Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Sclerocarya birrea
Species name
Sclerocarya birrea is a species of eudicot in the family Anacardiaceae (sumac family).
Species info
Gene sequence info
Sclerocarya_birrea.COMT.fa
Download
>Sclbi88S17096_SCLBI
MASSAIRSNEEKDESFAYAIQLVMGSVLPMTLKAAIDLDIFEIIAKAGPGAKLSASEIAVQMSARNKDAPMMVDRILGLLASHSVLTCSVVGFQRLYSLAPVSKYFVRDQTGVSLGPFMALIQDKVPQLKEAVLEGGVPFDRVHGTHAFEYPSLDPRFNKVFNTAMFNHTTIVINEILEVYKGFEKINQLVDVGGGLGITLKAITAKYPHIKAINFDLPHVIEQAPHHPGVEHEGGDMFDSVPKGDAIFMKWILHDWSDEYCLKLLKNCYKSTAKEGKVIVVESILPVMAQVNAASKAISQLDLFMMTQNPGGKERTRSEFMELATAAGFSGITYECFWLYNLVPMSKYCLQPRWPSIGKVNGQTSGQLKEAVLEARVPFDRVHGTHAFKYSGSHSRFNKVFNKAMFNHTSILINNILRFARVLRTSISWLMLVIDGLGSYPQSASISTCLMLYNMPSNMPFSNSLLIIANISQIKDYELKTILCVYLQSTKTTRGTKSFYRSGTRRGRFLKAFQMYPRKWEGIVVEAILPIMPGTNVTSKGTSALDVLMMTQSSGGKERTRHQFMPLADGAGFRGIRFECFVFNYRIMEFYG
>Sclbi438S12777_SCLBI
MMIPQGLRQLKGKDYAADEPKFKNIFYDNMISDSQFVAKVLIENYKRGVQGSVVNVGGSTGTMVEAIAKAFPEIQCTSFDLLHVVDNLQGT
>Sclbi575S13950_SCLBI
MSSLQDQSKPSNDEEDFLSAMQLVNGFVLPMVMKAAVELNLFDIMAKASPSQLSSSEIASHIPTNNQDAPALIDRILRLLACHSIITCDLATNEEGQVLRLYSLTPVCKYFVQNENGASLACPLLTFLDKAFMEPWDYVKEVVLEGGLPFRKAHNGMAFFEYASKDGRLNSLFNQSMYNFTTIVMNKILEIYNGFEDLNELVDVAGGIGANLKLIVAKYPQIKGINFDLPHVIKDAPSCSGVEHVGGDMFVEVPKGEAIFTKTVLHNWGDDQCLKILKNCYNALPESGKVIVVDSMLPDFPETDLVSQNISALDIALFTAHPGAKERTKEEFQALATRAGFAAFKVICRVYCYWVIEFCKMCPA
>Sclbi561S13855_SCLBI
MSGNEEDDDDIHGQYAMQLVSASVLRMVLKSTIELGVLDIIHKAGPGGQLSRSQIAAPLVTQNKPHASLILDQILRLLATTVAKYFIRKQDGGGRCLASLLELIQDKVMLNMWYRLKEAVVEGDIPFNKAYEISAVEYIGKNAKLGEIFKDCMRDFNPIFMQKILEMCKGFDGLKSLLMWVVGMYPNIKAVNYDLRLTIEKSTIYPGINFSLLVIRNVSGDTFVDIPKGEAFFMKLILKNCYEALPINGEVIAVDLVIPEAPEDILSAESFFQLDMFMMNMNSRGKERT
>Sclbi850S16794_SCLBI
MGSAGETQITPTQVSDEEANLFAMQLTSASVLPMVLKSAIELDLLEIIAKAGTGAFVSPKEIASQLPTKNPDAPVMLDRILRLLASYSVLKCSLSNLPDGKVERLYGLGPVCKFLTRNEDGVNIGDLCLMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNNGMSSHSTITMKKILETYKGFEGLKSVVDVGGGIGATLNMIISKYPSIKGINFDLPHVIEDAPSFPGVEHVGGDMFISVPKGDAIFMKWICHDWSDEHCLKFLKNCYEALPDNGKVIVCECILPVTPDPSLSSKVTIHIDCIMLAHNPGGKERTEQEFKALARASGFQGFQVVCCAFNTYIMEFLKSV
