEATKRTIDKEGWLHSGDIGYVDSSDEVFIVDRLKELIKYKGFHIAPAELEALLISHPSISKAAVISMVDEDAGEVPVAFVVRANGSDINEQEIKKYISEHVVFYKRIHRVFFTDHIPISPSGKILRKNLRARI
>Sb07t01470.mRNA1
MLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYFLNSVLLCSIKGFADAEI
>Sb09t15340.mRNA1
MEKSGYGRDGIYRSLRPPLYLPKNPNLSLVSFLFRNVSSFADNRALVDAHTGETLTFAQFKSTVSKVAHGLLQLGIKKNDVVLIFAPNSIEFPISFFGVIATGAVATTVNPMYTVSELSKQVQDSTAKLIVTVEGLLPKVKDFGLPVILLGNEKKSVLPIGRIPSITSFSELVNNEGLDLDSNFNGIKQDDTAALLYSSGTTGMSKGVILTHRNFIASSLMITADQESAGEMHNVFLCVLPMFHVFGLAVIMLSQLQRGNTIVSMSKFDFEMILKTVEKYGITHMWVVPPIILALAKNNVVKKYNLSSLQQIGSGAAPLGRELMQECAKNFPQAVVVQGYGMTETCGIVSVENVYAGPRHSGSAGTLVPGVECQIVSVDKLKPLPPGQLGEICVRGPNMMQGYFKNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPSAYVVRAPNSSLSEEDIKNFIAKQVAPFKRLGRVTFINSIPKSAAGKILRKELIEKVLY
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University