Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Sclerocarya birrea
Species name
Sclerocarya birrea is a species of eudicot in the family Anacardiaceae (sumac family).
Species info
Gene sequence info
Sclerocarya_birrea.4CL.fa
Download
>Sclbi15S08087_SCLBI
MLTEAVYAEKVKDFAEEHGVKIMPIDSTADQNFFHFIIPDDVVALPYSSGIKGLPRGVMLTHKGLVTSKHQVTIAPFLPPIVLAIAKSPIVDKYDLSSVRMVMSGAAPMGKELEDDVRAKLPNPKLGQKD
>Sclbi57S14101_SCLBI
MEKSGYGHDGIYRSLRPPLVLPKDPNLSMVNFIFRNSSSYQSRLAIIDADSGESLTFSQFKSTLIKVSHSFRHLGIRKNDVVMIYAPNSIQFPICFLGIIAIGAIATTVNPVYTVTELSKQVKDSKPKLVITVPELWDKVNGFNLPAVILGSKEKLSSCDLPSSSKIVYFHELVELSGIVSEFPVVSIKQTDIAALLYSSGTTGTSKGVILTHRNFIAASLTITMDQDIAGETDNVYLCVLPMFHVFGLAVILYSQLQRGNTVLSMGKFDFEMVLRNVEKYKVTYMWVVPPIVLALAKQSLVKKYNLSSLKFIGSGAAPLGKELMEECAKNIPHAVLTQGYGMTETCAIVSVENPYVGVRRSGSAGKLAAGVESKIVSVDTLKPLPPNQLGEIWVRGPNVMQGYLNNKEATMLTIDKEGWLHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPKISDAVVIPFPDAEAGEVPIAYVVRSPNSLLTEDDVKNFIANQVAPFKRLRRVTFINSVPKSVSGKILRRELIENVRSKM
>Sclbi57S14098_SCLBI
MEKSGYGRDGIYRSLRPPLVLPKDPNLSMVNYLFRNSFPYQSRLALIDADSGESLTYSQLKSTVIKISHGFRHLGIKKTDVVLIFAPNSIQYPLCFLGVIAIGGIATTANPVYTVAELSKQIKDSKPKLVVTVPELWDKVKDFSLPAVILGSREKLSSSVLTSNSKIINFHDLIGLSGNVSDFPDVSIKHTDIAALLYSSGTTGTSKGVILTHRNFIAASLMIIMDQDIAGETGNVYLCVLPMFHVFGLAVITYAQLQKGNTVVSMGKFDFEMVLRTIEKYRVSHLWIVPPIVLALAKQSLVKKFDLSSLKQIGSGAAPLGKELMEDCAKNFPHAMVLQGYGMTETCGIVSVENQNASGVRHSGSAGVLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNKQATMLTIDKQGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQIAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPSSSLTEEDVKKFVSSQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVRSKI
>Sclbi306S11108_SCLBI
MEVQAKKQDDIIIYRSKLPDIYIPNHLPLHSYCFQNISEVASRPCLINGTTGDVYTYSEVELTARKIASGLNKLGIQQYEVIMLLLPNTPEFILSFLGASYRGAVATAANPFFTPAEISKQAEASNARLIITQACYVDKVKDLAEKKDVKIMCIDSAPHGCLHFSELTQAEENDLPEVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHNQDVILCVLPLFHIYALNSIMLCGLRAGATILLMQKFEINALLQLIERYKITIAPIVPPIVLSIAKSPDVDKYDLSSIRIIKSGAAPLGKELEDSVRAKFPNATLGQGYGMTEAGPVLAMGLAFAKKPFPIKPGACGTVVRNAEMKIIDPDTGAYLPRNQAGEICIRGDQIMKGYLNDEESTKGTIDDEGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAELEAMLLTHPKISDAAVVPMKDEQAGEVPVAFVVMSNDSQITEDEVKQFISKQVVFYKRIGRVFFIEAIPKAPSGKILRKDLRAKLAAGSPN
>Sclbi394S11981_SCLBI
MEKSGYGRDGIYRSLRPPLVLPKDPNLSMVNCLFRNSFSYQSRLALIDADSGESLAYSQLKSTVVKISHGFRHLGIKKTDVVLIFAPNSIQYPLCFLGVIAIGGIATTANPVYTVAELSKQIKDSKPKLVVTVPELWDKVRDFSLPAVILGSREKLSSSVLTSNSKIINFHDLIGLSGNVSDFPDVSIKQTDIAALLYSSGTTGTSKGVVLTHRNFIAASLMIIMDQDIAGETGNVYLCVLPMFHAFGLAVITYAQLQKGNTVVSMGKFDFEMVLRTIEKYRVSHLWIVPPIVLALAKQSLVKKFDLSSLKQIASGAAPLGKELMEDCAKNFPHAMLLQGYGMTETCGIVSVENPNASGVRHSGSAGVLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNKQATMLTIDKQGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQIAPAELEGLLVSYPEILDAVVIPFPDAEAGEVPISYVVRSPSSSLTEEDVKKFVSSQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVRSKI
>Sclbi1069S06296_SCLBI
MATISFNPKTRIYTSPRPPIQLPTNPNHSFTSFLFHSTSTISHNTALINAETTQTLTFRELKHVTNLAHSLLHLSIAKNDVVLILAPNSIHFPVSFLAIVSIGAIASTCNTTYTMAELSKQNEDCNPKLIIAVPELFHKXTSPTSLTRYFTSASPKTMSFLYWLQTQSTSLFLAIVSIGAIATTCNTAYTMAELSKQNEDCNPKLIITVPELFHKVKHFNLPLIFLTNSHSKILHDSKIYYFSELIKRNSNQLPVNVTQNDTAVLLYSSGTTGTSKGVVLTHKNLIATSIIWTVDQDRYSEPKNVFLCFLRMFHVFGLLMATLVQLRRGNAVVSMEKFELKKALKLVEKYRVTYICVVPIVVIALAKNPSVVKEYDTSSLKVILSGAAPMGKDVMDDCAKNLPHVDIIQGYGLTEASGAVSQENRKEEAGLAGSTGTLLPGVEAQIVSTHMLNPLPPNQRGQIRLRGTPIMQGYLNNPLAAKQIINEEGWLHTGDIGYFNEEGQLYVVDRIKELIKCYGFQVAPSELEGLLLSHSEILDAAVIPFPDAKAGEVPIAFVVRSSNSSLTEQDIQKFIAKQVAPFKRLRKSPKSASGKILRRELMKKVQSKI
>Sclbi1719S08498_SCLBI
MEGEQHHQDFIFRSKLPDIYIPNHLPLHTYCFEHVSQFGDRPCIINGPTGEIYSYSDVELTARKVAAGLSKLGINQGDVIMLLLQNCCEFVYAFLGASNIGAISTTANPFYTPAEIAKQAAASKAKLIITQAVYAEKVKDFAEEHGVKIMTIDSAADQNFLHFVELTQADENEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHKEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMQKFEIVTLMELVQKHKVTIAPFVPPIVLSIAKSPIVDKYDLSSVRMVMSGAAPMGKELEDDVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGISLPRHQSGEICIRGSQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHANISDAAVVPMKDEVAGEVPVAFVVRSNGSKITEDEIKQYISKQVIFYKRINRVFFTEAIPKAPSGKILRKDLRAKLAAGVPN
>Sclbi2805S10629_SCLBI
MEMERSHEEHIFRSRYPGVQVPDKMTLPEFVLQEAELYAERVAFVEAVSGKAYTYAEVVRDVKRFAKALRSLELRKGRVVIVVLPNVAEYGIVALGIMAAGGVFSGANPTAHVSELEKQVKAADAKLIVTNGTIYEKVKGLGLPVIVVGDERIESAINWSELLEAADRASNNFITEDVQQTDLCALPFSSGTTGMSKGVMLTHRNLVANLCSTLFSVGPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVMMNRFELRTFLNALITHEVTFAPIVPPIILALVKNPIVEEFDLTKLKLRAVMTAAAPLAPELLHAFEKKFPGIQVQEAYGLTEHSCITLTHGDPSKNHGTAKKNSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVRSQCVMQGYYNNEEETSRTIDKNGWLHTGDIGHIDDDGHIFIVDRIKELIKYKGFQVAPAELEAILLSHPSIEDAAVVPLPDEEAGEIPAACVVMSTNSKESEEDIVNYVASNVAHYKKVRVLQFVDTIPKSPSGKIMRRLLKEKMVEKMRSKVQGHS
>Sclbi59922S14747_SCLBI
MISVANSLEAAQKPELSPTISPPSNENKVDHVFKSKLPEIPISNHLPLHTYCFENLSAFADNPCLVVGSTGKTYSFAETHLICRRTAAGLMNLGIKKGDVIMILLQNCAEFVFSFMGASMIGAVTTTANPFYTSAEIFKQFNVSRAKLIITQSQYVDKLRDSENFQKIREDFTVITVDEPPENCIHFTTLSEANENQIPDVSIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKNDDMVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIRTLLELIQRHKVSVAAVVPPLVLALAKNPMVAEFDLSSIRVVLSGAAPLGKELEGALRSRVPQATLGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGSQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDEEIFIVDRVKEIIKFKGFQVPPAELEALLINHSSIADAAVVPQKDEVAGEVPVAFVVRTNDLELNEEAVKEYIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLATPSPLP
MLTEAVYAEKVKDFAEEHGVKIMPIDSTADQNFFHFIIPDDVVALPYSSGIKGLPRGVMLTHKGLVTSKHQVTIAPFLPPIVLAIAKSPIVDKYDLSSVRMVMSGAAPMGKELEDDVRAKLPNPKLGQKD
>Sclbi57S14101_SCLBI
MEKSGYGHDGIYRSLRPPLVLPKDPNLSMVNFIFRNSSSYQSRLAIIDADSGESLTFSQFKSTLIKVSHSFRHLGIRKNDVVMIYAPNSIQFPICFLGIIAIGAIATTVNPVYTVTELSKQVKDSKPKLVITVPELWDKVNGFNLPAVILGSKEKLSSCDLPSSSKIVYFHELVELSGIVSEFPVVSIKQTDIAALLYSSGTTGTSKGVILTHRNFIAASLTITMDQDIAGETDNVYLCVLPMFHVFGLAVILYSQLQRGNTVLSMGKFDFEMVLRNVEKYKVTYMWVVPPIVLALAKQSLVKKYNLSSLKFIGSGAAPLGKELMEECAKNIPHAVLTQGYGMTETCAIVSVENPYVGVRRSGSAGKLAAGVESKIVSVDTLKPLPPNQLGEIWVRGPNVMQGYLNNKEATMLTIDKEGWLHTGDLGYFDGDGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPKISDAVVIPFPDAEAGEVPIAYVVRSPNSLLTEDDVKNFIANQVAPFKRLRRVTFINSVPKSVSGKILRRELIENVRSKM
>Sclbi57S14098_SCLBI
MEKSGYGRDGIYRSLRPPLVLPKDPNLSMVNYLFRNSFPYQSRLALIDADSGESLTYSQLKSTVIKISHGFRHLGIKKTDVVLIFAPNSIQYPLCFLGVIAIGGIATTANPVYTVAELSKQIKDSKPKLVVTVPELWDKVKDFSLPAVILGSREKLSSSVLTSNSKIINFHDLIGLSGNVSDFPDVSIKHTDIAALLYSSGTTGTSKGVILTHRNFIAASLMIIMDQDIAGETGNVYLCVLPMFHVFGLAVITYAQLQKGNTVVSMGKFDFEMVLRTIEKYRVSHLWIVPPIVLALAKQSLVKKFDLSSLKQIGSGAAPLGKELMEDCAKNFPHAMVLQGYGMTETCGIVSVENQNASGVRHSGSAGVLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNKQATMLTIDKQGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQIAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPSSSLTEEDVKKFVSSQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVRSKI
>Sclbi306S11108_SCLBI
MEVQAKKQDDIIIYRSKLPDIYIPNHLPLHSYCFQNISEVASRPCLINGTTGDVYTYSEVELTARKIASGLNKLGIQQYEVIMLLLPNTPEFILSFLGASYRGAVATAANPFFTPAEISKQAEASNARLIITQACYVDKVKDLAEKKDVKIMCIDSAPHGCLHFSELTQAEENDLPEVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHNQDVILCVLPLFHIYALNSIMLCGLRAGATILLMQKFEINALLQLIERYKITIAPIVPPIVLSIAKSPDVDKYDLSSIRIIKSGAAPLGKELEDSVRAKFPNATLGQGYGMTEAGPVLAMGLAFAKKPFPIKPGACGTVVRNAEMKIIDPDTGAYLPRNQAGEICIRGDQIMKGYLNDEESTKGTIDDEGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAELEAMLLTHPKISDAAVVPMKDEQAGEVPVAFVVMSNDSQITEDEVKQFISKQVVFYKRIGRVFFIEAIPKAPSGKILRKDLRAKLAAGSPN
>Sclbi394S11981_SCLBI
MEKSGYGRDGIYRSLRPPLVLPKDPNLSMVNCLFRNSFSYQSRLALIDADSGESLAYSQLKSTVVKISHGFRHLGIKKTDVVLIFAPNSIQYPLCFLGVIAIGGIATTANPVYTVAELSKQIKDSKPKLVVTVPELWDKVRDFSLPAVILGSREKLSSSVLTSNSKIINFHDLIGLSGNVSDFPDVSIKQTDIAALLYSSGTTGTSKGVVLTHRNFIAASLMIIMDQDIAGETGNVYLCVLPMFHAFGLAVITYAQLQKGNTVVSMGKFDFEMVLRTIEKYRVSHLWIVPPIVLALAKQSLVKKFDLSSLKQIASGAAPLGKELMEDCAKNFPHAMLLQGYGMTETCGIVSVENPNASGVRHSGSAGVLVAGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNKQATMLTIDKQGWVHTGDLGYFDGDGQLYVVDRIKELIKYKGFQIAPAELEGLLVSYPEILDAVVIPFPDAEAGEVPISYVVRSPSSSLTEEDVKKFVSSQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVRSKI
>Sclbi1069S06296_SCLBI
MATISFNPKTRIYTSPRPPIQLPTNPNHSFTSFLFHSTSTISHNTALINAETTQTLTFRELKHVTNLAHSLLHLSIAKNDVVLILAPNSIHFPVSFLAIVSIGAIASTCNTTYTMAELSKQNEDCNPKLIIAVPELFHKXTSPTSLTRYFTSASPKTMSFLYWLQTQSTSLFLAIVSIGAIATTCNTAYTMAELSKQNEDCNPKLIITVPELFHKVKHFNLPLIFLTNSHSKILHDSKIYYFSELIKRNSNQLPVNVTQNDTAVLLYSSGTTGTSKGVVLTHKNLIATSIIWTVDQDRYSEPKNVFLCFLRMFHVFGLLMATLVQLRRGNAVVSMEKFELKKALKLVEKYRVTYICVVPIVVIALAKNPSVVKEYDTSSLKVILSGAAPMGKDVMDDCAKNLPHVDIIQGYGLTEASGAVSQENRKEEAGLAGSTGTLLPGVEAQIVSTHMLNPLPPNQRGQIRLRGTPIMQGYLNNPLAAKQIINEEGWLHTGDIGYFNEEGQLYVVDRIKELIKCYGFQVAPSELEGLLLSHSEILDAAVIPFPDAKAGEVPIAFVVRSSNSSLTEQDIQKFIAKQVAPFKRLRKSPKSASGKILRRELMKKVQSKI
>Sclbi1719S08498_SCLBI
MEGEQHHQDFIFRSKLPDIYIPNHLPLHTYCFEHVSQFGDRPCIINGPTGEIYSYSDVELTARKVAAGLSKLGINQGDVIMLLLQNCCEFVYAFLGASNIGAISTTANPFYTPAEIAKQAAASKAKLIITQAVYAEKVKDFAEEHGVKIMTIDSAADQNFLHFVELTQADENEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHKEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMQKFEIVTLMELVQKHKVTIAPFVPPIVLSIAKSPIVDKYDLSSVRMVMSGAAPMGKELEDDVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGISLPRHQSGEICIRGSQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHANISDAAVVPMKDEVAGEVPVAFVVRSNGSKITEDEIKQYISKQVIFYKRINRVFFTEAIPKAPSGKILRKDLRAKLAAGVPN
>Sclbi2805S10629_SCLBI
MEMERSHEEHIFRSRYPGVQVPDKMTLPEFVLQEAELYAERVAFVEAVSGKAYTYAEVVRDVKRFAKALRSLELRKGRVVIVVLPNVAEYGIVALGIMAAGGVFSGANPTAHVSELEKQVKAADAKLIVTNGTIYEKVKGLGLPVIVVGDERIESAINWSELLEAADRASNNFITEDVQQTDLCALPFSSGTTGMSKGVMLTHRNLVANLCSTLFSVGPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVMMNRFELRTFLNALITHEVTFAPIVPPIILALVKNPIVEEFDLTKLKLRAVMTAAAPLAPELLHAFEKKFPGIQVQEAYGLTEHSCITLTHGDPSKNHGTAKKNSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVRSQCVMQGYYNNEEETSRTIDKNGWLHTGDIGHIDDDGHIFIVDRIKELIKYKGFQVAPAELEAILLSHPSIEDAAVVPLPDEEAGEIPAACVVMSTNSKESEEDIVNYVASNVAHYKKVRVLQFVDTIPKSPSGKIMRRLLKEKMVEKMRSKVQGHS
>Sclbi59922S14747_SCLBI
MISVANSLEAAQKPELSPTISPPSNENKVDHVFKSKLPEIPISNHLPLHTYCFENLSAFADNPCLVVGSTGKTYSFAETHLICRRTAAGLMNLGIKKGDVIMILLQNCAEFVFSFMGASMIGAVTTTANPFYTSAEIFKQFNVSRAKLIITQSQYVDKLRDSENFQKIREDFTVITVDEPPENCIHFTTLSEANENQIPDVSIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKNDDMVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIRTLLELIQRHKVSVAAVVPPLVLALAKNPMVAEFDLSSIRVVLSGAAPLGKELEGALRSRVPQATLGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGSQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDEEIFIVDRVKEIIKFKGFQVPPAELEALLINHSSIADAAVVPQKDEVAGEVPVAFVVRTNDLELNEEAVKEYIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLATPSPLP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University