>Sclbi1213S06816_SCLBI
MEDETTESRKKARLAIIELANMISVPMSLNAVVRLNVPDAIWQGGKNTPLSASQILARVLPSGGGDSNNLQRILRVLTSHGVFAEHLNADSHERKYSLTETGRTLVTDSEGLSYAPYVLQHHQDALMRAWPLVHEAVVDPTTEPFVKANGESAYSYYGKKPEMNGLMLKAMSGVSVPFMKAILDGYDGFNGAKRLVDVGGSAGDCLRMIIQKHPNVLEGINFDLPEVVAKAPSIPGVTHVGGDMFNSIPGGDAIFMKWILTTWTDDECKLIMENCCKALPVGGKLIACEPVLPDKSDDSLRTRALLEGDIFVMTIYRAKGKHRTEEEFKQLGVSAGFPHFRAFYIDYFYTVLEFRK
>Sclbi2355S01447_SCLBI
MSSLQDQSKPSNDEEDFLSAMQLANGHVLSMVMKAAVELNLFDIMAKATPSQLSSSEIASHLPTNNQDAPVLIDRILRLLACHSIITCNLATNEDGQVLRLYGITPVCKYFVQNENGGSLASQLVTFHDKAFMESWHCLKEVVLEGGMPIRKAHNGMQFFEYASKDSRLNSLFNQAMYDHTTIVMNKILETYNGFEDLNELVDVAGGIGANLKLIVAKYPQVKGINFDLTHVIENALSCSGVEHVGGDMFVEVPKGKAIFMKMVLHNWGDERCLKILKNCYDALPESGKAIVVDSILPDFPEADLVSQNISILDVAVFTAFPGAKERPKEEFQALATRAGFAAFKVICRVYCYWVIEFYKKTCSSLDQWLNFLLLLKFLSEILSKINF
>Sclbi3387S11502_SCLBI
MSQDHQGVGKLAIGLSNAIVFPMVLKSAIELNLIDIISASVTSPPRTPTRVPFFDRILRLLTSDDILKCSVRTGENGQVERVYGAAPISKFLTKNQDGGSLAPSVLLHHESAKSWYHLNDAILEGGIAFERAHGMKMIECLAMDQRLSRLFNQAMSNHTTLIMKQIVDVYKGFEGLKVLVDVGGGIGISLDIITSKYPHIKGINFDLPHVIADAPSYSSVEHVEGDMFVSVPEGDSIFMKWILHGFSDEDCLKLLKNCWEALPNSGKVIIVEMILPETPDIGISSKIGFTQDSFMMTNAGVGKERTQKEFEALAVKSGFSGCEIRCSAYDSCVMEFCK
>Sclbi3894S18467_SCLBI
MAKASPSQLSYFEIASYVPTENQDAPLIIDRILRVLACHSIMTCNLATNEDGQVLRLYGLAPVCKYFAQKGASLASPLLTFPDKTPCI
>Sclbi12418S06881_SCLBI
MNSVKQQITDSIDNEQEACLDAFLISHCLAFPMVLKAAVELDLFGIIAKAGSGRHVSASKIASQLPTKNPAAPSLLDRMLHLLASHSVLTYSMRTLEDGRFEKLYGLKPASQLFVRDNDGHSFSDAVDMFCHPAALEAWLHMKDAILEETSGDLYKKIHGISRYEYMNNNPSHQNIFNKAMASMSKFTMKGILDVYTGYEGLASLVDVGGGIGQCLHMITSKYPSIKAINFDLPHVTQGAPSYPGIQHIGGDMFSAVPKADAIMLKDVCHNWSDENCIKILRNCYEALPTNGKLIIITQIMREEPESSKSSMFVSRADNAMLTGTSSGKERTAKELENLCKKAGFSNFHIVCSYQGLRFVVECFCRN
>Sclbi60077S03382_SCLBI
MNSLKQQVTDSIDNEQEACLDAFLISHCLAFPMVLKAAIELDLFGIIAKAGSGRHISASEIASQLPTKNPGAPSLLDRMLHLLASHSVLTYSMRTLEDGRFEKLYGLKPASQLFVRDNDGHSFSDAVAMFCHPATLEAWLHMKDAILEETSGDLFKKIHGISRYEYMNNNPSHQNIFNKAMASMSKFTMKGILDVYTGYEGLASLVDVGGGIGQCLHIITSKYPSIKAINFDLPHVTQSAPSYPGIQHTGGDMFSAVPTADAIMLKDVCHNWSDENCIKILKNCYEALPTNGKLIIITQIMREEPESSKSSMFVSRADNAMLTGTSSGKERTAKELENLCKQAGFSNFHIVCSYQGLRFVVECFCRN
>Sclbi60077S03383_SCLBI
MNSVEQQVTDSVNHEQEACLDAFLISHCLAFPMVLKAAVELDLFGIIAKAGSGRHISATEIASQLPTKNPAAPSLLDRMLHLLASHSVFTYSMRTLEDGRLEKLYGLTPASQLFVRDEDGHSFSDAVAMVYHPAPLEAWLHMKDAILEESSGDLFKKIHGTSKYEYMNNNPSHQNIFNKAMASVSKFTMKGILDVYSGYGGLASLVDVGGGIGQCLHMITSKYPFIKAINFDLPHVIKSAPSYPGIQHIGGDMFSAVPTADAIMLKDVCHNWSDENCIKILKNCHEGLPTNGKLIIITQIMREEPESSKYSMLVSRADNTMLAFTSSGKERTAKELEKLCKEAGFSNFQIVCSYQGLRFVVECFK
>Sclbi60077S15657_SCLBI
MLGRMLHLLATHSVLTYSMHTLEDGRAEKLYGLTPASQFLVRDNDTFSLSDTFSMKFHPAILEDAILDETGGDFFKKIHGMSMYEYMNNNPTYKNIFTKTMASMSDFIMKGILDAYTGNEGLASLVDVGGGIGQCLHMITSKYPSIKAFNFDLPHVTQGAPSYPGIQHTGGDMFSAVATADAIMLKNCYEALPTNGKLIIITQIMQEEPESSKYSMIVSRADNTMLSLTSSGKERTAKEQETLCKNAGFSSFQIICAYQGPRFVIECFK
MASSAIRSNEEKDESFAYAIQLVMGSVLPMTLKAAIDLDIFEIIAKAGPGAKLSASEIAVQMSARNKDAPMMVDRILGLLASHSVLTCSVVGFQRLYSLAPVSKYFVRDQTGVSLGPFMALIQDKVPQLKEAVLEGGVPFDRVHGTHAFEYPSLDPRFNKVFNTAMFNHTTIVINEILEVYKGFEKINQLVDVGGGLGITLKAITAKYPHIKAINFDLPHVIEQAPHHPGVEHEGGDMFDSVPKGDAIFMKWILHDWSDEYCLKLLKNCYKSTAKEGKVIVVESILPVMAQVNAASKAISQLDLFMMTQNPGGKERTRSEFMELATAAGFSGITYECFWLYNLVPMSKYCLQPRWPSIGKVNGQTSGQLKEAVLEARVPFDRVHGTHAFKYSGSHSRFNKVFNKAMFNHTSILINNILRFARVLRTSISWLMLVIDGLGSYPQSASISTCLMLYNMPSNMPFSNSLLIIANISQIKDYELKTILCVYLQSTKTTRGTKSFYRSGTRRGRFLKAFQMYPRKWEGIVVEAILPIMPGTNVTSKGTSALDVLMMTQSSGGKERTRHQFMPLADGAGFRGIRFECFVFNYRIMEFYG
>Sclbi438S12777_SCLBI
MMIPQGLRQLKGKDYAADEPKFKNIFYDNMISDSQFVAKVLIENYKRGVQGSVVNVGGSTGTMVEAIAKAFPEIQCTSFDLLHVVDNLQGT
>Sclbi575S13950_SCLBI
MSSLQDQSKPSNDEEDFLSAMQLVNGFVLPMVMKAAVELNLFDIMAKASPSQLSSSEIASHIPTNNQDAPALIDRILRLLACHSIITCDLATNEEGQVLRLYSLTPVCKYFVQNENGASLACPLLTFLDKAFMEPWDYVKEVVLEGGLPFRKAHNGMAFFEYASKDGRLNSLFNQSMYNFTTIVMNKILEIYNGFEDLNELVDVAGGIGANLKLIVAKYPQIKGINFDLPHVIKDAPSCSGVEHVGGDMFVEVPKGEAIFTKTVLHNWGDDQCLKILKNCYNALPESGKVIVVDSMLPDFPETDLVSQNISALDIALFTAHPGAKERTKEEFQALATRAGFAAFKVICRVYCYWVIEFCKMCPA
>Sclbi561S13855_SCLBI
MSGNEEDDDDIHGQYAMQLVSASVLRMVLKSTIELGVLDIIHKAGPGGQLSRSQIAAPLVTQNKPHASLILDQILRLLATTVAKYFIRKQDGGGRCLASLLELIQDKVMLNMWYRLKEAVVEGDIPFNKAYEISAVEYIGKNAKLGEIFKDCMRDFNPIFMQKILEMCKGFDGLKSLLMWVVGMYPNIKAVNYDLRLTIEKSTIYPGINFSLLVIRNVSGDTFVDIPKGEAFFMKLILKNCYEALPINGEVIAVDLVIPEAPEDILSAESFFQLDMFMMNMNSRGKERT
>Sclbi850S16794_SCLBI
MGSAGETQITPTQVSDEEANLFAMQLTSASVLPMVLKSAIELDLLEIIAKAGTGAFVSPKEIASQLPTKNPDAPVMLDRILRLLASYSVLKCSLSNLPDGKVERLYGLGPVCKFLTRNEDGVNIGDLCLMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNNGMSSHSTITMKKILETYKGFEGLKSVVDVGGGIGATLNMIISKYPSIKGINFDLPHVIEDAPSFPGVEHVGGDMFISVPKGDAIFMKWICHDWSDEHCLKFLKNCYEALPDNGKVIVCECILPVTPDPSLSSKVTIHIDCIMLAHNPGGKERTEQEFKALARASGFQGFQVVCCAFNTYIMEFLKSV
>Sclbi1213S06816_SCLBI
MEDETTESRKKARLAIIELANMISVPMSLNAVVRLNVPDAIWQGGKNTPLSASQILARVLPSGGGDSNNLQRILRVLTSHGVFAEHLNADSHERKYSLTETGRTLVTDSEGLSYAPYVLQHHQDALMRAWPLVHEAVVDPTTEPFVKANGESAYSYYGKKPEMNGLMLKAMSGVSVPFMKAILDGYDGFNGAKRLVDVGGSAGDCLRMIIQKHPNVLEGINFDLPEVVAKAPSIPGVTHVGGDMFNSIPGGDAIFMKWILTTWTDDECKLIMENCCKALPVGGKLIACEPVLPDKSDDSLRTRALLEGDIFVMTIYRAKGKHRTEEEFKQLGVSAGFPHFRAFYIDYFYTVLEFRK
>Sclbi2355S01447_SCLBI
MSSLQDQSKPSNDEEDFLSAMQLANGHVLSMVMKAAVELNLFDIMAKATPSQLSSSEIASHLPTNNQDAPVLIDRILRLLACHSIITCNLATNEDGQVLRLYGITPVCKYFVQNENGGSLASQLVTFHDKAFMESWHCLKEVVLEGGMPIRKAHNGMQFFEYASKDSRLNSLFNQAMYDHTTIVMNKILETYNGFEDLNELVDVAGGIGANLKLIVAKYPQVKGINFDLTHVIENALSCSGVEHVGGDMFVEVPKGKAIFMKMVLHNWGDERCLKILKNCYDALPESGKAIVVDSILPDFPEADLVSQNISILDVAVFTAFPGAKERPKEEFQALATRAGFAAFKVICRVYCYWVIEFYKKTCSSLDQWLNFLLLLKFLSEILSKINF
>Sclbi3387S11502_SCLBI
MSQDHQGVGKLAIGLSNAIVFPMVLKSAIELNLIDIISASVTSPPRTPTRVPFFDRILRLLTSDDILKCSVRTGENGQVERVYGAAPISKFLTKNQDGGSLAPSVLLHHESAKSWYHLNDAILEGGIAFERAHGMKMIECLAMDQRLSRLFNQAMSNHTTLIMKQIVDVYKGFEGLKVLVDVGGGIGISLDIITSKYPHIKGINFDLPHVIADAPSYSSVEHVEGDMFVSVPEGDSIFMKWILHGFSDEDCLKLLKNCWEALPNSGKVIIVEMILPETPDIGISSKIGFTQDSFMMTNAGVGKERTQKEFEALAVKSGFSGCEIRCSAYDSCVMEFCK
>Sclbi3894S18467_SCLBI
MAKASPSQLSYFEIASYVPTENQDAPLIIDRILRVLACHSIMTCNLATNEDGQVLRLYGLAPVCKYFAQKGASLASPLLTFPDKTPCI
>Sclbi12418S06881_SCLBI
MNSVKQQITDSIDNEQEACLDAFLISHCLAFPMVLKAAVELDLFGIIAKAGSGRHVSASKIASQLPTKNPAAPSLLDRMLHLLASHSVLTYSMRTLEDGRFEKLYGLKPASQLFVRDNDGHSFSDAVDMFCHPAALEAWLHMKDAILEETSGDLYKKIHGISRYEYMNNNPSHQNIFNKAMASMSKFTMKGILDVYTGYEGLASLVDVGGGIGQCLHMITSKYPSIKAINFDLPHVTQGAPSYPGIQHIGGDMFSAVPKADAIMLKDVCHNWSDENCIKILRNCYEALPTNGKLIIITQIMREEPESSKSSMFVSRADNAMLTGTSSGKERTAKELENLCKKAGFSNFHIVCSYQGLRFVVECFCRN
>Sclbi60077S03382_SCLBI
MNSLKQQVTDSIDNEQEACLDAFLISHCLAFPMVLKAAIELDLFGIIAKAGSGRHISASEIASQLPTKNPGAPSLLDRMLHLLASHSVLTYSMRTLEDGRFEKLYGLKPASQLFVRDNDGHSFSDAVAMFCHPATLEAWLHMKDAILEETSGDLFKKIHGISRYEYMNNNPSHQNIFNKAMASMSKFTMKGILDVYTGYEGLASLVDVGGGIGQCLHIITSKYPSIKAINFDLPHVTQSAPSYPGIQHTGGDMFSAVPTADAIMLKDVCHNWSDENCIKILKNCYEALPTNGKLIIITQIMREEPESSKSSMFVSRADNAMLTGTSSGKERTAKELENLCKQAGFSNFHIVCSYQGLRFVVECFCRN
>Sclbi60077S03383_SCLBI
MNSVEQQVTDSVNHEQEACLDAFLISHCLAFPMVLKAAVELDLFGIIAKAGSGRHISATEIASQLPTKNPAAPSLLDRMLHLLASHSVFTYSMRTLEDGRLEKLYGLTPASQLFVRDEDGHSFSDAVAMVYHPAPLEAWLHMKDAILEESSGDLFKKIHGTSKYEYMNNNPSHQNIFNKAMASVSKFTMKGILDVYSGYGGLASLVDVGGGIGQCLHMITSKYPFIKAINFDLPHVIKSAPSYPGIQHIGGDMFSAVPTADAIMLKDVCHNWSDENCIKILKNCHEGLPTNGKLIIITQIMREEPESSKYSMLVSRADNTMLAFTSSGKERTAKELEKLCKEAGFSNFQIVCSYQGLRFVVECFK
>Sclbi60077S15657_SCLBI
MLGRMLHLLATHSVLTYSMHTLEDGRAEKLYGLTPASQFLVRDNDTFSLSDTFSMKFHPAILEDAILDETGGDFFKKIHGMSMYEYMNNNPTYKNIFTKTMASMSDFIMKGILDAYTGNEGLASLVDVGGGIGQCLHMITSKYPSIKAFNFDLPHVTQGAPSYPGIQHTGGDMFSAVATADAIMLKNCYEALPTNGKLIIITQIMQEEPESSKYSMIVSRADNTMLSLTSSGKERTAKEQETLCKNAGFSSFQIICAYQGPRFVIECFK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University